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Protein

Relaxin-3 receptor 1

Gene

RXFP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.1 Publication

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3 receptor 1
Short name:
RLN3 receptor 1
Alternative name(s):
G protein-coupled receptor SALPR
G-protein coupled receptor GPCR135
Relaxin family peptide receptor 3
Somatostatin- and angiotensin-like peptide receptor
Gene namesi
Name:RXFP3
Synonyms:RLN3R1, SALPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24883. RXFP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini103 – 11917CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini141 – 15616ExtracellularSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini178 – 21538CytoplasmicSequence analysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini237 – 27034ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini292 – 32938CytoplasmicSequence analysisAdd
BLAST
Transmembranei330 – 35021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini351 – 3566ExtracellularSequence analysis
Transmembranei357 – 37721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini378 – 46992CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868535.

Chemistry

ChEMBLiCHEMBL1628472.
GuidetoPHARMACOLOGYi353.

Polymorphism and mutation databases

BioMutaiRXFP3.
DMDMi20455271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Relaxin-3 receptor 1PRO_0000070104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 247PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NSD7.
PeptideAtlasiQ9NSD7.
PRIDEiQ9NSD7.

PTM databases

iPTMnetiQ9NSD7.

Expressioni

Tissue specificityi

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

Gene expression databases

BgeeiQ9NSD7.
CleanExiHS_RXFP3.
GenevisibleiQ9NSD7. HS.

Organism-specific databases

HPAiHPA027833.

Interactioni

Protein-protein interaction databases

BioGridi119440. 2 interactions.
STRINGi9606.ENSP00000328708.

Chemistry

BindingDBiQ9NSD7.

Structurei

3D structure databases

ProteinModelPortaliQ9NSD7.
SMRiQ9NSD7. Positions 82-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ9NSD7.
KOiK08397.
OMAiWVVCALG.
OrthoDBiEOG7BP82T.
PhylomeDBiQ9NSD7.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW
60 70 80 90 100
ELGLELPDGA PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL
110 120 130 140 150
LVLYLMKSMQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF
160 170 180 190 200
GKAMCKIVSM VTSMNMYASV FFLTAMSVTR YHSVASALKS HRTRGHGRGD
210 220 230 240 250
CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK VMGEELCLVR
260 270 280 290 300
FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA
310 320 330 340 350
GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI
360 370 380 390 400
LIKFNAVPFS QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL
410 420 430 440 450
KSLLWRIASP SITSMRPFTA TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP
460
GVVVYSGGRY DLLPSSSAY
Length:469
Mass (Da):51,124
Last modified:October 1, 2000 - v1
Checksum:i932E7B3001689F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88437 mRNA. Translation: BAA93001.1.
AY236541 Genomic DNA. Translation: AAO92063.1.
AY394501 mRNA. Translation: AAQ92315.1.
BC113438 mRNA. Translation: AAI13439.1.
BC113440 mRNA. Translation: AAI13441.1.
CCDSiCCDS3900.1.
RefSeqiNP_057652.1. NM_016568.3.
UniGeneiHs.170146.

Genome annotation databases

EnsembliENST00000330120; ENSP00000328708; ENSG00000182631.
ENST00000616205; ENSP00000480733; ENSG00000277069.
GeneIDi51289.
KEGGihsa:51289.
UCSCiuc003jic.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88437 mRNA. Translation: BAA93001.1.
AY236541 Genomic DNA. Translation: AAO92063.1.
AY394501 mRNA. Translation: AAQ92315.1.
BC113438 mRNA. Translation: AAI13439.1.
BC113440 mRNA. Translation: AAI13441.1.
CCDSiCCDS3900.1.
RefSeqiNP_057652.1. NM_016568.3.
UniGeneiHs.170146.

3D structure databases

ProteinModelPortaliQ9NSD7.
SMRiQ9NSD7. Positions 82-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119440. 2 interactions.
STRINGi9606.ENSP00000328708.

Chemistry

BindingDBiQ9NSD7.
ChEMBLiCHEMBL1628472.
GuidetoPHARMACOLOGYi353.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NSD7.

Polymorphism and mutation databases

BioMutaiRXFP3.
DMDMi20455271.

Proteomic databases

PaxDbiQ9NSD7.
PeptideAtlasiQ9NSD7.
PRIDEiQ9NSD7.

Protocols and materials databases

DNASUi51289.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330120; ENSP00000328708; ENSG00000182631.
ENST00000616205; ENSP00000480733; ENSG00000277069.
GeneIDi51289.
KEGGihsa:51289.
UCSCiuc003jic.3. human.

Organism-specific databases

CTDi51289.
GeneCardsiRXFP3.
HGNCiHGNC:24883. RXFP3.
HPAiHPA027833.
MIMi609445. gene.
neXtProtiNX_Q9NSD7.
PharmGKBiPA134868535.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ9NSD7.
KOiK08397.
OMAiWVVCALG.
OrthoDBiEOG7BP82T.
PhylomeDBiQ9NSD7.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444821. Relaxin receptors.

Miscellaneous databases

GeneWikiiRelaxin/insulin-like_family_peptide_receptor_3.
GenomeRNAii51289.
PROiQ9NSD7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NSD7.
CleanExiHS_RXFP3.
GenevisibleiQ9NSD7. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors."
    Matsumoto M., Kamohara M., Sugimoto T., Hidaka K., Takasaki J., Saito T., Okada M., Yamaguchi T., Furuichi K.
    Gene 248:183-189(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135."
    Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., Joernvall H., Sillard R., Lovenberg T.W.
    J. Biol. Chem. 278:50754-50764(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS A RECEPTOR FOR RLN3.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiRL3R1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSD7
Secondary accession number(s): Q14DA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.