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Protein

Uncharacterized protein C1orf112

Gene

C1orf112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf112
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000000460.16.
HGNCiHGNC:25565. C1orf112.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55732.
OpenTargetsiENSG00000000460.
PharmGKBiPA142672496.

Polymorphism and mutation databases

BioMutaiC1orf112.
DMDMi74761679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794611 – 853Uncharacterized protein C1orf112Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1
Modified residuei792N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NSG2.
MaxQBiQ9NSG2.
PaxDbiQ9NSG2.
PeptideAtlasiQ9NSG2.
PRIDEiQ9NSG2.

PTM databases

iPTMnetiQ9NSG2.
PhosphoSitePlusiQ9NSG2.

Expressioni

Gene expression databases

BgeeiENSG00000000460.
CleanExiHS_C1orf112.
ExpressionAtlasiQ9NSG2. baseline and differential.
GenevisibleiQ9NSG2. HS.

Organism-specific databases

HPAiHPA023778.
HPA024451.

Interactioni

Protein-protein interaction databases

BioGridi120851. 31 interactors.
IntActiQ9NSG2. 6 interactors.
STRINGi9606.ENSP00000286031.

Structurei

3D structure databases

ProteinModelPortaliQ9NSG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEFN. Eukaryota.
ENOG4110VTC. LUCA.
GeneTreeiENSGT00390000004791.
HOGENOMiHOG000111244.
HOVERGENiHBG080966.
InParanoidiQ9NSG2.
OMAiYGTAELC.
OrthoDBiEOG091G0IIK.
PhylomeDBiQ9NSG2.
TreeFamiTF328571.

Family and domain databases

InterProiView protein in InterPro
IPR027902. DUF4487.
PfamiView protein in Pfam
PF14868. DUF4487. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLPHMNHLT LEQTFFSQVL PKTVKLFDDM MYELTSQARG LSSQNLEIQT
60 70 80 90 100
TLRNILQTMV QLLGALTGCV QHICATQESI ILENIQSLPS SVLHIIKSTF
110 120 130 140 150
VHCKNSESVY SGCLHLVSDL LQALFKEAYS LQKQLMELLD MVCMDPLVDD
160 170 180 190 200
NDDILNMVIV IHSLLDICSV ISSMDHAFHA NTWKFIIKQS LKHQSIIKSQ
210 220 230 240 250
LKHKDIITSL CEDILFSFHS CLQLAEQMTQ SDAQDNADYR LFQKTLKLCR
260 270 280 290 300
FFANSLLHYA KEFLPFLSDS CCTLHQLYLQ IHSKFPPSLY ATRISKAHQE
310 320 330 340 350
EIAGAFLVTL DPLISQLLTF QPFMQVVLDS KLDLPCELQF PQCLLLVVVM
360 370 380 390 400
DKLPSQPKEV QTLWCTDSQV SETTTRISLL KAVFYSFEQC SGELSLPVHL
410 420 430 440 450
QGLKSKGKAE VAVTLYQHVC VHLCTFITSF HPSLFAELDA ALLNAVLSAN
460 470 480 490 500
MITSLLAMDA WCFLARYGTA ELCAHHVTIV AHLIKSCPGE CYQLINLSIL
510 520 530 540 550
LKRLFFFMAP PHQLEFIQKF SPKEAENLPL WQHISFQALP PELREQTVHE
560 570 580 590 600
VTTVGTAECR KWLSRSRTLG ELESLNTVLS ALLAVCNSAG EALDTGKQTA
610 620 630 640 650
IIEVVSQLWA FLNIKQVADQ PYVQQTFSLL LPLLGFFIQT LDPKLILQAV
660 670 680 690 700
TLQTSLLKLE LPDYVRLAML DFVSSLGKLF IPEAIQDRIL PNLSCMFALL
710 720 730 740 750
LADRSWLLEQ HTLEAFTQFA EGTNHEEIVP QCLSSEETKN KVVSFLEKTG
760 770 780 790 800
FVDETEAAKV ERVKQEKGIF WEPFANVTVE EAKRSSLQPY AKRARQEFPW
810 820 830 840 850
EEEYRSALHT IAGALEATES LLQKGPAPAW LSMEMEALQE RMDKLKRYIH

TLG
Length:853
Mass (Da):96,554
Last modified:October 1, 2000 - v1
Checksum:iE7FCA875C87052B1
GO
Isoform 2 (identifier: Q9NSG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:718
Mass (Da):81,317
Checksum:i57D3D29E04065B56
GO
Isoform 3 (identifier: Q9NSG2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Show »
Length:530
Mass (Da):59,697
Checksum:iDAF923C6DC39C8DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti594D → G in BAB14600 (PubMed:14702039).Curated1
Sequence conflicti655S → L in BAA91761 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030906481A → S. Corresponds to variant dbSNP:rs2272920Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234441 – 323Missing in isoform 3. 2 PublicationsAdd BLAST323
Alternative sequenceiVSP_0234451 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354614 mRNA. Translation: CAB89727.1.
AK001568 mRNA. Translation: BAA91761.1.
AK023532 mRNA. Translation: BAB14600.1.
AK096493 mRNA. Translation: BAG53304.1.
AL031297, AL021940 Genomic DNA. Translation: CAI23519.1.
AL021940, AL031297 Genomic DNA. Translation: CAI19363.1.
CH471067 Genomic DNA. Translation: EAW90863.1.
BC091516 mRNA. Translation: AAH91516.1.
BC107168 mRNA. Translation: AAI07169.1.
BC107169 mRNA. Translation: AAI07170.1.
CCDSiCCDS1285.1. [Q9NSG2-1]
RefSeqiNP_001306976.1. NM_001320047.1. [Q9NSG2-1]
NP_001306977.1. NM_001320048.1. [Q9NSG2-2]
NP_001306979.1. NM_001320050.1.
NP_001306980.1. NM_001320051.1.
NP_060656.2. NM_018186.3. [Q9NSG2-1]
XP_011508037.1. XM_011509735.2. [Q9NSG2-3]
XP_016857213.1. XM_017001724.1. [Q9NSG2-3]
XP_016857214.1. XM_017001725.1. [Q9NSG2-3]
UniGeneiHs.443551.

Genome annotation databases

EnsembliENST00000286031; ENSP00000286031; ENSG00000000460. [Q9NSG2-1]
ENST00000359326; ENSP00000352276; ENSG00000000460. [Q9NSG2-1]
ENST00000413811; ENSP00000389257; ENSG00000000460. [Q9NSG2-3]
GeneIDi55732.
KEGGihsa:55732.
UCSCiuc001ggp.4. human. [Q9NSG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCA112_HUMAN
AccessioniPrimary (citable) accession number: Q9NSG2
Secondary accession number(s): A6NFP1
, B3KU42, Q3KNQ1, Q9H8L5, Q9NVJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations