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Q9NSA1

- FGF21_HUMAN

UniProt

Q9NSA1 - FGF21_HUMAN

Protein

Fibroblast growth factor 21

Gene

FGF21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. positive regulation of cell proliferation Source: Ensembl
    3. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    4. positive regulation of glucose import Source: UniProtKB
    5. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
    6. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
    7. regulation of low-density lipoprotein particle clearance Source: BHF-UCL
    8. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 21
    Short name:
    FGF-21
    Gene namesi
    Name:FGF21
    ORF Names:UNQ3115/PRO10196
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3678. FGF21.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28117.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 209181Fibroblast growth factor 21PRO_0000008994Add
    BLAST

    Proteomic databases

    PaxDbiQ9NSA1.
    PRIDEiQ9NSA1.

    Expressioni

    Gene expression databases

    BgeeiQ9NSA1.
    CleanExiHS_FGF21.
    GenevestigatoriQ9NSA1.

    Organism-specific databases

    HPAiHPA061286.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KLBQ86Z142EBI-3909329,EBI-8515198

    Protein-protein interaction databases

    BioGridi117672. 6 interactions.
    IntActiQ9NSA1. 4 interactions.
    MINTiMINT-6799873.
    STRINGi9606.ENSP00000222157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSA1.
    SMRiQ9NSA1. Positions 44-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG311125.
    HOGENOMiHOG000112572.
    HOVERGENiHBG051612.
    InParanoidiQ9NSA1.
    KOiK04358.
    OMAiTLYGSLH.
    OrthoDBiEOG7X6M1F.
    PhylomeDBiQ9NSA1.
    TreeFamiTF335872.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028292. FGF21.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF62. PTHR11486:SF62. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NSA1-1 [UniParc]FASTAAdd to Basket

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    MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY    50
    TDDAQQTEAH LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR 100
    FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK 150
    SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS 200
    QGRSPSYAS 209
    Length:209
    Mass (Da):22,300
    Last modified:October 1, 2000 - v1
    Checksum:i27925C52A0023823
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231Missing in AAQ89444. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411G → S.1 Publication
    Corresponds to variant rs41308776 [ dbSNP | Ensembl ].
    VAR_055375
    Natural varianti174 – 1741L → P.1 Publication
    Corresponds to variant rs739320 [ dbSNP | Ensembl ].
    VAR_049064

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021975 mRNA. Translation: BAA99415.1.
    AY359086 mRNA. Translation: AAQ89444.1.
    DQ847413 Genomic DNA. Translation: ABI75345.1.
    CH471177 Genomic DNA. Translation: EAW52402.1.
    BC018404 mRNA. Translation: AAH18404.1.
    CCDSiCCDS12734.1.
    RefSeqiNP_061986.1. NM_019113.2.
    XP_005258788.1. XM_005258731.1.
    UniGeneiHs.283015.

    Genome annotation databases

    EnsembliENST00000222157; ENSP00000222157; ENSG00000105550.
    ENST00000593756; ENSP00000471477; ENSG00000105550.
    GeneIDi26291.
    KEGGihsa:26291.
    UCSCiuc002pkn.1. human.

    Polymorphism databases

    DMDMi13626703.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021975 mRNA. Translation: BAA99415.1 .
    AY359086 mRNA. Translation: AAQ89444.1 .
    DQ847413 Genomic DNA. Translation: ABI75345.1 .
    CH471177 Genomic DNA. Translation: EAW52402.1 .
    BC018404 mRNA. Translation: AAH18404.1 .
    CCDSi CCDS12734.1.
    RefSeqi NP_061986.1. NM_019113.2.
    XP_005258788.1. XM_005258731.1.
    UniGenei Hs.283015.

    3D structure databases

    ProteinModelPortali Q9NSA1.
    SMRi Q9NSA1. Positions 44-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117672. 6 interactions.
    IntActi Q9NSA1. 4 interactions.
    MINTi MINT-6799873.
    STRINGi 9606.ENSP00000222157.

    Polymorphism databases

    DMDMi 13626703.

    Proteomic databases

    PaxDbi Q9NSA1.
    PRIDEi Q9NSA1.

    Protocols and materials databases

    DNASUi 26291.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222157 ; ENSP00000222157 ; ENSG00000105550 .
    ENST00000593756 ; ENSP00000471477 ; ENSG00000105550 .
    GeneIDi 26291.
    KEGGi hsa:26291.
    UCSCi uc002pkn.1. human.

    Organism-specific databases

    CTDi 26291.
    GeneCardsi GC19P049259.
    HGNCi HGNC:3678. FGF21.
    HPAi HPA061286.
    MIMi 609436. gene.
    neXtProti NX_Q9NSA1.
    PharmGKBi PA28117.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311125.
    HOGENOMi HOG000112572.
    HOVERGENi HBG051612.
    InParanoidi Q9NSA1.
    KOi K04358.
    OMAi TLYGSLH.
    OrthoDBi EOG7X6M1F.
    PhylomeDBi Q9NSA1.
    TreeFami TF335872.

    Miscellaneous databases

    GeneWikii FGF21.
    GenomeRNAii 26291.
    NextBioi 48635.
    PROi Q9NSA1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NSA1.
    CleanExi HS_FGF21.
    Genevestigatori Q9NSA1.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028292. FGF21.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF62. PTHR11486:SF62. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
      Nishimura T., Nakatake Y., Konishi M., Itoh N.
      Biochim. Biophys. Acta 1492:203-206(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIEHS SNPs program
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-141 AND PRO-174.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.
    7. Cited for: FUNCTION, INTERACTION WITH FGFR4 AND KLB.
    8. "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."
      Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M.
      J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
      Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y.
      J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KLB.
    10. "Different roles of N- and C- termini in the functional activity of FGF21."
      Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., Kharitonenkov A.
      J. Cell. Physiol. 219:227-234(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KLB.
    11. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF21_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSA1
    Secondary accession number(s): Q8N683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3