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Q9NSB4 (KRT82_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cuticular Hb2
Alternative name(s):
Keratin-82
Short name=K82
Type II hair keratin Hb2
Type-II keratin Kb22
Gene names
Name:KRT82
Synonyms:KRTHB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionstructural constituent of epidermis

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Keratin, type II cuticular Hb2
PRO_0000063697

Regions

Region1 – 120120Head
Region121 – 427307Rod
Region121 – 15535Coil 1A
Region156 – 16510Linker 1
Region166 – 266101Coil 1B
Region267 – 28317Linker 12
Region284 – 427144Coil 2
Region428 – 51386Tail

Natural variations

Natural variant2191E → Q.
Corresponds to variant rs1791634 [ dbSNP | Ensembl ].
VAR_032786
Natural variant4521E → D.
Corresponds to variant rs1732263 [ dbSNP | Ensembl ].
VAR_032787
Natural variant4581T → M.
Corresponds to variant rs2658658 [ dbSNP | Ensembl ].
VAR_018118

Sequences

Sequence LengthMass (Da)Tools
Q9NSB4 [UniParc].

Last modified June 12, 2007. Version 3.
Checksum: 69BB9256BB3B6587

FASTA51356,653
        10         20         30         40         50         60 
MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV 

        70         80         90        100        110        120 
GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE 

       130        140        150        160        170        180 
KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL 

       190        200        210        220        230        240 
DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE 

       250        260        270        280        290        300 
TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 

       310        320        330        340        350        360 
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL 

       370        380        390        400        410        420 
EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY 

       430        440        450        460        470        480 
RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL 

       490        500        510 
YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y19207 Genomic DNA. Translation: CAB76827.2.
AC078865 Genomic DNA. No translation available.
RefSeqNP_149022.3. NM_033033.3.
UniGeneHs.134640.

3D structure databases

ProteinModelPortalQ9NSB4.
SMRQ9NSB4. Positions 119-268, 283-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110086. 8 interactions.
IntActQ9NSB4. 3 interactions.
STRING9606.ENSP00000257974.

PTM databases

PhosphoSiteQ9NSB4.

Polymorphism databases

DMDM148887391.

Proteomic databases

PaxDbQ9NSB4.
PeptideAtlasQ9NSB4.
PRIDEQ9NSB4.

Protocols and materials databases

DNASU3888.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257974; ENSP00000257974; ENSG00000161850.
GeneID3888.
KEGGhsa:3888.
UCSCuc001sai.1. human.

Organism-specific databases

CTD3888.
GeneCardsGC12M052787.
HGNCHGNC:6459. KRT82.
HPAHPA049946.
HPA058715.
MIM601078. gene.
neXtProtNX_Q9NSB4.
PharmGKBPA30248.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150879.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidQ9NSB4.
KOK07605.
OMAELSLRPC.
OrthoDBEOG7FV3Q8.
PhylomeDBQ9NSB4.
TreeFamTF317854.

Gene expression databases

BgeeQ9NSB4.
CleanExHS_KRT82.
GenevestigatorQ9NSB4.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3888.
NextBio15263.
PROQ9NSB4.
SOURCESearch...

Entry information

Entry nameKRT82_HUMAN
AccessionPrimary (citable) accession number: Q9NSB4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 12, 2007
Last modified: March 19, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM