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Protein

Keratin, type II cuticular Hb2

Gene

KRT82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161850-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb2
Alternative name(s):
Keratin-82
Short name:
K82
Type II hair keratin Hb2
Type-II keratin Kb22
Gene namesi
Name:KRT82
Synonyms:KRTHB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6459. KRT82.

Subcellular locationi

GO - Cellular componenti

  • keratin filament Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161850.
PharmGKBiPA30248.

Polymorphism and mutation databases

BioMutaiKRT82.
DMDMi148887391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636971 – 513Keratin, type II cuticular Hb2Add BLAST513

Proteomic databases

EPDiQ9NSB4.
PaxDbiQ9NSB4.
PeptideAtlasiQ9NSB4.
PRIDEiQ9NSB4.

PTM databases

iPTMnetiQ9NSB4.
PhosphoSitePlusiQ9NSB4.

Expressioni

Gene expression databases

BgeeiENSG00000161850.
CleanExiHS_KRT82.
GenevisibleiQ9NSB4. HS.

Organism-specific databases

HPAiHPA049946.
HPA058715.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi110086. 11 interactors.
IntActiQ9NSB4. 10 interactors.
STRINGi9606.ENSP00000257974.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB4.
SMRiQ9NSB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 120HeadAdd BLAST120
Regioni121 – 427RodAdd BLAST307
Regioni121 – 155Coil 1AAdd BLAST35
Regioni156 – 165Linker 110
Regioni166 – 266Coil 1BAdd BLAST101
Regioni267 – 283Linker 12Add BLAST17
Regioni284 – 427Coil 2Add BLAST144
Regioni428 – 513TailAdd BLAST86

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB4.
KOiK07605.
OMAiCDNLRNR.
OrthoDBiEOG091G09KR.
PhylomeDBiQ9NSB4.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG
60 70 80 90 100
CLGSRSLCNV GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES
110 120 130 140 150
LLVPLALEID PTVQRVKRDE KEQIKCLNNR FASFINKVRF LEQKNKLLET
160 170 180 190 200
KWNFMQQQRC CQTNIEPIFE GYISALRRQL DCVSGDRVRL ESELCSLQAA
210 220 230 240 250
LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE TNAEALVQEI
260 270 280 290 300
DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA
310 320 330 340 350
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET
360 370 380 390 400
ENVKAQRCKL EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL
410 420 430 440 450
KEYQEVMNSK LGLDIEIATY RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL
460 470 480 490 500
YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL YVPCEPQGLL SCGSGRKSSM
510
TLGAGGSSPS HKH
Length:513
Mass (Da):56,653
Last modified:June 12, 2007 - v3
Checksum:i69BB9256BB3B6587
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032786219E → Q.Corresponds to variant rs1791634dbSNPEnsembl.1
Natural variantiVAR_032787452E → D.Corresponds to variant rs1732263dbSNPEnsembl.1
Natural variantiVAR_018118458T → M.Corresponds to variant rs2658658dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19207 Genomic DNA. Translation: CAB76827.2.
AC078865 Genomic DNA. No translation available.
CCDSiCCDS8826.1.
RefSeqiNP_149022.3. NM_033033.3.
UniGeneiHs.134640.

Genome annotation databases

EnsembliENST00000257974; ENSP00000257974; ENSG00000161850.
GeneIDi3888.
KEGGihsa:3888.
UCSCiuc001sai.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19207 Genomic DNA. Translation: CAB76827.2.
AC078865 Genomic DNA. No translation available.
CCDSiCCDS8826.1.
RefSeqiNP_149022.3. NM_033033.3.
UniGeneiHs.134640.

3D structure databases

ProteinModelPortaliQ9NSB4.
SMRiQ9NSB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110086. 11 interactors.
IntActiQ9NSB4. 10 interactors.
STRINGi9606.ENSP00000257974.

PTM databases

iPTMnetiQ9NSB4.
PhosphoSitePlusiQ9NSB4.

Polymorphism and mutation databases

BioMutaiKRT82.
DMDMi148887391.

Proteomic databases

EPDiQ9NSB4.
PaxDbiQ9NSB4.
PeptideAtlasiQ9NSB4.
PRIDEiQ9NSB4.

Protocols and materials databases

DNASUi3888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257974; ENSP00000257974; ENSG00000161850.
GeneIDi3888.
KEGGihsa:3888.
UCSCiuc001sai.2. human.

Organism-specific databases

CTDi3888.
GeneCardsiKRT82.
HGNCiHGNC:6459. KRT82.
HPAiHPA049946.
HPA058715.
MIMi601078. gene.
neXtProtiNX_Q9NSB4.
OpenTargetsiENSG00000161850.
PharmGKBiPA30248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB4.
KOiK07605.
OMAiCDNLRNR.
OrthoDBiEOG091G09KR.
PhylomeDBiQ9NSB4.
TreeFamiTF317854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161850-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii3888.
PROiQ9NSB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161850.
CleanExiHS_KRT82.
GenevisibleiQ9NSB4. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT82_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.