Reviewed, UniProtKB/Swiss-Prot Q9NSA1 (FGF21_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 21
      Short name=FGF-21

Gene names

Name:	FGF21
ORF Names:	UNQ3115/PRO10196

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1, but not SLC2A4/GLUT4, expression. Ref.7
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Growth factor
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular region Ref.1 Traceable author statement. Source: ProtInc soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Ref.6
	Chain	29 – 209	181	Fibroblast growth factor 21		PRO_0000008994
Natural variations
	Natural variant	141	1	G → S		VAR_055375
	Natural variant	174	1	L → P: dbSNP rs739320.		VAR_049064
Experimental info
	Sequence conflict	23	1	Missing in AAQ89444. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9NSA1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 27925C52A0023823	FASTA	209	22,300
	10 20 30 40 50 60 MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH 70 80 90 100 110 120 LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA 130 140 150 160 170 180 CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI 190 200 LAPQPPDVGS SDPLSMVGPS QGRSPSYAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel FGF, FGF-21, preferentially expressed in the liver." Nishimura T., Nakatake Y., Konishi M., Itoh N. Biochim. Biophys. Acta 1492:203-206(2000) [PubMed: 10858549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIEHS SNPs program Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-141 AND PRO-174.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-43.
[7]	"FGF-21 as a novel metabolic regulator." Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B. J. Clin. Invest. 115:1627-1635(2005) [PubMed: 15902306] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB021975 mRNA. Translation: BAA99415.1. AY359086 mRNA. Translation: AAQ89444.1. DQ847413 Genomic DNA. Translation: ABI75345.1. CH471177 Genomic DNA. Translation: EAW52402.1. BC018404 mRNA. Translation: AAH18404.1.
IPI	IPI00017149.
RefSeq	NP_061986.1.
UniGene	Hs.283015
3D structure databases
HSSP	HSSP built from PDB template 1BAR based on UniProtKB P03968.
ModBase	Search...
Proteomic databases
PRIDE	Q9NSA1.
Genome annotation databases
Ensembl	ENSG00000105550. Homo sapiens. [Contig view]
GeneID	26291.
KEGG	hsa:26291.
Organism-specific databases
GeneCards	GC19P053951.
H-InvDB	HIX0027440.
HGNC	HGNC:3678. FGF21.
MIM	609436. gene.
PharmGKB	PA28117.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NSA1.
HOVERGEN	Q9NSA1.
OMA	Q9NSA1. HPIPDSS.
Gene expression databases
ArrayExpress	Q9NSA1.
Bgee	Q9NSA1.
CleanEx	HS_FGF21.
GermOnline	ENSG00000105550. Homo sapiens.
Family and domain databases
InterPro	IPR017338. Fibroblast_GF_15/19/21. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PIRSF	PIRSF037961. FGF-19_FGF-21. 1 hit.
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48635.
SOURCE	Search...

Entry information

Entry name

FGF21_HUMAN

Accession

Primary (citable) accession number: Q9NSA1
Secondary accession number(s): Q8N683

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)