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Q9NSC7 (SIA7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

EC=2.4.99.3
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name=ST6GalNAcI
Sialyltransferase 7A
Short name=SIAT7-A
Gene names
Name:ST6GALNAC1
Synonyms:SIAT7A
ORF Names:UNQ543/PRO848
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
PRO_0000149269

Regions

Topological domain1 – 1414Cytoplasmic Potential
Transmembrane15 – 3521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain36 – 600565Lumenal Potential

Amino acid modifications

Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation4601N-linked (GlcNAc...) Potential
Disulfide bond365 ↔ 533 By similarity

Natural variations

Natural variant801V → A. Ref.3
Corresponds to variant rs8077382 [ dbSNP | Ensembl ].
VAR_021514
Natural variant4241I → V.
Corresponds to variant rs35948039 [ dbSNP | Ensembl ].
VAR_049226

Sequences

Sequence LengthMass (Da)Tools
Q9NSC7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9A28399A3DC8AB30

FASTA60068,564
        10         20         30         40         50         60 
MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN IKERSLQSLA 

        70         80         90        100        110        120 
KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR GKEANQAPPE EQDKVPHTAQ 

       130        140        150        160        170        180 
RAAWKSPEKE KTMVNTLSPR GQDAGMASGR TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV 

       190        200        210        220        230        240 
SEKHQGKAAT TAKTLIPKSQ HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF 

       250        260        270        280        290        300 
QSPTTQRNQR LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN 

       310        320        330        340        350        360 
LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL LLASLPAGSL 

       370        380        390        400        410        420 
RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY EQDVGTRTSF YGFTAFSLTQ 

       430        440        450        460        470        480 
SLLILGNRGF KNVPLGKDVR YLHFLEGTRD YEWLEALLMN QTVMSKNLFW FRHRPQEAFR 

       490        500        510        520        530        540 
EALHMDRYLL LHPDFLRYMK NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG 

       550        560        570        580        590        600 
FITEGHERFS DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNac I); a candidate for synthesis of cancer-associated sialyl-Tnantigens."
Ikehara Y., Kojima N., Kurosawa N., Kudo T., Kono M., Nishihara S., Issiki S., Morozumi K., Itzkowitz S., Tsuda T., Nishimura S., Tsuji S., Narimatsu H.
Glycobiology 9:1213-1224(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA."
Julien S., Krzewinski-Recchi M.A., Harduin-Lepers A., Gouyer V., Huet G., Le Bourhis X., Delannoy P.
Glycoconj. J. 18:883-893(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-80.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11339 mRNA. Translation: CAA72179.2.
Y11340 Genomic DNA. Translation: CAA72180.1.
AY096001 mRNA. Translation: AAM22800.1.
AY358918 mRNA. Translation: AAQ89277.1.
RefSeqNP_060884.1. NM_018414.4.
UniGeneHs.105352.

3D structure databases

ProteinModelPortalQ9NSC7.
SMRQ9NSC7. Positions 277-589.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120918. 2 interactions.
IntActQ9NSC7. 1 interaction.
STRING9606.ENSP00000156626.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteQ9NSC7.

Polymorphism databases

DMDM21759444.

Proteomic databases

PaxDbQ9NSC7.
PRIDEQ9NSC7.

Protocols and materials databases

DNASU55808.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000156626; ENSP00000156626; ENSG00000070526.
GeneID55808.
KEGGhsa:55808.
UCSCuc002jsh.3. human.

Organism-specific databases

CTD55808.
GeneCardsGC17M074620.
HGNCHGNC:23614. ST6GALNAC1.
HPAHPA014975.
MIM610138. gene.
neXtProtNX_Q9NSC7.
PharmGKBPA134935906.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292294.
HOGENOMHOG000231097.
HOVERGENHBG073351.
InParanoidQ9NSC7.
KOK03479.
OMADFEEQYS.
OrthoDBEOG7J17ZK.
PhylomeDBQ9NSC7.
TreeFamTF354325.

Enzyme and pathway databases

BRENDA2.4.99.3. 2681.
UniPathwayUPA00378.

Gene expression databases

ArrayExpressQ9NSC7.
BgeeQ9NSC7.
CleanExHS_ST6GALNAC1.
GenevestigatorQ9NSC7.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiST6GALNAC1.
GenomeRNAi55808.
NextBio60965.
PROQ9NSC7.
SOURCESearch...

Entry information

Entry nameSIA7A_HUMAN
AccessionPrimary (citable) accession number: Q9NSC7
Secondary accession number(s): Q6UW90, Q9NSC6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM