Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NSC7

- SIA7A_HUMAN

UniProt

Q9NSC7 - SIA7A_HUMAN

Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

ST6GALNAC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

    Pathwayi

    GO - Molecular functioni

    1. alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Source: UniProtKB-EC
    2. sialyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: Ensembl
    2. protein glycosylation Source: UniProtKB
    3. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.99.3. 2681.
    ReactomeiREACT_200874. Sialic acid metabolism.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
    Alternative name(s):
    GalNAc alpha-2,6-sialyltransferase I
    ST6GalNAc I
    Short name:
    ST6GalNAcI
    Sialyltransferase 7A
    Short name:
    SIAT7-A
    Gene namesi
    Name:ST6GALNAC1
    Synonyms:SIAT7A
    ORF Names:UNQ543/PRO848
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:23614. ST6GALNAC1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134935906.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1PRO_0000149269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi365 ↔ 533By similarity
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9NSC7.
    PaxDbiQ9NSC7.
    PRIDEiQ9NSC7.

    PTM databases

    PhosphoSiteiQ9NSC7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NSC7.
    BgeeiQ9NSC7.
    CleanExiHS_ST6GALNAC1.
    GenevestigatoriQ9NSC7.

    Organism-specific databases

    HPAiHPA014975.

    Interactioni

    Protein-protein interaction databases

    BioGridi120918. 2 interactions.
    IntActiQ9NSC7. 1 interaction.
    STRINGi9606.ENSP00000156626.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSC7.
    SMRiQ9NSC7. Positions 277-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 600565LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292294.
    HOGENOMiHOG000231097.
    HOVERGENiHBG073351.
    InParanoidiQ9NSC7.
    KOiK03479.
    OMAiEEKYSFE.
    OrthoDBiEOG7J17ZK.
    PhylomeDBiQ9NSC7.
    TreeFamiTF354325.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NSC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN    50
    IKERSLQSLA KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR 100
    GKEANQAPPE EQDKVPHTAQ RAAWKSPEKE KTMVNTLSPR GQDAGMASGR 150
    TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV SEKHQGKAAT TAKTLIPKSQ 200
    HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF QSPTTQRNQR 250
    LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN 300
    LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL 350
    LLASLPAGSL RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY 400
    EQDVGTRTSF YGFTAFSLTQ SLLILGNRGF KNVPLGKDVR YLHFLEGTRD 450
    YEWLEALLMN QTVMSKNLFW FRHRPQEAFR EALHMDRYLL LHPDFLRYMK 500
    NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG FITEGHERFS 550
    DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN 600
    Length:600
    Mass (Da):68,564
    Last modified:October 1, 2000 - v1
    Checksum:i9A28399A3DC8AB30
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801V → A.1 Publication
    Corresponds to variant rs8077382 [ dbSNP | Ensembl ].
    VAR_021514
    Natural varianti424 – 4241I → V.
    Corresponds to variant rs35948039 [ dbSNP | Ensembl ].
    VAR_049226

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11339 mRNA. Translation: CAA72179.2.
    Y11340 Genomic DNA. Translation: CAA72180.1.
    AY096001 mRNA. Translation: AAM22800.1.
    AY358918 mRNA. Translation: AAQ89277.1.
    CCDSiCCDS11748.1.
    RefSeqiNP_060884.1. NM_018414.4.
    UniGeneiHs.105352.

    Genome annotation databases

    EnsembliENST00000156626; ENSP00000156626; ENSG00000070526.
    GeneIDi55808.
    KEGGihsa:55808.
    UCSCiuc002jsh.3. human.

    Polymorphism databases

    DMDMi21759444.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    ST6GalNAc I

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11339 mRNA. Translation: CAA72179.2 .
    Y11340 Genomic DNA. Translation: CAA72180.1 .
    AY096001 mRNA. Translation: AAM22800.1 .
    AY358918 mRNA. Translation: AAQ89277.1 .
    CCDSi CCDS11748.1.
    RefSeqi NP_060884.1. NM_018414.4.
    UniGenei Hs.105352.

    3D structure databases

    ProteinModelPortali Q9NSC7.
    SMRi Q9NSC7. Positions 277-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120918. 2 interactions.
    IntActi Q9NSC7. 1 interaction.
    STRINGi 9606.ENSP00000156626.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei Q9NSC7.

    Polymorphism databases

    DMDMi 21759444.

    Proteomic databases

    MaxQBi Q9NSC7.
    PaxDbi Q9NSC7.
    PRIDEi Q9NSC7.

    Protocols and materials databases

    DNASUi 55808.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000156626 ; ENSP00000156626 ; ENSG00000070526 .
    GeneIDi 55808.
    KEGGi hsa:55808.
    UCSCi uc002jsh.3. human.

    Organism-specific databases

    CTDi 55808.
    GeneCardsi GC17M074620.
    HGNCi HGNC:23614. ST6GALNAC1.
    HPAi HPA014975.
    MIMi 610138. gene.
    neXtProti NX_Q9NSC7.
    PharmGKBi PA134935906.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292294.
    HOGENOMi HOG000231097.
    HOVERGENi HBG073351.
    InParanoidi Q9NSC7.
    KOi K03479.
    OMAi EEKYSFE.
    OrthoDBi EOG7J17ZK.
    PhylomeDBi Q9NSC7.
    TreeFami TF354325.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.99.3. 2681.
    Reactomei REACT_200874. Sialic acid metabolism.

    Miscellaneous databases

    GeneWikii ST6GALNAC1.
    GenomeRNAii 55808.
    NextBioi 60965.
    PROi Q9NSC7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSC7.
    Bgeei Q9NSC7.
    CleanExi HS_ST6GALNAC1.
    Genevestigatori Q9NSC7.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens."
      Ikehara Y., Kojima N., Kurosawa N., Kudo T., Kono M., Nishihara S., Issiki S., Morozumi K., Itzkowitz S., Tsuda T., Nishimura S., Tsuji S., Narimatsu H.
      Glycobiology 9:1213-1224(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA."
      Julien S., Krzewinski-Recchi M.A., Harduin-Lepers A., Gouyer V., Huet G., Le Bourhis X., Delannoy P.
      Glycoconj. J. 18:883-893(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-80.

    Entry informationi

    Entry nameiSIA7A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSC7
    Secondary accession number(s): Q6UW90, Q9NSC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3