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Q9NSB4

- KRT82_HUMAN

UniProt

Q9NSB4 - KRT82_HUMAN

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Protein

Keratin, type II cuticular Hb2

Gene
KRT82, KRTHB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of epidermis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb2
Alternative name(s):
Keratin-82
Short name:
K82
Type II hair keratin Hb2
Type-II keratin Kb22
Gene namesi
Name:KRT82
Synonyms:KRTHB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6459. KRT82.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Keratin, type II cuticular Hb2PRO_0000063697Add
BLAST

Proteomic databases

MaxQBiQ9NSB4.
PaxDbiQ9NSB4.
PeptideAtlasiQ9NSB4.
PRIDEiQ9NSB4.

PTM databases

PhosphoSiteiQ9NSB4.

Expressioni

Gene expression databases

BgeeiQ9NSB4.
CleanExiHS_KRT82.
GenevestigatoriQ9NSB4.

Organism-specific databases

HPAiHPA049946.
HPA058715.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi110086. 8 interactions.
IntActiQ9NSB4. 3 interactions.
STRINGi9606.ENSP00000257974.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB4.
SMRiQ9NSB4. Positions 119-268, 333-426.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 120120HeadAdd
BLAST
Regioni121 – 427307RodAdd
BLAST
Regioni121 – 15535Coil 1AAdd
BLAST
Regioni156 – 16510Linker 1
Regioni166 – 266101Coil 1BAdd
BLAST
Regioni267 – 28317Linker 12Add
BLAST
Regioni284 – 427144Coil 2Add
BLAST
Regioni428 – 51386TailAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG150879.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB4.
KOiK07605.
OMAiELSLRPC.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ9NSB4.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSB4-1 [UniParc]FASTAAdd to Basket

« Hide

MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG    50
CLGSRSLCNV GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES 100
LLVPLALEID PTVQRVKRDE KEQIKCLNNR FASFINKVRF LEQKNKLLET 150
KWNFMQQQRC CQTNIEPIFE GYISALRRQL DCVSGDRVRL ESELCSLQAA 200
LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE TNAEALVQEI 250
DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 300
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET 350
ENVKAQRCKL EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL 400
KEYQEVMNSK LGLDIEIATY RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL 450
YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL YVPCEPQGLL SCGSGRKSSM 500
TLGAGGSSPS HKH 513
Length:513
Mass (Da):56,653
Last modified:June 12, 2007 - v3
Checksum:i69BB9256BB3B6587
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191E → Q.
Corresponds to variant rs1791634 [ dbSNP | Ensembl ].
VAR_032786
Natural varianti452 – 4521E → D.
Corresponds to variant rs1732263 [ dbSNP | Ensembl ].
VAR_032787
Natural varianti458 – 4581T → M.
Corresponds to variant rs2658658 [ dbSNP | Ensembl ].
VAR_018118

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19207 Genomic DNA. Translation: CAB76827.2.
AC078865 Genomic DNA. No translation available.
CCDSiCCDS8826.1.
RefSeqiNP_149022.3. NM_033033.3.
UniGeneiHs.134640.

Genome annotation databases

EnsembliENST00000257974; ENSP00000257974; ENSG00000161850.
GeneIDi3888.
KEGGihsa:3888.
UCSCiuc001sai.1. human.

Polymorphism databases

DMDMi148887391.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19207 Genomic DNA. Translation: CAB76827.2 .
AC078865 Genomic DNA. No translation available.
CCDSi CCDS8826.1.
RefSeqi NP_149022.3. NM_033033.3.
UniGenei Hs.134640.

3D structure databases

ProteinModelPortali Q9NSB4.
SMRi Q9NSB4. Positions 119-268, 333-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110086. 8 interactions.
IntActi Q9NSB4. 3 interactions.
STRINGi 9606.ENSP00000257974.

PTM databases

PhosphoSitei Q9NSB4.

Polymorphism databases

DMDMi 148887391.

Proteomic databases

MaxQBi Q9NSB4.
PaxDbi Q9NSB4.
PeptideAtlasi Q9NSB4.
PRIDEi Q9NSB4.

Protocols and materials databases

DNASUi 3888.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257974 ; ENSP00000257974 ; ENSG00000161850 .
GeneIDi 3888.
KEGGi hsa:3888.
UCSCi uc001sai.1. human.

Organism-specific databases

CTDi 3888.
GeneCardsi GC12M052787.
HGNCi HGNC:6459. KRT82.
HPAi HPA049946.
HPA058715.
MIMi 601078. gene.
neXtProti NX_Q9NSB4.
PharmGKBi PA30248.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150879.
HOGENOMi HOG000230976.
HOVERGENi HBG013015.
InParanoidi Q9NSB4.
KOi K07605.
OMAi ELSLRPC.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q9NSB4.
TreeFami TF317854.

Miscellaneous databases

GenomeRNAii 3888.
NextBioi 15263.
PROi Q9NSB4.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSB4.
CleanExi HS_KRT82.
Genevestigatori Q9NSB4.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
    Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
    J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKRT82_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 12, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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