SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NSB8

- HOME2_HUMAN

UniProt

Q9NSB8 - HOME2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homer protein homolog 2

Gene
HOMER2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

GO - Biological processi

  1. behavioral response to cocaine Source: Ensembl
  2. calcium-mediated signaling using intracellular calcium source Source: Ensembl
  3. chemical homeostasis within a tissue Source: Ensembl
  4. G-protein coupled glutamate receptor signaling pathway Source: ProtInc
  5. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9NSB8.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 2
Short name:
Homer-2
Alternative name(s):
Cupidin
Gene namesi
Name:HOMER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:17513. HOMER2.

Subcellular locationi

Cytoplasm. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell junctionsynapse
Note: Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell junction Source: HPA
  3. cytoplasm Source: HPA
  4. dendrite Source: Ensembl
  5. neuronal cell body Source: Ensembl
  6. nucleolus Source: HPA
  7. nucleus Source: HPA
  8. plasma membrane Source: HPA
  9. postsynaptic density Source: UniProtKB-SubCell
  10. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homer protein homolog 2PRO_0000191008Add
BLAST

Proteomic databases

MaxQBiQ9NSB8.
PaxDbiQ9NSB8.
PRIDEiQ9NSB8.

PTM databases

PhosphoSiteiQ9NSB8.

Expressioni

Gene expression databases

ArrayExpressiQ9NSB8.
BgeeiQ9NSB8.
CleanExiHS_HOMER2.
GenevestigatoriQ9NSB8.

Organism-specific databases

HPAiHPA040134.
HPA053233.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Protein-protein interaction databases

BioGridi114844. 8 interactions.
IntActiQ9NSB8. 2 interactions.
STRINGi9606.ENSP00000305632.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB8.
SMRiQ9NSB8. Positions 3-111.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110WH1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili92 – 12231 Reviewed predictionAdd
BLAST
Coiled coili160 – 329170 Reviewed predictionAdd
BLAST

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.
Contains 1 WH1 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG68331.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSB8.
KOiK15010.
OMAiNWMPASK.
PhylomeDBiQ9NSB8.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSB8-1) [UniParc]FASTAAdd to Basket

Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV    50
DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA 100
EKFQEVKEAA KIAKDKTQEK IETSSNHSQE SGRETPSSTQ ASSVNGTDDE 150
KASHAGPANT HLKSENDKLK IALTQSAANV KKWEIELQTL RESNARLTTA 200
LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN REKEKNTQLK 250
RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN 300
LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL 350
GTDN 354
Length:354
Mass (Da):40,627
Last modified:October 1, 2000 - v1
Checksum:i33D258177F798373
GO
Isoform 2 (identifier: Q9NSB8-2) [UniParc]FASTAAdd to Basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Show »
Length:343
Mass (Da):39,467
Checksum:i2980EBF0280F1772
GO

Sequence cautioni

The sequence CAB75539.1 differs from that shown. Reason: Aberrant splicing.
The sequence CAB75540.1 differs from that shown. Reason: Aberrant splicing.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191R → H.
Corresponds to variant rs7175005 [ dbSNP | Ensembl ].
VAR_053366
Natural varianti239 – 2391I → S.
Corresponds to variant rs17158223 [ dbSNP | Ensembl ].
VAR_053367

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei130 – 14011Missing in isoform 2. VSP_041731Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491D → E in AAC71027. 1 Publication
Sequence conflicti149 – 1491D → E in AAC71028. 1 Publication
Sequence conflicti161 – 1611H → Q in AAC71027. 1 Publication
Sequence conflicti161 – 1611H → Q in AAC71028. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093263 mRNA. Translation: AAC71027.1.
AF093264 mRNA. Translation: AAC71028.1.
Y19025 mRNA. Translation: CAB75537.1.
Y19026 mRNA. Translation: CAB75538.1.
Y19027 mRNA. Translation: CAB75539.1. Sequence problems.
Y19028 mRNA. Translation: CAB75540.1. Sequence problems.
AF081530 mRNA. Translation: AAD13748.1.
AC022558 Genomic DNA. No translation available.
AC044907 Genomic DNA. No translation available.
BC012109 mRNA. Translation: AAH12109.1.
CCDSiCCDS45334.1. [Q9NSB8-1]
CCDS45336.1. [Q9NSB8-2]
RefSeqiNP_004830.2. NM_004839.3. [Q9NSB8-2]
NP_955362.1. NM_199330.2. [Q9NSB8-1]
UniGeneiHs.578443.
Hs.729618.

Genome annotation databases

EnsembliENST00000304231; ENSP00000305632; ENSG00000103942. [Q9NSB8-1]
ENST00000450735; ENSP00000407634; ENSG00000103942. [Q9NSB8-2]
GeneIDi9455.
KEGGihsa:9455.
UCSCiuc002bjg.3. human. [Q9NSB8-1]
uc002bjh.3. human. [Q9NSB8-2]

Polymorphism databases

DMDMi38605067.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093263 mRNA. Translation: AAC71027.1 .
AF093264 mRNA. Translation: AAC71028.1 .
Y19025 mRNA. Translation: CAB75537.1 .
Y19026 mRNA. Translation: CAB75538.1 .
Y19027 mRNA. Translation: CAB75539.1 . Sequence problems.
Y19028 mRNA. Translation: CAB75540.1 . Sequence problems.
AF081530 mRNA. Translation: AAD13748.1 .
AC022558 Genomic DNA. No translation available.
AC044907 Genomic DNA. No translation available.
BC012109 mRNA. Translation: AAH12109.1 .
CCDSi CCDS45334.1. [Q9NSB8-1 ]
CCDS45336.1. [Q9NSB8-2 ]
RefSeqi NP_004830.2. NM_004839.3. [Q9NSB8-2 ]
NP_955362.1. NM_199330.2. [Q9NSB8-1 ]
UniGenei Hs.578443.
Hs.729618.

3D structure databases

ProteinModelPortali Q9NSB8.
SMRi Q9NSB8. Positions 3-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114844. 8 interactions.
IntActi Q9NSB8. 2 interactions.
STRINGi 9606.ENSP00000305632.

PTM databases

PhosphoSitei Q9NSB8.

Polymorphism databases

DMDMi 38605067.

Proteomic databases

MaxQBi Q9NSB8.
PaxDbi Q9NSB8.
PRIDEi Q9NSB8.

Protocols and materials databases

DNASUi 9455.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304231 ; ENSP00000305632 ; ENSG00000103942 . [Q9NSB8-1 ]
ENST00000450735 ; ENSP00000407634 ; ENSG00000103942 . [Q9NSB8-2 ]
GeneIDi 9455.
KEGGi hsa:9455.
UCSCi uc002bjg.3. human. [Q9NSB8-1 ]
uc002bjh.3. human. [Q9NSB8-2 ]

Organism-specific databases

CTDi 9455.
GeneCardsi GC15M083517.
H-InvDB HIX0037900.
HGNCi HGNC:17513. HOMER2.
HPAi HPA040134.
HPA053233.
MIMi 604799. gene.
neXtProti NX_Q9NSB8.
PharmGKBi PA134870500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68331.
HOGENOMi HOG000006979.
HOVERGENi HBG051918.
InParanoidi Q9NSB8.
KOi K15010.
OMAi NWMPASK.
PhylomeDBi Q9NSB8.
TreeFami TF325627.

Enzyme and pathway databases

SignaLinki Q9NSB8.

Miscellaneous databases

GeneWikii HOMER2.
GenomeRNAii 9455.
NextBioi 35424.
PROi Q9NSB8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NSB8.
Bgeei Q9NSB8.
CleanExi HS_HOMER2.
Genevestigatori Q9NSB8.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view ]
Pfami PF00568. WH1. 1 hit.
[Graphical view ]
SMARTi SM00461. WH1. 1 hit.
[Graphical view ]
PROSITEi PS50229. WH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
    Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
    Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Frontal cortex.
  2. "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
    Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
    J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-182 (ISOFORMS 1/2).
  3. "Mammalian neuralized interacts with a novel protein which has a EVH1-like domain."
    Yoshida M., Ueno M., Nakamura H., Saya H.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
    Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
    Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRM1; GRM5; DYN3 AND ITPR1.

Entry informationi

Entry nameiHOME2_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB8
Secondary accession number(s): O95269
, O95349, Q9NSB6, Q9NSB7, Q9UNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi