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Q9NSE2

- CISH_HUMAN

UniProt

Q9NSE2 - CISH_HUMAN

Protein

Cytokine-inducible SH2-containing protein

Gene

CISH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. JAK-STAT cascade involved in growth hormone signaling pathway Source: Reactome
    3. negative regulation of signal transduction Source: UniProtKB-KW
    4. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    5. protein ubiquitination Source: UniProtKB-UniPathway
    6. regulation of cell growth Source: UniProtKB

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Growth regulation, Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_111133. Growth hormone receptor signaling.
    SignaLinkiQ9NSE2.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine-inducible SH2-containing protein
    Short name:
    CIS
    Alternative name(s):
    CIS-1
    Protein G18
    Suppressor of cytokine signaling
    Short name:
    SOCS
    Gene namesi
    Name:CISH
    Synonyms:G18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1984. CISH.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    MIMi607948. phenotype.
    611162. phenotype.
    614383. phenotype.
    PharmGKBiPA26521.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Cytokine-inducible SH2-containing proteinPRO_0000181231Add
    BLAST

    Post-translational modificationi

    Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9NSE2.
    PaxDbiQ9NSE2.
    PRIDEiQ9NSE2.

    PTM databases

    PhosphoSiteiQ9NSE2.

    Expressioni

    Tissue specificityi

    Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.1 Publication

    Inductioni

    By a subset of cytokines including EPO/erythropoietin.

    Gene expression databases

    ArrayExpressiQ9NSE2.
    BgeeiQ9NSE2.
    CleanExiHS_CISH.
    GenevestigatoriQ9NSE2.

    Organism-specific databases

    HPAiCAB034039.
    HPA040812.

    Interactioni

    Subunit structurei

    Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046264EBI-617866,EBI-641062

    Protein-protein interaction databases

    BioGridi107574. 21 interactions.
    IntActiQ9NSE2. 9 interactions.
    MINTiMINT-1191268.
    STRINGi9606.ENSP00000409346.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSE2.
    SMRiQ9NSE2. Positions 61-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 16382SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini209 – 25749SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG301272.
    HOGENOMiHOG000236320.
    HOVERGENiHBG002457.
    InParanoidiQ9NSE2.
    KOiK04701.
    OMAiEYADSKF.
    OrthoDBiEOG71RXKX.
    PhylomeDBiQ9NSE2.
    TreeFamiTF321368.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    InterProiIPR028425. CIS.
    IPR000980. SH2.
    IPR028413. SOCS.
    IPR001496. SOCS_C.
    [Graphical view]
    PANTHERiPTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF7. PTHR10385:SF7. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSE2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT    50
    PAQTESEPKV LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP 100
    EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI 150
    LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPMPKED APSDPALPAP 200
    PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC LPLPRRMADY 250
    LRQYPFQL 258
    Length:258
    Mass (Da):28,663
    Last modified:October 1, 2000 - v1
    Checksum:i0BA97804E3B0F608
    GO
    Isoform 1B (identifier: Q9NSE2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MVLCVQG → MGPPLTAHPLPSR

    Show »
    Length:264
    Mass (Da):29,288
    Checksum:i0C1C5791EAFE56DC
    GO
    Isoform 1C (identifier: Q9NSE2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MVLCVQG → MYLEHTSHCPHHDDDTAMDTPLPR

    Show »
    Length:275
    Mass (Da):30,734
    Checksum:i6F9A0020F2D27A19
    GO

    Sequence cautioni

    The sequence AAD28471.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Polymorphismi

    Note: CISH polymorphisms are involved in susceptibilty to malaria [MIMi:611162].
    Note: Genetic variations in CISH are involved in susceptibilty to tuberculosis [MIMi:607948].
    Note: Genetic variations in CISH are associated with susceptibility to bacterial invasion of the blood and define the bacteremia susceptibility locus 2 (BACTS2) [MIMi:614383].

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 77MVLCVQG → MGPPLTAHPLPSR in isoform 1B. 1 PublicationVSP_006194
    Alternative sequencei1 – 77MVLCVQG → MYLEHTSHCPHHDDDTAMDT PLPR in isoform 1C. 1 PublicationVSP_006195

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83532 mRNA. Translation: BAA92328.1.
    AF035947 mRNA. Translation: AAF97410.1.
    AF132297 mRNA. Translation: AAD28471.2. Different initiation.
    AK313850 mRNA. Translation: BAG36578.1.
    AC096920 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65128.1.
    CH471055 Genomic DNA. Translation: EAW65129.1.
    BC031590 mRNA. Translation: AAH31590.1.
    BC064354 mRNA. Translation: AAH64354.1.
    CCDSiCCDS2831.1. [Q9NSE2-1]
    CCDS46834.1. [Q9NSE2-3]
    PIRiJC7512.
    RefSeqiNP_037456.5. NM_013324.5. [Q9NSE2-3]
    NP_659508.1. NM_145071.2. [Q9NSE2-1]
    XP_005264903.1. XM_005264846.2. [Q9NSE2-3]
    UniGeneiHs.655334.

    Genome annotation databases

    EnsembliENST00000348721; ENSP00000294173; ENSG00000114737. [Q9NSE2-1]
    ENST00000443053; ENSP00000409346; ENSG00000114737. [Q9NSE2-3]
    GeneIDi1154.
    KEGGihsa:1154.
    UCSCiuc003dax.3. human. [Q9NSE2-1]
    uc010hlq.3. human.

    Polymorphism databases

    DMDMi13124022.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83532 mRNA. Translation: BAA92328.1 .
    AF035947 mRNA. Translation: AAF97410.1 .
    AF132297 mRNA. Translation: AAD28471.2 . Different initiation.
    AK313850 mRNA. Translation: BAG36578.1 .
    AC096920 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65128.1 .
    CH471055 Genomic DNA. Translation: EAW65129.1 .
    BC031590 mRNA. Translation: AAH31590.1 .
    BC064354 mRNA. Translation: AAH64354.1 .
    CCDSi CCDS2831.1. [Q9NSE2-1 ]
    CCDS46834.1. [Q9NSE2-3 ]
    PIRi JC7512.
    RefSeqi NP_037456.5. NM_013324.5. [Q9NSE2-3 ]
    NP_659508.1. NM_145071.2. [Q9NSE2-1 ]
    XP_005264903.1. XM_005264846.2. [Q9NSE2-3 ]
    UniGenei Hs.655334.

    3D structure databases

    ProteinModelPortali Q9NSE2.
    SMRi Q9NSE2. Positions 61-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107574. 21 interactions.
    IntActi Q9NSE2. 9 interactions.
    MINTi MINT-1191268.
    STRINGi 9606.ENSP00000409346.

    PTM databases

    PhosphoSitei Q9NSE2.

    Polymorphism databases

    DMDMi 13124022.

    Proteomic databases

    MaxQBi Q9NSE2.
    PaxDbi Q9NSE2.
    PRIDEi Q9NSE2.

    Protocols and materials databases

    DNASUi 1154.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348721 ; ENSP00000294173 ; ENSG00000114737 . [Q9NSE2-1 ]
    ENST00000443053 ; ENSP00000409346 ; ENSG00000114737 . [Q9NSE2-3 ]
    GeneIDi 1154.
    KEGGi hsa:1154.
    UCSCi uc003dax.3. human. [Q9NSE2-1 ]
    uc010hlq.3. human.

    Organism-specific databases

    CTDi 1154.
    GeneCardsi GC03M050618.
    HGNCi HGNC:1984. CISH.
    HPAi CAB034039.
    HPA040812.
    MIMi 602441. gene.
    607948. phenotype.
    611162. phenotype.
    614383. phenotype.
    neXtProti NX_Q9NSE2.
    PharmGKBi PA26521.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301272.
    HOGENOMi HOG000236320.
    HOVERGENi HBG002457.
    InParanoidi Q9NSE2.
    KOi K04701.
    OMAi EYADSKF.
    OrthoDBi EOG71RXKX.
    PhylomeDBi Q9NSE2.
    TreeFami TF321368.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_111133. Growth hormone receptor signaling.
    SignaLinki Q9NSE2.

    Miscellaneous databases

    GeneWikii CISH.
    GenomeRNAii 1154.
    NextBioi 4792.
    PROi Q9NSE2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSE2.
    Bgeei Q9NSE2.
    CleanExi HS_CISH.
    Genevestigatori Q9NSE2.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    InterProi IPR028425. CIS.
    IPR000980. SH2.
    IPR028413. SOCS.
    IPR001496. SOCS_C.
    [Graphical view ]
    PANTHERi PTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF7. PTHR10385:SF7. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues."
      Uchida K., Yoshimura A., Inazawa J., Yanagisawa K., Osada H., Masuda A., Saito T., Takahashi T., Miyajima A., Takahashi K.
      Cytogenet. Cell Genet. 78:209-212(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal lung.
    2. "Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene."
      Jiang C., Yu L., Zhao Y., Zhang M., Liu Q., Mao N., Geng Z., Zhao S.
      DNA Seq. 11:149-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1B).
      Tissue: Placenta.
    3. "The human G18 is an ortholog of the rodent gene CIS-2 and is located in 3p21.3 and homozygously deleted in lung cancer."
      Wei M.-H., Minna J.D., Lerman M.I.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C).
    4. "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF."
      Yousefi S., Cooper P.R., Mueck B., Potter S.L., Jarai G.
      Biochem. Biophys. Res. Commun. 277:401-409(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon and Skin.
    9. "Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein."
      Verdier F., Chretien S., Muller O., Varlet P., Yoshimura A., Gisselbrecht S., Lacombe C., Mayeux P.
      J. Biol. Chem. 273:28185-28190(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPOR, UBIQUITINATION.
    10. Cited for: POLYMORPHISM, INVOLVEMENT IN SUSCEPTIBILITY TO TUBERCULOSIS; MALARIA AND BACTS2.

    Entry informationi

    Entry nameiCISH_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSE2
    Secondary accession number(s): B2R9N1
    , G5E9R1, Q9NS38, Q9Y5R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3