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Protein

Solute carrier family 22 member 11

Gene

SLC22A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.3 Publications

GO - Molecular functioni

  • inorganic anion exchanger activity Source: UniProtKB
  • organic anion transmembrane transporter activity Source: UniProtKB
  • sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • organic anion transport Source: UniProtKB
  • sodium-independent organic anion transport Source: GO_Central
  • urate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168065-MONOMER.
ReactomeiR-HSA-561048. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.10. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 11
Alternative name(s):
Organic anion transporter 4
Gene namesi
Name:SLC22A11
Synonyms:OAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18120. SLC22A11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 142ExtracellularSequence analysisAdd BLAST111
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 174CytoplasmicSequence analysisAdd BLAST11
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 200ExtracellularSequence analysis5
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 256ExtracellularSequence analysis4
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 346CytoplasmicSequence analysisAdd BLAST69
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 378ExtracellularSequence analysisAdd BLAST11
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 402CytoplasmicSequence analysis3
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 430ExtracellularSequence analysis7
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 463CytoplasmicSequence analysisAdd BLAST12
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 490ExtracellularSequence analysis6
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 550CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • external side of plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99. 1 Publication1
Mutagenesisi47H → A: Reduced cell surface expression and estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-52; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi52H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi56N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99. 1 Publication1
Mutagenesisi63N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99. 1 Publication1
Mutagenesisi83H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-305 and A-469. 1 Publication1
Mutagenesisi99N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63. 1 Publication1
Mutagenesisi241G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi305H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-469. 1 Publication1
Mutagenesisi400G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi469H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-305. 1 Publication1

Organism-specific databases

DisGeNETi55867.
OpenTargetsiENSG00000168065.
PharmGKBiPA38295.

Chemistry databases

ChEMBLiCHEMBL2073677.
DrugBankiDB00345. Aminohippurate.
DB00168. Aspartame.
DB01053. Benzylpenicillin.
DB00887. Bumetanide.
DB00456. Cefalotin.
DB01326. Cefamandole.
DB01327. Cefazolin.
DB01329. Cefoperazone.
DB00493. Cefotaxime.
DB01212. Ceftriaxone.
DB00501. Cimetidine.
DB00286. Conjugated Estrogens.
DB00586. Diclofenac.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00254. Doxycycline.
DB00783. Estradiol.
DB00695. Furosemide.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00563. Methotrexate.
DB01017. Minocycline.
DB01051. Novobiocin.
DB00595. Oxytetracycline.
DB00812. Phenylbutazone.
DB00554. Piroxicam.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00936. Salicylic acid.
DB00759. Tetracycline.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi1030.

Polymorphism and mutation databases

BioMutaiSLC22A11.
DMDMi74734337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002344351 – 550Solute carrier family 22 member 11Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated. Contains several complex-type N-glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NSA0.
PeptideAtlasiQ9NSA0.
PRIDEiQ9NSA0.

PTM databases

iPTMnetiQ9NSA0.
PhosphoSitePlusiQ9NSA0.

Expressioni

Tissue specificityi

Detected in placenta and kidney.1 Publication

Gene expression databases

BgeeiENSG00000168065.
CleanExiHS_SLC22A11.
ExpressionAtlasiQ9NSA0. baseline and differential.
GenevisibleiQ9NSA0. HS.

Organism-specific databases

HPAiHPA026076.

Interactioni

Protein-protein interaction databases

BioGridi120967. 3 interactors.
STRINGi9606.ENSP00000301891.

Chemistry databases

BindingDBiQ9NSA0.

Structurei

3D structure databases

ProteinModelPortaliQ9NSA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9NSA0.
KOiK08207.
OMAiCLVIPSQ.
OrthoDBiEOG091G05EB.
PhylomeDBiQ9NSA0.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW
60 70 80 90 100
THMLDNGSAV STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA
110 120 130 140 150
TATSWSEADT EPCVDGWVYD RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM
160 170 180 190 200
SGILVGSFIW GLLSYRFGRK PMLSWCCLQL AVAGTSTIFA PTFVIYCGLR
210 220 230 240 250
FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA GQAALGGLAF
260 270 280 290 300
ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
310 320 330 340 350
RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML
360 370 380 390 400
VVNFSLLISY YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG
410 420 430 440 450
RRTIQAGSQA MAGLAILANM LVPQDLQTLR VVFAVLGKGC FGISLTCLTI
460 470 480 490 500
YKAELFPTPV RMTADGILHT VGRLGAMMGP LILMSRQALP LLPPLLYGVI
510 520 530 540 550
SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ EAVTVESTSL
Length:550
Mass (Da):59,972
Last modified:October 1, 2000 - v1
Checksum:i233BE6C4A520E58A
GO
Isoform 2 (identifier: Q9NSA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-461: NFSLLISYYG...KAELFPTPVR → K

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,301
Checksum:iF9D42F38249733FB
GO

Sequence cautioni

The sequence BAC11483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180L → S in BAD96589 (Ref. 3) Curated1
Sequence conflicti376L → R in BAC85252 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053962155V → G.Corresponds to variant rs12785832dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018319353 – 461NFSLL…PTPVR → K in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA. Translation: BAA95316.1.
AK075224 mRNA. Translation: BAC11483.1. Different initiation.
AK129930 mRNA. Translation: BAC85252.1.
AK222869 mRNA. Translation: BAD96589.1.
AK290791 mRNA. Translation: BAF83480.1.
AC044790 Genomic DNA. Translation: AAK68155.1.
CH471076 Genomic DNA. Translation: EAW74269.1.
BC034384 mRNA. Translation: AAH34384.1.
CCDSiCCDS76425.1. [Q9NSA0-2]
CCDS8074.1. [Q9NSA0-1]
RefSeqiNP_001294914.1. NM_001307985.1. [Q9NSA0-2]
NP_060954.1. NM_018484.3. [Q9NSA0-1]
UniGeneiHs.220844.
Hs.657603.

Genome annotation databases

EnsembliENST00000301891; ENSP00000301891; ENSG00000168065. [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065. [Q9NSA0-2]
GeneIDi55867.
KEGGihsa:55867.
UCSCiuc001oai.4. human. [Q9NSA0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA. Translation: BAA95316.1.
AK075224 mRNA. Translation: BAC11483.1. Different initiation.
AK129930 mRNA. Translation: BAC85252.1.
AK222869 mRNA. Translation: BAD96589.1.
AK290791 mRNA. Translation: BAF83480.1.
AC044790 Genomic DNA. Translation: AAK68155.1.
CH471076 Genomic DNA. Translation: EAW74269.1.
BC034384 mRNA. Translation: AAH34384.1.
CCDSiCCDS76425.1. [Q9NSA0-2]
CCDS8074.1. [Q9NSA0-1]
RefSeqiNP_001294914.1. NM_001307985.1. [Q9NSA0-2]
NP_060954.1. NM_018484.3. [Q9NSA0-1]
UniGeneiHs.220844.
Hs.657603.

3D structure databases

ProteinModelPortaliQ9NSA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120967. 3 interactors.
STRINGi9606.ENSP00000301891.

Chemistry databases

BindingDBiQ9NSA0.
ChEMBLiCHEMBL2073677.
DrugBankiDB00345. Aminohippurate.
DB00168. Aspartame.
DB01053. Benzylpenicillin.
DB00887. Bumetanide.
DB00456. Cefalotin.
DB01326. Cefamandole.
DB01327. Cefazolin.
DB01329. Cefoperazone.
DB00493. Cefotaxime.
DB01212. Ceftriaxone.
DB00501. Cimetidine.
DB00286. Conjugated Estrogens.
DB00586. Diclofenac.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00254. Doxycycline.
DB00783. Estradiol.
DB00695. Furosemide.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00563. Methotrexate.
DB01017. Minocycline.
DB01051. Novobiocin.
DB00595. Oxytetracycline.
DB00812. Phenylbutazone.
DB00554. Piroxicam.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00936. Salicylic acid.
DB00759. Tetracycline.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi1030.

Protein family/group databases

TCDBi2.A.1.19.10. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9NSA0.
PhosphoSitePlusiQ9NSA0.

Polymorphism and mutation databases

BioMutaiSLC22A11.
DMDMi74734337.

Proteomic databases

PaxDbiQ9NSA0.
PeptideAtlasiQ9NSA0.
PRIDEiQ9NSA0.

Protocols and materials databases

DNASUi55867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301891; ENSP00000301891; ENSG00000168065. [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065. [Q9NSA0-2]
GeneIDi55867.
KEGGihsa:55867.
UCSCiuc001oai.4. human. [Q9NSA0-1]

Organism-specific databases

CTDi55867.
DisGeNETi55867.
GeneCardsiSLC22A11.
HGNCiHGNC:18120. SLC22A11.
HPAiHPA026076.
MIMi607097. gene.
neXtProtiNX_Q9NSA0.
OpenTargetsiENSG00000168065.
PharmGKBiPA38295.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9NSA0.
KOiK08207.
OMAiCLVIPSQ.
OrthoDBiEOG091G05EB.
PhylomeDBiQ9NSA0.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168065-MONOMER.
ReactomeiR-HSA-561048. Organic anion transport.

Miscellaneous databases

ChiTaRSiSLC22A11. human.
GeneWikiiSLC22A11.
GenomeRNAii55867.
PROiQ9NSA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168065.
CleanExiHS_SLC22A11.
ExpressionAtlasiQ9NSA0. baseline and differential.
GenevisibleiQ9NSA0. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AB_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA0
Secondary accession number(s): A8K426
, Q53GR2, Q6ZP72, Q8NBU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.