Reviewed, UniProtKB/Swiss-Prot Q9NSA3 (CNBP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Beta-catenin-interacting protein 1
Alternative name(s):
    Inhibitor of beta-catenin and Tcf-4

Gene names

Name:	CTNNBIP1
Synonyms:	ICAT

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Ref.3
Subunit structure	Binds CTNNB1.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the CTNNBIP1 family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASP4	P49662	1	EBI-747082,EBI-1057327
CPVL	Q9H3G5	1	EBI-747082,EBI-357542
CTNNB1	P35222	2	EBI-747082,EBI-491549
Ctnnb1	Q02248	3	EBI-747082,EBI-397872	From a different organism.
CTSA	P10619	1	EBI-747082,EBI-989654
GLB1	P16278	1	EBI-747082,EBI-989638
JUP	P14923	1	EBI-747082,EBI-702484
NACAP1	Q9BZK3	1	EBI-747082,EBI-1044076
PNMA2	Q9UL42	1	EBI-747082,EBI-302355
PPP2R1A	P30153	1	EBI-747082,EBI-302388

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 81

81

Beta-catenin-interacting protein 1

PRO_0000152882

Secondary structure

1

.

.

.

.

.

.

.

81

Helix Strand Turn

Details...

Helix

11 – 28

18

Helix

35 – 43

9

Helix

45 – 52

8

Sequences

	Sequence		Length	Mass (Da)
	Q9NSA3-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3DA6CF90B50CE942	FASTA	81	9,170
	10 20 30 40 50 60 MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI 70 80 DQGAEDVVMA FSRSETEDRR Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein." Tago K., Nakamura T., Nishita M., Hyodo J., Nagai S., Murata Y., Adachi S., Ohwada S., Morishita Y., Shibuya H., Akiyama T. Genes Dev. 14:1741-1749(2000) [PubMed: 10898789] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT." Graham T.A., Clements W.K., Kimelman D., Xu W. Mol. Cell 10:563-571(2002) [PubMed: 12408824] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH CTNNB1, FUNCTION.
[4]	"ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules." Daniels D.L., Weis W.I. Mol. Cell 10:573-584(2002) [PubMed: 12408825] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH CTNNB1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB021262 mRNA. Translation: BAB03458.1.
BC014300 mRNA. Translation: AAH14300.1.

IPI

IPI00025001.

RefSeq

NP_001012329.1.
NP_064633.1.

UniGene

Hs.463759

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LUJ	X-ray	2.50	B	1-75	[»]
1M1E	X-ray	2.10	B	1-81	[»]
1T08	X-ray	2.10	B	8-53	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NSA3. 16 interactions.

STRING

Q9NSA3.

Proteomic databases

PeptideAtlas

Q9NSA3.

PRIDE

Q9NSA3.

Genome annotation databases

Ensembl

ENST00000361853; ENSP00000354792; ENSG00000178585; Homo sapiens. [Genome view]
ENST00000377256; ENSP00000366466; ENSG00000178585; Homo sapiens. [Genome view]
ENST00000377258; ENSP00000366468; ENSG00000178585; Homo sapiens. [Genome view]
ENST00000377263; ENSP00000366474; ENSG00000178585; Homo sapiens. [Genome view]
ENST00000400904; ENSP00000383696; ENSG00000178585; Homo sapiens. [Genome view]

GeneID

56998.

KEGG

hsa:56998.

UCSC

uc001aqk.1. human.

Organism-specific databases

CTD

56998.

GeneCards

GC01M009842.

H-InvDB

HIX0000109.

HGNC

HGNC:16913. CTNNBIP1.

HPA

CAB024893.

MIM

607758. gene.

PharmGKB

PA27014.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q9NSA3.

InParanoid

Q9NSA3.

OrthoDB

EOG9QVFX3.

Gene expression databases

ArrayExpress

Q9NSA3.

Bgee

Q9NSA3.

CleanEx

HS_CTNNBIP1.

Genevestigator

Q9NSA3.

GermOnline

ENSG00000178585. Homo sapiens.

Family and domain databases

InterPro

IPR009428. ICAT.
[Graphical view]

Gene3D

G3DSA:1.10.10.490. ICAT. 1 hit.

Pfam

PF06384. ICAT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

62715.

SOURCE

Search...

Entry information

Entry name

CNBP1_HUMAN

Accession

Primary (citable) accession number: Q9NSA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	October 1, 2000
Last modified:	December 15, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.