Q9NSC7 (SIA7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
EC=2.4.99.3

Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name=ST6GalNAcI
Sialyltransferase 7A
Short name=SIAT7-A

Gene names

Name:	ST6GALNAC1
Synonyms:	SIAT7A
ORF Names:	UNQ543/PRO848

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	600 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oligosaccharide biosynthetic process Inferred from electronic annotation. Source: Compara protein glycosylation Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC sialyltransferase activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 600	600	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1		PRO_0000149269
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 35	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	36 – 600	565	Lumenal Potential
Amino acid modifications
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	331	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	460	1	N-linked (GlcNAc...) Potential
	Disulfide bond	365 ↔ 533		By similarity
Natural variations
	Natural variant	80	1	V → A. Ref.3 Corresponds to variant rs8077382 [ dbSNP | Ensembl ].		VAR_021514
	Natural variant	424	1	I → V. Corresponds to variant rs35948039 [ dbSNP | Ensembl ].		VAR_049226

Sequences

	Sequence		Length	Mass (Da)
	Q9NSC7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9A28399A3DC8AB30	FASTA	600	68,564
	10 20 30 40 50 60 MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN IKERSLQSLA 70 80 90 100 110 120 KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR GKEANQAPPE EQDKVPHTAQ 130 140 150 160 170 180 RAAWKSPEKE KTMVNTLSPR GQDAGMASGR TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV 190 200 210 220 230 240 SEKHQGKAAT TAKTLIPKSQ HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF 250 260 270 280 290 300 QSPTTQRNQR LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN 310 320 330 340 350 360 LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL LLASLPAGSL 370 380 390 400 410 420 RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY EQDVGTRTSF YGFTAFSLTQ 430 440 450 460 470 480 SLLILGNRGF KNVPLGKDVR YLHFLEGTRD YEWLEALLMN QTVMSKNLFW FRHRPQEAFR 490 500 510 520 530 540 EALHMDRYLL LHPDFLRYMK NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG 550 560 570 580 590 600 FITEGHERFS DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens." Ikehara Y., Kojima N., Kurosawa N., Kudo T., Kono M., Nishihara S., Issiki S., Morozumi K., Itzkowitz S., Tsuda T., Nishimura S., Tsuji S., Narimatsu H. Glycobiology 9:1213-1224(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA." Julien S., Krzewinski-Recchi M.A., Harduin-Lepers A., Gouyer V., Huet G., Le Bourhis X., Delannoy P. Glycoconj. J. 18:883-893(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-80.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

ST6GalNAc I

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11339 mRNA. Translation: CAA72179.2. Y11340 Genomic DNA. Translation: CAA72180.1. AY096001 mRNA. Translation: AAM22800.1. AY358918 mRNA. Translation: AAQ89277.1.
IPI	IPI00031534.
RefSeq	NP_060884.1. NM_018414.3.
UniGene	Hs.105352.
3D structure databases
ProteinModelPortal	Q9NSC7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NSC7. 1 interaction.
STRING	9606.ENSP00000156626.
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
PTM databases
PhosphoSite	Q9NSC7.
Polymorphism databases
DMDM	21759444.
Proteomic databases
PaxDb	Q9NSC7.
PRIDE	Q9NSC7.
Protocols and materials databases
DNASU	55808.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000156626; ENSP00000156626; ENSG00000070526.
GeneID	55808.
KEGG	hsa:55808.
UCSC	uc002jsh.3. human.
Organism-specific databases
CTD	55808.
GeneCards	GC17M074620.
HGNC	HGNC:23614. ST6GALNAC1.
HPA	HPA014975.
MIM	610138. gene.
neXtProt	NX_Q9NSC7.
PharmGKB	PA134935906.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG292294.
HOGENOM	HOG000231097.
HOVERGEN	HBG073351.
InParanoid	Q9NSC7.
KO	K03479.
OMA	LQTTCPD.
OrthoDB	EOG4CJVHZ.
PhylomeDB	Q9NSC7.
Enzyme and pathway databases
BRENDA	2.4.99.3. 2681.
UniPathway	UPA00378.
Gene expression databases
ArrayExpress	Q9NSC7.
Bgee	Q9NSC7.
CleanEx	HS_ST6GALNAC1.
Genevestigator	Q9NSC7.
GermOnline	ENSG00000070526. Homo sapiens.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55808.
NextBio	60965.
SOURCE	Search...

Entry information

Entry name

SIA7A_HUMAN

Accession

Primary (citable) accession number: Q9NSC7
Secondary accession number(s): Q6UW90, Q9NSC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.