Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NSB8 (HOME2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homer protein homolog 2

Short name=Homer-2
Alternative name(s):
Cupidin
Gene names
Name:HOMER2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.

Subunit structure

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Subcellular location

Cytoplasm. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell junctionsynapse. Note: Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Domain

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similarities

Belongs to the Homer family.

Contains 1 WH1 domain.

Sequence caution

The sequence CAB75539.1 differs from that shown. Reason: Aberrant splicing.

The sequence CAB75540.1 differs from that shown. Reason: Aberrant splicing.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NSB8-1)

Also known as: 2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NSB8-2)

Also known as: 2a;

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Homer protein homolog 2
PRO_0000191008

Regions

Domain1 – 110110WH1
Coiled coil92 – 12231 Potential
Coiled coil160 – 329170 Potential

Natural variations

Alternative sequence130 – 14011Missing in isoform 2.
VSP_041731
Natural variant2191R → H.
Corresponds to variant rs7175005 [ dbSNP | Ensembl ].
VAR_053366
Natural variant2391I → S.
Corresponds to variant rs17158223 [ dbSNP | Ensembl ].
VAR_053367

Experimental info

Sequence conflict1491D → E in AAC71027. Ref.1
Sequence conflict1491D → E in AAC71028. Ref.1
Sequence conflict1611H → Q in AAC71027. Ref.1
Sequence conflict1611H → Q in AAC71028. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (2b) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 33D258177F798373

FASTA35440,627
        10         20         30         40         50         60 
MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV DGAKVIINST 

        70         80         90        100        110        120 
ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA EKFQEVKEAA KIAKDKTQEK 

       130        140        150        160        170        180 
IETSSNHSQE SGRETPSSTQ ASSVNGTDDE KASHAGPANT HLKSENDKLK IALTQSAANV 

       190        200        210        220        230        240 
KKWEIELQTL RESNARLTTA LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN 

       250        260        270        280        290        300 
REKEKNTQLK RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN 

       310        320        330        340        350 
LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL GTDN 

« Hide

Isoform 2 (2a) [UniParc].

Checksum: 2980EBF0280F1772
Show »

FASTA34339,467

References

« Hide 'large scale' references
[1]"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins."
Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.
Neuron 21:707-716(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Frontal cortex.
[2]"Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing."
Soloviev M., Ciruela F., Chan W.-Y., McIlhinney R.A.J.
J. Mol. Biol. 295:1185-1200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-182 (ISOFORMS 1/2).
[3]"Mammalian neuralized interacts with a novel protein which has a EVH1-like domain."
Yoshida M., Ueno M., Nakamura H., Saya H.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[6]"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GRM1; GRM5; DYN3 AND ITPR1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF093263 mRNA. Translation: AAC71027.1.
AF093264 mRNA. Translation: AAC71028.1.
Y19025 mRNA. Translation: CAB75537.1.
Y19026 mRNA. Translation: CAB75538.1.
Y19027 mRNA. Translation: CAB75539.1. Sequence problems.
Y19028 mRNA. Translation: CAB75540.1. Sequence problems.
AF081530 mRNA. Translation: AAD13748.1.
AC022558 Genomic DNA. No translation available.
AC044907 Genomic DNA. No translation available.
BC012109 mRNA. Translation: AAH12109.1.
CCDSCCDS45334.1. [Q9NSB8-1]
CCDS45336.1. [Q9NSB8-2]
RefSeqNP_004830.2. NM_004839.3. [Q9NSB8-2]
NP_955362.1. NM_199330.2. [Q9NSB8-1]
UniGeneHs.578443.
Hs.729618.

3D structure databases

ProteinModelPortalQ9NSB8.
SMRQ9NSB8. Positions 3-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114844. 8 interactions.
IntActQ9NSB8. 2 interactions.
STRING9606.ENSP00000305632.

PTM databases

PhosphoSiteQ9NSB8.

Polymorphism databases

DMDM38605067.

Proteomic databases

MaxQBQ9NSB8.
PaxDbQ9NSB8.
PRIDEQ9NSB8.

Protocols and materials databases

DNASU9455.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304231; ENSP00000305632; ENSG00000103942. [Q9NSB8-1]
ENST00000450735; ENSP00000407634; ENSG00000103942. [Q9NSB8-2]
GeneID9455.
KEGGhsa:9455.
UCSCuc002bjg.3. human. [Q9NSB8-1]
uc002bjh.3. human. [Q9NSB8-2]

Organism-specific databases

CTD9455.
GeneCardsGC15M083517.
H-InvDBHIX0037900.
HGNCHGNC:17513. HOMER2.
HPAHPA040134.
HPA053233.
MIM604799. gene.
neXtProtNX_Q9NSB8.
PharmGKBPA134870500.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68331.
HOGENOMHOG000006979.
HOVERGENHBG051918.
InParanoidQ9NSB8.
KOK15010.
OMANWMPASK.
PhylomeDBQ9NSB8.
TreeFamTF325627.

Enzyme and pathway databases

SignaLinkQ9NSB8.

Gene expression databases

ArrayExpressQ9NSB8.
BgeeQ9NSB8.
CleanExHS_HOMER2.
GenevestigatorQ9NSB8.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF00568. WH1. 1 hit.
[Graphical view]
SMARTSM00461. WH1. 1 hit.
[Graphical view]
PROSITEPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOMER2.
GenomeRNAi9455.
NextBio35424.
PROQ9NSB8.
SOURCESearch...

Entry information

Entry nameHOME2_HUMAN
AccessionPrimary (citable) accession number: Q9NSB8
Secondary accession number(s): O95269 expand/collapse secondary AC list , O95349, Q9NSB6, Q9NSB7, Q9UNT7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM