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Q9NSA2

- KCND1_HUMAN

UniProt

Q9NSA2 - KCND1_HUMAN

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Protein
Potassium voltage-gated channel subfamily D member 1
Gene
KCND1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi104 – 1041Zinc By similarity
Metal bindingi131 – 1311Zinc By similarity
Metal bindingi132 – 1321Zinc By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein homooligomerization Source: InterPro
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Metal-binding, Potassium, Zinc

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily D member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv4.1
Gene namesi
Name:KCND1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6237. KCND1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 184184Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini248 – 26114Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini313 – 32513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei326 – 34621Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Intramembranei365 – 38521Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini408 – 647240Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. dendrite Source: UniProtKB-SubCell
  2. neuronal cell body Source: Ensembl
  3. plasma membrane Source: Reactome
  4. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Potassium voltage-gated channel subfamily D member 1
PRO_0000054061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NSA2.
PRIDEiQ9NSA2.

PTM databases

PhosphoSiteiQ9NSA2.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.1 Publication

Gene expression databases

ArrayExpressiQ9NSA2.
BgeeiQ9NSA2.
CleanExiHS_KCND1.
GenevestigatoriQ9NSA2.

Organism-specific databases

HPAiHPA000524.
HPA001066.

Interactioni

Subunit structurei

Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 By similarity. Interacts with DPP10 Inferred.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000218176.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA2.
SMRiQ9NSA2. Positions 6-417.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2019Interaction with KCNIP2 By similarity
Add
BLAST
Regioni474 – 48916Mediates dendritic targeting By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi372 – 3776Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231013.
HOVERGENiHBG106687.
InParanoidiQ9NSA2.
KOiK04891.
OMAiECIQAFD.
PhylomeDBiQ9NSA2.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NSA2-1 [UniParc]FASTAAdd to Basket

« Hide

MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR    50
FETWKNTLDR YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT 100
GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED 150
EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV 200
IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL IFTGEYLLRL 250
FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF 300
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG 350
TNKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI 400
ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK 450
QNGGLEDSGS GEEQALCVRN RSAFEQQHHH LLHCLEKTTC HEFTDELTFS 500
EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR AIRLANSTAS 550
VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS 600
IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL 647
Length:647
Mass (Da):71,330
Last modified:November 7, 2003 - v2
Checksum:i8672C299CDB7C5AA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti358 – 3581S → N in BAA96454. 1 Publication
Sequence conflicti406 – 4061V → I in BAA96454. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF166003 mRNA. Translation: AAF65516.1.
AF166006, AF166004, AF166005 Genomic DNA. Translation: AAF65617.1.
AB021865 mRNA. Translation: BAA96454.1.
AJ005898 mRNA. Translation: CAA06755.1.
AK315092 mRNA. Translation: BAG37557.1.
CH471224 Genomic DNA. Translation: EAW50721.1.
BC045659 mRNA. Translation: AAH45659.1.
CCDSiCCDS14314.1.
RefSeqiNP_004970.3. NM_004979.5.
UniGeneiHs.55276.

Genome annotation databases

EnsembliENST00000218176; ENSP00000218176; ENSG00000102057.
ENST00000593940; ENSP00000471039; ENSG00000267829.
GeneIDi3750.
KEGGihsa:3750.
UCSCiuc004dlx.1. human.

Polymorphism databases

DMDMi38258256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF166003 mRNA. Translation: AAF65516.1 .
AF166006 , AF166004 , AF166005 Genomic DNA. Translation: AAF65617.1 .
AB021865 mRNA. Translation: BAA96454.1 .
AJ005898 mRNA. Translation: CAA06755.1 .
AK315092 mRNA. Translation: BAG37557.1 .
CH471224 Genomic DNA. Translation: EAW50721.1 .
BC045659 mRNA. Translation: AAH45659.1 .
CCDSi CCDS14314.1.
RefSeqi NP_004970.3. NM_004979.5.
UniGenei Hs.55276.

3D structure databases

ProteinModelPortali Q9NSA2.
SMRi Q9NSA2. Positions 6-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000218176.

Chemistry

ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 552.

PTM databases

PhosphoSitei Q9NSA2.

Polymorphism databases

DMDMi 38258256.

Proteomic databases

PaxDbi Q9NSA2.
PRIDEi Q9NSA2.

Protocols and materials databases

DNASUi 3750.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218176 ; ENSP00000218176 ; ENSG00000102057 .
ENST00000593940 ; ENSP00000471039 ; ENSG00000267829 .
GeneIDi 3750.
KEGGi hsa:3750.
UCSCi uc004dlx.1. human.

Organism-specific databases

CTDi 3750.
GeneCardsi GC0XM048818.
HGNCi HGNC:6237. KCND1.
HPAi HPA000524.
HPA001066.
MIMi 300281. gene.
neXtProti NX_Q9NSA2.
PharmGKBi PA30029.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231013.
HOVERGENi HBG106687.
InParanoidi Q9NSA2.
KOi K04891.
OMAi ECIQAFD.
PhylomeDBi Q9NSA2.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCND1.
GenomeRNAii 3750.
NextBioi 14683.
PROi Q9NSA2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NSA2.
Bgeei Q9NSA2.
CleanExi HS_KCND1.
Genevestigatori Q9NSA2.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004054. K_chnl_volt-dep_Kv4.1.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01516. KV41CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)."
    Isbrandt D., Leicher T., Waldschuetz R., Zhu X.-R., Luhmann U., Michel U., Sauter K., Pongs O.
    Genomics 64:144-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic kidney.
  2. "Homo sapiens mRNA for shal-type potassium channel KCND1 (Kv4.1)."
    Makita N., Shirai N., Sawa H., Sasaki K., Nagashima K., Yoshida M.C., Kitabatake A.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Transcription map in Xp11.23."
    Strom T.M., Nyakatura G., Hellebrand H., Drescher B., Rosenthal A., Meindl A.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
    Jerng H.H., Qian Y., Pfaffinger P.J.
    Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DPP10.

Entry informationi

Entry nameiKCND1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA2
Secondary accession number(s): B2RCG0, O75671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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