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Protein

Beta-catenin-interacting protein 1

Gene

CTNNBIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.1 Publication

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • beta-catenin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SIGNORiQ9NSA3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-interacting protein 1
Alternative name(s):
Inhibitor of beta-catenin and Tcf-4
Gene namesi
Name:CTNNBIP1
Synonyms:ICAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16913. CTNNBIP1.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • cytosol Source: BHF-UCL
  • nucleoplasm Source: Reactome
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56998.
OpenTargetsiENSG00000178585.
PharmGKBiPA27014.

Polymorphism and mutation databases

BioMutaiCTNNBIP1.
DMDMi29428025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001528821 – 81Beta-catenin-interacting protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSA3.
MaxQBiQ9NSA3.
PaxDbiQ9NSA3.
PeptideAtlasiQ9NSA3.
PRIDEiQ9NSA3.
TopDownProteomicsiQ9NSA3.

PTM databases

iPTMnetiQ9NSA3.
PhosphoSitePlusiQ9NSA3.

Expressioni

Gene expression databases

BgeeiENSG00000178585.
CleanExiHS_CTNNBIP1.
ExpressionAtlasiQ9NSA3. baseline and differential.
GenevisibleiQ9NSA3. HS.

Organism-specific databases

HPAiCAB024893.
HPA042617.

Interactioni

Subunit structurei

Binds CTNNB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P3522210EBI-747082,EBI-491549
Ctnnb1Q022487EBI-747082,EBI-397872From a different organism.
INCA1Q0VD863EBI-747082,EBI-6509505
JUPP149233EBI-747082,EBI-702484
KRTAP10-7P604093EBI-747082,EBI-10172290
RELQ048643EBI-747082,EBI-307352
USHBP1Q8N6Y03EBI-747082,EBI-739895

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • beta-catenin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi121313. 26 interactors.
IntActiQ9NSA3. 14 interactors.
MINTiMINT-249497.
STRINGi9606.ENSP00000366466.

Structurei

Secondary structure

181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 28Combined sources18
Helixi35 – 43Combined sources9
Helixi45 – 52Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUJX-ray2.50B1-75[»]
1M1EX-ray2.10B1-81[»]
1T08X-ray2.10B8-53[»]
ProteinModelPortaliQ9NSA3.
SMRiQ9NSA3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSA3.

Family & Domainsi

Sequence similaritiesi

Belongs to the CTNNBIP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM5. Eukaryota.
ENOG4111UJF. LUCA.
GeneTreeiENSGT00860000133817.
HOGENOMiHOG000037432.
HOVERGENiHBG051037.
InParanoidiQ9NSA3.
KOiK04493.
OMAiSHEEMYI.
OrthoDBiEOG091G0RZ1.
PhylomeDBiQ9NSA3.

Family and domain databases

Gene3Di1.10.10.490. 1 hit.
InterProiIPR009428. ICAT.
[Graphical view]
PfamiPF06384. ICAT. 1 hit.
[Graphical view]
SUPFAMiSSF81730. SSF81730. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NSA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS
60 70 80
QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q
Length:81
Mass (Da):9,170
Last modified:October 1, 2000 - v1
Checksum:i3DA6CF90B50CE942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021262 mRNA. Translation: BAB03458.1.
AL357140 Genomic DNA. Translation: CAI16886.1.
CH471130 Genomic DNA. Translation: EAW71631.1.
BC014300 mRNA. Translation: AAH14300.1.
BC146892 mRNA. Translation: AAI46893.1.
BC146896 mRNA. Translation: AAI46897.1.
CCDSiCCDS106.1.
RefSeqiNP_001012329.1. NM_001012329.1.
NP_064633.1. NM_020248.2.
XP_016857342.1. XM_017001853.1.
XP_016857343.1. XM_017001854.1.
XP_016857344.1. XM_017001855.1.
UniGeneiHs.463759.
Hs.685322.

Genome annotation databases

EnsembliENST00000377256; ENSP00000366466; ENSG00000178585.
ENST00000377258; ENSP00000366468; ENSG00000178585.
ENST00000377263; ENSP00000366474; ENSG00000178585.
ENST00000400904; ENSP00000383696; ENSG00000178585.
GeneIDi56998.
KEGGihsa:56998.
UCSCiuc001aqk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021262 mRNA. Translation: BAB03458.1.
AL357140 Genomic DNA. Translation: CAI16886.1.
CH471130 Genomic DNA. Translation: EAW71631.1.
BC014300 mRNA. Translation: AAH14300.1.
BC146892 mRNA. Translation: AAI46893.1.
BC146896 mRNA. Translation: AAI46897.1.
CCDSiCCDS106.1.
RefSeqiNP_001012329.1. NM_001012329.1.
NP_064633.1. NM_020248.2.
XP_016857342.1. XM_017001853.1.
XP_016857343.1. XM_017001854.1.
XP_016857344.1. XM_017001855.1.
UniGeneiHs.463759.
Hs.685322.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUJX-ray2.50B1-75[»]
1M1EX-ray2.10B1-81[»]
1T08X-ray2.10B8-53[»]
ProteinModelPortaliQ9NSA3.
SMRiQ9NSA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121313. 26 interactors.
IntActiQ9NSA3. 14 interactors.
MINTiMINT-249497.
STRINGi9606.ENSP00000366466.

PTM databases

iPTMnetiQ9NSA3.
PhosphoSitePlusiQ9NSA3.

Polymorphism and mutation databases

BioMutaiCTNNBIP1.
DMDMi29428025.

Proteomic databases

EPDiQ9NSA3.
MaxQBiQ9NSA3.
PaxDbiQ9NSA3.
PeptideAtlasiQ9NSA3.
PRIDEiQ9NSA3.
TopDownProteomicsiQ9NSA3.

Protocols and materials databases

DNASUi56998.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377256; ENSP00000366466; ENSG00000178585.
ENST00000377258; ENSP00000366468; ENSG00000178585.
ENST00000377263; ENSP00000366474; ENSG00000178585.
ENST00000400904; ENSP00000383696; ENSG00000178585.
GeneIDi56998.
KEGGihsa:56998.
UCSCiuc001aqk.2. human.

Organism-specific databases

CTDi56998.
DisGeNETi56998.
GeneCardsiCTNNBIP1.
HGNCiHGNC:16913. CTNNBIP1.
HPAiCAB024893.
HPA042617.
MIMi607758. gene.
neXtProtiNX_Q9NSA3.
OpenTargetsiENSG00000178585.
PharmGKBiPA27014.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYM5. Eukaryota.
ENOG4111UJF. LUCA.
GeneTreeiENSGT00860000133817.
HOGENOMiHOG000037432.
HOVERGENiHBG051037.
InParanoidiQ9NSA3.
KOiK04493.
OMAiSHEEMYI.
OrthoDBiEOG091G0RZ1.
PhylomeDBiQ9NSA3.

Enzyme and pathway databases

ReactomeiR-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SIGNORiQ9NSA3.

Miscellaneous databases

EvolutionaryTraceiQ9NSA3.
GeneWikiiCTNNBIP1.
GenomeRNAii56998.
PROiQ9NSA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178585.
CleanExiHS_CTNNBIP1.
ExpressionAtlasiQ9NSA3. baseline and differential.
GenevisibleiQ9NSA3. HS.

Family and domain databases

Gene3Di1.10.10.490. 1 hit.
InterProiIPR009428. ICAT.
[Graphical view]
PfamiPF06384. ICAT. 1 hit.
[Graphical view]
SUPFAMiSSF81730. SSF81730. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCNBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA3
Secondary accession number(s): Q5T4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.