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Q9NS98

- SEM3G_HUMAN

UniProt

Q9NS98 - SEM3G_HUMAN

Protein

Semaphorin-3G

Gene

SEMA3G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3G
    Alternative name(s):
    Semaphorin sem2
    Gene namesi
    Name:SEMA3G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30400. SEMA3G.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670937.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 782760Semaphorin-3GPRO_0000257791Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 116By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi134 ↔ 143By similarity
    Disulfide bondi270 ↔ 382By similarity
    Disulfide bondi294 ↔ 342By similarity
    Disulfide bondi522 ↔ 540By similarity
    Disulfide bondi603 ↔ 655By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NS98.
    PRIDEiQ9NS98.

    PTM databases

    PhosphoSiteiQ9NS98.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NS98.
    BgeeiQ9NS98.
    CleanExiHS_SEMA3G.
    GenevestigatoriQ9NS98.

    Organism-specific databases

    HPAiHPA001761.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000231721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS98.
    SMRiQ9NS98. Positions 29-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 519488SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini569 – 671103Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG265742.
    HOGENOMiHOG000039964.
    HOVERGENiHBG055071.
    InParanoidiQ9NS98.
    KOiK06840.
    OMAiTEHNSTF.
    OrthoDBiEOG7P02HC.
    PhylomeDBiQ9NS98.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NS98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL    50
    GPQGSLNLQA MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG 100
    QREECVRKGR DPLTECANFV RVLQPHNRTH LLACGTGAFQ PTCALITVGH 150
    RGEHVLHLEP GSVESGRGRC PHEPSRPFAS TFIDGELYTG LTADFLGREA 200
    MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN DKVYFFFSET 250
    VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG 300
    GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW 350
    EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY 400
    PDEVLQFARA HPLMFWPVRP RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT 450
    YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV VLEELQVFKV PTPITEMEIS 500
    VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC AWDGASCTHY 550
    RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF 600
    LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA 650
    GTYTCTTLEH GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS 700
    TPPKAWYKDI LQLIGFANLP RVDEYCERVW CRGTTECSGC FRSRSRGKQA 750
    RGKSWAGLEL GKKMKSRVHA EHNRTPREVE AT 782
    Length:782
    Mass (Da):86,701
    Last modified:October 1, 2000 - v1
    Checksum:i85CB424874DF6663
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti180 – 1801S → N.
    Corresponds to variant rs35811072 [ dbSNP | Ensembl ].
    VAR_051929
    Natural varianti232 – 2321I → T.
    Corresponds to variant rs2276833 [ dbSNP | Ensembl ].
    VAR_030292
    Natural varianti332 – 3321V → I.
    Corresponds to variant rs34540591 [ dbSNP | Ensembl ].
    VAR_051930

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029496 mRNA. Translation: BAA98132.1.
    AK024425 mRNA. Translation: BAB15715.1.
    BC098104 mRNA. Translation: AAH98104.1.
    BC098137 mRNA. Translation: AAH98137.1.
    BC099724 mRNA. Translation: AAH99724.1.
    CCDSiCCDS2856.1.
    RefSeqiNP_064548.1. NM_020163.1.
    UniGeneiHs.59729.

    Genome annotation databases

    EnsembliENST00000231721; ENSP00000231721; ENSG00000010319.
    GeneIDi56920.
    KEGGihsa:56920.
    UCSCiuc003dea.1. human.

    Polymorphism databases

    DMDMi74761676.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029496 mRNA. Translation: BAA98132.1 .
    AK024425 mRNA. Translation: BAB15715.1 .
    BC098104 mRNA. Translation: AAH98104.1 .
    BC098137 mRNA. Translation: AAH98137.1 .
    BC099724 mRNA. Translation: AAH99724.1 .
    CCDSi CCDS2856.1.
    RefSeqi NP_064548.1. NM_020163.1.
    UniGenei Hs.59729.

    3D structure databases

    ProteinModelPortali Q9NS98.
    SMRi Q9NS98. Positions 29-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000231721.

    PTM databases

    PhosphoSitei Q9NS98.

    Polymorphism databases

    DMDMi 74761676.

    Proteomic databases

    PaxDbi Q9NS98.
    PRIDEi Q9NS98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231721 ; ENSP00000231721 ; ENSG00000010319 .
    GeneIDi 56920.
    KEGGi hsa:56920.
    UCSCi uc003dea.1. human.

    Organism-specific databases

    CTDi 56920.
    GeneCardsi GC03M052467.
    HGNCi HGNC:30400. SEMA3G.
    HPAi HPA001761.
    neXtProti NX_Q9NS98.
    PharmGKBi PA142670937.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265742.
    HOGENOMi HOG000039964.
    HOVERGENi HBG055071.
    InParanoidi Q9NS98.
    KOi K06840.
    OMAi TEHNSTF.
    OrthoDBi EOG7P02HC.
    PhylomeDBi Q9NS98.
    TreeFami TF316102.

    Miscellaneous databases

    GenomeRNAii 56920.
    NextBioi 62424.
    PROi Q9NS98.

    Gene expression databases

    ArrayExpressi Q9NS98.
    Bgeei Q9NS98.
    CleanExi HS_SEMA3G.
    Genevestigatori Q9NS98.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human semaphorin."
      Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSEM3G_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS98
    Secondary accession number(s): Q7L9D9, Q9H7Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3