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Q9NSC5 (HOME3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homer protein homolog 3

Short name=Homer-3
Gene names
Name:HOMER3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

Subunit structure

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Subcellular location

Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity. Note: Postsynaptic density of neuronal cells By similarity.

Domain

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similarities

Belongs to the Homer family.

Contains 1 WH1 domain.

Sequence caution

The sequence AAB81545.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NSC5-1)

Also known as: 3a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NSC5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     299-301: Missing.
Isoform 3 (identifier: Q9NSC5-3)

Also known as: 3c;

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: GELTSPALGLASHQVPPSPLVS → WGGPQSALVVGSFGAVFELLIV
     146-361: Missing.
Isoform 4 (identifier: Q9NSC5-4)

Also known as: 3d;

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: EKSQ → QLQR
     122-361: Missing.
Isoform 5 (identifier: Q9NSC5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     101-136: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Homer protein homolog 3
PRO_0000191011

Regions

Domain1 – 113113WH1
Coiled coil191 – 24353 Potential
Coiled coil254 – 358105 Potential
Compositional bias206 – 2116Poly-Ala

Natural variations

Alternative sequence101 – 13636Missing in isoform 5.
VSP_045715
Alternative sequence118 – 1214EKSQ → QLQR in isoform 4.
VSP_009073
Alternative sequence122 – 361240Missing in isoform 4.
VSP_009074
Alternative sequence124 – 14522GELTS…SPLVS → WGGPQSALVVGSFGAVFELL IV in isoform 3.
VSP_009075
Alternative sequence146 – 361216Missing in isoform 3.
VSP_009076
Alternative sequence299 – 3013Missing in isoform 2.
VSP_009077
Natural variant3421S → R. Ref.2 Ref.4
Corresponds to variant rs1059240 [ dbSNP | Ensembl ].
VAR_017410

Secondary structure

....................... 361
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (3a) [UniParc].

Last modified November 28, 2003. Version 2.
Checksum: 9FCC62319FF5165A

FASTA36139,836
        10         20         30         40         50         60 
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII 

        70         80         90        100        110        120 
NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT QFAEKFQEVK EAARLAREKS 

       130        140        150        160        170        180 
QDGGELTSPA LGLASHQVPP SPLVSANGPG EEKLFRSQSA DAPGPTERER LKKMLSEGSV 

       190        200        210        220        230        240 
GEVQWEAEFF ALQDSNNKLA GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS 

       250        260        270        280        290        300 
EVTPTGEKEG LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL 

       310        320        330        340        350        360 
ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR EGLARLAEAA 


P 

« Hide

Isoform 2 [UniParc].

Checksum: 0799594DEABE399F
Show »

FASTA35839,479
Isoform 3 (3c) [UniParc].

Checksum: 4DA4F12F2893744C
Show »

FASTA14516,032
Isoform 4 (3d) [UniParc].

Checksum: 42C572EB13211534
Show »

FASTA12113,685
Isoform 5 [UniParc].

Checksum: F51CA5A05CB92734
Show »

FASTA32535,954

References

« Hide 'large scale' references
[1]"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT ARG-342.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-342.
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF093265 mRNA. Translation: AAC71029.1.
Y17573 mRNA. Translation: CAB75536.1.
Y18894 mRNA. Translation: CAB75543.1.
Y18895 mRNA. Translation: CAB75544.1.
Y18896 mRNA. Translation: CAB75545.1.
AC002985 Genomic DNA. Translation: AAB81545.1. Sequence problems.
BC012113 mRNA. Translation: AAH12113.1.
CCDSCCDS12391.1. [Q9NSC5-1]
CCDS46022.1. [Q9NSC5-5]
CCDS46023.1. [Q9NSC5-2]
RefSeqNP_001139193.1. NM_001145721.1. [Q9NSC5-2]
NP_001139194.1. NM_001145722.1. [Q9NSC5-1]
NP_001139196.1. NM_001145724.1. [Q9NSC5-5]
NP_004829.3. NM_004838.3. [Q9NSC5-1]
XP_006723006.1. XM_006722943.1. [Q9NSC5-1]
XP_006723007.1. XM_006722944.1. [Q9NSC5-1]
UniGeneHs.720208.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2P8VX-ray1.85A2-118[»]
3CVFX-ray2.90A/B/C/D287-361[»]
ProteinModelPortalQ9NSC5.
SMRQ9NSC5. Positions 2-142, 290-361.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114843. 18 interactions.
IntActQ9NSC5. 26 interactions.
MINTMINT-1473946.
STRING9606.ENSP00000348150.

PTM databases

PhosphoSiteQ9NSC5.

Polymorphism databases

DMDM38605068.

Proteomic databases

MaxQBQ9NSC5.
PaxDbQ9NSC5.
PRIDEQ9NSC5.

Protocols and materials databases

DNASU9454.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221222; ENSP00000221222; ENSG00000051128. [Q9NSC5-2]
ENST00000355887; ENSP00000348150; ENSG00000051128. [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128. [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128. [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128. [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128. [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128. [Q9NSC5-5]
GeneID9454.
KEGGhsa:9454.
UCSCuc002nku.2. human. [Q9NSC5-1]
uc002nkw.2. human. [Q9NSC5-2]

Organism-specific databases

CTD9454.
GeneCardsGC19M019040.
HGNCHGNC:17514. HOMER3.
HPACAB032656.
HPA040999.
MIM604800. gene.
neXtProtNX_Q9NSC5.
PharmGKBPA134988320.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76046.
HOGENOMHOG000006979.
HOVERGENHBG051918.
InParanoidQ9NSC5.
KOK15010.
OMAAEREETQ.
OrthoDBEOG72C50J.
PhylomeDBQ9NSC5.
TreeFamTF325627.

Gene expression databases

ArrayExpressQ9NSC5.
BgeeQ9NSC5.
CleanExHS_HOMER3.
GenevestigatorQ9NSC5.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF00568. WH1. 1 hit.
[Graphical view]
SMARTSM00461. WH1. 1 hit.
[Graphical view]
PROSITEPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9NSC5.
GeneWikiHOMER3.
GenomeRNAi9454.
NextBio35420.
PROQ9NSC5.
SOURCESearch...

Entry information

Entry nameHOME3_HUMAN
AccessionPrimary (citable) accession number: Q9NSC5
Secondary accession number(s): E9PCW9 expand/collapse secondary AC list , O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM