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Q9NSB2

- KRT84_HUMAN

UniProt

Q9NSB2 - KRT84_HUMAN

Protein

Keratin, type II cuticular Hb4

Gene

KRT84

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of cytoskeleton Source: UniProtKB
    2. structural constituent of epidermis Source: Ensembl

    GO - Biological processi

    1. hair follicle development Source: UniProtKB
    2. nail development Source: UniProtKB
    3. regulation of keratinocyte differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cuticular Hb4
    Alternative name(s):
    Keratin-84
    Short name:
    K84
    Type II hair keratin Hb4
    Type-II keratin Kb24
    Gene namesi
    Name:KRT84
    Synonyms:KRTHB4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6461. KRT84.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: UniProtKB

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30250.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Keratin, type II cuticular Hb4PRO_0000063700Add
    BLAST

    Proteomic databases

    MaxQBiQ9NSB2.
    PaxDbiQ9NSB2.
    PRIDEiQ9NSB2.

    PTM databases

    PhosphoSiteiQ9NSB2.

    Expressioni

    Tissue specificityi

    Expressed in the hair follicles.1 Publication

    Gene expression databases

    BgeeiQ9NSB2.
    CleanExiHS_KRT84.
    GenevestigatoriQ9NSB2.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    BioGridi110088. 4 interactions.
    IntActiQ9NSB2. 2 interactions.
    STRINGi9606.ENSP00000257951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSB2.
    SMRiQ9NSB2. Positions 164-313, 336-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 165165HeadAdd
    BLAST
    Regioni166 – 472307RodAdd
    BLAST
    Regioni166 – 20035Coil 1AAdd
    BLAST
    Regioni201 – 21010Linker 1
    Regioni211 – 311101Coil 1BAdd
    BLAST
    Regioni312 – 32817Linker 12Add
    BLAST
    Regioni329 – 472144Coil 2Add
    BLAST
    Regioni473 – 600128TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG149575.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiQ9NSB2.
    KOiK07605.
    OMAiEEIRICE.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ9NSB2.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NSB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCRSYRVSS GHRVGNFSSC SAMTPQNLNR FRANSVSCWS GPGFRGLGSF    50
    GSRSVITFGS YSPRIAAVGS RPIHCGVRFG AGCGMGFGDG RGVGLGPRAD 100
    SCVGLGFGAG SGIGYGFGGP GFGYRVGGVG VPAAPSITAV TVNKSLLTPL 150
    NLEIDPNAQR VKKDEKEQIK TLNNKFASFI DKVRFLEQQN KLLETKWSFL 200
    QEQKCIRSNL EPLFESYITN LRRQLEVLVS DQARLQAERN HLQDVLEGFK 250
    KKYEEEVVCR ANAENEFVAL KKDVDAAFMN KSDLEANVDT LTQEIDFLKT 300
    LYMEEIQLLQ SHISETSVIV KMDNSRDLNL DGIIAEVKAQ YEEVARRSRA 350
    DAEAWYQTKY EEMQVTAGQH CDNLRNIRNE INELTRLIQR LKAEIEHAKA 400
    QRAKLEAAVA EAEQQGEATL SDAKCKLADL ECALQQAKQD MARQLCEYQE 450
    LMNAKLGLDI EIATYRRLLE GEESRLCEGV GPVNISVSSS RGGLVCGPEP 500
    LVAGSTLSRG GVTFSGSSSV CATSGVLASC GPSLGGARVA PATGDLLSTG 550
    TRSGSMLISE ACVPSVPCPL PTQGGFSSCS GGRSSSVRFV STTTSCRTKY 600
    Length:600
    Mass (Da):64,842
    Last modified:November 2, 2010 - v2
    Checksum:i5266B0C4E5AE13F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731I → V in CAF31524. (PubMed:15737194)Curated
    Sequence conflicti159 – 1591Q → H in BAG36740. (PubMed:14702039)Curated
    Sequence conflicti177 – 1771A → T in CAF31524. (PubMed:15737194)Curated
    Sequence conflicti459 – 4591D → G in BAG36740. (PubMed:14702039)Curated
    Sequence conflicti548 – 5481S → G in CAF31524. (PubMed:15737194)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841R → Q.
    Corresponds to variant rs1613931 [ dbSNP | Ensembl ].
    VAR_018122
    Natural varianti198 – 1981S → N.
    Corresponds to variant rs1732301 [ dbSNP | Ensembl ].
    VAR_030734
    Natural varianti206 – 2061I → V.
    Corresponds to variant rs2245203 [ dbSNP | Ensembl ].
    VAR_018123
    Natural varianti446 – 4461C → R.1 Publication
    Corresponds to variant rs951773 [ dbSNP | Ensembl ].
    VAR_018124
    Natural varianti497 – 4971G → R.
    Corresponds to variant rs7297413 [ dbSNP | Ensembl ].
    VAR_030735

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19209 Genomic DNA. Translation: CAB76829.1.
    AK314030 mRNA. Translation: BAG36740.1.
    AC078865 Genomic DNA. No translation available.
    BC069647 mRNA. Translation: AAH69647.1.
    AJ628420 mRNA. Translation: CAF31524.1.
    CCDSiCCDS8825.1.
    RefSeqiNP_149034.2. NM_033045.3.
    UniGeneiHs.272336.

    Genome annotation databases

    EnsembliENST00000257951; ENSP00000257951; ENSG00000161849.
    GeneIDi3890.
    KEGGihsa:3890.
    UCSCiuc001sah.1. human.

    Polymorphism databases

    DMDMi311033397.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y19209 Genomic DNA. Translation: CAB76829.1 .
    AK314030 mRNA. Translation: BAG36740.1 .
    AC078865 Genomic DNA. No translation available.
    BC069647 mRNA. Translation: AAH69647.1 .
    AJ628420 mRNA. Translation: CAF31524.1 .
    CCDSi CCDS8825.1.
    RefSeqi NP_149034.2. NM_033045.3.
    UniGenei Hs.272336.

    3D structure databases

    ProteinModelPortali Q9NSB2.
    SMRi Q9NSB2. Positions 164-313, 336-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110088. 4 interactions.
    IntActi Q9NSB2. 2 interactions.
    STRINGi 9606.ENSP00000257951.

    PTM databases

    PhosphoSitei Q9NSB2.

    Polymorphism databases

    DMDMi 311033397.

    Proteomic databases

    MaxQBi Q9NSB2.
    PaxDbi Q9NSB2.
    PRIDEi Q9NSB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257951 ; ENSP00000257951 ; ENSG00000161849 .
    GeneIDi 3890.
    KEGGi hsa:3890.
    UCSCi uc001sah.1. human.

    Organism-specific databases

    CTDi 3890.
    GeneCardsi GC12M052771.
    HGNCi HGNC:6461. KRT84.
    MIMi 602766. gene.
    neXtProti NX_Q9NSB2.
    PharmGKBi PA30250.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149575.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi Q9NSB2.
    KOi K07605.
    OMAi EEIRICE.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q9NSB2.
    TreeFami TF317854.

    Miscellaneous databases

    GenomeRNAii 3890.
    NextBioi 15273.
    PROi Q9NSB2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NSB2.
    CleanExi HS_KRT84.
    Genevestigatori Q9NSB2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 300 kbp region of human DNA containing the type II hair keratin."
      Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
      J. Invest. Dermatol. 114:464-472(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT ARG-446.
      Tissue: Scalp.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."
      Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.
      J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-600.
      Tissue: Scalp.

    Entry informationi

    Entry nameiKRT84_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSB2
    Secondary accession number(s): B2RA43, Q6ISB0, Q701L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3