Q9NSD7 (RL3R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Relaxin-3 receptor 1
Short name=RLN3 receptor 1

Alternative name(s):
G protein-coupled receptor SALPR
G-protein coupled receptor GPCR135
Relaxin family peptide receptor 3
Somatostatin- and angiotensin-like peptide receptor

Gene names

Name:	RXFP3
Synonyms:	RLN3R1, SALPR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Relaxin-3 receptor 1		PRO_0000070104
Regions
	Topological domain	1 – 81	81	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Name=1; Potential
	Topological domain	103 – 119	17	Cytoplasmic Potential
	Transmembrane	120 – 140	21	Helical; Name=2; Potential
	Topological domain	141 – 156	16	Extracellular Potential
	Transmembrane	157 – 177	21	Helical; Name=3; Potential
	Topological domain	178 – 215	38	Cytoplasmic Potential
	Transmembrane	216 – 236	21	Helical; Name=4; Potential
	Topological domain	237 – 270	34	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Name=5; Potential
	Topological domain	292 – 329	38	Cytoplasmic Potential
	Transmembrane	330 – 350	21	Helical; Name=6; Potential
	Topological domain	351 – 356	6	Extracellular Potential
	Transmembrane	357 – 377	21	Helical; Name=7; Potential
	Topological domain	378 – 469	92	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Disulfide bond	155 ↔ 247		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NSD7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 932E7B3001689F7B	FASTA	469	51,124
	10 20 30 40 50 60 MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA 70 80 90 100 110 120 PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF 130 140 150 160 170 180 VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR 190 200 210 220 230 240 YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK 250 260 270 280 290 300 VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA 310 320 330 340 350 360 GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS 370 380 390 400 410 420 QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA 430 440 450 460 TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors." Matsumoto M., Kamohara M., Sugimoto T., Hidaka K., Takasaki J., Saito T., Okada M., Yamaguchi T., Furuichi K. Gene 248:183-189(2000) [PubMed: 10806363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain cortex.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135." Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., Joernvall H., Sillard R., Lovenberg T.W. J. Biol. Chem. 278:50754-50764(2003) [PubMed: 14522968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS A RECEPTOR FOR RLN3.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88437 mRNA. Translation: BAA93001.1. AY236541 Genomic DNA. Translation: AAO92063.1. AY394501 mRNA. Translation: AAQ92315.1. BC113438 mRNA. Translation: AAI13439.1. BC113440 mRNA. Translation: AAI13441.1.
IPI	IPI00009828.
RefSeq	NP_057652.1. NM_016568.3.
UniGene	Hs.170146.
3D structure databases
ProteinModelPortal	Q9NSD7.
SMR	Q9NSD7. Positions 82-405.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NSD7.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	20455271.
Proteomic databases
PRIDE	Q9NSD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330120; ENSP00000328708; ENSG00000182631.
GeneID	51289.
KEGG	hsa:51289.
UCSC	uc003jic.1. human.
Organism-specific databases
CTD	51289.
GeneCards	GC05P033974.
H-InvDB	HIX0032032.
HGNC	HGNC:24883. RXFP3.
HPA	HPA027833.
MIM	609445. gene.
neXtProt	NX_Q9NSD7.
PharmGKB	PA134868535.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08584.
GeneTree	ENSGT00560000076900.
HOGENOM	HBG445265.
HOVERGEN	HBG101327.
InParanoid	Q9NSD7.
OMA	QGWRKSS.
OrthoDB	EOG4X3H22.
PhylomeDB	Q9NSD7.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9NSD7.
Bgee	Q9NSD7.
CleanEx	HS_RXFP3.
Genevestigator	Q9NSD7.
GermOnline	ENSG00000182631. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR000826. Frt_met_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K08397.
Pfam	PF00001. 7tm_1. 2 hits. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	54543.
SOURCE	Search...

Entry information

Entry name

RL3R1_HUMAN

Accession

Primary (citable) accession number: Q9NSD7
Secondary accession number(s): Q14DA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.