Q9NS98 (SEM3G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-3G

Alternative name(s):
Semaphorin sem2

Gene names

Name:

SEMA3G

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Sema domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 782	760	Semaphorin-3G		PRO_0000257791
Regions
	Domain	32 – 519	488	Sema
	Domain	569 – 671	103	Ig-like C2-type
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 116		By similarity
	Disulfide bond	134 ↔ 143		By similarity
	Disulfide bond	270 ↔ 382		By similarity
	Disulfide bond	294 ↔ 342		By similarity
	Disulfide bond	522 ↔ 540		By similarity
	Disulfide bond	603 ↔ 655		By similarity
Natural variations
	Natural variant	180	1	S → N. Corresponds to variant rs35811072 [ dbSNP | Ensembl ].		VAR_051929
	Natural variant	232	1	I → T. Corresponds to variant rs2276833 [ dbSNP | Ensembl ].		VAR_030292
	Natural variant	332	1	V → I. Corresponds to variant rs34540591 [ dbSNP | Ensembl ].		VAR_051930

Sequences

	Sequence		Length	Mass (Da)
	Q9NS98 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 85CB424874DF6663	FASTA	782	86,701
	10 20 30 40 50 60 MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL GPQGSLNLQA 70 80 90 100 110 120 MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG QREECVRKGR DPLTECANFV 130 140 150 160 170 180 RVLQPHNRTH LLACGTGAFQ PTCALITVGH RGEHVLHLEP GSVESGRGRC PHEPSRPFAS 190 200 210 220 230 240 TFIDGELYTG LTADFLGREA MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN 250 260 270 280 290 300 DKVYFFFSET VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG 310 320 330 340 350 360 GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW EVFNGPFAHR 370 380 390 400 410 420 DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY PDEVLQFARA HPLMFWPVRP 430 440 450 460 470 480 RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV 490 500 510 520 530 540 VLEELQVFKV PTPITEMEIS VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC 550 560 570 580 590 600 AWDGASCTHY RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF 610 620 630 640 650 660 LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA GTYTCTTLEH 670 680 690 700 710 720 GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS TPPKAWYKDI LQLIGFANLP 730 740 750 760 770 780 RVDEYCERVW CRGTTECSGC FRSRSRGKQA RGKSWAGLEL GKKMKSRVHA EHNRTPREVE AT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human semaphorin." Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N., Saito T. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB029496 mRNA. Translation: BAA98132.1. AK024425 mRNA. Translation: BAB15715.1. BC098104 mRNA. Translation: AAH98104.1. BC098137 mRNA. Translation: AAH98137.1. BC099724 mRNA. Translation: AAH99724.1.
IPI	IPI00024570.
RefSeq	NP_064548.1. NM_020163.1.
UniGene	Hs.59729.
3D structure databases
HSSP	HSSP built from PDB template 1Q47 based on UniProtKB O08665.
ProteinModelPortal	Q9NS98.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000231721.
PTM databases
PhosphoSite	Q9NS98.
Polymorphism databases
DMDM	74761676.
Proteomic databases
PaxDb	Q9NS98.
PRIDE	Q9NS98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231721; ENSP00000231721; ENSG00000010319.
GeneID	56920.
KEGG	hsa:56920.
UCSC	uc003dea.1. human.
Organism-specific databases
CTD	56920.
GeneCards	GC03M052467.
HGNC	HGNC:30400. SEMA3G.
HPA	HPA001761.
neXtProt	NX_Q9NS98.
PharmGKB	PA142670937.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG265742.
HOGENOM	HOG000039964.
HOVERGEN	HBG055071.
InParanoid	Q9NS98.
KO	K06840.
OMA	TEHNSTF.
OrthoDB	EOG42820Z.
PhylomeDB	Q9NS98.
Gene expression databases
ArrayExpress	Q9NS98.
Bgee	Q9NS98.
CleanEx	HS_SEMA3G.
Genevestigator	Q9NS98.
GermOnline	ENSG00000010319. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002165. Plexin_repeat. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56920.
NextBio	62424.

Entry information

Entry name

SEM3G_HUMAN

Accession

Primary (citable) accession number: Q9NS98
Secondary accession number(s): Q7L9D9, Q9H7Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.