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Q9NSA3

- CNBP1_HUMAN

UniProt

Q9NSA3 - CNBP1_HUMAN

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Protein
Beta-catenin-interacting protein 1
Gene
CTNNBIP1, ICAT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.1 Publication

GO - Molecular functioni

  1. armadillo repeat domain binding Source: BHF-UCL
  2. beta-catenin binding Source: BHF-UCL
  3. protein binding Source: IntAct

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. anterior/posterior pattern specification Source: RefGenome
  3. branching involved in ureteric bud morphogenesis Source: RefGenome
  4. negative regulation of DNA binding Source: Ensembl
  5. negative regulation of Wnt signaling pathway Source: RefGenome
  6. negative regulation of mesenchymal cell proliferation Source: BHF-UCL
  7. negative regulation of protein binding Source: BHF-UCL
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  9. negative regulation of smooth muscle cell proliferation Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. negative regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
  12. positive regulation of monocyte differentiation Source: BHF-UCL
  13. positive regulation of osteoblast differentiation Source: BHF-UCL
  14. regulation of vascular permeability involved in acute inflammatory response Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200731. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-interacting protein 1
Alternative name(s):
Inhibitor of beta-catenin and Tcf-4
Gene namesi
Synonyms:ICAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16913. CTNNBIP1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. beta-catenin destruction complex Source: BHF-UCL
  2. cytoplasm Source: BHF-UCL
  3. cytosol Source: BHF-UCL
  4. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181Beta-catenin-interacting protein 1
PRO_0000152882Add
BLAST

Proteomic databases

MaxQBiQ9NSA3.
PaxDbiQ9NSA3.
PeptideAtlasiQ9NSA3.
PRIDEiQ9NSA3.

PTM databases

PhosphoSiteiQ9NSA3.

Expressioni

Gene expression databases

BgeeiQ9NSA3.
CleanExiHS_CTNNBIP1.
GenevestigatoriQ9NSA3.

Organism-specific databases

HPAiCAB024893.
HPA042617.

Interactioni

Subunit structurei

Binds CTNNB1.

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352229EBI-747082,EBI-491549
Ctnnb1Q022487EBI-747082,EBI-397872From a different organism.

Protein-protein interaction databases

BioGridi121313. 16 interactions.
IntActiQ9NSA3. 7 interactions.
MINTiMINT-249497.
STRINGi9606.ENSP00000366466.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2818
Helixi35 – 439
Helixi45 – 528

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LUJX-ray2.50B1-75[»]
1M1EX-ray2.10B1-81[»]
1T08X-ray2.10B8-53[»]
ProteinModelPortaliQ9NSA3.
SMRiQ9NSA3. Positions 8-53.

Miscellaneous databases

EvolutionaryTraceiQ9NSA3.

Family & Domainsi

Sequence similaritiesi

Belongs to the CTNNBIP1 family.

Phylogenomic databases

eggNOGiNOG39852.
HOGENOMiHOG000037432.
HOVERGENiHBG051037.
InParanoidiQ9NSA3.
KOiK04493.
OMAiMNREGAS.
OrthoDBiEOG71P2DG.
PhylomeDBiQ9NSA3.

Family and domain databases

Gene3Di1.10.10.490. 1 hit.
InterProiIPR009428. ICAT.
[Graphical view]
PfamiPF06384. ICAT. 1 hit.
[Graphical view]
SUPFAMiSSF81730. SSF81730. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NSA3-1 [UniParc]FASTAAdd to Basket

« Hide

MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS   50
QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q 81
Length:81
Mass (Da):9,170
Last modified:October 1, 2000 - v1
Checksum:i3DA6CF90B50CE942
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021262 mRNA. Translation: BAB03458.1.
AL357140 Genomic DNA. Translation: CAI16886.1.
CH471130 Genomic DNA. Translation: EAW71631.1.
BC014300 mRNA. Translation: AAH14300.1.
BC146892 mRNA. Translation: AAI46893.1.
BC146896 mRNA. Translation: AAI46897.1.
CCDSiCCDS106.1.
RefSeqiNP_001012329.1. NM_001012329.1.
NP_064633.1. NM_020248.2.
XP_006710842.1. XM_006710779.1.
UniGeneiHs.463759.

Genome annotation databases

EnsembliENST00000377256; ENSP00000366466; ENSG00000178585.
ENST00000377258; ENSP00000366468; ENSG00000178585.
ENST00000377263; ENSP00000366474; ENSG00000178585.
ENST00000400904; ENSP00000383696; ENSG00000178585.
ENST00000537447; ENSP00000444681; ENSG00000178585.
GeneIDi56998.
KEGGihsa:56998.
UCSCiuc001aqk.1. human.

Polymorphism databases

DMDMi29428025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021262 mRNA. Translation: BAB03458.1 .
AL357140 Genomic DNA. Translation: CAI16886.1 .
CH471130 Genomic DNA. Translation: EAW71631.1 .
BC014300 mRNA. Translation: AAH14300.1 .
BC146892 mRNA. Translation: AAI46893.1 .
BC146896 mRNA. Translation: AAI46897.1 .
CCDSi CCDS106.1.
RefSeqi NP_001012329.1. NM_001012329.1.
NP_064633.1. NM_020248.2.
XP_006710842.1. XM_006710779.1.
UniGenei Hs.463759.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LUJ X-ray 2.50 B 1-75 [» ]
1M1E X-ray 2.10 B 1-81 [» ]
1T08 X-ray 2.10 B 8-53 [» ]
ProteinModelPortali Q9NSA3.
SMRi Q9NSA3. Positions 8-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121313. 16 interactions.
IntActi Q9NSA3. 7 interactions.
MINTi MINT-249497.
STRINGi 9606.ENSP00000366466.

PTM databases

PhosphoSitei Q9NSA3.

Polymorphism databases

DMDMi 29428025.

Proteomic databases

MaxQBi Q9NSA3.
PaxDbi Q9NSA3.
PeptideAtlasi Q9NSA3.
PRIDEi Q9NSA3.

Protocols and materials databases

DNASUi 56998.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377256 ; ENSP00000366466 ; ENSG00000178585 .
ENST00000377258 ; ENSP00000366468 ; ENSG00000178585 .
ENST00000377263 ; ENSP00000366474 ; ENSG00000178585 .
ENST00000400904 ; ENSP00000383696 ; ENSG00000178585 .
ENST00000537447 ; ENSP00000444681 ; ENSG00000178585 .
GeneIDi 56998.
KEGGi hsa:56998.
UCSCi uc001aqk.1. human.

Organism-specific databases

CTDi 56998.
GeneCardsi GC01M009908.
HGNCi HGNC:16913. CTNNBIP1.
HPAi CAB024893.
HPA042617.
MIMi 607758. gene.
neXtProti NX_Q9NSA3.
PharmGKBi PA27014.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39852.
HOGENOMi HOG000037432.
HOVERGENi HBG051037.
InParanoidi Q9NSA3.
KOi K04493.
OMAi MNREGAS.
OrthoDBi EOG71P2DG.
PhylomeDBi Q9NSA3.

Enzyme and pathway databases

Reactomei REACT_200731. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

EvolutionaryTracei Q9NSA3.
GeneWikii CTNNBIP1.
GenomeRNAii 56998.
NextBioi 62715.
PROi Q9NSA3.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSA3.
CleanExi HS_CTNNBIP1.
Genevestigatori Q9NSA3.

Family and domain databases

Gene3Di 1.10.10.490. 1 hit.
InterProi IPR009428. ICAT.
[Graphical view ]
Pfami PF06384. ICAT. 1 hit.
[Graphical view ]
SUPFAMi SSF81730. SSF81730. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein."
    Tago K., Nakamura T., Nishita M., Hyodo J., Nagai S., Murata Y., Adachi S., Ohwada S., Morishita Y., Shibuya H., Akiyama T.
    Genes Dev. 14:1741-1749(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT."
    Graham T.A., Clements W.K., Kimelman D., Xu W.
    Mol. Cell 10:563-571(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH CTNNB1, FUNCTION.
  7. "ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules."
    Daniels D.L., Weis W.I.
    Mol. Cell 10:573-584(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH CTNNB1.

Entry informationi

Entry nameiCNBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA3
Secondary accession number(s): Q5T4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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