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Q9NS98

- SEM3G_HUMAN

UniProt

Q9NS98 - SEM3G_HUMAN

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Protein

Semaphorin-3G

Gene

SEMA3G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3G
Alternative name(s):
Semaphorin sem2
Gene namesi
Name:SEMA3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30400. SEMA3G.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 782760Semaphorin-3GPRO_0000257791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 116By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi134 ↔ 143By similarity
Disulfide bondi270 ↔ 382By similarity
Disulfide bondi294 ↔ 342By similarity
Disulfide bondi522 ↔ 540By similarity
Disulfide bondi603 ↔ 655By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS98.
PRIDEiQ9NS98.

PTM databases

PhosphoSiteiQ9NS98.

Expressioni

Gene expression databases

BgeeiQ9NS98.
CleanExiHS_SEMA3G.
ExpressionAtlasiQ9NS98. baseline and differential.
GenevestigatoriQ9NS98.

Organism-specific databases

HPAiHPA001761.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000231721.

Structurei

3D structure databases

ProteinModelPortaliQ9NS98.
SMRiQ9NS98. Positions 29-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 519488SemaPROSITE-ProRule annotationAdd
BLAST
Domaini569 – 671103Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG265742.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ9NS98.
KOiK06840.
OMAiTEHNSTF.
OrthoDBiEOG7P02HC.
PhylomeDBiQ9NS98.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL
60 70 80 90 100
GPQGSLNLQA MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG
110 120 130 140 150
QREECVRKGR DPLTECANFV RVLQPHNRTH LLACGTGAFQ PTCALITVGH
160 170 180 190 200
RGEHVLHLEP GSVESGRGRC PHEPSRPFAS TFIDGELYTG LTADFLGREA
210 220 230 240 250
MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN DKVYFFFSET
260 270 280 290 300
VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
310 320 330 340 350
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW
360 370 380 390 400
EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY
410 420 430 440 450
PDEVLQFARA HPLMFWPVRP RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT
460 470 480 490 500
YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV VLEELQVFKV PTPITEMEIS
510 520 530 540 550
VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC AWDGASCTHY
560 570 580 590 600
RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF
610 620 630 640 650
LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA
660 670 680 690 700
GTYTCTTLEH GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS
710 720 730 740 750
TPPKAWYKDI LQLIGFANLP RVDEYCERVW CRGTTECSGC FRSRSRGKQA
760 770 780
RGKSWAGLEL GKKMKSRVHA EHNRTPREVE AT
Length:782
Mass (Da):86,701
Last modified:October 1, 2000 - v1
Checksum:i85CB424874DF6663
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti180 – 1801S → N.
Corresponds to variant rs35811072 [ dbSNP | Ensembl ].
VAR_051929
Natural varianti232 – 2321I → T.
Corresponds to variant rs2276833 [ dbSNP | Ensembl ].
VAR_030292
Natural varianti332 – 3321V → I.
Corresponds to variant rs34540591 [ dbSNP | Ensembl ].
VAR_051930

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029496 mRNA. Translation: BAA98132.1.
AK024425 mRNA. Translation: BAB15715.1.
BC098104 mRNA. Translation: AAH98104.1.
BC098137 mRNA. Translation: AAH98137.1.
BC099724 mRNA. Translation: AAH99724.1.
CCDSiCCDS2856.1.
RefSeqiNP_064548.1. NM_020163.1.
UniGeneiHs.59729.

Genome annotation databases

EnsembliENST00000231721; ENSP00000231721; ENSG00000010319.
GeneIDi56920.
KEGGihsa:56920.
UCSCiuc003dea.1. human.

Polymorphism databases

DMDMi74761676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029496 mRNA. Translation: BAA98132.1 .
AK024425 mRNA. Translation: BAB15715.1 .
BC098104 mRNA. Translation: AAH98104.1 .
BC098137 mRNA. Translation: AAH98137.1 .
BC099724 mRNA. Translation: AAH99724.1 .
CCDSi CCDS2856.1.
RefSeqi NP_064548.1. NM_020163.1.
UniGenei Hs.59729.

3D structure databases

ProteinModelPortali Q9NS98.
SMRi Q9NS98. Positions 29-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000231721.

PTM databases

PhosphoSitei Q9NS98.

Polymorphism databases

DMDMi 74761676.

Proteomic databases

PaxDbi Q9NS98.
PRIDEi Q9NS98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231721 ; ENSP00000231721 ; ENSG00000010319 .
GeneIDi 56920.
KEGGi hsa:56920.
UCSCi uc003dea.1. human.

Organism-specific databases

CTDi 56920.
GeneCardsi GC03M052467.
HGNCi HGNC:30400. SEMA3G.
HPAi HPA001761.
neXtProti NX_Q9NS98.
PharmGKBi PA142670937.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265742.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi Q9NS98.
KOi K06840.
OMAi TEHNSTF.
OrthoDBi EOG7P02HC.
PhylomeDBi Q9NS98.
TreeFami TF316102.

Miscellaneous databases

ChiTaRSi SEMA3G. human.
GenomeRNAii 56920.
NextBioi 62424.
PROi Q9NS98.

Gene expression databases

Bgeei Q9NS98.
CleanExi HS_SEMA3G.
ExpressionAtlasi Q9NS98. baseline and differential.
Genevestigatori Q9NS98.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human semaphorin."
    Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSEM3G_HUMAN
AccessioniPrimary (citable) accession number: Q9NS98
Secondary accession number(s): Q7L9D9, Q9H7Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3