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Q9NSA0

- S22AB_HUMAN

UniProt

Q9NSA0 - S22AB_HUMAN

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Protein

Solute carrier family 22 member 11

Gene

SLC22A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.3 Publications

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: UniProtKB
  2. organic anion transmembrane transporter activity Source: UniProtKB
  3. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. organic anion transport Source: UniProtKB
  2. transmembrane transport Source: Reactome
  3. urate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22310. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.10. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 11
Alternative name(s):
Organic anion transporter 4
Gene namesi
Name:SLC22A11
Synonyms:OAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18120. SLC22A11.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 142111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 17411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 2005ExtracellularSequence Analysis
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Topological domaini222 – 23110CytoplasmicSequence Analysis
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 2564ExtracellularSequence Analysis
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 34669CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence AnalysisAdd
BLAST
Topological domaini368 – 37811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Topological domaini400 – 4023CytoplasmicSequence Analysis
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 4307ExtracellularSequence Analysis
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Topological domaini452 – 46312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence AnalysisAdd
BLAST
Topological domaini485 – 4906ExtracellularSequence Analysis
Transmembranei491 – 51121HelicalSequence AnalysisAdd
BLAST
Topological domaini512 – 55039CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. external side of plasma membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: UniProtKB
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi39 – 391N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99. 1 Publication
Mutagenesisi47 – 471H → A: Reduced cell surface expression and estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-52; A-83; A-305 and A-469. 1 Publication
Mutagenesisi52 – 521H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-83; A-305 and A-469. 1 Publication
Mutagenesisi56 – 561N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99. 1 Publication
Mutagenesisi63 – 631N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99. 1 Publication
Mutagenesisi83 – 831H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-305 and A-469. 1 Publication
Mutagenesisi99 – 991N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63. 1 Publication
Mutagenesisi241 – 2411G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication
Mutagenesisi305 – 3051H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-469. 1 Publication
Mutagenesisi400 – 4001G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication
Mutagenesisi469 – 4691H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-305. 1 Publication

Organism-specific databases

PharmGKBiPA38295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Solute carrier family 22 member 11PRO_0000234435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated. Contains several complex-type N-glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NSA0.
PRIDEiQ9NSA0.

Expressioni

Tissue specificityi

Detected in placenta and kidney.1 Publication

Gene expression databases

BgeeiQ9NSA0.
CleanExiHS_SLC22A11.
ExpressionAtlasiQ9NSA0. baseline and differential.
GenevestigatoriQ9NSA0.

Organism-specific databases

HPAiHPA026076.

Interactioni

Protein-protein interaction databases

BioGridi120967. 1 interaction.
STRINGi9606.ENSP00000301891.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA0.
SMRiQ9NSA0. Positions 119-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9NSA0.
KOiK08207.
OMAiNPRHPME.
OrthoDBiEOG7C5M82.
PhylomeDBiQ9NSA0.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NSA0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW
60 70 80 90 100
THMLDNGSAV STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA
110 120 130 140 150
TATSWSEADT EPCVDGWVYD RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM
160 170 180 190 200
SGILVGSFIW GLLSYRFGRK PMLSWCCLQL AVAGTSTIFA PTFVIYCGLR
210 220 230 240 250
FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA GQAALGGLAF
260 270 280 290 300
ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
310 320 330 340 350
RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML
360 370 380 390 400
VVNFSLLISY YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG
410 420 430 440 450
RRTIQAGSQA MAGLAILANM LVPQDLQTLR VVFAVLGKGC FGISLTCLTI
460 470 480 490 500
YKAELFPTPV RMTADGILHT VGRLGAMMGP LILMSRQALP LLPPLLYGVI
510 520 530 540 550
SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ EAVTVESTSL
Length:550
Mass (Da):59,972
Last modified:October 1, 2000 - v1
Checksum:i233BE6C4A520E58A
GO
Isoform 2 (identifier: Q9NSA0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-461: NFSLLISYYG...KAELFPTPVR → K

Note: No experimental confirmation available.

Show »
Length:442
Mass (Da):48,301
Checksum:iF9D42F38249733FB
GO

Sequence cautioni

The sequence BAC11483.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801L → S in BAD96589. 1 PublicationCurated
Sequence conflicti376 – 3761L → R in BAC85252. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551V → G.
Corresponds to variant rs12785832 [ dbSNP | Ensembl ].
VAR_053962

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei353 – 461109NFSLL…PTPVR → K in isoform 2. 1 PublicationVSP_018319Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA. Translation: BAA95316.1.
AK075224 mRNA. Translation: BAC11483.1. Different initiation.
AK129930 mRNA. Translation: BAC85252.1.
AK222869 mRNA. Translation: BAD96589.1.
AK290791 mRNA. Translation: BAF83480.1.
AC044790 Genomic DNA. Translation: AAK68155.1.
CH471076 Genomic DNA. Translation: EAW74269.1.
BC034384 mRNA. Translation: AAH34384.1.
CCDSiCCDS8074.1. [Q9NSA0-1]
RefSeqiNP_060954.1. NM_018484.2. [Q9NSA0-1]
UniGeneiHs.220844.

Genome annotation databases

EnsembliENST00000301891; ENSP00000301891; ENSG00000168065. [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065. [Q9NSA0-2]
GeneIDi55867.
KEGGihsa:55867.
UCSCiuc001oai.3. human. [Q9NSA0-1]
uc009ypq.3. human. [Q9NSA0-2]

Polymorphism databases

DMDMi74734337.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA. Translation: BAA95316.1 .
AK075224 mRNA. Translation: BAC11483.1 . Different initiation.
AK129930 mRNA. Translation: BAC85252.1 .
AK222869 mRNA. Translation: BAD96589.1 .
AK290791 mRNA. Translation: BAF83480.1 .
AC044790 Genomic DNA. Translation: AAK68155.1 .
CH471076 Genomic DNA. Translation: EAW74269.1 .
BC034384 mRNA. Translation: AAH34384.1 .
CCDSi CCDS8074.1. [Q9NSA0-1 ]
RefSeqi NP_060954.1. NM_018484.2. [Q9NSA0-1 ]
UniGenei Hs.220844.

3D structure databases

ProteinModelPortali Q9NSA0.
SMRi Q9NSA0. Positions 119-529.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120967. 1 interaction.
STRINGi 9606.ENSP00000301891.

Chemistry

BindingDBi Q9NSA0.
ChEMBLi CHEMBL2073677.
DrugBanki DB00345. Aminohippurate.
DB00168. Aspartame.
DB01053. Benzylpenicillin.
DB00887. Bumetanide.
DB00456. Cefalotin.
DB01326. Cefamandole.
DB01327. Cefazolin.
DB01329. Cefoperazone.
DB00493. Cefotaxime.
DB01212. Ceftriaxone.
DB00501. Cimetidine.
DB00286. Conjugated Estrogens.
DB00586. Diclofenac.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00254. Doxycycline.
DB00783. Estradiol.
DB00695. Furosemide.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00563. Methotrexate.
DB01017. Minocycline.
DB01051. Novobiocin.
DB00595. Oxytetracycline.
DB00812. Phenylbutazone.
DB00554. Piroxicam.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00936. Salicylic acid.
DB00759. Tetracycline.
DB00495. Zidovudine.

Protein family/group databases

TCDBi 2.A.1.19.10. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 74734337.

Proteomic databases

PaxDbi Q9NSA0.
PRIDEi Q9NSA0.

Protocols and materials databases

DNASUi 55867.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301891 ; ENSP00000301891 ; ENSG00000168065 . [Q9NSA0-1 ]
ENST00000377585 ; ENSP00000366809 ; ENSG00000168065 . [Q9NSA0-2 ]
GeneIDi 55867.
KEGGi hsa:55867.
UCSCi uc001oai.3. human. [Q9NSA0-1 ]
uc009ypq.3. human. [Q9NSA0-2 ]

Organism-specific databases

CTDi 55867.
GeneCardsi GC11P064324.
HGNCi HGNC:18120. SLC22A11.
HPAi HPA026076.
MIMi 607097. gene.
neXtProti NX_Q9NSA0.
PharmGKBi PA38295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q9NSA0.
KOi K08207.
OMAi NPRHPME.
OrthoDBi EOG7C5M82.
PhylomeDBi Q9NSA0.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_22310. Organic anion transport.

Miscellaneous databases

ChiTaRSi SLC22A11. human.
GeneWikii SLC22A11.
GenomeRNAii 55867.
NextBioi 61178.
PROi Q9NSA0.
SOURCEi Search...

Gene expression databases

Bgeei Q9NSA0.
CleanExi HS_SLC22A11.
ExpressionAtlasi Q9NSA0. baseline and differential.
Genevestigatori Q9NSA0.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta."
    Cha S.H., Sekine T., Kusuhara H., Yu E., Kim J.Y., Kim D.K., Sugiyama Y., Kanai Y., Endou H.
    J. Biol. Chem. 275:4507-4512(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Placenta.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  7. "Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)."
    Zhou F., Pan Z., Ma J., You G.
    Biochem. J. 384:87-92(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF HIS-47; HIS-52; HIS-83; HIS-305 AND HIS-469, FUNCTION, SUBCELLULAR LOCATION.
  8. "The role of glycine residues in the function of human organic anion transporter 4."
    Zhou F., Tanaka K., Pan Z., Ma J., You G.
    Mol. Pharmacol. 65:1141-1147(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLY-241 AND GLY-400.
  9. "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4."
    Zhou F., Xu W., Hong M., Pan Z., Sinko P.J., Ma J., You G.
    Mol. Pharmacol. 67:868-876(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASN-39; ASN-56; ASN-63 AND ASN-99, SUBCELLULAR LOCATION, GLYCOSYLATION.

Entry informationi

Entry nameiS22AB_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA0
Secondary accession number(s): A8K426
, Q53GR2, Q6ZP72, Q8NBU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3