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Protein

Keratin, type II cuticular Hb2

Gene

KRT82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb2
Alternative name(s):
Keratin-82
Short name:
K82
Type II hair keratin Hb2
Type-II keratin Kb22
Gene namesi
Name:KRT82
Synonyms:KRTHB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000161850.2
HGNCiHGNC:6459 KRT82
MIMi601078 gene
neXtProtiNX_Q9NSB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161850
PharmGKBiPA30248

Polymorphism and mutation databases

BioMutaiKRT82
DMDMi148887391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636971 – 513Keratin, type II cuticular Hb2Add BLAST513

Proteomic databases

EPDiQ9NSB4
PaxDbiQ9NSB4
PeptideAtlasiQ9NSB4
PRIDEiQ9NSB4

PTM databases

iPTMnetiQ9NSB4
PhosphoSitePlusiQ9NSB4

Expressioni

Gene expression databases

BgeeiENSG00000161850
CleanExiHS_KRT82
GenevisibleiQ9NSB4 HS

Organism-specific databases

HPAiHPA058715
HPA067230

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110086, 11 interactors
IntActiQ9NSB4, 15 interactors
STRINGi9606.ENSP00000257974

Structurei

3D structure databases

ProteinModelPortaliQ9NSB4
SMRiQ9NSB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 431IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 120HeadAdd BLAST120
Regioni121 – 155Coil 1AAdd BLAST35
Regioni156 – 165Linker 110
Regioni166 – 266Coil 1BAdd BLAST101
Regioni267 – 283Linker 12Add BLAST17
Regioni284 – 427Coil 2Add BLAST144
Regioni428 – 513TailAdd BLAST86

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ9NSB4
KOiK07605
OMAiTAGNHCD
OrthoDBiEOG091G09KR
PhylomeDBiQ9NSB4
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NSB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG
60 70 80 90 100
CLGSRSLCNV GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES
110 120 130 140 150
LLVPLALEID PTVQRVKRDE KEQIKCLNNR FASFINKVRF LEQKNKLLET
160 170 180 190 200
KWNFMQQQRC CQTNIEPIFE GYISALRRQL DCVSGDRVRL ESELCSLQAA
210 220 230 240 250
LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE TNAEALVQEI
260 270 280 290 300
DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA
310 320 330 340 350
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET
360 370 380 390 400
ENVKAQRCKL EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL
410 420 430 440 450
KEYQEVMNSK LGLDIEIATY RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL
460 470 480 490 500
YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL YVPCEPQGLL SCGSGRKSSM
510
TLGAGGSSPS HKH
Length:513
Mass (Da):56,653
Last modified:June 12, 2007 - v3
Checksum:i69BB9256BB3B6587
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032786219E → Q. Corresponds to variant dbSNP:rs1791634Ensembl.1
Natural variantiVAR_032787452E → D. Corresponds to variant dbSNP:rs1732263Ensembl.1
Natural variantiVAR_018118458T → M. Corresponds to variant dbSNP:rs2658658Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19207 Genomic DNA Translation: CAB76827.2
AC078865 Genomic DNA No translation available.
CCDSiCCDS8826.1
RefSeqiNP_149022.3, NM_033033.3
UniGeneiHs.134640

Genome annotation databases

EnsembliENST00000257974; ENSP00000257974; ENSG00000161850
GeneIDi3888
KEGGihsa:3888
UCSCiuc001sai.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRT82_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health