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Q9NSA1 (FGF21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 21

Short name=FGF-21
Gene names
Name:FGF21
ORF Names:UNQ3115/PRO10196
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Ref.7 Ref.8

Subunit structure

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4. Ref.7 Ref.9 Ref.10

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KLBQ86Z142EBI-3909329,EBI-8515198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.6
Chain29 – 209181Fibroblast growth factor 21
PRO_0000008994

Natural variations

Natural variant1411G → S. Ref.3
Corresponds to variant rs41308776 [ dbSNP | Ensembl ].
VAR_055375
Natural variant1741L → P. Ref.3
Corresponds to variant rs739320 [ dbSNP | Ensembl ].
VAR_049064

Experimental info

Sequence conflict231Missing in AAQ89444. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NSA1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 27925C52A0023823

FASTA20922,300
        10         20         30         40         50         60 
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH 

        70         80         90        100        110        120 
LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA 

       130        140        150        160        170        180 
CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI 

       190        200 
LAPQPPDVGS SDPLSMVGPS QGRSPSYAS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
Nishimura T., Nakatake Y., Konishi M., Itoh N.
Biochim. Biophys. Acta 1492:203-206(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIEHS SNPs program
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-141 AND PRO-174.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-43.
[7]"FGF-21 as a novel metabolic regulator."
Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B.
J. Clin. Invest. 115:1627-1635(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FGFR4 AND KLB.
[8]"Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."
Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M.
J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y.
J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KLB.
[10]"Different roles of N- and C- termini in the functional activity of FGF21."
Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., Kharitonenkov A.
J. Cell. Physiol. 219:227-234(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KLB.
[11]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021975 mRNA. Translation: BAA99415.1.
AY359086 mRNA. Translation: AAQ89444.1.
DQ847413 Genomic DNA. Translation: ABI75345.1.
CH471177 Genomic DNA. Translation: EAW52402.1.
BC018404 mRNA. Translation: AAH18404.1.
CCDSCCDS12734.1.
RefSeqNP_061986.1. NM_019113.2.
XP_005258788.1. XM_005258731.1.
UniGeneHs.283015.

3D structure databases

ProteinModelPortalQ9NSA1.
SMRQ9NSA1. Positions 44-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117672. 6 interactions.
IntActQ9NSA1. 4 interactions.
MINTMINT-6799873.
STRING9606.ENSP00000222157.

Polymorphism databases

DMDM13626703.

Proteomic databases

PaxDbQ9NSA1.
PRIDEQ9NSA1.

Protocols and materials databases

DNASU26291.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222157; ENSP00000222157; ENSG00000105550.
ENST00000593756; ENSP00000471477; ENSG00000105550.
GeneID26291.
KEGGhsa:26291.
UCSCuc002pkn.1. human.

Organism-specific databases

CTD26291.
GeneCardsGC19P049259.
HGNCHGNC:3678. FGF21.
HPAHPA061286.
MIM609436. gene.
neXtProtNX_Q9NSA1.
PharmGKBPA28117.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311125.
HOGENOMHOG000112572.
HOVERGENHBG051612.
InParanoidQ9NSA1.
KOK04358.
OMATLYGSLH.
OrthoDBEOG7X6M1F.
PhylomeDBQ9NSA1.
TreeFamTF335872.

Gene expression databases

BgeeQ9NSA1.
CleanExHS_FGF21.
GenevestigatorQ9NSA1.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF62. PTHR11486:SF62. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGF21.
GenomeRNAi26291.
NextBio48635.
PROQ9NSA1.
SOURCESearch...

Entry information

Entry nameFGF21_HUMAN
AccessionPrimary (citable) accession number: Q9NSA1
Secondary accession number(s): Q8N683
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM