Reviewed,
UniProtKB/Swiss-Prot Q9NSA1 (FGF21_HUMAN)
Last modified
January 19, 2010.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fibroblast growth factor 21 Short name=FGF-21 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 209 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Ref.7 Ref.8 |
| Subunit structure | Interacts (via C-terminus) with KLB; this interaction is direct. Ref.9 Ref.10 |
| Subcellular location | Secreted Potential. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Growth factor |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc positive regulation of ERK1 and ERK2 cascade Ref.8Inferred from direct assay. Source: UniProtKB positive regulation of glucose import Ref.8Inferred from direct assay. Source: UniProtKB signal transduction Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | extracellular region Ref.1 Traceable author statement. Source: ProtInc soluble fraction Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 28 | 28 | Ref.6 | ||||||
| Chain | 29 – 209 | 181 | Fibroblast growth factor 21 | PRO_0000008994 | |||||
Natural variations | |||||||||
| Natural variant | 141 | 1 | G → S: dbSNP rs41308776. Ref.3 | VAR_055375 | |||||
| Natural variant | 174 | 1 | L → P: dbSNP rs739320. Ref.3 | VAR_049064 | |||||
Experimental info | |||||||||
| Sequence conflict | 23 | 1 | Missing in AAQ89444. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel FGF, FGF-21, preferentially expressed in the liver." Nishimura T., Nakatake Y., Konishi M., Itoh N. Biochim. Biophys. Acta 1492:203-206(2000) [PubMed: 10858549] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | NIEHS SNPs program Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-141 AND PRO-174. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-43. |
| [7] | "FGF-21 as a novel metabolic regulator." Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B. J. Clin. Invest. 115:1627-1635(2005) [PubMed: 15902306] [Abstract] Cited for: FUNCTION. |
| [8] | "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21." Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M. J. Biol. Chem. 282:26687-26695(2007) [PubMed: 17623664] [Abstract] Cited for: FUNCTION. |
| [9] | "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors." Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y. J. Biol. Chem. 283:33304-33309(2008) [PubMed: 18829467] [Abstract] Cited for: INTERACTION WITH KLB. |
| [10] | "Different roles of N- and C- termini in the functional activity of FGF21." Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., Kharitonenkov A. J. Cell. Physiol. 219:227-234(2009) [PubMed: 19117008] [Abstract] Cited for: INTERACTION WITH KLB. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB021975 mRNA. Translation: BAA99415.1. AY359086 mRNA. Translation: AAQ89444.1. DQ847413 Genomic DNA. Translation: ABI75345.1. CH471177 Genomic DNA. Translation: EAW52402.1. BC018404 mRNA. Translation: AAH18404.1. |
| IPI | IPI00017149. |
| RefSeq | NP_061986.1. |
| UniGene | Hs.283015 |
3D structure databases | |
| SMR | Q9NSA1. Positions 35-172. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NSA1. |
Proteomic databases | |
| PRIDE | Q9NSA1. |
Genome annotation databases | |
| Ensembl | ENST00000222157; ENSP00000222157; ENSG00000105550; Homo sapiens. [Genome view] |
| GeneID | 26291. |
| KEGG | hsa:26291. |
| UCSC | uc002pkn.1. human. |
Organism-specific databases | |
| CTD | 26291. |
| GeneCards | GC19P053951. |
| H-InvDB | HIX0027440. |
| HGNC | HGNC:3678. FGF21. |
| MIM | 609436. gene. |
| PharmGKB | PA28117. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG16938. |
| HOGENOM | HBG126920. |
| HOVERGEN | Q9NSA1. |
| InParanoid | Q9NSA1. |
| OMA | HPIPDSS. |
| OrthoDB | EOG9HHRMK. |
| PhylomeDB | Q9NSA1. |
Gene expression databases | |
| ArrayExpress | Q9NSA1. |
| Bgee | Q9NSA1. |
| CleanEx | HS_FGF21. |
| Genevestigator | Q9NSA1. |
| GermOnline | ENSG00000105550. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008996. Cytokine_IL1-like. IPR017338. Fibroblast_GF_15/19/21. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] |
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. |
| Pfam | PF00167. FGF. 1 hit. [Graphical view] |
| PIRSF | PIRSF037961. FGF-19_FGF-21. 1 hit. |
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. |
| SMART | SM00442. FGF. 1 hit. [Graphical view] |
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 48635. |
| SOURCE | Search... |
Entry information
| Entry name | FGF21_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NSA1 Secondary accession number(s): Q8N683 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


