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Protein

Homer protein homolog 2

Gene

HOMER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9NSB8.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 2
Short name:
Homer-2
Alternative name(s):
Cupidin
Gene namesi
Name:HOMER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17513. HOMER2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870500.

Polymorphism and mutation databases

BioMutaiHOMER2.
DMDMi38605067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homer protein homolog 2PRO_0000191008Add
BLAST

Proteomic databases

MaxQBiQ9NSB8.
PaxDbiQ9NSB8.
PRIDEiQ9NSB8.

PTM databases

PhosphoSiteiQ9NSB8.

Expressioni

Gene expression databases

BgeeiQ9NSB8.
CleanExiHS_HOMER2.
ExpressionAtlasiQ9NSB8. baseline and differential.
GenevisibleiQ9NSB8. HS.

Organism-specific databases

HPAiHPA040134.
HPA053233.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Binary interactionsi

WithEntry#Exp.IntActNotes
LZTS2Q9BRK43EBI-2126733,EBI-741037
RNF41Q9H4P43EBI-2126733,EBI-2130266

Protein-protein interaction databases

BioGridi114844. 12 interactions.
IntActiQ9NSB8. 4 interactions.
STRINGi9606.ENSP00000305632.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB8.
SMRiQ9NSB8. Positions 3-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110WH1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili92 – 12231Sequence AnalysisAdd
BLAST
Coiled coili160 – 329170Sequence AnalysisAdd
BLAST

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG68331.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSB8.
KOiK15010.
OMAiMAECESI.
PhylomeDBiQ9NSB8.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSB8-1) [UniParc]FASTAAdd to basket

Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV
60 70 80 90 100
DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA
110 120 130 140 150
EKFQEVKEAA KIAKDKTQEK IETSSNHSQE SGRETPSSTQ ASSVNGTDDE
160 170 180 190 200
KASHAGPANT HLKSENDKLK IALTQSAANV KKWEIELQTL RESNARLTTA
210 220 230 240 250
LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN REKEKNTQLK
260 270 280 290 300
RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
310 320 330 340 350
LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL

GTDN
Length:354
Mass (Da):40,627
Last modified:October 1, 2000 - v1
Checksum:i33D258177F798373
GO
Isoform 2 (identifier: Q9NSB8-2) [UniParc]FASTAAdd to basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Show »
Length:343
Mass (Da):39,467
Checksum:i2980EBF0280F1772
GO

Sequence cautioni

The sequence CAB75539.1 differs from that shown.Aberrant splicing.Curated
The sequence CAB75540.1 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491D → E in AAC71027 (PubMed:9808458).Curated
Sequence conflicti149 – 1491D → E in AAC71028 (PubMed:9808458).Curated
Sequence conflicti161 – 1611H → Q in AAC71027 (PubMed:9808458).Curated
Sequence conflicti161 – 1611H → Q in AAC71028 (PubMed:9808458).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191R → H.
Corresponds to variant rs7175005 [ dbSNP | Ensembl ].
VAR_053366
Natural varianti239 – 2391I → S.
Corresponds to variant rs17158223 [ dbSNP | Ensembl ].
VAR_053367

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei130 – 14011Missing in isoform 2. 4 PublicationsVSP_041731Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093263 mRNA. Translation: AAC71027.1.
AF093264 mRNA. Translation: AAC71028.1.
Y19025 mRNA. Translation: CAB75537.1.
Y19026 mRNA. Translation: CAB75538.1.
Y19027 mRNA. Translation: CAB75539.1. Sequence problems.
Y19028 mRNA. Translation: CAB75540.1. Sequence problems.
AF081530 mRNA. Translation: AAD13748.1.
AC022558 Genomic DNA. No translation available.
AC044907 Genomic DNA. No translation available.
BC012109 mRNA. Translation: AAH12109.1.
CCDSiCCDS45334.1. [Q9NSB8-1]
CCDS45336.1. [Q9NSB8-2]
RefSeqiNP_004830.2. NM_004839.3. [Q9NSB8-2]
NP_955362.1. NM_199330.2. [Q9NSB8-1]
UniGeneiHs.578443.
Hs.729618.

Genome annotation databases

EnsembliENST00000304231; ENSP00000305632; ENSG00000103942.
ENST00000450735; ENSP00000407634; ENSG00000103942. [Q9NSB8-2]
GeneIDi9455.
KEGGihsa:9455.
UCSCiuc002bjg.3. human. [Q9NSB8-1]
uc002bjh.3. human. [Q9NSB8-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093263 mRNA. Translation: AAC71027.1.
AF093264 mRNA. Translation: AAC71028.1.
Y19025 mRNA. Translation: CAB75537.1.
Y19026 mRNA. Translation: CAB75538.1.
Y19027 mRNA. Translation: CAB75539.1. Sequence problems.
Y19028 mRNA. Translation: CAB75540.1. Sequence problems.
AF081530 mRNA. Translation: AAD13748.1.
AC022558 Genomic DNA. No translation available.
AC044907 Genomic DNA. No translation available.
BC012109 mRNA. Translation: AAH12109.1.
CCDSiCCDS45334.1. [Q9NSB8-1]
CCDS45336.1. [Q9NSB8-2]
RefSeqiNP_004830.2. NM_004839.3. [Q9NSB8-2]
NP_955362.1. NM_199330.2. [Q9NSB8-1]
UniGeneiHs.578443.
Hs.729618.

3D structure databases

ProteinModelPortaliQ9NSB8.
SMRiQ9NSB8. Positions 3-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114844. 12 interactions.
IntActiQ9NSB8. 4 interactions.
STRINGi9606.ENSP00000305632.

PTM databases

PhosphoSiteiQ9NSB8.

Polymorphism and mutation databases

BioMutaiHOMER2.
DMDMi38605067.

Proteomic databases

MaxQBiQ9NSB8.
PaxDbiQ9NSB8.
PRIDEiQ9NSB8.

Protocols and materials databases

DNASUi9455.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304231; ENSP00000305632; ENSG00000103942.
ENST00000450735; ENSP00000407634; ENSG00000103942. [Q9NSB8-2]
GeneIDi9455.
KEGGihsa:9455.
UCSCiuc002bjg.3. human. [Q9NSB8-1]
uc002bjh.3. human. [Q9NSB8-2]

Organism-specific databases

CTDi9455.
GeneCardsiGC15M083517.
H-InvDBHIX0037900.
HGNCiHGNC:17513. HOMER2.
HPAiHPA040134.
HPA053233.
MIMi604799. gene.
neXtProtiNX_Q9NSB8.
PharmGKBiPA134870500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68331.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9NSB8.
KOiK15010.
OMAiMAECESI.
PhylomeDBiQ9NSB8.
TreeFamiTF325627.

Enzyme and pathway databases

SignaLinkiQ9NSB8.

Miscellaneous databases

GeneWikiiHOMER2.
GenomeRNAii9455.
NextBioi35424.
PROiQ9NSB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NSB8.
CleanExiHS_HOMER2.
ExpressionAtlasiQ9NSB8. baseline and differential.
GenevisibleiQ9NSB8. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
    Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
    Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Frontal cortex.
  2. "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
    Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
    J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-182 (ISOFORMS 1/2).
  3. "Mammalian neuralized interacts with a novel protein which has a EVH1-like domain."
    Yoshida M., Ueno M., Nakamura H., Saya H.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
    Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
    Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRM1; GRM5; DYN3 AND ITPR1.

Entry informationi

Entry nameiHOME2_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB8
Secondary accession number(s): O95269
, O95349, Q9NSB6, Q9NSB7, Q9UNT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.