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Q9NSC7

- SIA7A_HUMAN

UniProt

Q9NSC7 - SIA7A_HUMAN

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Protein
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene
ST6GALNAC1, SIAT7A, UNQ543/PRO848
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi

GO - Molecular functioni

  1. alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Source: UniProtKB-EC
  2. sialyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: Ensembl
  2. protein glycosylation Source: UniProtKB
  3. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.3. 2681.
ReactomeiREACT_200874. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Synonyms:SIAT7A
ORF Names:UNQ543/PRO848
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23614. ST6GALNAC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei15 – 3521Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini36 – 600565Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
PRO_0000149269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi365 ↔ 533 By similarity
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NSC7.
PaxDbiQ9NSC7.
PRIDEiQ9NSC7.

PTM databases

PhosphoSiteiQ9NSC7.

Expressioni

Gene expression databases

ArrayExpressiQ9NSC7.
BgeeiQ9NSC7.
CleanExiHS_ST6GALNAC1.
GenevestigatoriQ9NSC7.

Organism-specific databases

HPAiHPA014975.

Interactioni

Protein-protein interaction databases

BioGridi120918. 2 interactions.
IntActiQ9NSC7. 1 interaction.
STRINGi9606.ENSP00000156626.

Structurei

3D structure databases

ProteinModelPortaliQ9NSC7.
SMRiQ9NSC7. Positions 277-589.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292294.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ9NSC7.
KOiK03479.
OMAiEEKYSFE.
OrthoDBiEOG7J17ZK.
PhylomeDBiQ9NSC7.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSC7-1 [UniParc]FASTAAdd to Basket

« Hide

MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN    50
IKERSLQSLA KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR 100
GKEANQAPPE EQDKVPHTAQ RAAWKSPEKE KTMVNTLSPR GQDAGMASGR 150
TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV SEKHQGKAAT TAKTLIPKSQ 200
HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF QSPTTQRNQR 250
LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN 300
LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL 350
LLASLPAGSL RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY 400
EQDVGTRTSF YGFTAFSLTQ SLLILGNRGF KNVPLGKDVR YLHFLEGTRD 450
YEWLEALLMN QTVMSKNLFW FRHRPQEAFR EALHMDRYLL LHPDFLRYMK 500
NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG FITEGHERFS 550
DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN 600
Length:600
Mass (Da):68,564
Last modified:October 1, 2000 - v1
Checksum:i9A28399A3DC8AB30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801V → A.1 Publication
Corresponds to variant rs8077382 [ dbSNP | Ensembl ].
VAR_021514
Natural varianti424 – 4241I → V.
Corresponds to variant rs35948039 [ dbSNP | Ensembl ].
VAR_049226

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11339 mRNA. Translation: CAA72179.2.
Y11340 Genomic DNA. Translation: CAA72180.1.
AY096001 mRNA. Translation: AAM22800.1.
AY358918 mRNA. Translation: AAQ89277.1.
CCDSiCCDS11748.1.
RefSeqiNP_060884.1. NM_018414.4.
UniGeneiHs.105352.

Genome annotation databases

EnsembliENST00000156626; ENSP00000156626; ENSG00000070526.
GeneIDi55808.
KEGGihsa:55808.
UCSCiuc002jsh.3. human.

Polymorphism databases

DMDMi21759444.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

ST6GalNAc I

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11339 mRNA. Translation: CAA72179.2 .
Y11340 Genomic DNA. Translation: CAA72180.1 .
AY096001 mRNA. Translation: AAM22800.1 .
AY358918 mRNA. Translation: AAQ89277.1 .
CCDSi CCDS11748.1.
RefSeqi NP_060884.1. NM_018414.4.
UniGenei Hs.105352.

3D structure databases

ProteinModelPortali Q9NSC7.
SMRi Q9NSC7. Positions 277-589.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120918. 2 interactions.
IntActi Q9NSC7. 1 interaction.
STRINGi 9606.ENSP00000156626.

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSitei Q9NSC7.

Polymorphism databases

DMDMi 21759444.

Proteomic databases

MaxQBi Q9NSC7.
PaxDbi Q9NSC7.
PRIDEi Q9NSC7.

Protocols and materials databases

DNASUi 55808.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000156626 ; ENSP00000156626 ; ENSG00000070526 .
GeneIDi 55808.
KEGGi hsa:55808.
UCSCi uc002jsh.3. human.

Organism-specific databases

CTDi 55808.
GeneCardsi GC17M074620.
HGNCi HGNC:23614. ST6GALNAC1.
HPAi HPA014975.
MIMi 610138. gene.
neXtProti NX_Q9NSC7.
PharmGKBi PA134935906.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292294.
HOGENOMi HOG000231097.
HOVERGENi HBG073351.
InParanoidi Q9NSC7.
KOi K03479.
OMAi EEKYSFE.
OrthoDBi EOG7J17ZK.
PhylomeDBi Q9NSC7.
TreeFami TF354325.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.99.3. 2681.
Reactomei REACT_200874. Sialic acid metabolism.

Miscellaneous databases

GeneWikii ST6GALNAC1.
GenomeRNAii 55808.
NextBioi 60965.
PROi Q9NSC7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NSC7.
Bgeei Q9NSC7.
CleanExi HS_ST6GALNAC1.
Genevestigatori Q9NSC7.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens."
    Ikehara Y., Kojima N., Kurosawa N., Kudo T., Kono M., Nishihara S., Issiki S., Morozumi K., Itzkowitz S., Tsuda T., Nishimura S., Tsuji S., Narimatsu H.
    Glycobiology 9:1213-1224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA."
    Julien S., Krzewinski-Recchi M.A., Harduin-Lepers A., Gouyer V., Huet G., Le Bourhis X., Delannoy P.
    Glycoconj. J. 18:883-893(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-80.

Entry informationi

Entry nameiSIA7A_HUMAN
AccessioniPrimary (citable) accession number: Q9NSC7
Secondary accession number(s): Q6UW90, Q9NSC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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