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Protein

Keratin, type II cuticular Hb4

Gene

KRT84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: UniProtKB
  • structural constituent of epidermis Source: Ensembl

GO - Biological processi

  • hair follicle development Source: UniProtKB
  • nail development Source: UniProtKB
  • regulation of keratinocyte differentiation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161849-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb4
Alternative name(s):
Keratin-84
Short name:
K84
Type II hair keratin Hb4
Type-II keratin Kb24
Gene namesi
Name:KRT84
Synonyms:KRTHB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6461. KRT84.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • keratin filament Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161849.
PharmGKBiPA30250.

Polymorphism and mutation databases

BioMutaiKRT84.
DMDMi311033397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637001 – 600Keratin, type II cuticular Hb4Add BLAST600

Proteomic databases

PaxDbiQ9NSB2.
PeptideAtlasiQ9NSB2.
PRIDEiQ9NSB2.

PTM databases

iPTMnetiQ9NSB2.
PhosphoSitePlusiQ9NSB2.
SwissPalmiQ9NSB2.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

CleanExiHS_KRT84.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi110088. 5 interactors.
IntActiQ9NSB2. 2 interactors.
STRINGi9606.ENSP00000257951.

Structurei

3D structure databases

ProteinModelPortaliQ9NSB2.
SMRiQ9NSB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 165HeadAdd BLAST165
Regioni166 – 472RodAdd BLAST307
Regioni166 – 200Coil 1AAdd BLAST35
Regioni201 – 210Linker 110
Regioni211 – 311Coil 1BAdd BLAST101
Regioni312 – 328Linker 12Add BLAST17
Regioni329 – 472Coil 2Add BLAST144
Regioni473 – 600TailAdd BLAST128

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB2.
KOiK07605.
OMAiPQNLNRF.
OrthoDBiEOG091G09KR.
PhylomeDBiQ9NSB2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 4 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NSB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF
60 70 80 90 100
GSRSVITFGS YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD
110 120 130 140 150
SCVGLGFGAG SGIGYGFGGP GFGYRVGGVG VPAAPSITAV TVNKSLLTPL
160 170 180 190 200
NLEIDPNAQR VKKDEKEQIK TLNNKFASFI DKVRFLEQQN KLLETKWSFL
210 220 230 240 250
QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN HLQDVLEGFK
260 270 280 290 300
KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT
310 320 330 340 350
LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA
360 370 380 390 400
DAEAWYQTKY EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA
410 420 430 440 450
QRAKLEAAVA EAEQQGEATL SDAKCKLADL ECALQQAKQD MARQLCEYQE
460 470 480 490 500
LMNAKLGLDI EIATYRRLLE GEESRLCEGV GPVNISVSSS RGGLVCGPEP
510 520 530 540 550
LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA PATGDLLSTG
560 570 580 590 600
TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY
Length:600
Mass (Da):64,842
Last modified:November 2, 2010 - v2
Checksum:i5266B0C4E5AE13F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73I → V in CAF31524 (PubMed:15737194).Curated1
Sequence conflicti159Q → H in BAG36740 (PubMed:14702039).Curated1
Sequence conflicti177A → T in CAF31524 (PubMed:15737194).Curated1
Sequence conflicti459D → G in BAG36740 (PubMed:14702039).Curated1
Sequence conflicti548S → G in CAF31524 (PubMed:15737194).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018122184R → Q.Corresponds to variant rs1613931dbSNPEnsembl.1
Natural variantiVAR_030734198S → N.Corresponds to variant rs1732301dbSNPEnsembl.1
Natural variantiVAR_018123206I → V.Corresponds to variant rs2245203dbSNPEnsembl.1
Natural variantiVAR_018124446C → R.1 PublicationCorresponds to variant rs951773dbSNPEnsembl.1
Natural variantiVAR_030735497G → R.Corresponds to variant rs7297413dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19209 Genomic DNA. Translation: CAB76829.1.
AK314030 mRNA. Translation: BAG36740.1.
AC078865 Genomic DNA. No translation available.
BC069647 mRNA. Translation: AAH69647.1.
AJ628420 mRNA. Translation: CAF31524.1.
CCDSiCCDS8825.1.
RefSeqiNP_149034.2. NM_033045.3.
XP_011536637.1. XM_011538335.2.
UniGeneiHs.272336.

Genome annotation databases

EnsembliENST00000257951; ENSP00000257951; ENSG00000161849.
GeneIDi3890.
KEGGihsa:3890.
UCSCiuc001sah.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19209 Genomic DNA. Translation: CAB76829.1.
AK314030 mRNA. Translation: BAG36740.1.
AC078865 Genomic DNA. No translation available.
BC069647 mRNA. Translation: AAH69647.1.
AJ628420 mRNA. Translation: CAF31524.1.
CCDSiCCDS8825.1.
RefSeqiNP_149034.2. NM_033045.3.
XP_011536637.1. XM_011538335.2.
UniGeneiHs.272336.

3D structure databases

ProteinModelPortaliQ9NSB2.
SMRiQ9NSB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110088. 5 interactors.
IntActiQ9NSB2. 2 interactors.
STRINGi9606.ENSP00000257951.

PTM databases

iPTMnetiQ9NSB2.
PhosphoSitePlusiQ9NSB2.
SwissPalmiQ9NSB2.

Polymorphism and mutation databases

BioMutaiKRT84.
DMDMi311033397.

Proteomic databases

PaxDbiQ9NSB2.
PeptideAtlasiQ9NSB2.
PRIDEiQ9NSB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257951; ENSP00000257951; ENSG00000161849.
GeneIDi3890.
KEGGihsa:3890.
UCSCiuc001sah.2. human.

Organism-specific databases

CTDi3890.
GeneCardsiKRT84.
HGNCiHGNC:6461. KRT84.
MIMi602766. gene.
neXtProtiNX_Q9NSB2.
OpenTargetsiENSG00000161849.
PharmGKBiPA30250.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ9NSB2.
KOiK07605.
OMAiPQNLNRF.
OrthoDBiEOG091G09KR.
PhylomeDBiQ9NSB2.
TreeFamiTF317854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161849-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii3890.
PROiQ9NSB2.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KRT84.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 4 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT84_HUMAN
AccessioniPrimary (citable) accession number: Q9NSB2
Secondary accession number(s): B2RA43, Q6ISB0, Q701L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.