Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 22 member 11

Gene

SLC22A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.3 Publications

Caution

GO - Molecular functioni

  • inorganic anion exchanger activity Source: UniProtKB
  • organic anion transmembrane transporter activity Source: UniProtKB
  • sodium-independent organic anion transmembrane transporter activity Source: UniProtKB
  • urate transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • organic anion transport Source: UniProtKB
  • sodium-independent organic anion transport Source: GO_Central
  • urate metabolic process Source: BHF-UCL
  • urate transport Source: GO_Central

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-561048 Organic anion transport

Protein family/group databases

TCDBi2.A.1.19.10 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 11
Alternative name(s):
Organic anion transporter 4
Gene namesi
Name:SLC22A11
Synonyms:OAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000168065.15
HGNCiHGNC:18120 SLC22A11
MIMi607097 gene
neXtProtiNX_Q9NSA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 142ExtracellularSequence analysisAdd BLAST111
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 174CytoplasmicSequence analysisAdd BLAST11
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 200ExtracellularSequence analysis5
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 256ExtracellularSequence analysis4
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 346CytoplasmicSequence analysisAdd BLAST69
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 378ExtracellularSequence analysisAdd BLAST11
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 402CytoplasmicSequence analysis3
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 430ExtracellularSequence analysis7
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 463CytoplasmicSequence analysisAdd BLAST12
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 490ExtracellularSequence analysis6
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 550CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99. 1 Publication1
Mutagenesisi47H → A: Reduced cell surface expression and estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-52; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi52H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi56N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99. 1 Publication1
Mutagenesisi63N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99. 1 Publication1
Mutagenesisi83H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-305 and A-469. 1 Publication1
Mutagenesisi99N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63. 1 Publication1
Mutagenesisi241G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi305H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-469. 1 Publication1
Mutagenesisi400G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi469H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-305. 1 Publication1

Organism-specific databases

DisGeNETi55867
OpenTargetsiENSG00000168065
PharmGKBiPA38295

Chemistry databases

ChEMBLiCHEMBL2073677
DrugBankiDB00345 Aminohippuric acid
DB00168 Aspartame
DB01053 Benzylpenicillin
DB00887 Bumetanide
DB04519 Caprylic acid
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01212 Ceftriaxone
DB00501 Cimetidine
DB00286 Conjugated Equine Estrogens
DB04133 Degraded Cephaloridine
DB00586 Diclofenac
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB08846 Ellagic Acid
DB00783 Estradiol
DB00695 Furosemide
DB03553 Glutaric Acid
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB11560 Lesinurad
DB00563 Methotrexate
DB01017 Minocycline
DB01051 Novobiocin
DB00595 Oxytetracycline
DB00812 Phenylbutazone
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00936 Salicylic acid
DB00759 Tetracycline
DB00495 Zidovudine
GuidetoPHARMACOLOGYi1030

Polymorphism and mutation databases

BioMutaiSLC22A11
DMDMi74734337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002344351 – 550Solute carrier family 22 member 11Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. Contains several complex-type N-glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NSA0
PeptideAtlasiQ9NSA0
PRIDEiQ9NSA0

PTM databases

iPTMnetiQ9NSA0
PhosphoSitePlusiQ9NSA0

Expressioni

Tissue specificityi

Detected in placenta and kidney.1 Publication

Gene expression databases

BgeeiENSG00000168065
CleanExiHS_SLC22A11
ExpressionAtlasiQ9NSA0 baseline and differential
GenevisibleiQ9NSA0 HS

Organism-specific databases

HPAiHPA026076

Interactioni

Protein-protein interaction databases

BioGridi1209673 interactors.
IntActiQ9NSA0 1 interactor.
STRINGi9606.ENSP00000301891

Chemistry databases

BindingDBiQ9NSA0

Structurei

3D structure databases

ProteinModelPortaliQ9NSA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ9NSA0
KOiK08207
OMAiISLISWW
OrthoDBiEOG091G05EB
PhylomeDBiQ9NSA0
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NSA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW
60 70 80 90 100
THMLDNGSAV STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA
110 120 130 140 150
TATSWSEADT EPCVDGWVYD RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM
160 170 180 190 200
SGILVGSFIW GLLSYRFGRK PMLSWCCLQL AVAGTSTIFA PTFVIYCGLR
210 220 230 240 250
FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA GQAALGGLAF
260 270 280 290 300
ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
310 320 330 340 350
RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML
360 370 380 390 400
VVNFSLLISY YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG
410 420 430 440 450
RRTIQAGSQA MAGLAILANM LVPQDLQTLR VVFAVLGKGC FGISLTCLTI
460 470 480 490 500
YKAELFPTPV RMTADGILHT VGRLGAMMGP LILMSRQALP LLPPLLYGVI
510 520 530 540 550
SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ EAVTVESTSL
Length:550
Mass (Da):59,972
Last modified:October 1, 2000 - v1
Checksum:i233BE6C4A520E58A
GO
Isoform 2 (identifier: Q9NSA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-461: NFSLLISYYG...KAELFPTPVR → K

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,301
Checksum:iF9D42F38249733FB
GO

Sequence cautioni

The sequence BAC11483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180L → S in BAD96589 (Ref. 3) Curated1
Sequence conflicti376L → R in BAC85252 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053962155V → G. Corresponds to variant dbSNP:rs12785832Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018319353 – 461NFSLL…PTPVR → K in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA Translation: BAA95316.1
AK075224 mRNA Translation: BAC11483.1 Different initiation.
AK129930 mRNA Translation: BAC85252.1
AK222869 mRNA Translation: BAD96589.1
AK290791 mRNA Translation: BAF83480.1
AC044790 Genomic DNA Translation: AAK68155.1
CH471076 Genomic DNA Translation: EAW74269.1
BC034384 mRNA Translation: AAH34384.1
CCDSiCCDS76425.1 [Q9NSA0-2]
CCDS8074.1 [Q9NSA0-1]
RefSeqiNP_001294914.1, NM_001307985.1 [Q9NSA0-2]
NP_060954.1, NM_018484.3 [Q9NSA0-1]
UniGeneiHs.220844
Hs.657603

Genome annotation databases

EnsembliENST00000301891; ENSP00000301891; ENSG00000168065 [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065 [Q9NSA0-2]
GeneIDi55867
KEGGihsa:55867
UCSCiuc001oai.4 human [Q9NSA0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS22AB_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA0
Secondary accession number(s): A8K426
, Q53GR2, Q6ZP72, Q8NBU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome