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Protein

Homer protein homolog 3

Gene

HOMER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

GO - Molecular functioni

  1. G-protein coupled glutamate receptor binding Source: GO_Central

GO - Biological processi

  1. G-protein coupled glutamate receptor signaling pathway Source: ProtInc
  2. protein targeting Source: UniProtKB
  3. regulation of store-operated calcium entry Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 3
Short name:
Homer-3
Gene namesi
Name:HOMER3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17514. HOMER3.

Subcellular locationi

Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
Note: Postsynaptic density of neuronal cells.By similarity

GO - Cellular componenti

  1. basal part of cell Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: HPA
  4. cytosol Source: Ensembl
  5. neuronal postsynaptic density Source: GO_Central
  6. plasma membrane Source: HPA
  7. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Homer protein homolog 3PRO_0000191011Add
BLAST

Proteomic databases

MaxQBiQ9NSC5.
PaxDbiQ9NSC5.
PRIDEiQ9NSC5.

PTM databases

PhosphoSiteiQ9NSC5.

Expressioni

Gene expression databases

BgeeiQ9NSC5.
CleanExiHS_HOMER3.
ExpressionAtlasiQ9NSC5. baseline and differential.
GenevestigatoriQ9NSC5.

Organism-specific databases

HPAiCAB032656.
HPA040999.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP05067-83EBI-748420,EBI-302661
FAT1Q145174EBI-748420,EBI-1171918
PAX6P263673EBI-748420,EBI-747278

Protein-protein interaction databases

BioGridi114843. 34 interactions.
IntActiQ9NSC5. 26 interactions.
MINTiMINT-1473946.
STRINGi9606.ENSP00000348150.

Structurei

Secondary structure

1
361
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 1915Combined sources
Turni21 – 233Combined sources
Beta strandi26 – 338Combined sources
Beta strandi35 – 428Combined sources
Turni43 – 464Combined sources
Beta strandi47 – 548Combined sources
Beta strandi57 – 637Combined sources
Beta strandi70 – 723Combined sources
Beta strandi74 – 829Combined sources
Turni83 – 864Combined sources
Beta strandi87 – 926Combined sources
Helixi96 – 11722Combined sources
Helixi295 – 35864Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P8VX-ray1.85A2-118[»]
3CVFX-ray2.90A/B/C/D287-361[»]
ProteinModelPortaliQ9NSC5.
SMRiQ9NSC5. Positions 2-142, 290-361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSC5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili191 – 24353Sequence AnalysisAdd
BLAST
Coiled coili254 – 358105Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi206 – 2116Poly-Ala

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG76046.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSC5.
KOiK15010.
OMAiAEREETQ.
OrthoDBiEOG72C50J.
PhylomeDBiQ9NSC5.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSC5-1) [UniParc]FASTAAdd to Basket

Also known as: 3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGELTSPA LGLASHQVPP SPLVSANGPG
160 170 180 190 200
EEKLFRSQSA DAPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNNKLA
210 220 230 240 250
GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS EVTPTGEKEG
260 270 280 290 300
LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL
310 320 330 340 350
ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR
360
EGLARLAEAA P
Length:361
Mass (Da):39,836
Last modified:November 28, 2003 - v2
Checksum:i9FCC62319FF5165A
GO
Isoform 2 (identifier: Q9NSC5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-301: Missing.

Show »
Length:358
Mass (Da):39,479
Checksum:i0799594DEABE399F
GO
Isoform 3 (identifier: Q9NSC5-3) [UniParc]FASTAAdd to Basket

Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: GELTSPALGLASHQVPPSPLVS → WGGPQSALVVGSFGAVFELLIV
     146-361: Missing.

Show »
Length:145
Mass (Da):16,032
Checksum:i4DA4F12F2893744C
GO
Isoform 4 (identifier: Q9NSC5-4) [UniParc]FASTAAdd to Basket

Also known as: 3d

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: EKSQ → QLQR
     122-361: Missing.

Show »
Length:121
Mass (Da):13,685
Checksum:i42C572EB13211534
GO
Isoform 5 (identifier: Q9NSC5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-136: Missing.

Show »
Length:325
Mass (Da):35,954
Checksum:iF51CA5A05CB92734
GO

Sequence cautioni

The sequence AAB81545.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti342 – 3421S → R.2 Publications
Corresponds to variant rs1059240 [ dbSNP | Ensembl ].
VAR_017410

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 13636Missing in isoform 5. 1 PublicationVSP_045715Add
BLAST
Alternative sequencei118 – 1214EKSQ → QLQR in isoform 4. 1 PublicationVSP_009073
Alternative sequencei122 – 361240Missing in isoform 4. 1 PublicationVSP_009074Add
BLAST
Alternative sequencei124 – 14522GELTS…SPLVS → WGGPQSALVVGSFGAVFELL IV in isoform 3. 1 PublicationVSP_009075Add
BLAST
Alternative sequencei146 – 361216Missing in isoform 3. 1 PublicationVSP_009076Add
BLAST
Alternative sequencei299 – 3013Missing in isoform 2. 1 PublicationVSP_009077

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093265 mRNA. Translation: AAC71029.1.
Y17573 mRNA. Translation: CAB75536.1.
Y18894 mRNA. Translation: CAB75543.1.
Y18895 mRNA. Translation: CAB75544.1.
Y18896 mRNA. Translation: CAB75545.1.
AC002985 Genomic DNA. Translation: AAB81545.1. Sequence problems.
BC012113 mRNA. Translation: AAH12113.1.
CCDSiCCDS12391.1. [Q9NSC5-1]
CCDS46022.1. [Q9NSC5-5]
CCDS46023.1. [Q9NSC5-2]
RefSeqiNP_001139193.1. NM_001145721.1. [Q9NSC5-2]
NP_001139194.1. NM_001145722.1. [Q9NSC5-1]
NP_001139196.1. NM_001145724.1. [Q9NSC5-5]
NP_004829.3. NM_004838.3. [Q9NSC5-1]
XP_006723006.1. XM_006722943.1. [Q9NSC5-1]
XP_006723007.1. XM_006722944.1. [Q9NSC5-1]
UniGeneiHs.720208.

Genome annotation databases

EnsembliENST00000221222; ENSP00000221222; ENSG00000051128. [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128. [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128. [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128. [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128. [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128. [Q9NSC5-5]
GeneIDi9454.
KEGGihsa:9454.
UCSCiuc002nku.2. human. [Q9NSC5-1]
uc002nkw.2. human. [Q9NSC5-2]

Polymorphism databases

DMDMi38605068.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093265 mRNA. Translation: AAC71029.1.
Y17573 mRNA. Translation: CAB75536.1.
Y18894 mRNA. Translation: CAB75543.1.
Y18895 mRNA. Translation: CAB75544.1.
Y18896 mRNA. Translation: CAB75545.1.
AC002985 Genomic DNA. Translation: AAB81545.1. Sequence problems.
BC012113 mRNA. Translation: AAH12113.1.
CCDSiCCDS12391.1. [Q9NSC5-1]
CCDS46022.1. [Q9NSC5-5]
CCDS46023.1. [Q9NSC5-2]
RefSeqiNP_001139193.1. NM_001145721.1. [Q9NSC5-2]
NP_001139194.1. NM_001145722.1. [Q9NSC5-1]
NP_001139196.1. NM_001145724.1. [Q9NSC5-5]
NP_004829.3. NM_004838.3. [Q9NSC5-1]
XP_006723006.1. XM_006722943.1. [Q9NSC5-1]
XP_006723007.1. XM_006722944.1. [Q9NSC5-1]
UniGeneiHs.720208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P8VX-ray1.85A2-118[»]
3CVFX-ray2.90A/B/C/D287-361[»]
ProteinModelPortaliQ9NSC5.
SMRiQ9NSC5. Positions 2-142, 290-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114843. 34 interactions.
IntActiQ9NSC5. 26 interactions.
MINTiMINT-1473946.
STRINGi9606.ENSP00000348150.

PTM databases

PhosphoSiteiQ9NSC5.

Polymorphism databases

DMDMi38605068.

Proteomic databases

MaxQBiQ9NSC5.
PaxDbiQ9NSC5.
PRIDEiQ9NSC5.

Protocols and materials databases

DNASUi9454.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221222; ENSP00000221222; ENSG00000051128. [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128. [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128. [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128. [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128. [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128. [Q9NSC5-5]
GeneIDi9454.
KEGGihsa:9454.
UCSCiuc002nku.2. human. [Q9NSC5-1]
uc002nkw.2. human. [Q9NSC5-2]

Organism-specific databases

CTDi9454.
GeneCardsiGC19M019040.
HGNCiHGNC:17514. HOMER3.
HPAiCAB032656.
HPA040999.
MIMi604800. gene.
neXtProtiNX_Q9NSC5.
PharmGKBiPA134988320.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76046.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSC5.
KOiK15010.
OMAiAEREETQ.
OrthoDBiEOG72C50J.
PhylomeDBiQ9NSC5.
TreeFamiTF325627.

Miscellaneous databases

ChiTaRSiHOMER3. human.
EvolutionaryTraceiQ9NSC5.
GeneWikiiHOMER3.
GenomeRNAii9454.
NextBioi35420.
PROiQ9NSC5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NSC5.
CleanExiHS_HOMER3.
ExpressionAtlasiQ9NSC5. baseline and differential.
GenevestigatoriQ9NSC5.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
    Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
    Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
    Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
    J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT ARG-342.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-342.
    Tissue: Uterus.

Entry informationi

Entry nameiHOME3_HUMAN
AccessioniPrimary (citable) accession number: Q9NSC5
Secondary accession number(s): E9PCW9
, O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: February 4, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.