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Protein

Transmembrane 7 superfamily member 3

Gene

TM7SF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 7 superfamily member 3
Alternative name(s):
Seven span transmembrane protein
Gene namesi
Name:TM7SF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:23049. TM7SF3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei296 – 31318HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34223HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36923HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39323HelicalSequence analysisAdd
BLAST
Transmembranei408 – 43023HelicalSequence analysisAdd
BLAST
Transmembranei437 – 45923HelicalSequence analysisAdd
BLAST
Transmembranei479 – 50123HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949354.

Polymorphism and mutation databases

BioMutaiTM7SF3.
DMDMi21542266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 570549Transmembrane 7 superfamily member 3PRO_0000022537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NS93.
MaxQBiQ9NS93.
PaxDbiQ9NS93.
PeptideAtlasiQ9NS93.
PRIDEiQ9NS93.

PTM databases

iPTMnetiQ9NS93.
PhosphoSiteiQ9NS93.

Expressioni

Tissue specificityi

Ubiquitous. The highest expression is in kidney.

Gene expression databases

BgeeiQ9NS93.
CleanExiHS_TM7SF3.
ExpressionAtlasiQ9NS93. baseline and differential.
GenevisibleiQ9NS93. HS.

Organism-specific databases

HPAiHPA041097.

Interactioni

Protein-protein interaction databases

BioGridi119723. 2 interactions.
IntActiQ9NS93. 1 interaction.
STRINGi9606.ENSP00000342322.

Structurei

3D structure databases

ProteinModelPortaliQ9NS93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 33236Phe-richAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH4P. Eukaryota.
ENOG41117R0. LUCA.
GeneTreeiENSGT00390000008702.
HOGENOMiHOG000065675.
HOVERGENiHBG055710.
InParanoidiQ9NS93.
OMAiVHTYACS.
OrthoDBiEOG7NW68Z.
PhylomeDBiQ9NS93.
TreeFamiTF332291.

Family and domain databases

InterProiIPR025256. DUF4203.
[Graphical view]
PfamiPF13886. DUF4203. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP
60 70 80 90 100
EEAILHDISS NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI
110 120 130 140 150
LRPEQSTCTW YLGTSGIQPV QNMAILLSYS ERDPVPGGCN LEFDLDIDPN
160 170 180 190 200
IYLEYNFFET TIKFAPANLG YARGVDPPPC DAGTDQDSRW RLQYDVYQYF
210 220 230 240 250
LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT SVSFSSLPGQ
260 270 280 290 300
GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL
310 320 330 340 350
FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL
360 370 380 390 400
TAVTGSVGGM FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK
410 420 430 440 450
IFHDDGVFWV TFSCIAILIP VVFMGCLRIL NILTCGVIGS YSVVLAIDSY
460 470 480 490 500
WSTSLSYITL NVLKRALNKD FHRAFTNVPF QTNDFIILAV WGMLAVSGIT
510 520 530 540 550
LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP LRERLYGRLT
560 570
QIKGLFQKEQ PAGERTPLLL
Length:570
Mass (Da):64,166
Last modified:October 1, 2000 - v1
Checksum:iCC296D7C22AD894C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti564 – 5641E → A in BAA92046 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791P → R.
Corresponds to variant rs34735713 [ dbSNP | Ensembl ].
VAR_034556
Natural varianti248 – 2481P → L.
Corresponds to variant rs10771314 [ dbSNP | Ensembl ].
VAR_051437

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032470 mRNA. Translation: BAA92856.1.
AK002031 mRNA. Translation: BAA92046.1.
AK023085 mRNA. Translation: BAG51155.1.
CH471094 Genomic DNA. Translation: EAW96542.1.
BC005176 mRNA. Translation: AAH05176.1.
CCDSiCCDS8710.1.
RefSeqiNP_057635.1. NM_016551.2.
UniGeneiHs.438641.

Genome annotation databases

EnsembliENST00000343028; ENSP00000342322; ENSG00000064115.
GeneIDi51768.
KEGGihsa:51768.
UCSCiuc010sjl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032470 mRNA. Translation: BAA92856.1.
AK002031 mRNA. Translation: BAA92046.1.
AK023085 mRNA. Translation: BAG51155.1.
CH471094 Genomic DNA. Translation: EAW96542.1.
BC005176 mRNA. Translation: AAH05176.1.
CCDSiCCDS8710.1.
RefSeqiNP_057635.1. NM_016551.2.
UniGeneiHs.438641.

3D structure databases

ProteinModelPortaliQ9NS93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119723. 2 interactions.
IntActiQ9NS93. 1 interaction.
STRINGi9606.ENSP00000342322.

PTM databases

iPTMnetiQ9NS93.
PhosphoSiteiQ9NS93.

Polymorphism and mutation databases

BioMutaiTM7SF3.
DMDMi21542266.

Proteomic databases

EPDiQ9NS93.
MaxQBiQ9NS93.
PaxDbiQ9NS93.
PeptideAtlasiQ9NS93.
PRIDEiQ9NS93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343028; ENSP00000342322; ENSG00000064115.
GeneIDi51768.
KEGGihsa:51768.
UCSCiuc010sjl.4. human.

Organism-specific databases

CTDi51768.
GeneCardsiTM7SF3.
HGNCiHGNC:23049. TM7SF3.
HPAiHPA041097.
MIMi605181. gene.
neXtProtiNX_Q9NS93.
PharmGKBiPA134949354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH4P. Eukaryota.
ENOG41117R0. LUCA.
GeneTreeiENSGT00390000008702.
HOGENOMiHOG000065675.
HOVERGENiHBG055710.
InParanoidiQ9NS93.
OMAiVHTYACS.
OrthoDBiEOG7NW68Z.
PhylomeDBiQ9NS93.
TreeFamiTF332291.

Miscellaneous databases

ChiTaRSiTM7SF3. human.
GenomeRNAii51768.
PROiQ9NS93.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NS93.
CleanExiHS_TM7SF3.
ExpressionAtlasiQ9NS93. baseline and differential.
GenevisibleiQ9NS93. HS.

Family and domain databases

InterProiIPR025256. DUF4203.
[Graphical view]
PfamiPF13886. DUF4203. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3."
    Akashi H., Han H.-J., Iizaka M., Nakajima Y., Furukawa Y., Sugano S., Imai K., Nakamura Y.
    Cytogenet. Cell Genet. 88:305-309(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTM7S3_HUMAN
AccessioniPrimary (citable) accession number: Q9NS93
Secondary accession number(s): B3KMZ3, Q9NUS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.