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Protein

Potassium voltage-gated channel subfamily D member 1

Gene

KCND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi104ZincBy similarity1
Metal bindingi131ZincBy similarity1
Metal bindingi132ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Metal-binding, Potassium, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
R-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily D member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv4.1
Gene namesi
Name:KCND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6237. KCND1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 184CytoplasmicSequence analysisAdd BLAST184
Transmembranei185 – 205Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei227 – 247Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini248 – 261CytoplasmicSequence analysisAdd BLAST14
Transmembranei262 – 282Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini313 – 325CytoplasmicSequence analysisAdd BLAST13
Transmembranei326 – 346Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei365 – 385Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei387 – 407Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini408 – 647CytoplasmicSequence analysisAdd BLAST240

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102057.
PharmGKBiPA30029.

Chemistry databases

ChEMBLiCHEMBL2362996.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi552.

Polymorphism and mutation databases

BioMutaiKCND1.
DMDMi38258256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540611 – 647Potassium voltage-gated channel subfamily D member 1Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi352N-linked (GlcNAc...)Sequence analysis1
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Modified residuei458PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NSA2.
PeptideAtlasiQ9NSA2.
PRIDEiQ9NSA2.

PTM databases

iPTMnetiQ9NSA2.
PhosphoSitePlusiQ9NSA2.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.1 Publication

Gene expression databases

BgeeiENSG00000102057.
CleanExiHS_KCND1.
ExpressionAtlasiQ9NSA2. baseline and differential.
GenevisibleiQ9NSA2. HS.

Organism-specific databases

HPAiHPA000524.
HPA001066.

Interactioni

Subunit structurei

Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity). Interacts with DPP10 (Probable).By similarityCurated

Protein-protein interaction databases

STRINGi9606.ENSP00000218176.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA2.
SMRiQ9NSA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 20Interaction with KCNIP2By similarityAdd BLAST19
Regioni474 – 489Mediates dendritic targetingBy similarityAdd BLAST16

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 377Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231013.
HOVERGENiHBG106687.
InParanoidiQ9NSA2.
KOiK04891.
OMAiPREQPCG.
OrthoDBiEOG091G18X0.
PhylomeDBiQ9NSA2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR
60 70 80 90 100
FETWKNTLDR YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT
110 120 130 140 150
GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED
160 170 180 190 200
EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV
210 220 230 240 250
IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL IFTGEYLLRL
260 270 280 290 300
FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF
310 320 330 340 350
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG
360 370 380 390 400
TNKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI
410 420 430 440 450
ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK
460 470 480 490 500
QNGGLEDSGS GEEQALCVRN RSAFEQQHHH LLHCLEKTTC HEFTDELTFS
510 520 530 540 550
EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR AIRLANSTAS
560 570 580 590 600
VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS
610 620 630 640
IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL
Length:647
Mass (Da):71,330
Last modified:November 7, 2003 - v2
Checksum:i8672C299CDB7C5AA
GO
Isoform 2 (identifier: Q9NSA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-377: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):28,860
Checksum:iF81F0635F3FB4D8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358S → N in BAA96454 (Ref. 2) Curated1
Sequence conflicti406V → I in BAA96454 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570401 – 377Missing in isoform 2. 1 PublicationAdd BLAST377

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166003 mRNA. Translation: AAF65516.1.
AF166006, AF166004, AF166005 Genomic DNA. Translation: AAF65617.1.
AB021865 mRNA. Translation: BAA96454.1.
AJ005898 mRNA. Translation: CAA06755.1.
AK094431 mRNA. Translation: BAG52865.1.
AK315092 mRNA. Translation: BAG37557.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50720.1.
CH471224 Genomic DNA. Translation: EAW50721.1.
BC045659 mRNA. Translation: AAH45659.1.
CCDSiCCDS14314.1. [Q9NSA2-1]
RefSeqiNP_004970.3. NM_004979.5. [Q9NSA2-1]
XP_011542212.1. XM_011543910.2. [Q9NSA2-1]
UniGeneiHs.55276.

Genome annotation databases

EnsembliENST00000218176; ENSP00000218176; ENSG00000102057. [Q9NSA2-1]
ENST00000376477; ENSP00000365660; ENSG00000102057. [Q9NSA2-2]
GeneIDi3750.
KEGGihsa:3750.
UCSCiuc004dlw.1. human. [Q9NSA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166003 mRNA. Translation: AAF65516.1.
AF166006, AF166004, AF166005 Genomic DNA. Translation: AAF65617.1.
AB021865 mRNA. Translation: BAA96454.1.
AJ005898 mRNA. Translation: CAA06755.1.
AK094431 mRNA. Translation: BAG52865.1.
AK315092 mRNA. Translation: BAG37557.1.
AF207550 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50720.1.
CH471224 Genomic DNA. Translation: EAW50721.1.
BC045659 mRNA. Translation: AAH45659.1.
CCDSiCCDS14314.1. [Q9NSA2-1]
RefSeqiNP_004970.3. NM_004979.5. [Q9NSA2-1]
XP_011542212.1. XM_011543910.2. [Q9NSA2-1]
UniGeneiHs.55276.

3D structure databases

ProteinModelPortaliQ9NSA2.
SMRiQ9NSA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000218176.

Chemistry databases

ChEMBLiCHEMBL2362996.
DrugBankiDB06637. Dalfampridine.
GuidetoPHARMACOLOGYi552.

PTM databases

iPTMnetiQ9NSA2.
PhosphoSitePlusiQ9NSA2.

Polymorphism and mutation databases

BioMutaiKCND1.
DMDMi38258256.

Proteomic databases

PaxDbiQ9NSA2.
PeptideAtlasiQ9NSA2.
PRIDEiQ9NSA2.

Protocols and materials databases

DNASUi3750.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218176; ENSP00000218176; ENSG00000102057. [Q9NSA2-1]
ENST00000376477; ENSP00000365660; ENSG00000102057. [Q9NSA2-2]
GeneIDi3750.
KEGGihsa:3750.
UCSCiuc004dlw.1. human. [Q9NSA2-1]

Organism-specific databases

CTDi3750.
GeneCardsiKCND1.
HGNCiHGNC:6237. KCND1.
HPAiHPA000524.
HPA001066.
MIMi300281. gene.
neXtProtiNX_Q9NSA2.
OpenTargetsiENSG00000102057.
PharmGKBiPA30029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231013.
HOVERGENiHBG106687.
InParanoidiQ9NSA2.
KOiK04891.
OMAiPREQPCG.
OrthoDBiEOG091G18X0.
PhylomeDBiQ9NSA2.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
R-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

GeneWikiiKCND1.
GenomeRNAii3750.
PROiQ9NSA2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102057.
CleanExiHS_KCND1.
ExpressionAtlasiQ9NSA2. baseline and differential.
GenevisibleiQ9NSA2. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCND1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA2
Secondary accession number(s): A6NEF1, B2RCG0, O75671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.