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Protein

Zinc finger protein 275

Gene

ZNF275

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 275
Gene namesi
Name:ZNF275
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13069. ZNF275.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi308153531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Zinc finger protein 275PRO_0000047502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NSD4.
PaxDbiQ9NSD4.
PeptideAtlasiQ9NSD4.
PRIDEiQ9NSD4.

PTM databases

iPTMnetiQ9NSD4.
PhosphoSiteiQ9NSD4.

Expressioni

Gene expression databases

BgeeiENSG00000063587.
CleanExiHS_ZNF275.
ExpressionAtlasiQ9NSD4. baseline and differential.
GenevisibleiQ9NSD4. HS.

Organism-specific databases

HPAiHPA000566.

Interactioni

Protein-protein interaction databases

BioGridi116051. 1 interaction.
STRINGi9606.ENSP00000411097.

Structurei

3D structure databases

ProteinModelPortaliQ9NSD4.
SMRiQ9NSD4. Positions 98-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130038.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NSD4.
OMAiGDCRKVF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NSD4.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSHPCVSLL GVPVLNPALV PHLAQGQVLL VSDPSPNTDP AKYSESTSAT
60 70 80 90 100
RHQMKGEDAQ PQEMASTSFP RASGPSPEFR QHGDSDGKRG SPQNLPIEHH
110 120 130 140 150
FACKECGDTF RLKVLLVQHQ RVHSEEKGWE CGDCGKVFRG VAEFNEHRKS
160 170 180 190 200
HVAAEPQPGP SRALENAAEK REQMEREAKP FECEECGKRF KKNAGLSQHL
210 220 230 240 250
RVHSREKPFD CEECGRSFKV NTHLFRHQKL HTSEKPFACK ACSRDFLDRQ
260 270 280 290 300
ELLKHQRMHT GHLPFDCDDC GKSFRGVNGL AEHQRIHSGA KPYGCPHCGK
310 320 330 340 350
LFRRSSELTK HRRIHTGEKP YACGQCGKAF RQSSSLLEHA RIHSGERPYA
360 370 380 390 400
CGECGKAFRG PSDLIKHRRI HSGLKPYECD KCGKAFRRSS GLSRHRRIHS
410 420
GARRCECSQC GRVFKRRSAL QKHQPTHHE
Length:429
Mass (Da):48,443
Last modified:October 5, 2010 - v2
Checksum:i85601FAC3129FB3A
GO
Isoform 2 (identifier: Q9NSD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):42,868
Checksum:i04B730447B4AA5C2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 2. 1 PublicationVSP_055944Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82670 Genomic DNA. No translation available.
AC152007 Genomic DNA. No translation available.
AC152008 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72883.1.
BC136634 mRNA. Translation: AAI36635.1.
UniGeneiHs.348963.

Genome annotation databases

EnsembliENST00000370249; ENSP00000359269; ENSG00000063587. [Q9NSD4-2]
UCSCiuc065bsr.1. human. [Q9NSD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82670 Genomic DNA. No translation available.
AC152007 Genomic DNA. No translation available.
AC152008 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72883.1.
BC136634 mRNA. Translation: AAI36635.1.
UniGeneiHs.348963.

3D structure databases

ProteinModelPortaliQ9NSD4.
SMRiQ9NSD4. Positions 98-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116051. 1 interaction.
STRINGi9606.ENSP00000411097.

PTM databases

iPTMnetiQ9NSD4.
PhosphoSiteiQ9NSD4.

Polymorphism and mutation databases

DMDMi308153531.

Proteomic databases

MaxQBiQ9NSD4.
PaxDbiQ9NSD4.
PeptideAtlasiQ9NSD4.
PRIDEiQ9NSD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370249; ENSP00000359269; ENSG00000063587. [Q9NSD4-2]
UCSCiuc065bsr.1. human. [Q9NSD4-1]

Organism-specific databases

CTDi10838.
GeneCardsiZNF275.
HGNCiHGNC:13069. ZNF275.
HPAiHPA000566.
neXtProtiNX_Q9NSD4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130038.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NSD4.
OMAiGDCRKVF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NSD4.

Miscellaneous databases

ChiTaRSiZNF275. human.
GenomeRNAii10838.
PROiQ9NSD4.

Gene expression databases

BgeeiENSG00000063587.
CleanExiHS_ZNF275.
ExpressionAtlasiQ9NSD4. baseline and differential.
GenevisibleiQ9NSD4. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN275_HUMAN
AccessioniPrimary (citable) accession number: Q9NSD4
Secondary accession number(s): A6NE92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.