Reviewed, UniProtKB/Swiss-Prot Q9NSB4 (KRT82_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type II cuticular Hb2
Alternative name(s):
    Type II hair keratin Hb2
    Keratin-82
      Short name=K82

Gene names

Name:	KRT82
Synonyms:	KRTHB2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.
Caution	Maps to a duplicated region on chromosome 12.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	keratin filament Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural constituent of epidermis Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DLG3	Q92796	1	EBI-1045341,EBI-80440
DNPEP	Q9ULA0	1	EBI-1045341,EBI-748356
ELF3	P78545	1	EBI-1045341,EBI-1057285
LYAR	Q9NX58	1	EBI-1045341,EBI-713507
PLEKHB2	Q96CS7	1	EBI-1045341,EBI-373552
TWF2	Q6IBS0	1	EBI-1045341,EBI-722204

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Keratin, type II cuticular Hb2		PRO_0000063697
Regions
	Region	1 – 120	120	Head
	Region	121 – 427	307	Rod
	Region	121 – 155	35	Coil 1A
	Region	156 – 165	10	Linker 1
	Region	166 – 266	101	Coil 1B
	Region	267 – 283	17	Linker 12
	Region	284 – 427	144	Coil 2
	Region	428 – 513	86	Tail
Natural variations
	Natural variant	219	1	E → Q: dbSNP rs1791634.		VAR_032786
	Natural variant	452	1	E → D: dbSNP rs1732263.		VAR_032787
	Natural variant	458	1	T → M: dbSNP rs2658658.		VAR_018118

Sequences

	Sequence		Length	Mass (Da)
	Q9NSB4-1 [UniParc]. Last modified June 12, 2007. Version 3. Checksum: 69BB9256BB3B6587	FASTA	513	56,653
	10 20 30 40 50 60 MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV 70 80 90 100 110 120 GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE 130 140 150 160 170 180 KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL 190 200 210 220 230 240 DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE 250 260 270 280 290 300 TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 310 320 330 340 350 360 SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL 370 380 390 400 410 420 EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY 430 440 450 460 470 480 RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL 490 500 510 YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 300 kbp region of human DNA containing the type II hair keratin." Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J. J. Invest. Dermatol. 114:464-472(2000) [PubMed: 10692104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y19207 Genomic DNA. Translation: CAB76827.2. AC078865 Genomic DNA. No translation available.
IPI	IPI00300053.
RefSeq	NP_149022.3.
UniGene	Hs.134640
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NSB4. 8 interactions.
PTM databases
PhosphoSite	Q9NSB4.
Proteomic databases
PeptideAtlas	Q9NSB4.
PRIDE	Q9NSB4.
Genome annotation databases
Ensembl	ENSG00000161850. Homo sapiens. [Contig view]
GeneID	3888.
KEGG	hsa:3888.
UCSC	uc001sai.1. human.
Organism-specific databases
GeneCards	GC12M051075.
HGNC	HGNC:6459. KRT82.
MIM	601078. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NSB4.
OMA	Q9NSB4. CKLEGAI.
Gene expression databases
ArrayExpress	Q9NSB4.
Bgee	Q9NSB4.
CleanEx	HS_KRT82.
GermOnline	ENSG00000161850. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit. PTHR23239:SF18. Keratin_II. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15263.
SOURCE	Search...

Entry information

Entry name

KRT82_HUMAN

Accession

Primary (citable) accession number: Q9NSB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 12, 2007
Last modified:	July 7, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)