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Q9NSB2

- KRT84_HUMAN

UniProt

Q9NSB2 - KRT84_HUMAN

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Protein
Keratin, type II cuticular Hb4
Gene
KRT84, KRTHB4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: UniProtKB
  2. structural constituent of epidermis Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. hair follicle development Source: UniProtKB
  2. nail development Source: UniProtKB
  3. regulation of keratinocyte differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb4
Alternative name(s):
Keratin-84
Short name:
K84
Type II hair keratin Hb4
Type-II keratin Kb24
Gene namesi
Name:KRT84
Synonyms:KRTHB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6461. KRT84.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Keratin, type II cuticular Hb4
PRO_0000063700Add
BLAST

Proteomic databases

MaxQBiQ9NSB2.
PaxDbiQ9NSB2.
PRIDEiQ9NSB2.

PTM databases

PhosphoSiteiQ9NSB2.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiQ9NSB2.
CleanExiHS_KRT84.
GenevestigatoriQ9NSB2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi110088. 4 interactions.
IntActiQ9NSB2. 2 interactions.
STRINGi9606.ENSP00000257951.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB2.
SMRiQ9NSB2. Positions 164-313, 336-471.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 165165Head
Add
BLAST
Regioni166 – 472307Rod
Add
BLAST
Regioni166 – 20035Coil 1A
Add
BLAST
Regioni201 – 21010Linker 1
Regioni211 – 311101Coil 1B
Add
BLAST
Regioni312 – 32817Linker 12
Add
BLAST
Regioni329 – 472144Coil 2
Add
BLAST
Regioni473 – 600128Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149575.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB2.
KOiK07605.
OMAiEEIRICE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ9NSB2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSB2-1 [UniParc]FASTAAdd to Basket

« Hide

MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF    50
GSRSVITFGS YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD 100
SCVGLGFGAG SGIGYGFGGP GFGYRVGGVG VPAAPSITAV TVNKSLLTPL 150
NLEIDPNAQR VKKDEKEQIK TLNNKFASFI DKVRFLEQQN KLLETKWSFL 200
QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN HLQDVLEGFK 250
KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT 300
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA 350
DAEAWYQTKY EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA 400
QRAKLEAAVA EAEQQGEATL SDAKCKLADL ECALQQAKQD MARQLCEYQE 450
LMNAKLGLDI EIATYRRLLE GEESRLCEGV GPVNISVSSS RGGLVCGPEP 500
LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA PATGDLLSTG 550
TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY 600
Length:600
Mass (Da):64,842
Last modified:November 2, 2010 - v2
Checksum:i5266B0C4E5AE13F1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841R → Q.
Corresponds to variant rs1613931 [ dbSNP | Ensembl ].
VAR_018122
Natural varianti198 – 1981S → N.
Corresponds to variant rs1732301 [ dbSNP | Ensembl ].
VAR_030734
Natural varianti206 – 2061I → V.
Corresponds to variant rs2245203 [ dbSNP | Ensembl ].
VAR_018123
Natural varianti446 – 4461C → R.1 Publication
Corresponds to variant rs951773 [ dbSNP | Ensembl ].
VAR_018124
Natural varianti497 – 4971G → R.
Corresponds to variant rs7297413 [ dbSNP | Ensembl ].
VAR_030735

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731I → V in CAF31524. 1 Publication
Sequence conflicti159 – 1591Q → H in BAG36740. 1 Publication
Sequence conflicti177 – 1771A → T in CAF31524. 1 Publication
Sequence conflicti459 – 4591D → G in BAG36740. 1 Publication
Sequence conflicti548 – 5481S → G in CAF31524. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19209 Genomic DNA. Translation: CAB76829.1.
AK314030 mRNA. Translation: BAG36740.1.
AC078865 Genomic DNA. No translation available.
BC069647 mRNA. Translation: AAH69647.1.
AJ628420 mRNA. Translation: CAF31524.1.
CCDSiCCDS8825.1.
RefSeqiNP_149034.2. NM_033045.3.
UniGeneiHs.272336.

Genome annotation databases

EnsembliENST00000257951; ENSP00000257951; ENSG00000161849.
GeneIDi3890.
KEGGihsa:3890.
UCSCiuc001sah.1. human.

Polymorphism databases

DMDMi311033397.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y19209 Genomic DNA. Translation: CAB76829.1 .
AK314030 mRNA. Translation: BAG36740.1 .
AC078865 Genomic DNA. No translation available.
BC069647 mRNA. Translation: AAH69647.1 .
AJ628420 mRNA. Translation: CAF31524.1 .
CCDSi CCDS8825.1.
RefSeqi NP_149034.2. NM_033045.3.
UniGenei Hs.272336.

3D structure databases

ProteinModelPortali Q9NSB2.
SMRi Q9NSB2. Positions 164-313, 336-471.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110088. 4 interactions.
IntActi Q9NSB2. 2 interactions.
STRINGi 9606.ENSP00000257951.

PTM databases

PhosphoSitei Q9NSB2.

Polymorphism databases

DMDMi 311033397.

Proteomic databases

MaxQBi Q9NSB2.
PaxDbi Q9NSB2.
PRIDEi Q9NSB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257951 ; ENSP00000257951 ; ENSG00000161849 .
GeneIDi 3890.
KEGGi hsa:3890.
UCSCi uc001sah.1. human.

Organism-specific databases

CTDi 3890.
GeneCardsi GC12M052771.
HGNCi HGNC:6461. KRT84.
MIMi 602766. gene.
neXtProti NX_Q9NSB2.
PharmGKBi PA30250.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149575.
HOGENOMi HOG000230976.
HOVERGENi HBG013015.
InParanoidi Q9NSB2.
KOi K07605.
OMAi EEIRICE.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q9NSB2.
TreeFami TF317854.

Miscellaneous databases

GenomeRNAii 3890.
NextBioi 15273.
PROi Q9NSB2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSB2.
CleanExi HS_KRT84.
Genevestigatori Q9NSB2.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
    Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
    J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT ARG-446.
    Tissue: Scalp.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
    Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
    J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-600.
    Tissue: Scalp.

Entry informationi

Entry nameiKRT84_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB2
Secondary accession number(s): B2RA43, Q6ISB0, Q701L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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