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Protein

Homer protein homolog 3

Gene

HOMER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled glutamate receptor signaling pathway Source: ProtInc
  • protein targeting Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Neurexins and neuroligins.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 3
Short name:
Homer-3
Gene namesi
Name:HOMER3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000051128.18.
HGNCiHGNC:17514. HOMER3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9454.
OpenTargetsiENSG00000051128.
PharmGKBiPA134988320.

Polymorphism and mutation databases

BioMutaiHOMER3.
DMDMi38605068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910111 – 361Homer protein homolog 3Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSC5.
MaxQBiQ9NSC5.
PaxDbiQ9NSC5.
PeptideAtlasiQ9NSC5.
PRIDEiQ9NSC5.

PTM databases

iPTMnetiQ9NSC5.
PhosphoSitePlusiQ9NSC5.

Expressioni

Gene expression databases

BgeeiENSG00000051128.
CleanExiHS_HOMER3.
ExpressionAtlasiQ9NSC5. baseline and differential.
GenevisibleiQ9NSC5. HS.

Organism-specific databases

HPAiCAB032656.
HPA040999.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114843. 58 interactors.
IntActiQ9NSC5. 101 interactors.
MINTiMINT-1473946.
STRINGi9606.ENSP00000376162.

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 19Combined sources15
Turni21 – 23Combined sources3
Beta strandi26 – 33Combined sources8
Beta strandi35 – 42Combined sources8
Turni43 – 46Combined sources4
Beta strandi47 – 54Combined sources8
Beta strandi57 – 63Combined sources7
Beta strandi70 – 72Combined sources3
Beta strandi74 – 82Combined sources9
Turni83 – 86Combined sources4
Beta strandi87 – 92Combined sources6
Helixi96 – 117Combined sources22
Helixi295 – 358Combined sources64

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P8VX-ray1.85A2-118[»]
3CVFX-ray2.90A/B/C/D287-361[»]
ProteinModelPortaliQ9NSC5.
SMRiQ9NSC5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSC5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 243Sequence analysisAdd BLAST53
Coiled coili254 – 358Sequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 211Poly-Ala6

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIX6. Eukaryota.
ENOG41101PM. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSC5.
KOiK15010.
OMAiQDKTELT.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ9NSC5.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
PfamiView protein in Pfam
PF00568. WH1. 1 hit.
SMARTiView protein in SMART
SM00461. WH1. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50229. WH1. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSC5-1) [UniParc]FASTAAdd to basket
Also known as: 3a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGELTSPA LGLASHQVPP SPLVSANGPG
160 170 180 190 200
EEKLFRSQSA DAPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNNKLA
210 220 230 240 250
GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS EVTPTGEKEG
260 270 280 290 300
LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL
310 320 330 340 350
ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR
360
EGLARLAEAA P
Length:361
Mass (Da):39,836
Last modified:November 28, 2003 - v2
Checksum:i9FCC62319FF5165A
GO
Isoform 2 (identifier: Q9NSC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-301: Missing.

Show »
Length:358
Mass (Da):39,479
Checksum:i0799594DEABE399F
GO
Isoform 3 (identifier: Q9NSC5-3) [UniParc]FASTAAdd to basket
Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: GELTSPALGLASHQVPPSPLVS → WGGPQSALVVGSFGAVFELLIV
     146-361: Missing.

Show »
Length:145
Mass (Da):16,032
Checksum:i4DA4F12F2893744C
GO
Isoform 4 (identifier: Q9NSC5-4) [UniParc]FASTAAdd to basket
Also known as: 3d

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: EKSQ → QLQR
     122-361: Missing.

Show »
Length:121
Mass (Da):13,685
Checksum:i42C572EB13211534
GO
Isoform 5 (identifier: Q9NSC5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-136: Missing.

Show »
Length:325
Mass (Da):35,954
Checksum:iF51CA5A05CB92734
GO

Sequence cautioni

The sequence AAB81545 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017410342S → R4 PublicationsCorresponds to variant dbSNP:rs1059240Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045715101 – 136Missing in isoform 5. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_009073118 – 121EKSQ → QLQR in isoform 4. 1 Publication4
Alternative sequenceiVSP_009074122 – 361Missing in isoform 4. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_009075124 – 145GELTS…SPLVS → WGGPQSALVVGSFGAVFELL IV in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_009076146 – 361Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_009077299 – 301Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093265 mRNA. Translation: AAC71029.1.
Y17573 mRNA. Translation: CAB75536.1.
Y18894 mRNA. Translation: CAB75543.1.
Y18895 mRNA. Translation: CAB75544.1.
Y18896 mRNA. Translation: CAB75545.1.
AK124450 mRNA. Translation: BAG54040.1.
AK313995 mRNA. Translation: BAG36707.1.
AC002985 Genomic DNA. Translation: AAB81545.1. Sequence problems.
CH471106 Genomic DNA. Translation: EAW84763.1.
BC012113 mRNA. Translation: AAH12113.1.
CCDSiCCDS12391.1. [Q9NSC5-1]
CCDS46022.1. [Q9NSC5-5]
CCDS46023.1. [Q9NSC5-2]
RefSeqiNP_001139193.1. NM_001145721.1. [Q9NSC5-2]
NP_001139194.1. NM_001145722.1. [Q9NSC5-1]
NP_001139196.1. NM_001145724.1. [Q9NSC5-5]
NP_004829.3. NM_004838.3. [Q9NSC5-1]
XP_006723006.1. XM_006722943.1. [Q9NSC5-1]
XP_006723007.1. XM_006722944.1. [Q9NSC5-1]
UniGeneiHs.720208.

Genome annotation databases

EnsembliENST00000221222; ENSP00000221222; ENSG00000051128. [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128. [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128. [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128. [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128. [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128. [Q9NSC5-5]
GeneIDi9454.
KEGGihsa:9454.
UCSCiuc002nku.3. human. [Q9NSC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHOME3_HUMAN
AccessioniPrimary (citable) accession number: Q9NSC5
Secondary accession number(s): B2RA10
, E9PCW9, O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: September 27, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families