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Q9NSA0

- S22AB_HUMAN

UniProt

Q9NSA0 - S22AB_HUMAN

Protein

Solute carrier family 22 member 11

Gene

SLC22A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.3 Publications

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: UniProtKB
    2. organic anion transmembrane transporter activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. organic anion transport Source: UniProtKB
    2. transmembrane transport Source: Reactome
    3. urate metabolic process Source: BHF-UCL

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.10. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 11
    Alternative name(s):
    Organic anion transporter 4
    Gene namesi
    Name:SLC22A11
    Synonyms:OAT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:18120. SLC22A11.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. external side of plasma membrane Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of plasma membrane Source: UniProtKB
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi39 – 391N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99. 1 Publication
    Mutagenesisi47 – 471H → A: Reduced cell surface expression and estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-52; A-83; A-305 and A-469. 1 Publication
    Mutagenesisi52 – 521H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-83; A-305 and A-469. 1 Publication
    Mutagenesisi56 – 561N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99. 1 Publication
    Mutagenesisi63 – 631N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99. 1 Publication
    Mutagenesisi83 – 831H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-305 and A-469. 1 Publication
    Mutagenesisi99 – 991N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63. 1 Publication
    Mutagenesisi241 – 2411G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication
    Mutagenesisi305 – 3051H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-469. 1 Publication
    Mutagenesisi400 – 4001G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication
    Mutagenesisi469 – 4691H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-305. 1 Publication

    Organism-specific databases

    PharmGKBiPA38295.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Solute carrier family 22 member 11PRO_0000234435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated. Contains several complex-type N-glycans.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NSA0.
    PRIDEiQ9NSA0.

    Expressioni

    Tissue specificityi

    Detected in placenta and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9NSA0.
    BgeeiQ9NSA0.
    CleanExiHS_SLC22A11.
    GenevestigatoriQ9NSA0.

    Organism-specific databases

    HPAiHPA026076.

    Interactioni

    Protein-protein interaction databases

    BioGridi120967. 1 interaction.
    STRINGi9606.ENSP00000301891.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NSA0.
    SMRiQ9NSA0. Positions 119-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 142111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini196 – 2005ExtracellularSequence Analysis
    Topological domaini222 – 23110CytoplasmicSequence Analysis
    Topological domaini253 – 2564ExtracellularSequence Analysis
    Topological domaini278 – 34669CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini368 – 37811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini400 – 4023CytoplasmicSequence Analysis
    Topological domaini424 – 4307ExtracellularSequence Analysis
    Topological domaini452 – 46312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini485 – 4906ExtracellularSequence Analysis
    Topological domaini512 – 55039CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei347 – 36721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9NSA0.
    KOiK08207.
    OMAiNPRHPME.
    OrthoDBiEOG7C5M82.
    PhylomeDBiQ9NSA0.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NSA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW    50
    THMLDNGSAV STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA 100
    TATSWSEADT EPCVDGWVYD RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM 150
    SGILVGSFIW GLLSYRFGRK PMLSWCCLQL AVAGTSTIFA PTFVIYCGLR 200
    FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA GQAALGGLAF 250
    ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA 300
    RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML 350
    VVNFSLLISY YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG 400
    RRTIQAGSQA MAGLAILANM LVPQDLQTLR VVFAVLGKGC FGISLTCLTI 450
    YKAELFPTPV RMTADGILHT VGRLGAMMGP LILMSRQALP LLPPLLYGVI 500
    SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ EAVTVESTSL 550
    Length:550
    Mass (Da):59,972
    Last modified:October 1, 2000 - v1
    Checksum:i233BE6C4A520E58A
    GO
    Isoform 2 (identifier: Q9NSA0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         353-461: NFSLLISYYG...KAELFPTPVR → K

    Note: No experimental confirmation available.

    Show »
    Length:442
    Mass (Da):48,301
    Checksum:iF9D42F38249733FB
    GO

    Sequence cautioni

    The sequence BAC11483.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801L → S in BAD96589. 1 PublicationCurated
    Sequence conflicti376 – 3761L → R in BAC85252. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551V → G.
    Corresponds to variant rs12785832 [ dbSNP | Ensembl ].
    VAR_053962

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei353 – 461109NFSLL…PTPVR → K in isoform 2. 1 PublicationVSP_018319Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026116 mRNA. Translation: BAA95316.1.
    AK075224 mRNA. Translation: BAC11483.1. Different initiation.
    AK129930 mRNA. Translation: BAC85252.1.
    AK222869 mRNA. Translation: BAD96589.1.
    AK290791 mRNA. Translation: BAF83480.1.
    AC044790 Genomic DNA. Translation: AAK68155.1.
    CH471076 Genomic DNA. Translation: EAW74269.1.
    BC034384 mRNA. Translation: AAH34384.1.
    CCDSiCCDS8074.1. [Q9NSA0-1]
    RefSeqiNP_060954.1. NM_018484.2. [Q9NSA0-1]
    UniGeneiHs.220844.

    Genome annotation databases

    EnsembliENST00000301891; ENSP00000301891; ENSG00000168065. [Q9NSA0-1]
    ENST00000377585; ENSP00000366809; ENSG00000168065. [Q9NSA0-2]
    GeneIDi55867.
    KEGGihsa:55867.
    UCSCiuc001oai.3. human. [Q9NSA0-1]
    uc009ypq.3. human. [Q9NSA0-2]

    Polymorphism databases

    DMDMi74734337.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026116 mRNA. Translation: BAA95316.1 .
    AK075224 mRNA. Translation: BAC11483.1 . Different initiation.
    AK129930 mRNA. Translation: BAC85252.1 .
    AK222869 mRNA. Translation: BAD96589.1 .
    AK290791 mRNA. Translation: BAF83480.1 .
    AC044790 Genomic DNA. Translation: AAK68155.1 .
    CH471076 Genomic DNA. Translation: EAW74269.1 .
    BC034384 mRNA. Translation: AAH34384.1 .
    CCDSi CCDS8074.1. [Q9NSA0-1 ]
    RefSeqi NP_060954.1. NM_018484.2. [Q9NSA0-1 ]
    UniGenei Hs.220844.

    3D structure databases

    ProteinModelPortali Q9NSA0.
    SMRi Q9NSA0. Positions 119-529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120967. 1 interaction.
    STRINGi 9606.ENSP00000301891.

    Chemistry

    ChEMBLi CHEMBL2073677.
    DrugBanki DB01032. Probenecid.

    Protein family/group databases

    TCDBi 2.A.1.19.10. the major facilitator superfamily (mfs).

    Polymorphism databases

    DMDMi 74734337.

    Proteomic databases

    PaxDbi Q9NSA0.
    PRIDEi Q9NSA0.

    Protocols and materials databases

    DNASUi 55867.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301891 ; ENSP00000301891 ; ENSG00000168065 . [Q9NSA0-1 ]
    ENST00000377585 ; ENSP00000366809 ; ENSG00000168065 . [Q9NSA0-2 ]
    GeneIDi 55867.
    KEGGi hsa:55867.
    UCSCi uc001oai.3. human. [Q9NSA0-1 ]
    uc009ypq.3. human. [Q9NSA0-2 ]

    Organism-specific databases

    CTDi 55867.
    GeneCardsi GC11P064324.
    HGNCi HGNC:18120. SLC22A11.
    HPAi HPA026076.
    MIMi 607097. gene.
    neXtProti NX_Q9NSA0.
    PharmGKBi PA38295.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q9NSA0.
    KOi K08207.
    OMAi NPRHPME.
    OrthoDBi EOG7C5M82.
    PhylomeDBi Q9NSA0.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_22310. Organic anion transport.

    Miscellaneous databases

    ChiTaRSi SLC22A11. human.
    GeneWikii SLC22A11.
    GenomeRNAii 55867.
    NextBioi 61178.
    PROi Q9NSA0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NSA0.
    Bgeei Q9NSA0.
    CleanExi HS_SLC22A11.
    Genevestigatori Q9NSA0.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta."
      Cha S.H., Sekine T., Kusuhara H., Yu E., Kim J.Y., Kim D.K., Sugiyama Y., Kanai Y., Endou H.
      J. Biol. Chem. 275:4507-4512(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney and Placenta.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    7. "Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)."
      Zhou F., Pan Z., Ma J., You G.
      Biochem. J. 384:87-92(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF HIS-47; HIS-52; HIS-83; HIS-305 AND HIS-469, FUNCTION, SUBCELLULAR LOCATION.
    8. "The role of glycine residues in the function of human organic anion transporter 4."
      Zhou F., Tanaka K., Pan Z., Ma J., You G.
      Mol. Pharmacol. 65:1141-1147(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLY-241 AND GLY-400.
    9. "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4."
      Zhou F., Xu W., Hong M., Pan Z., Sinko P.J., Ma J., You G.
      Mol. Pharmacol. 67:868-876(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASN-39; ASN-56; ASN-63 AND ASN-99, SUBCELLULAR LOCATION, GLYCOSYLATION.

    Entry informationi

    Entry nameiS22AB_HUMAN
    AccessioniPrimary (citable) accession number: Q9NSA0
    Secondary accession number(s): A8K426
    , Q53GR2, Q6ZP72, Q8NBU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3