Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NSB4

- KRT82_HUMAN

UniProt

Q9NSB4 - KRT82_HUMAN

Protein

Keratin, type II cuticular Hb2

Gene

KRT82

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (12 Jun 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. structural constituent of epidermis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cuticular Hb2
    Alternative name(s):
    Keratin-82
    Short name:
    K82
    Type II hair keratin Hb2
    Type-II keratin Kb22
    Gene namesi
    Name:KRT82
    Synonyms:KRTHB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6459. KRT82.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: UniProtKB

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30248.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Keratin, type II cuticular Hb2PRO_0000063697Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSB4.
    PaxDbiQ9NSB4.
    PeptideAtlasiQ9NSB4.
    PRIDEiQ9NSB4.

    PTM databases

    PhosphoSiteiQ9NSB4.

    Expressioni

    Gene expression databases

    BgeeiQ9NSB4.
    CleanExiHS_KRT82.
    GenevestigatoriQ9NSB4.

    Organism-specific databases

    HPAiHPA049946.
    HPA058715.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    BioGridi110086. 8 interactions.
    IntActiQ9NSB4. 3 interactions.
    STRINGi9606.ENSP00000257974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSB4.
    SMRiQ9NSB4. Positions 119-268, 333-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 120120HeadAdd
    BLAST
    Regioni121 – 427307RodAdd
    BLAST
    Regioni121 – 15535Coil 1AAdd
    BLAST
    Regioni156 – 16510Linker 1
    Regioni166 – 266101Coil 1BAdd
    BLAST
    Regioni267 – 28317Linker 12Add
    BLAST
    Regioni284 – 427144Coil 2Add
    BLAST
    Regioni428 – 51386TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG150879.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiQ9NSB4.
    KOiK07605.
    OMAiELSLRPC.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ9NSB4.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NSB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG    50
    CLGSRSLCNV GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES 100
    LLVPLALEID PTVQRVKRDE KEQIKCLNNR FASFINKVRF LEQKNKLLET 150
    KWNFMQQQRC CQTNIEPIFE GYISALRRQL DCVSGDRVRL ESELCSLQAA 200
    LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE TNAEALVQEI 250
    DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 300
    SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET 350
    ENVKAQRCKL EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL 400
    KEYQEVMNSK LGLDIEIATY RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL 450
    YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL YVPCEPQGLL SCGSGRKSSM 500
    TLGAGGSSPS HKH 513
    Length:513
    Mass (Da):56,653
    Last modified:June 12, 2007 - v3
    Checksum:i69BB9256BB3B6587
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191E → Q.
    Corresponds to variant rs1791634 [ dbSNP | Ensembl ].
    VAR_032786
    Natural varianti452 – 4521E → D.
    Corresponds to variant rs1732263 [ dbSNP | Ensembl ].
    VAR_032787
    Natural varianti458 – 4581T → M.
    Corresponds to variant rs2658658 [ dbSNP | Ensembl ].
    VAR_018118

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19207 Genomic DNA. Translation: CAB76827.2.
    AC078865 Genomic DNA. No translation available.
    CCDSiCCDS8826.1.
    RefSeqiNP_149022.3. NM_033033.3.
    UniGeneiHs.134640.

    Genome annotation databases

    EnsembliENST00000257974; ENSP00000257974; ENSG00000161850.
    GeneIDi3888.
    KEGGihsa:3888.
    UCSCiuc001sai.1. human.

    Polymorphism databases

    DMDMi148887391.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19207 Genomic DNA. Translation: CAB76827.2 .
    AC078865 Genomic DNA. No translation available.
    CCDSi CCDS8826.1.
    RefSeqi NP_149022.3. NM_033033.3.
    UniGenei Hs.134640.

    3D structure databases

    ProteinModelPortali Q9NSB4.
    SMRi Q9NSB4. Positions 119-268, 333-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110086. 8 interactions.
    IntActi Q9NSB4. 3 interactions.
    STRINGi 9606.ENSP00000257974.

    PTM databases

    PhosphoSitei Q9NSB4.

    Polymorphism databases

    DMDMi 148887391.

    Proteomic databases

    MaxQBi Q9NSB4.
    PaxDbi Q9NSB4.
    PeptideAtlasi Q9NSB4.
    PRIDEi Q9NSB4.

    Protocols and materials databases

    DNASUi 3888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257974 ; ENSP00000257974 ; ENSG00000161850 .
    GeneIDi 3888.
    KEGGi hsa:3888.
    UCSCi uc001sai.1. human.

    Organism-specific databases

    CTDi 3888.
    GeneCardsi GC12M052787.
    HGNCi HGNC:6459. KRT82.
    HPAi HPA049946.
    HPA058715.
    MIMi 601078. gene.
    neXtProti NX_Q9NSB4.
    PharmGKBi PA30248.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150879.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi Q9NSB4.
    KOi K07605.
    OMAi ELSLRPC.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q9NSB4.
    TreeFami TF317854.

    Miscellaneous databases

    GenomeRNAii 3888.
    NextBioi 15263.
    PROi Q9NSB4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NSB4.
    CleanExi HS_KRT82.
    Genevestigatori Q9NSB4.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
      Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
      J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKRT82_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3