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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

ST6GALNAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathway: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.3. 2681.
ReactomeiREACT_264366. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Name:ST6GALNAC1
Synonyms:SIAT7A
ORF Names:UNQ543/PRO848
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:23614. ST6GALNAC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini36 – 600565LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935906.

Polymorphism and mutation databases

BioMutaiST6GALNAC1.
DMDMi21759444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1PRO_0000149269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi365 ↔ 533By similarity
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NSC7.
PaxDbiQ9NSC7.
PRIDEiQ9NSC7.

PTM databases

PhosphoSiteiQ9NSC7.

Expressioni

Gene expression databases

BgeeiQ9NSC7.
CleanExiHS_ST6GALNAC1.
ExpressionAtlasiQ9NSC7. baseline and differential.
GenevisibleiQ9NSC7. HS.

Organism-specific databases

HPAiHPA014975.

Interactioni

Protein-protein interaction databases

BioGridi120918. 2 interactions.
IntActiQ9NSC7. 1 interaction.
STRINGi9606.ENSP00000156626.

Structurei

3D structure databases

ProteinModelPortaliQ9NSC7.
SMRiQ9NSC7. Positions 277-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292294.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ9NSC7.
KOiK03479.
OMAiEEKYSFE.
OrthoDBiEOG7J17ZK.
PhylomeDBiQ9NSC7.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN
60 70 80 90 100
IKERSLQSLA KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR
110 120 130 140 150
GKEANQAPPE EQDKVPHTAQ RAAWKSPEKE KTMVNTLSPR GQDAGMASGR
160 170 180 190 200
TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV SEKHQGKAAT TAKTLIPKSQ
210 220 230 240 250
HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF QSPTTQRNQR
260 270 280 290 300
LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN
310 320 330 340 350
LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL
360 370 380 390 400
LLASLPAGSL RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY
410 420 430 440 450
EQDVGTRTSF YGFTAFSLTQ SLLILGNRGF KNVPLGKDVR YLHFLEGTRD
460 470 480 490 500
YEWLEALLMN QTVMSKNLFW FRHRPQEAFR EALHMDRYLL LHPDFLRYMK
510 520 530 540 550
NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG FITEGHERFS
560 570 580 590 600
DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN
Length:600
Mass (Da):68,564
Last modified:October 1, 2000 - v1
Checksum:i9A28399A3DC8AB30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801V → A.1 Publication
Corresponds to variant rs8077382 [ dbSNP | Ensembl ].
VAR_021514
Natural varianti424 – 4241I → V.
Corresponds to variant rs35948039 [ dbSNP | Ensembl ].
VAR_049226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11339 mRNA. Translation: CAA72179.2.
Y11340 Genomic DNA. Translation: CAA72180.1.
AY096001 mRNA. Translation: AAM22800.1.
AY358918 mRNA. Translation: AAQ89277.1.
CCDSiCCDS11748.1.
RefSeqiNP_060884.1. NM_018414.4.
UniGeneiHs.105352.

Genome annotation databases

EnsembliENST00000156626; ENSP00000156626; ENSG00000070526.
GeneIDi55808.
KEGGihsa:55808.
UCSCiuc002jsh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

ST6GalNAc I

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11339 mRNA. Translation: CAA72179.2.
Y11340 Genomic DNA. Translation: CAA72180.1.
AY096001 mRNA. Translation: AAM22800.1.
AY358918 mRNA. Translation: AAQ89277.1.
CCDSiCCDS11748.1.
RefSeqiNP_060884.1. NM_018414.4.
UniGeneiHs.105352.

3D structure databases

ProteinModelPortaliQ9NSC7.
SMRiQ9NSC7. Positions 277-589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120918. 2 interactions.
IntActiQ9NSC7. 1 interaction.
STRINGi9606.ENSP00000156626.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteiQ9NSC7.

Polymorphism and mutation databases

BioMutaiST6GALNAC1.
DMDMi21759444.

Proteomic databases

MaxQBiQ9NSC7.
PaxDbiQ9NSC7.
PRIDEiQ9NSC7.

Protocols and materials databases

DNASUi55808.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000156626; ENSP00000156626; ENSG00000070526.
GeneIDi55808.
KEGGihsa:55808.
UCSCiuc002jsh.3. human.

Organism-specific databases

CTDi55808.
GeneCardsiGC17M074620.
HGNCiHGNC:23614. ST6GALNAC1.
HPAiHPA014975.
MIMi610138. gene.
neXtProtiNX_Q9NSC7.
PharmGKBiPA134935906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG292294.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ9NSC7.
KOiK03479.
OMAiEEKYSFE.
OrthoDBiEOG7J17ZK.
PhylomeDBiQ9NSC7.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.99.3. 2681.
ReactomeiREACT_264366. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSiST6GALNAC1. human.
GeneWikiiST6GALNAC1.
GenomeRNAii55808.
NextBioi60965.
PROiQ9NSC7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NSC7.
CleanExiHS_ST6GALNAC1.
ExpressionAtlasiQ9NSC7. baseline and differential.
GenevisibleiQ9NSC7. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens."
    Ikehara Y., Kojima N., Kurosawa N., Kudo T., Kono M., Nishihara S., Issiki S., Morozumi K., Itzkowitz S., Tsuda T., Nishimura S., Tsuji S., Narimatsu H.
    Glycobiology 9:1213-1224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA."
    Julien S., Krzewinski-Recchi M.A., Harduin-Lepers A., Gouyer V., Huet G., Le Bourhis X., Delannoy P.
    Glycoconj. J. 18:883-893(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-80.

Entry informationi

Entry nameiSIA7A_HUMAN
AccessioniPrimary (citable) accession number: Q9NSC7
Secondary accession number(s): Q6UW90, Q9NSC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.