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Protein

Keratin, type II cuticular Hb4

Gene

KRT84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: UniProtKB
  • structural constituent of epidermis Source: Ensembl

GO - Biological processi

  • cornification Source: Reactome
  • hair follicle development Source: UniProtKB
  • keratinization Source: Reactome
  • nail development Source: UniProtKB
  • regulation of keratinocyte differentiation Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb4
Alternative name(s):
Keratin-84
Short name:
K84
Type II hair keratin Hb4
Type-II keratin Kb24
Gene namesi
Name:KRT84
Synonyms:KRTHB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000161849.3.
HGNCiHGNC:6461. KRT84.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161849.
PharmGKBiPA30250.

Polymorphism and mutation databases

BioMutaiKRT84.
DMDMi311033397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637001 – 600Keratin, type II cuticular Hb4Add BLAST600

Proteomic databases

PaxDbiQ9NSB2.
PeptideAtlasiQ9NSB2.
PRIDEiQ9NSB2.

PTM databases

iPTMnetiQ9NSB2.
PhosphoSitePlusiQ9NSB2.
SwissPalmiQ9NSB2.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000161849.
CleanExiHS_KRT84.

Organism-specific databases

HPAiHPA039714.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi110088. 5 interactors.
IntActiQ9NSB2. 2 interactors.
STRINGi9606.ENSP00000257951.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB2.
SMRiQ9NSB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 165HeadAdd BLAST165
Regioni166 – 472RodAdd BLAST307
Regioni166 – 200Coil 1AAdd BLAST35
Regioni201 – 210Linker 110
Regioni211 – 311Coil 1BAdd BLAST101
Regioni312 – 328Linker 12Add BLAST17
Regioni329 – 472Coil 2Add BLAST144
Regioni473 – 600TailAdd BLAST128

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB2.
KOiK07605.
OMAiLQEQKCA.
OrthoDBiEOG091G09KR.
PhylomeDBiQ9NSB2.
TreeFamiTF317854.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NSB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF
60 70 80 90 100
GSRSVITFGS YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD
110 120 130 140 150
SCVGLGFGAG SGIGYGFGGP GFGYRVGGVG VPAAPSITAV TVNKSLLTPL
160 170 180 190 200
NLEIDPNAQR VKKDEKEQIK TLNNKFASFI DKVRFLEQQN KLLETKWSFL
210 220 230 240 250
QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN HLQDVLEGFK
260 270 280 290 300
KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT
310 320 330 340 350
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA
360 370 380 390 400
DAEAWYQTKY EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA
410 420 430 440 450
QRAKLEAAVA EAEQQGEATL SDAKCKLADL ECALQQAKQD MARQLCEYQE
460 470 480 490 500
LMNAKLGLDI EIATYRRLLE GEESRLCEGV GPVNISVSSS RGGLVCGPEP
510 520 530 540 550
LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA PATGDLLSTG
560 570 580 590 600
TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY
Length:600
Mass (Da):64,842
Last modified:November 2, 2010 - v2
Checksum:i5266B0C4E5AE13F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73I → V in CAF31524 (PubMed:15737194).Curated1
Sequence conflicti159Q → H in BAG36740 (PubMed:14702039).Curated1
Sequence conflicti177A → T in CAF31524 (PubMed:15737194).Curated1
Sequence conflicti459D → G in BAG36740 (PubMed:14702039).Curated1
Sequence conflicti548S → G in CAF31524 (PubMed:15737194).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018122184R → Q. Corresponds to variant dbSNP:rs1613931Ensembl.1
Natural variantiVAR_030734198S → N. Corresponds to variant dbSNP:rs1732301Ensembl.1
Natural variantiVAR_018123206I → V. Corresponds to variant dbSNP:rs2245203Ensembl.1
Natural variantiVAR_018124446C → R1 PublicationCorresponds to variant dbSNP:rs951773Ensembl.1
Natural variantiVAR_030735497G → R. Corresponds to variant dbSNP:rs7297413Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19209 Genomic DNA. Translation: CAB76829.1.
AK314030 mRNA. Translation: BAG36740.1.
AC078865 Genomic DNA. No translation available.
BC069647 mRNA. Translation: AAH69647.1.
AJ628420 mRNA. Translation: CAF31524.1.
CCDSiCCDS8825.1.
RefSeqiNP_149034.2. NM_033045.3.
XP_011536637.1. XM_011538335.2.
UniGeneiHs.272336.

Genome annotation databases

EnsembliENST00000257951; ENSP00000257951; ENSG00000161849.
GeneIDi3890.
KEGGihsa:3890.
UCSCiuc001sah.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRT84_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB2
Secondary accession number(s): B2RA43, Q6ISB0, Q701L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families