Reviewed,
UniProtKB/Swiss-Prot Q9NSA3 (CNBP1_HUMAN)
Last modified
December 15, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-catenin-interacting protein 1 Alternative name(s): Inhibitor of beta-catenin and Tcf-4 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 81 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Ref.3 |
| Subunit structure | Binds CTNNB1. |
| Subcellular location | |
| Sequence similarities | Belongs to the CTNNBIP1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Cytoplasm Nucleus |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CASP4 | P49662 | 1 | EBI-747082,EBI-1057327 | |
| CPVL | Q9H3G5 | 1 | EBI-747082,EBI-357542 | |
| CTNNB1 | P35222 | 2 | EBI-747082,EBI-491549 | |
| Ctnnb1 | Q02248 | 3 | EBI-747082,EBI-397872 | From a different organism. |
| CTSA | P10619 | 1 | EBI-747082,EBI-989654 | |
| GLB1 | P16278 | 1 | EBI-747082,EBI-989638 | |
| JUP | P14923 | 1 | EBI-747082,EBI-702484 | |
| NACAP1 | Q9BZK3 | 1 | EBI-747082,EBI-1044076 | |
| PNMA2 | Q9UL42 | 1 | EBI-747082,EBI-302355 | |
| PPP2R1A | P30153 | 1 | EBI-747082,EBI-302388 |
Sequence annotation (Features)
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein." Tago K., Nakamura T., Nishita M., Hyodo J., Nagai S., Murata Y., Adachi S., Ohwada S., Morishita Y., Shibuya H., Akiyama T. Genes Dev. 14:1741-1749(2000) [PubMed: 10898789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [3] | "The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT." Graham T.A., Clements W.K., Kimelman D., Xu W. Mol. Cell 10:563-571(2002) [PubMed: 12408824] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH CTNNB1, FUNCTION. |
| [4] | "ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules." Daniels D.L., Weis W.I. Mol. Cell 10:573-584(2002) [PubMed: 12408825] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH CTNNB1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB021262 mRNA. Translation: BAB03458.1. BC014300 mRNA. Translation: AAH14300.1. | ||||||||||||||||||||||||
| IPI | IPI00025001. | ||||||||||||||||||||||||
| RefSeq | NP_001012329.1. NP_064633.1. | ||||||||||||||||||||||||
| UniGene | Hs.463759 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | Q9NSA3. 16 interactions. | ||||||||||||||||||||||||
| STRING | Q9NSA3. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PeptideAtlas | Q9NSA3. | ||||||||||||||||||||||||
| PRIDE | Q9NSA3. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000361853; ENSP00000354792; ENSG00000178585; Homo sapiens. [Genome view] ENST00000377256; ENSP00000366466; ENSG00000178585; Homo sapiens. [Genome view] ENST00000377258; ENSP00000366468; ENSG00000178585; Homo sapiens. [Genome view] ENST00000377263; ENSP00000366474; ENSG00000178585; Homo sapiens. [Genome view] ENST00000400904; ENSP00000383696; ENSG00000178585; Homo sapiens. [Genome view] | ||||||||||||||||||||||||
| GeneID | 56998. | ||||||||||||||||||||||||
| KEGG | hsa:56998. | ||||||||||||||||||||||||
| UCSC | uc001aqk.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 56998. | ||||||||||||||||||||||||
| GeneCards | GC01M009842. | ||||||||||||||||||||||||
| H-InvDB | HIX0000109. | ||||||||||||||||||||||||
| HGNC | HGNC:16913. CTNNBIP1. | ||||||||||||||||||||||||
| HPA | CAB024893. | ||||||||||||||||||||||||
| MIM | 607758. gene. | ||||||||||||||||||||||||
| PharmGKB | PA27014. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOVERGEN | Q9NSA3. | ||||||||||||||||||||||||
| InParanoid | Q9NSA3. | ||||||||||||||||||||||||
| OrthoDB | EOG9QVFX3. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q9NSA3. | ||||||||||||||||||||||||
| Bgee | Q9NSA3. | ||||||||||||||||||||||||
| CleanEx | HS_CTNNBIP1. | ||||||||||||||||||||||||
| Genevestigator | Q9NSA3. | ||||||||||||||||||||||||
| GermOnline | ENSG00000178585. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR009428. ICAT. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.10.490. ICAT. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF06384. ICAT. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 62715. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CNBP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NSA3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


