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Reviewed, UniProtKB/Swiss-Prot Q9NSB2 (KRT84_HUMAN)

Last modified July 7, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Keratin, type II cuticular Hb4
Alternative name(s):
    Type II hair keratin Hb4
    Keratin-84
      Short name=K84
Gene names
Name: KRT84
Synonyms: KRTHB4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Tissue specificity

Expressed in the hair follicle. Ref.1

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Caution

Maps to a duplicated region on chromosome 12.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular functionstructural constituent of epidermis

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Keratin, type II cuticular Hb4
PRO_0000063700

Regions

Region1 – 165165Head
Region166 – 472307Rod
Region166 – 20035Coil 1A
Region201 – 21010Linker 1
Region211 – 311101Coil 1B
Region312 – 32817Linker 12
Region329 – 472144Coil 2
Region473 – 600128Tail

Natural variations

Natural variant1841R → Q: dbSNP rs1613931.
VAR_018122
Natural variant1981S → N: dbSNP rs1732301.
VAR_030734
Natural variant2061I → V: dbSNP rs2245203.
VAR_018123
Natural variant4461R → C: dbSNP rs951773. Ref.2 Ref.3 Ref.4
VAR_018124
Natural variant4971G → R: dbSNP rs7297413.
VAR_030735

Experimental info

Sequence conflict731I → V in CAF31524. Ref.4
Sequence conflict1591Q → H in BAG36740. Ref.2
Sequence conflict1771A → T in CAF31524. Ref.4
Sequence conflict4591D → G in BAG36740. Ref.2
Sequence conflict5481S → G in CAF31524. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9NSB2-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 497C0A7F450F12F1

FASTA60064,895
        10         20         30         40         50         60 
MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF GSRSVITFGS 

        70         80         90        100        110        120 
YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD SCVGLGFGAG SGIGYGFGGP 

       130        140        150        160        170        180 
GFGYRVGGVG VPAAPSITAV TVNKSLLTPL NLEIDPNAQR VKKDEKEQIK TLNNKFASFI 

       190        200        210        220        230        240 
DKVRFLEQQN KLLETKWSFL QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN 

       250        260        270        280        290        300 
HLQDVLEGFK KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT 

       310        320        330        340        350        360 
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA DAEAWYQTKY 

       370        380        390        400        410        420 
EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA QRAKLEAAVA EAEQQGEATL 

       430        440        450        460        470        480 
SDAKCKLADL ECALQQAKQD MARQLREYQE LMNAKLGLDI EIATYRRLLE GEESRLCEGV 

       490        500        510        520        530        540 
GPVNISVSSS RGGLVCGPEP LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA 

       550        560        570        580        590        600 
PATGDLLSTG TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
J. Invest. Dermatol. 114:464-472(2000) [PubMed: 10692104] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Tissue: Scalp.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-446.
Tissue: Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-446.
[4]"Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
J. Invest. Dermatol. 124:536-544(2005) [PubMed: 15737194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-600, VARIANT CYS-446.
Tissue: Scalp.

Cross-references

Sequence databases

Y19209 Genomic DNA. Translation: CAB76829.1.
AK314030 mRNA. Translation: BAG36740.1.
BC069647 mRNA. Translation: AAH69647.1.
AJ628420 mRNA. Translation: CAF31524.1.
IPIIPI00300052.
RefSeqNP_149034.2.
UniGeneHs.272336

3D structure databases

HSSPHSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBaseSearch...

PTM databases

PhosphoSiteQ9NSB2.

Proteomic databases

PRIDEQ9NSB2.

Genome annotation databases

EnsemblENSG00000161849. Homo sapiens. [Contig view]
GeneID3890.
KEGGhsa:3890.
UCSCuc001sah.1. human.

Organism-specific databases

GeneCardsGC12M051058.
HGNCHGNC:6461. KRT84.
MIM602766. gene.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9NSB2.

Gene expression databases

ArrayExpressQ9NSB2.
CleanExHS_KRT84.
GermOnlineENSG00000161849. Homo sapiens.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. IF. 1 hit.
PTHR23239:SF18. Keratin_II. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio15273.
SOURCESearch...

Entry information

Entry nameKRT84_HUMAN
AccessionPrimary (citable) accession number: Q9NSB2
Secondary accession number(s): B2RA43, Q6ISB0, Q701L6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2000
Last modified: July 7, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents