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Q9NSA2

- KCND1_HUMAN

UniProt

Q9NSA2 - KCND1_HUMAN

Protein

Potassium voltage-gated channel subfamily D member 1

Gene

KCND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi104 – 1041ZincBy similarity
    Metal bindingi131 – 1311ZincBy similarity
    Metal bindingi132 – 1321ZincBy similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein homooligomerization Source: InterPro
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Metal-binding, Potassium, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily D member 1
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv4.1
    Gene namesi
    Name:KCND1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6237. KCND1.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: UniProtKB-SubCell
    2. neuronal cell body Source: Ensembl
    3. plasma membrane Source: Reactome
    4. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30029.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 647647Potassium voltage-gated channel subfamily D member 1PRO_0000054061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NSA2.
    PRIDEiQ9NSA2.

    PTM databases

    PhosphoSiteiQ9NSA2.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9NSA2.
    BgeeiQ9NSA2.
    CleanExiHS_KCND1.
    GenevestigatoriQ9NSA2.

    Organism-specific databases

    HPAiHPA000524.
    HPA001066.

    Interactioni

    Subunit structurei

    Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 By similarity. Interacts with DPP10 Probable.By similarityCurated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000218176.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSA2.
    SMRiQ9NSA2. Positions 6-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 184184CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 32513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 647240CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei365 – 38521Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei185 – 20521Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2019Interaction with KCNIP2By similarityAdd
    BLAST
    Regioni474 – 48916Mediates dendritic targetingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi372 – 3776Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231013.
    HOVERGENiHBG106687.
    InParanoidiQ9NSA2.
    KOiK04891.
    OMAiECIQAFD.
    PhylomeDBiQ9NSA2.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003975. K_chnl_volt-dep_Kv4.
    IPR004054. K_chnl_volt-dep_Kv4.1.
    IPR024587. K_chnl_volt-dep_Kv4_C.
    IPR021645. Shal-type.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF11879. DUF3399. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11601. Shal-type. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01516. KV41CHANNEL.
    PR01491. KVCHANNEL.
    PR01497. SHALCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NSA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR    50
    FETWKNTLDR YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT 100
    GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED 150
    EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV 200
    IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL IFTGEYLLRL 250
    FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF 300
    RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG 350
    TNKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI 400
    ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK 450
    QNGGLEDSGS GEEQALCVRN RSAFEQQHHH LLHCLEKTTC HEFTDELTFS 500
    EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR AIRLANSTAS 550
    VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS 600
    IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL 647
    Length:647
    Mass (Da):71,330
    Last modified:November 7, 2003 - v2
    Checksum:i8672C299CDB7C5AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti358 – 3581S → N in BAA96454. 1 PublicationCurated
    Sequence conflicti406 – 4061V → I in BAA96454. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF166003 mRNA. Translation: AAF65516.1.
    AF166006, AF166004, AF166005 Genomic DNA. Translation: AAF65617.1.
    AB021865 mRNA. Translation: BAA96454.1.
    AJ005898 mRNA. Translation: CAA06755.1.
    AK315092 mRNA. Translation: BAG37557.1.
    CH471224 Genomic DNA. Translation: EAW50721.1.
    BC045659 mRNA. Translation: AAH45659.1.
    CCDSiCCDS14314.1.
    RefSeqiNP_004970.3. NM_004979.5.
    UniGeneiHs.55276.

    Genome annotation databases

    EnsembliENST00000218176; ENSP00000218176; ENSG00000102057.
    GeneIDi3750.
    KEGGihsa:3750.
    UCSCiuc004dlx.1. human.

    Polymorphism databases

    DMDMi38258256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF166003 mRNA. Translation: AAF65516.1 .
    AF166006 , AF166004 , AF166005 Genomic DNA. Translation: AAF65617.1 .
    AB021865 mRNA. Translation: BAA96454.1 .
    AJ005898 mRNA. Translation: CAA06755.1 .
    AK315092 mRNA. Translation: BAG37557.1 .
    CH471224 Genomic DNA. Translation: EAW50721.1 .
    BC045659 mRNA. Translation: AAH45659.1 .
    CCDSi CCDS14314.1.
    RefSeqi NP_004970.3. NM_004979.5.
    UniGenei Hs.55276.

    3D structure databases

    ProteinModelPortali Q9NSA2.
    SMRi Q9NSA2. Positions 6-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000218176.

    Chemistry

    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 552.

    PTM databases

    PhosphoSitei Q9NSA2.

    Polymorphism databases

    DMDMi 38258256.

    Proteomic databases

    PaxDbi Q9NSA2.
    PRIDEi Q9NSA2.

    Protocols and materials databases

    DNASUi 3750.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218176 ; ENSP00000218176 ; ENSG00000102057 .
    GeneIDi 3750.
    KEGGi hsa:3750.
    UCSCi uc004dlx.1. human.

    Organism-specific databases

    CTDi 3750.
    GeneCardsi GC0XM048818.
    HGNCi HGNC:6237. KCND1.
    HPAi HPA000524.
    HPA001066.
    MIMi 300281. gene.
    neXtProti NX_Q9NSA2.
    PharmGKBi PA30029.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231013.
    HOVERGENi HBG106687.
    InParanoidi Q9NSA2.
    KOi K04891.
    OMAi ECIQAFD.
    PhylomeDBi Q9NSA2.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCND1.
    GenomeRNAii 3750.
    NextBioi 14683.
    PROi Q9NSA2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSA2.
    Bgeei Q9NSA2.
    CleanExi HS_KCND1.
    Genevestigatori Q9NSA2.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003975. K_chnl_volt-dep_Kv4.
    IPR004054. K_chnl_volt-dep_Kv4.1.
    IPR024587. K_chnl_volt-dep_Kv4_C.
    IPR021645. Shal-type.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF11879. DUF3399. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF11601. Shal-type. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01516. KV41CHANNEL.
    PR01491. KVCHANNEL.
    PR01497. SHALCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)."
      Isbrandt D., Leicher T., Waldschuetz R., Zhu X.-R., Luhmann U., Michel U., Sauter K., Pongs O.
      Genomics 64:144-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Tissue: Embryonic kidney.
    2. "Homo sapiens mRNA for shal-type potassium channel KCND1 (Kv4.1)."
      Makita N., Shirai N., Sawa H., Sasaki K., Nagashima K., Yoshida M.C., Kitabatake A.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "Transcription map in Xp11.23."
      Strom T.M., Nyakatura G., Hellebrand H., Drescher B., Rosenthal A., Meindl A.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    7. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."
      Jerng H.H., Qian Y., Pfaffinger P.J.
      Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DPP10.

    Entry informationi

    Entry nameiKCND1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSA2
    Secondary accession number(s): B2RCG0, O75671
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3