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Q9NSA1

- FGF21_HUMAN

UniProt

Q9NSA1 - FGF21_HUMAN

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Protein

Fibroblast growth factor 21

Gene

FGF21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.2 Publications

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. positive regulation of cell proliferation Source: Ensembl
  3. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  4. positive regulation of glucose import Source: UniProtKB
  5. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  6. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
  7. regulation of low-density lipoprotein particle clearance Source: BHF-UCL
  8. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 21
Short name:
FGF-21
Gene namesi
Name:FGF21
ORF Names:UNQ3115/PRO10196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3678. FGF21.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 209181Fibroblast growth factor 21PRO_0000008994Add
BLAST

Proteomic databases

PaxDbiQ9NSA1.
PRIDEiQ9NSA1.

Expressioni

Gene expression databases

BgeeiQ9NSA1.
CleanExiHS_FGF21.
GenevestigatoriQ9NSA1.

Organism-specific databases

HPAiHPA061286.

Interactioni

Subunit structurei

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLBQ86Z142EBI-3909329,EBI-8515198

Protein-protein interaction databases

BioGridi117672. 6 interactions.
IntActiQ9NSA1. 4 interactions.
MINTiMINT-6799873.
STRINGi9606.ENSP00000222157.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA1.
SMRiQ9NSA1. Positions 44-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG311125.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112572.
HOVERGENiHBG051612.
InParanoidiQ9NSA1.
KOiK04358.
OMAiTLYGSLH.
OrthoDBiEOG7X6M1F.
PhylomeDBiQ9NSA1.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF62. PTHR11486:SF62. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NSA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY
60 70 80 90 100
TDDAQQTEAH LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR
110 120 130 140 150
FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK
160 170 180 190 200
SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS

QGRSPSYAS
Length:209
Mass (Da):22,300
Last modified:October 1, 2000 - v1
Checksum:i27925C52A0023823
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231Missing in AAQ89444. (PubMed:12975309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411G → S.1 Publication
Corresponds to variant rs41308776 [ dbSNP | Ensembl ].
VAR_055375
Natural varianti174 – 1741L → P.1 Publication
Corresponds to variant rs739320 [ dbSNP | Ensembl ].
VAR_049064

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA. Translation: BAA99415.1.
AY359086 mRNA. Translation: AAQ89444.1.
DQ847413 Genomic DNA. Translation: ABI75345.1.
CH471177 Genomic DNA. Translation: EAW52402.1.
BC018404 mRNA. Translation: AAH18404.1.
CCDSiCCDS12734.1.
RefSeqiNP_061986.1. NM_019113.2.
XP_005258788.1. XM_005258731.1.
UniGeneiHs.283015.

Genome annotation databases

EnsembliENST00000222157; ENSP00000222157; ENSG00000105550.
ENST00000593756; ENSP00000471477; ENSG00000105550.
GeneIDi26291.
KEGGihsa:26291.
UCSCiuc002pkn.1. human.

Polymorphism databases

DMDMi13626703.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA. Translation: BAA99415.1 .
AY359086 mRNA. Translation: AAQ89444.1 .
DQ847413 Genomic DNA. Translation: ABI75345.1 .
CH471177 Genomic DNA. Translation: EAW52402.1 .
BC018404 mRNA. Translation: AAH18404.1 .
CCDSi CCDS12734.1.
RefSeqi NP_061986.1. NM_019113.2.
XP_005258788.1. XM_005258731.1.
UniGenei Hs.283015.

3D structure databases

ProteinModelPortali Q9NSA1.
SMRi Q9NSA1. Positions 44-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117672. 6 interactions.
IntActi Q9NSA1. 4 interactions.
MINTi MINT-6799873.
STRINGi 9606.ENSP00000222157.

Polymorphism databases

DMDMi 13626703.

Proteomic databases

PaxDbi Q9NSA1.
PRIDEi Q9NSA1.

Protocols and materials databases

DNASUi 26291.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222157 ; ENSP00000222157 ; ENSG00000105550 .
ENST00000593756 ; ENSP00000471477 ; ENSG00000105550 .
GeneIDi 26291.
KEGGi hsa:26291.
UCSCi uc002pkn.1. human.

Organism-specific databases

CTDi 26291.
GeneCardsi GC19P049259.
HGNCi HGNC:3678. FGF21.
HPAi HPA061286.
MIMi 609436. gene.
neXtProti NX_Q9NSA1.
PharmGKBi PA28117.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311125.
GeneTreei ENSGT00530000063469.
HOGENOMi HOG000112572.
HOVERGENi HBG051612.
InParanoidi Q9NSA1.
KOi K04358.
OMAi TLYGSLH.
OrthoDBi EOG7X6M1F.
PhylomeDBi Q9NSA1.
TreeFami TF335872.

Miscellaneous databases

GeneWikii FGF21.
GenomeRNAii 26291.
NextBioi 48635.
PROi Q9NSA1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSA1.
CleanExi HS_FGF21.
Genevestigatori Q9NSA1.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF62. PTHR11486:SF62. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel FGF, FGF-21, preferentially expressed in the liver."
    Nishimura T., Nakatake Y., Konishi M., Itoh N.
    Biochim. Biophys. Acta 1492:203-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIEHS SNPs program
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-141 AND PRO-174.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.
  7. Cited for: FUNCTION, INTERACTION WITH FGFR4 AND KLB.
  8. "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."
    Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M.
    J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."
    Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y.
    J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLB.
  10. "Different roles of N- and C- termini in the functional activity of FGF21."
    Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., Kharitonenkov A.
    J. Cell. Physiol. 219:227-234(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLB.
  11. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF21_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA1
Secondary accession number(s): Q8N683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3