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Q9NSB8

- HOME2_HUMAN

UniProt

Q9NSB8 - HOME2_HUMAN

Protein

Homer protein homolog 2

Gene

HOMER2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

    GO - Biological processi

    1. behavioral response to cocaine Source: Ensembl
    2. calcium-mediated signaling using intracellular calcium source Source: Ensembl
    3. chemical homeostasis within a tissue Source: Ensembl
    4. G-protein coupled glutamate receptor signaling pathway Source: ProtInc
    5. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl

    Enzyme and pathway databases

    SignaLinkiQ9NSB8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homer protein homolog 2
    Short name:
    Homer-2
    Alternative name(s):
    Cupidin
    Gene namesi
    Name:HOMER2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17513. HOMER2.

    Subcellular locationi

    Cytoplasm. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell junctionsynapse
    Note: Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cell junction Source: HPA
    3. cytoplasm Source: HPA
    4. dendrite Source: Ensembl
    5. neuronal cell body Source: Ensembl
    6. nucleolus Source: HPA
    7. nucleus Source: HPA
    8. plasma membrane Source: HPA
    9. postsynaptic density Source: UniProtKB-SubCell
    10. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134870500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Homer protein homolog 2PRO_0000191008Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSB8.
    PaxDbiQ9NSB8.
    PRIDEiQ9NSB8.

    PTM databases

    PhosphoSiteiQ9NSB8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NSB8.
    BgeeiQ9NSB8.
    CleanExiHS_HOMER2.
    GenevestigatoriQ9NSB8.

    Organism-specific databases

    HPAiHPA040134.
    HPA053233.

    Interactioni

    Subunit structurei

    Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

    Protein-protein interaction databases

    BioGridi114844. 9 interactions.
    IntActiQ9NSB8. 2 interactions.
    STRINGi9606.ENSP00000305632.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSB8.
    SMRiQ9NSB8. Positions 3-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 110110WH1PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili92 – 12231Sequence AnalysisAdd
    BLAST
    Coiled coili160 – 329170Sequence AnalysisAdd
    BLAST

    Domaini

    The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

    Sequence similaritiesi

    Belongs to the Homer family.Curated
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG68331.
    HOGENOMiHOG000006979.
    HOVERGENiHBG051918.
    InParanoidiQ9NSB8.
    KOiK15010.
    OMAiNWMPASK.
    PhylomeDBiQ9NSB8.
    TreeFamiTF325627.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF00568. WH1. 1 hit.
    [Graphical view]
    SMARTiSM00461. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS50229. WH1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSB8-1) [UniParc]FASTAAdd to Basket

    Also known as: 2b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV    50
    DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA 100
    EKFQEVKEAA KIAKDKTQEK IETSSNHSQE SGRETPSSTQ ASSVNGTDDE 150
    KASHAGPANT HLKSENDKLK IALTQSAANV KKWEIELQTL RESNARLTTA 200
    LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN REKEKNTQLK 250
    RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN 300
    LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL 350
    GTDN 354
    Length:354
    Mass (Da):40,627
    Last modified:October 1, 2000 - v1
    Checksum:i33D258177F798373
    GO
    Isoform 2 (identifier: Q9NSB8-2) [UniParc]FASTAAdd to Basket

    Also known as: 2a

    The sequence of this isoform differs from the canonical sequence as follows:
         130-140: Missing.

    Show »
    Length:343
    Mass (Da):39,467
    Checksum:i2980EBF0280F1772
    GO

    Sequence cautioni

    The sequence CAB75539.1 differs from that shown. Reason: Aberrant splicing.
    The sequence CAB75540.1 differs from that shown. Reason: Aberrant splicing.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491D → E in AAC71027. (PubMed:9808458)Curated
    Sequence conflicti149 – 1491D → E in AAC71028. (PubMed:9808458)Curated
    Sequence conflicti161 – 1611H → Q in AAC71027. (PubMed:9808458)Curated
    Sequence conflicti161 – 1611H → Q in AAC71028. (PubMed:9808458)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191R → H.
    Corresponds to variant rs7175005 [ dbSNP | Ensembl ].
    VAR_053366
    Natural varianti239 – 2391I → S.
    Corresponds to variant rs17158223 [ dbSNP | Ensembl ].
    VAR_053367

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei130 – 14011Missing in isoform 2. 4 PublicationsVSP_041731Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093263 mRNA. Translation: AAC71027.1.
    AF093264 mRNA. Translation: AAC71028.1.
    Y19025 mRNA. Translation: CAB75537.1.
    Y19026 mRNA. Translation: CAB75538.1.
    Y19027 mRNA. Translation: CAB75539.1. Sequence problems.
    Y19028 mRNA. Translation: CAB75540.1. Sequence problems.
    AF081530 mRNA. Translation: AAD13748.1.
    AC022558 Genomic DNA. No translation available.
    AC044907 Genomic DNA. No translation available.
    BC012109 mRNA. Translation: AAH12109.1.
    CCDSiCCDS45334.1. [Q9NSB8-1]
    CCDS45336.1. [Q9NSB8-2]
    RefSeqiNP_004830.2. NM_004839.3. [Q9NSB8-2]
    NP_955362.1. NM_199330.2. [Q9NSB8-1]
    UniGeneiHs.578443.
    Hs.729618.

    Genome annotation databases

    EnsembliENST00000304231; ENSP00000305632; ENSG00000103942. [Q9NSB8-1]
    ENST00000450735; ENSP00000407634; ENSG00000103942. [Q9NSB8-2]
    GeneIDi9455.
    KEGGihsa:9455.
    UCSCiuc002bjg.3. human. [Q9NSB8-1]
    uc002bjh.3. human. [Q9NSB8-2]

    Polymorphism databases

    DMDMi38605067.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093263 mRNA. Translation: AAC71027.1 .
    AF093264 mRNA. Translation: AAC71028.1 .
    Y19025 mRNA. Translation: CAB75537.1 .
    Y19026 mRNA. Translation: CAB75538.1 .
    Y19027 mRNA. Translation: CAB75539.1 . Sequence problems.
    Y19028 mRNA. Translation: CAB75540.1 . Sequence problems.
    AF081530 mRNA. Translation: AAD13748.1 .
    AC022558 Genomic DNA. No translation available.
    AC044907 Genomic DNA. No translation available.
    BC012109 mRNA. Translation: AAH12109.1 .
    CCDSi CCDS45334.1. [Q9NSB8-1 ]
    CCDS45336.1. [Q9NSB8-2 ]
    RefSeqi NP_004830.2. NM_004839.3. [Q9NSB8-2 ]
    NP_955362.1. NM_199330.2. [Q9NSB8-1 ]
    UniGenei Hs.578443.
    Hs.729618.

    3D structure databases

    ProteinModelPortali Q9NSB8.
    SMRi Q9NSB8. Positions 3-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114844. 9 interactions.
    IntActi Q9NSB8. 2 interactions.
    STRINGi 9606.ENSP00000305632.

    PTM databases

    PhosphoSitei Q9NSB8.

    Polymorphism databases

    DMDMi 38605067.

    Proteomic databases

    MaxQBi Q9NSB8.
    PaxDbi Q9NSB8.
    PRIDEi Q9NSB8.

    Protocols and materials databases

    DNASUi 9455.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304231 ; ENSP00000305632 ; ENSG00000103942 . [Q9NSB8-1 ]
    ENST00000450735 ; ENSP00000407634 ; ENSG00000103942 . [Q9NSB8-2 ]
    GeneIDi 9455.
    KEGGi hsa:9455.
    UCSCi uc002bjg.3. human. [Q9NSB8-1 ]
    uc002bjh.3. human. [Q9NSB8-2 ]

    Organism-specific databases

    CTDi 9455.
    GeneCardsi GC15M083517.
    H-InvDB HIX0037900.
    HGNCi HGNC:17513. HOMER2.
    HPAi HPA040134.
    HPA053233.
    MIMi 604799. gene.
    neXtProti NX_Q9NSB8.
    PharmGKBi PA134870500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68331.
    HOGENOMi HOG000006979.
    HOVERGENi HBG051918.
    InParanoidi Q9NSB8.
    KOi K15010.
    OMAi NWMPASK.
    PhylomeDBi Q9NSB8.
    TreeFami TF325627.

    Enzyme and pathway databases

    SignaLinki Q9NSB8.

    Miscellaneous databases

    GeneWikii HOMER2.
    GenomeRNAii 9455.
    NextBioi 35424.
    PROi Q9NSB8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSB8.
    Bgeei Q9NSB8.
    CleanExi HS_HOMER2.
    Genevestigatori Q9NSB8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF00568. WH1. 1 hit.
    [Graphical view ]
    SMARTi SM00461. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
      Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
      Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Frontal cortex.
    2. "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
      Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
      J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-182 (ISOFORMS 1/2).
    3. "Mammalian neuralized interacts with a novel protein which has a EVH1-like domain."
      Yoshida M., Ueno M., Nakamura H., Saya H.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    6. "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
      Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
      Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRM1; GRM5; DYN3 AND ITPR1.

    Entry informationi

    Entry nameiHOME2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSB8
    Secondary accession number(s): O95269
    , O95349, Q9NSB6, Q9NSB7, Q9UNT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3