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Q9NSC5

- HOME3_HUMAN

UniProt

Q9NSC5 - HOME3_HUMAN

Protein

Homer protein homolog 3

Gene

HOMER3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (28 Nov 2003)
      Previous versions | rss
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    Functioni

    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. G-protein coupled glutamate receptor signaling pathway Source: ProtInc
    2. protein targeting Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homer protein homolog 3
    Short name:
    Homer-3
    Gene namesi
    Name:HOMER3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17514. HOMER3.

    Subcellular locationi

    Cytoplasm By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
    Note: Postsynaptic density of neuronal cells.By similarity

    GO - Cellular componenti

    1. basal part of cell Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: HPA
    4. cytosol Source: Ensembl
    5. plasma membrane Source: HPA
    6. postsynaptic density Source: UniProtKB-SubCell
    7. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988320.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Homer protein homolog 3PRO_0000191011Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSC5.
    PaxDbiQ9NSC5.
    PRIDEiQ9NSC5.

    PTM databases

    PhosphoSiteiQ9NSC5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NSC5.
    BgeeiQ9NSC5.
    CleanExiHS_HOMER3.
    GenevestigatoriQ9NSC5.

    Organism-specific databases

    HPAiCAB032656.
    HPA040999.

    Interactioni

    Subunit structurei

    Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPP05067-83EBI-748420,EBI-302661
    FAT1Q145174EBI-748420,EBI-1171918
    PAX6P263673EBI-748420,EBI-747278

    Protein-protein interaction databases

    BioGridi114843. 18 interactions.
    IntActiQ9NSC5. 26 interactions.
    MINTiMINT-1473946.
    STRINGi9606.ENSP00000348150.

    Structurei

    Secondary structure

    1
    361
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 1915
    Turni21 – 233
    Beta strandi26 – 338
    Beta strandi35 – 428
    Turni43 – 464
    Beta strandi47 – 548
    Beta strandi57 – 637
    Beta strandi70 – 723
    Beta strandi74 – 829
    Turni83 – 864
    Beta strandi87 – 926
    Helixi96 – 11722
    Helixi295 – 35864

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2P8VX-ray1.85A2-118[»]
    3CVFX-ray2.90A/B/C/D287-361[»]
    ProteinModelPortaliQ9NSC5.
    SMRiQ9NSC5. Positions 2-142, 290-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NSC5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili191 – 24353Sequence AnalysisAdd
    BLAST
    Coiled coili254 – 358105Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi206 – 2116Poly-Ala

    Domaini

    The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

    Sequence similaritiesi

    Belongs to the Homer family.Curated
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG76046.
    HOGENOMiHOG000006979.
    HOVERGENiHBG051918.
    InParanoidiQ9NSC5.
    KOiK15010.
    OMAiAEREETQ.
    OrthoDBiEOG72C50J.
    PhylomeDBiQ9NSC5.
    TreeFamiTF325627.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF00568. WH1. 1 hit.
    [Graphical view]
    SMARTiSM00461. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS50229. WH1. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSC5-1) [UniParc]FASTAAdd to Basket

    Also known as: 3a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI    50
    ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT 100
    QFAEKFQEVK EAARLAREKS QDGGELTSPA LGLASHQVPP SPLVSANGPG 150
    EEKLFRSQSA DAPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNNKLA 200
    GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS EVTPTGEKEG 250
    LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL 300
    ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR 350
    EGLARLAEAA P 361
    Length:361
    Mass (Da):39,836
    Last modified:November 28, 2003 - v2
    Checksum:i9FCC62319FF5165A
    GO
    Isoform 2 (identifier: Q9NSC5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         299-301: Missing.

    Show »
    Length:358
    Mass (Da):39,479
    Checksum:i0799594DEABE399F
    GO
    Isoform 3 (identifier: Q9NSC5-3) [UniParc]FASTAAdd to Basket

    Also known as: 3c

    The sequence of this isoform differs from the canonical sequence as follows:
         124-145: GELTSPALGLASHQVPPSPLVS → WGGPQSALVVGSFGAVFELLIV
         146-361: Missing.

    Show »
    Length:145
    Mass (Da):16,032
    Checksum:i4DA4F12F2893744C
    GO
    Isoform 4 (identifier: Q9NSC5-4) [UniParc]FASTAAdd to Basket

    Also known as: 3d

    The sequence of this isoform differs from the canonical sequence as follows:
         118-121: EKSQ → QLQR
         122-361: Missing.

    Show »
    Length:121
    Mass (Da):13,685
    Checksum:i42C572EB13211534
    GO
    Isoform 5 (identifier: Q9NSC5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-136: Missing.

    Show »
    Length:325
    Mass (Da):35,954
    Checksum:iF51CA5A05CB92734
    GO

    Sequence cautioni

    The sequence AAB81545.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti342 – 3421S → R.2 Publications
    Corresponds to variant rs1059240 [ dbSNP | Ensembl ].
    VAR_017410

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei101 – 13636Missing in isoform 5. 1 PublicationVSP_045715Add
    BLAST
    Alternative sequencei118 – 1214EKSQ → QLQR in isoform 4. 1 PublicationVSP_009073
    Alternative sequencei122 – 361240Missing in isoform 4. 1 PublicationVSP_009074Add
    BLAST
    Alternative sequencei124 – 14522GELTS…SPLVS → WGGPQSALVVGSFGAVFELL IV in isoform 3. 1 PublicationVSP_009075Add
    BLAST
    Alternative sequencei146 – 361216Missing in isoform 3. 1 PublicationVSP_009076Add
    BLAST
    Alternative sequencei299 – 3013Missing in isoform 2. 1 PublicationVSP_009077

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093265 mRNA. Translation: AAC71029.1.
    Y17573 mRNA. Translation: CAB75536.1.
    Y18894 mRNA. Translation: CAB75543.1.
    Y18895 mRNA. Translation: CAB75544.1.
    Y18896 mRNA. Translation: CAB75545.1.
    AC002985 Genomic DNA. Translation: AAB81545.1. Sequence problems.
    BC012113 mRNA. Translation: AAH12113.1.
    CCDSiCCDS12391.1. [Q9NSC5-1]
    CCDS46022.1. [Q9NSC5-5]
    CCDS46023.1. [Q9NSC5-2]
    RefSeqiNP_001139193.1. NM_001145721.1. [Q9NSC5-2]
    NP_001139194.1. NM_001145722.1. [Q9NSC5-1]
    NP_001139196.1. NM_001145724.1. [Q9NSC5-5]
    NP_004829.3. NM_004838.3. [Q9NSC5-1]
    XP_006723006.1. XM_006722943.1. [Q9NSC5-1]
    XP_006723007.1. XM_006722944.1. [Q9NSC5-1]
    UniGeneiHs.720208.

    Genome annotation databases

    GeneIDi9454.
    KEGGihsa:9454.
    UCSCiuc002nku.2. human. [Q9NSC5-1]
    uc002nkw.2. human. [Q9NSC5-2]

    Polymorphism databases

    DMDMi38605068.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093265 mRNA. Translation: AAC71029.1 .
    Y17573 mRNA. Translation: CAB75536.1 .
    Y18894 mRNA. Translation: CAB75543.1 .
    Y18895 mRNA. Translation: CAB75544.1 .
    Y18896 mRNA. Translation: CAB75545.1 .
    AC002985 Genomic DNA. Translation: AAB81545.1 . Sequence problems.
    BC012113 mRNA. Translation: AAH12113.1 .
    CCDSi CCDS12391.1. [Q9NSC5-1 ]
    CCDS46022.1. [Q9NSC5-5 ]
    CCDS46023.1. [Q9NSC5-2 ]
    RefSeqi NP_001139193.1. NM_001145721.1. [Q9NSC5-2 ]
    NP_001139194.1. NM_001145722.1. [Q9NSC5-1 ]
    NP_001139196.1. NM_001145724.1. [Q9NSC5-5 ]
    NP_004829.3. NM_004838.3. [Q9NSC5-1 ]
    XP_006723006.1. XM_006722943.1. [Q9NSC5-1 ]
    XP_006723007.1. XM_006722944.1. [Q9NSC5-1 ]
    UniGenei Hs.720208.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2P8V X-ray 1.85 A 2-118 [» ]
    3CVF X-ray 2.90 A/B/C/D 287-361 [» ]
    ProteinModelPortali Q9NSC5.
    SMRi Q9NSC5. Positions 2-142, 290-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114843. 18 interactions.
    IntActi Q9NSC5. 26 interactions.
    MINTi MINT-1473946.
    STRINGi 9606.ENSP00000348150.

    PTM databases

    PhosphoSitei Q9NSC5.

    Polymorphism databases

    DMDMi 38605068.

    Proteomic databases

    MaxQBi Q9NSC5.
    PaxDbi Q9NSC5.
    PRIDEi Q9NSC5.

    Protocols and materials databases

    DNASUi 9454.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9454.
    KEGGi hsa:9454.
    UCSCi uc002nku.2. human. [Q9NSC5-1 ]
    uc002nkw.2. human. [Q9NSC5-2 ]

    Organism-specific databases

    CTDi 9454.
    GeneCardsi GC19M019040.
    HGNCi HGNC:17514. HOMER3.
    HPAi CAB032656.
    HPA040999.
    MIMi 604800. gene.
    neXtProti NX_Q9NSC5.
    PharmGKBi PA134988320.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76046.
    HOGENOMi HOG000006979.
    HOVERGENi HBG051918.
    InParanoidi Q9NSC5.
    KOi K15010.
    OMAi AEREETQ.
    OrthoDBi EOG72C50J.
    PhylomeDBi Q9NSC5.
    TreeFami TF325627.

    Miscellaneous databases

    EvolutionaryTracei Q9NSC5.
    GeneWikii HOMER3.
    GenomeRNAii 9454.
    NextBioi 35420.
    PROi Q9NSC5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSC5.
    Bgeei Q9NSC5.
    CleanExi HS_HOMER3.
    Genevestigatori Q9NSC5.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF00568. WH1. 1 hit.
    [Graphical view ]
    SMARTi SM00461. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
      Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
      Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
      Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
      J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT ARG-342.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-342.
      Tissue: Uterus.

    Entry informationi

    Entry nameiHOME3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSC5
    Secondary accession number(s): E9PCW9
    , O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 28, 2003
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3