Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 21

Gene

FGF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105550-MONOMER.
ReactomeiR-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-70153. Glucose transport.
SIGNORiQ9NSA1.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 21
Short name:
FGF-21
Gene namesi
Name:FGF21
ORF Names:UNQ3115/PRO10196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3678. FGF21.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: ProtInc
  • extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26291.
OpenTargetsiENSG00000105550.
PharmGKBiPA28117.

Polymorphism and mutation databases

BioMutaiFGF21.
DMDMi13626703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000000899429 – 209Fibroblast growth factor 21Add BLAST181

Proteomic databases

PaxDbiQ9NSA1.
PeptideAtlasiQ9NSA1.
PRIDEiQ9NSA1.

Expressioni

Gene expression databases

BgeeiENSG00000105550.
CleanExiHS_FGF21.
GenevisibleiQ9NSA1. HS.

Organism-specific databases

HPAiHPA061286.

Interactioni

Subunit structurei

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLBQ86Z142EBI-3909329,EBI-8515198

Protein-protein interaction databases

BioGridi117672. 7 interactors.
IntActiQ9NSA1. 6 interactors.
MINTiMINT-6799873.
STRINGi9606.ENSP00000222157.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA1.
SMRiQ9NSA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112572.
HOVERGENiHBG051612.
InParanoidiQ9NSA1.
KOiK04358.
OMAiYNIYHSE.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9NSA1.
TreeFamiTF335872.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF81. PTHR11486:SF81. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NSA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY
60 70 80 90 100
TDDAQQTEAH LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR
110 120 130 140 150
FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK
160 170 180 190 200
SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS

QGRSPSYAS
Length:209
Mass (Da):22,300
Last modified:October 1, 2000 - v1
Checksum:i27925C52A0023823
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Missing in AAQ89444 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055375141G → S.1 PublicationCorresponds to variant rs41308776dbSNPEnsembl.1
Natural variantiVAR_049064174L → P.1 PublicationCorresponds to variant rs739320dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA. Translation: BAA99415.1.
AY359086 mRNA. Translation: AAQ89444.1.
DQ847413 Genomic DNA. Translation: ABI75345.1.
CH471177 Genomic DNA. Translation: EAW52402.1.
BC018404 mRNA. Translation: AAH18404.1.
CCDSiCCDS12734.1.
RefSeqiNP_061986.1. NM_019113.3.
UniGeneiHs.283015.

Genome annotation databases

EnsembliENST00000222157; ENSP00000222157; ENSG00000105550.
ENST00000593756; ENSP00000471477; ENSG00000105550.
GeneIDi26291.
KEGGihsa:26291.
UCSCiuc002pkn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA. Translation: BAA99415.1.
AY359086 mRNA. Translation: AAQ89444.1.
DQ847413 Genomic DNA. Translation: ABI75345.1.
CH471177 Genomic DNA. Translation: EAW52402.1.
BC018404 mRNA. Translation: AAH18404.1.
CCDSiCCDS12734.1.
RefSeqiNP_061986.1. NM_019113.3.
UniGeneiHs.283015.

3D structure databases

ProteinModelPortaliQ9NSA1.
SMRiQ9NSA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117672. 7 interactors.
IntActiQ9NSA1. 6 interactors.
MINTiMINT-6799873.
STRINGi9606.ENSP00000222157.

Polymorphism and mutation databases

BioMutaiFGF21.
DMDMi13626703.

Proteomic databases

PaxDbiQ9NSA1.
PeptideAtlasiQ9NSA1.
PRIDEiQ9NSA1.

Protocols and materials databases

DNASUi26291.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222157; ENSP00000222157; ENSG00000105550.
ENST00000593756; ENSP00000471477; ENSG00000105550.
GeneIDi26291.
KEGGihsa:26291.
UCSCiuc002pkn.2. human.

Organism-specific databases

CTDi26291.
DisGeNETi26291.
GeneCardsiFGF21.
HGNCiHGNC:3678. FGF21.
HPAiHPA061286.
MIMi609436. gene.
neXtProtiNX_Q9NSA1.
OpenTargetsiENSG00000105550.
PharmGKBiPA28117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112572.
HOVERGENiHBG051612.
InParanoidiQ9NSA1.
KOiK04358.
OMAiYNIYHSE.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9NSA1.
TreeFamiTF335872.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105550-MONOMER.
ReactomeiR-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-70153. Glucose transport.
SIGNORiQ9NSA1.

Miscellaneous databases

GeneWikiiFGF21.
GenomeRNAii26291.
PROiQ9NSA1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105550.
CleanExiHS_FGF21.
GenevisibleiQ9NSA1. HS.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028292. FGF21.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF81. PTHR11486:SF81. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF21_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA1
Secondary accession number(s): Q8N683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.