Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-catenin-interacting protein 1

Gene

CTNNBIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.1 Publication

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • beta-catenin binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORiQ9NSA3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-interacting protein 1
Alternative name(s):
Inhibitor of beta-catenin and Tcf-4
Gene namesi
Name:CTNNBIP1
Synonyms:ICAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000178585.14
HGNCiHGNC:16913 CTNNBIP1
MIMi607758 gene
neXtProtiNX_Q9NSA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56998
OpenTargetsiENSG00000178585
PharmGKBiPA27014

Polymorphism and mutation databases

BioMutaiCTNNBIP1
DMDMi29428025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001528821 – 81Beta-catenin-interacting protein 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NSA3
MaxQBiQ9NSA3
PaxDbiQ9NSA3
PeptideAtlasiQ9NSA3
PRIDEiQ9NSA3
TopDownProteomicsiQ9NSA3

PTM databases

iPTMnetiQ9NSA3
PhosphoSitePlusiQ9NSA3

Expressioni

Gene expression databases

BgeeiENSG00000178585
CleanExiHS_CTNNBIP1
ExpressionAtlasiQ9NSA3 baseline and differential
GenevisibleiQ9NSA3 HS

Organism-specific databases

HPAiHPA042617

Interactioni

Subunit structurei

Binds CTNNB1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • beta-catenin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi121313, 26 interactors
CORUMiQ9NSA3
IntActiQ9NSA3, 16 interactors
MINTiQ9NSA3
STRINGi9606.ENSP00000366466

Structurei

Secondary structure

181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 28Combined sources18
Helixi35 – 43Combined sources9
Helixi45 – 52Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUJX-ray2.50B1-75[»]
1M1EX-ray2.10B1-81[»]
1T08X-ray2.10B8-53[»]
ProteinModelPortaliQ9NSA3
SMRiQ9NSA3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NSA3

Family & Domainsi

Sequence similaritiesi

Belongs to the CTNNBIP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM5 Eukaryota
ENOG4111UJF LUCA
GeneTreeiENSGT00860000133817
HOGENOMiHOG000037432
HOVERGENiHBG051037
InParanoidiQ9NSA3
KOiK04493
OMAiHPIDQGA
OrthoDBiEOG091G0RZ1
PhylomeDBiQ9NSA3

Family and domain databases

Gene3Di1.10.10.490, 1 hit
InterProiView protein in InterPro
IPR009428 ICAT
IPR036911 ICAT_sf
PfamiView protein in Pfam
PF06384 ICAT, 1 hit
SUPFAMiSSF81730 SSF81730, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NSA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS
60 70 80
QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q
Length:81
Mass (Da):9,170
Last modified:October 1, 2000 - v1
Checksum:i3DA6CF90B50CE942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021262 mRNA Translation: BAB03458.1
AL357140 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71631.1
BC014300 mRNA Translation: AAH14300.1
BC146892 mRNA Translation: AAI46893.1
BC146896 mRNA Translation: AAI46897.1
CCDSiCCDS106.1
RefSeqiNP_001012329.1, NM_001012329.1
NP_064633.1, NM_020248.2
XP_016857342.1, XM_017001853.1
XP_016857343.1, XM_017001854.1
XP_016857344.1, XM_017001855.1
UniGeneiHs.463759
Hs.685322

Genome annotation databases

EnsembliENST00000377256; ENSP00000366466; ENSG00000178585
ENST00000377258; ENSP00000366468; ENSG00000178585
ENST00000377263; ENSP00000366474; ENSG00000178585
ENST00000400904; ENSP00000383696; ENSG00000178585
GeneIDi56998
KEGGihsa:56998
UCSCiuc001aqk.2 human

Similar proteinsi

Entry informationi

Entry nameiCNBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA3
Secondary accession number(s): Q5T4V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health