Q9NSB4 (KRT82_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type II cuticular Hb2

Alternative name(s):
Keratin-82
Short name=K82
Type II hair keratin Hb2
Type-II keratin Kb22

Gene names

Name:	KRT82
Synonyms:	KRTHB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	structural constituent of epidermis Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Keratin, type II cuticular Hb2		PRO_0000063697
Regions
	Region	1 – 120	120	Head
	Region	121 – 427	307	Rod
	Region	121 – 155	35	Coil 1A
	Region	156 – 165	10	Linker 1
	Region	166 – 266	101	Coil 1B
	Region	267 – 283	17	Linker 12
	Region	284 – 427	144	Coil 2
	Region	428 – 513	86	Tail
Natural variations
	Natural variant	219	1	E → Q. Corresponds to variant rs1791634 [ dbSNP | Ensembl ].		VAR_032786
	Natural variant	452	1	E → D. Corresponds to variant rs1732263 [ dbSNP | Ensembl ].		VAR_032787
	Natural variant	458	1	T → M. Corresponds to variant rs2658658 [ dbSNP | Ensembl ].		VAR_018118

Sequences

	Sequence		Length	Mass (Da)
	Q9NSB4 [UniParc]. Last modified June 12, 2007. Version 3. Checksum: 69BB9256BB3B6587	FASTA	513	56,653
	10 20 30 40 50 60 MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV 70 80 90 100 110 120 GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE 130 140 150 160 170 180 KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL 190 200 210 220 230 240 DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE 250 260 270 280 290 300 TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 310 320 330 340 350 360 SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL 370 380 390 400 410 420 EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY 430 440 450 460 470 480 RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL 490 500 510 YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 300 kbp region of human DNA containing the type II hair keratin." Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J. J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y19207 Genomic DNA. Translation: CAB76827.2. AC078865 Genomic DNA. No translation available.
IPI	IPI00300053.
RefSeq	NP_149022.3. NM_033033.3.
UniGene	Hs.134640.
3D structure databases
ProteinModelPortal	Q9NSB4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NSB4. 3 interactions.
STRING	9606.ENSP00000257974.
PTM databases
PhosphoSite	Q9NSB4.
Polymorphism databases
DMDM	148887391.
Proteomic databases
PaxDb	Q9NSB4.
PeptideAtlas	Q9NSB4.
PRIDE	Q9NSB4.
Protocols and materials databases
DNASU	3888.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257974; ENSP00000257974; ENSG00000161850.
GeneID	3888.
KEGG	hsa:3888.
UCSC	uc001sai.1. human.
Organism-specific databases
CTD	3888.
GeneCards	GC12M052787.
HGNC	HGNC:6459. KRT82.
MIM	601078. gene.
neXtProt	NX_Q9NSB4.
PharmGKB	PA30248.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150879.
HOGENOM	HOG000230976.
HOVERGEN	HBG013015.
InParanoid	Q9NSB4.
KO	K07605.
OMA	AGNHCDN.
OrthoDB	EOG49W2F9.
PhylomeDB	Q9NSB4.
Gene expression databases
Bgee	Q9NSB4.
CleanEx	HS_KRT82.
Genevestigator	Q9NSB4.
GermOnline	ENSG00000161850. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit. PTHR23239:SF18. PTHR23239:SF18. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3888.
NextBio	15263.
SOURCE	Search...

Entry information

Entry name

KRT82_HUMAN

Accession

Primary (citable) accession number: Q9NSB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.