Alpha1A-voltage-dependent calcium channel

Contribute

Send feedback

Read comments (0) or add your own

Unreviewed, UniProtKB/TrEMBL Q9NS89 (Q9NS89_HUMAN)

Last modified January 19, 2010. Version 50. History...

Clusters with 100%, 90%, 50% identity |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Hide | Top

Names and origin

Protein names

Submitted name:
Alpha1A-voltage-dependent calcium channel EMBL BAA94765.1

Gene names

Name:

CACNA1A EMBL BAA94765.1

Organism

Homo sapiens (Human) EMBL BAA94765.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	2472 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

Hide | Top

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Hide | Top

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	adult walking behavior Inferred from electronic annotation. Source: Compara behavioral response to pain Inferred from electronic annotation. Source: Compara calcium ion transport Ref.1 Inferred from direct assay. Source: UniProtKB calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara calcium ion-dependent exocytosis of neurotransmitter Inferred from electronic annotation. Source: Compara cell death Ref.1 Non-traceable author statement. Source: UniProtKB cell growth Inferred from electronic annotation. Source: Compara cellular chloride ion homeostasis Inferred from electronic annotation. Source: Compara central nervous system neuron differentiation Inferred from electronic annotation. Source: Compara cerebellar Purkinje cell differentiation Inferred from electronic annotation. Source: Compara cerebellar molecular layer development Inferred from electronic annotation. Source: Compara cerebellum maturation Inferred from electronic annotation. Source: Compara dendrite morphogenesis Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Ref.1 Inferred from direct assay. Source: UniProtKB gamma-aminobutyric acid secretion Inferred from electronic annotation. Source: Compara gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara membrane depolarization Inferred from electronic annotation. Source: Compara musculoskeletal movement, spinal reflex action Inferred from electronic annotation. Source: Compara negative regulation of hormone biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from electronic annotation. Source: Compara neurotransmitter metabolic process Inferred from electronic annotation. Source: Compara receptor clustering Inferred from electronic annotation. Source: Compara regulation of acetylcholine secretion Inferred from electronic annotation. Source: Compara regulation of axonogenesis Inferred from electronic annotation. Source: Compara regulation of calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara rhythmic synaptic transmission Inferred from electronic annotation. Source: Compara spinal cord motor neuron differentiation Inferred from electronic annotation. Source: Compara sulfur amino acid metabolic process Inferred from electronic annotation. Source: Compara synapse assembly Inferred from electronic annotation. Source: Compara synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara thyroid hormone metabolic process Inferred from electronic annotation. Source: Compara transmembrane transport Inferred from electronic annotation. Source: InterPro vestibular nucleus development Inferred from electronic annotation. Source: Compara
Cellular component	dendrite Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular function	calcium ion binding Ref.1 Non-traceable author statement. Source: UniProtKB calmodulin binding Inferred from electronic annotation. Source: Compara high voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

2472

EMBL BAA94765.1

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q9NS89-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7336313446F56240
Show »

FASTA

2,472

278,848

        10         20         30         40         50         60 
MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA 

        70         80         90        100        110        120 
LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH 

       130        140        150        160        170        180 
LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG 

       190        200        210        220        230        240 
ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF 

       250        260        270        280        290        300 
AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ 

       310        320        330        340        350        360 
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS 

       370        380        390        400        410        420 
GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD GEQRHPFDGA 

       430        440        450        460        470        480 
LRRTTIKKSK TDLLNPEEAE DQLADIASVG SPFARASIKS TKLENSTFFH KKERRMRFYI 

       490        500        510        520        530        540 
RRMVKTQAFY WTVLSLVALN TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG 

       550        560        570        580        590        600 
LGTRPYFHSS FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL 

       610        620        630        640        650        660 
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN FDTFPAARMT 

       670        680        690        700        710        720 
VFQSLTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF GNYTLLNVFL AIAVDNLANV 

       730        740        750        760        770        780 
LELTKDEQEE EEAANQKLAL QKAKEVAEVS PLSAANMSIA VKEQQKNQKP AKSVWEQRTS 

       790        800        810        820        830        840 
EMRKQNLLAS REALYNEMDP DERWKAAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR 

       850        860        870        880        890        900 
AAEPTVDQRL GQQRAEDFLR KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREDPYGR 

       910        920        930        940        950        960 
ESDHHAREGS LEQPGFWDGE AERGKAGDPH RRHVHRQGGS RESRSGSPRT GADGEHRRHR 

       970        980        990       1000       1010       1020 
AHRRPGEEGP EDKAERRARH REGSRPARGG EGEGEGPDGG ERRRRHRHGA PATYEGDARR 

      1030       1040       1050       1060       1070       1080 
EDKERRHRRR KENQGSGVPV SGPNLSTTRP IQQDLGRQDP PLAEDIDNMK NNKLATAESA 

      1090       1100       1110       1120       1130       1140 
APHGSLGHAG LPQSPAKMGN STDPGPMLAI PAMATNPQNA ASRRTPNNPG NPSNPGPPKT 

      1150       1160       1170       1180       1190       1200 
PENSLIVTNP SGTQTNSAKT ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKEE 

      1210       1220       1230       1240       1250       1260 
EKKEEEEDDR GEDGPKPMPP YSSMFILSTT NPLRRLCHYI LNLRYFEMCI LMVIAMSSIA 

      1270       1280       1290       1300       1310       1320 
LAAEDPVQPN APRNNVLRYF DYVFTGVFTF EMVIKMIDLG LVLHQGAYFR DLWNILDFIV 

      1330       1340       1350       1360       1370       1380 
VSGALVAFAF TGNSKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI 

      1390       1400       1410       1420       1430       1440 
LIVYMLFMFI FAVVAVQLFK GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE 

      1450       1460       1470       1480       1490       1500 
FHYDNVLWAL LTLFTVSTGE GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF 

      1510       1520       1530       1540       1550       1560 
FFVNIFVALI IITFQEQGDK MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ NKQSFQYRMW 

      1570       1580       1590       1600       1610       1620 
QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV FNIVFTSLFS LECVLKVMAF 

      1630       1640       1650       1660       1670       1680 
GILNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL RLFRAARLIK LLRQGYTIRI 

      1690       1700       1710       1720       1730       1740 
LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID VEDEDSDEDE FQITEHNNFR 

      1750       1760       1770       1780       1790       1800 
TFFQALMLLF RSATGEAWHN IMLSCLSGKP CDKNSGILTR ECGNEFAYFY FVSFIFLCSF 

      1810       1820       1830       1840       1850       1860 
LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EYVRVWAEYD PAACGRIHYK DMYSLLRVMS 

      1870       1880       1890       1900       1910       1920 
PPLGLGKKCP PGVAYKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA KGGADKQQMD 

      1930       1940       1950       1960       1970       1980 
AELRKEMMAI WPNLSQKTLD LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK AKKLQAMREE 

      1990       2000       2010       2020       2030       2040 
QDRTPLMFQR MEPPSPTQEG GPGQNALPST QLDPGGALMA HESGLKESPS WVTQRAQEMF 

      2050       2060       2070       2080       2090       2100 
QKTGTWSPEQ GPPTDMPNSQ PNSQSVEMRE MGRDGYSDSE HYLPMEGQGR AASMPRLPAE 

      2110       2120       2130       2140       2150       2160 
NQRRRGRPRG NNLSTISDTS PMKRSASVLG PKARRLDDYS LERVPPEENQ RHHQRRRDRS 

      2170       2180       2190       2200       2210       2220 
HRASERSLGR YTDVDTGLGT DLSMTTQSGD LPSKERDQER GRPKDRKHRQ HHHHHHHHHH 

      2230       2240       2250       2260       2270       2280 
PPPPDKDRYA QERPDHGRAR ARDQRWSRSP SEGREHMAHR QGSSSVSGSP APSTSGTSTS 

      2290       2300       2310       2320       2330       2340 
RRGRRQLPQT PSTPRPHVSY SPVIRKAGGS GPPQQQQQQQ QQQQQQQQQQ QQQQQQQAVA 

      2350       2360       2370       2380       2390       2400 
RPGRAATSGP RRYPGPTAEP LAGDRPPTGG HSSGRSPRME RRVPGPARSE SPRACRHGGA 

      2410       2420       2430       2440       2450       2460 
RWPASGPHVS EGPPGPRHHG YYRGSDYDEA DGPGSGGGEE AMAGAYDAPP PVRHASSGAT 

      2470 
GRSPRTPRAS GP

« Hide

Hide | Top

References

[1]	"Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function." Toru S., Murakoshi T., Ishikawa K., Saegusa H., Fujigasaki H., Uchihara T., Nagayama S., Osanai M., Mizusawa H., Tanabe T. J. Biol. Chem. 275:10893-10898(2000) [PubMed: 10753886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: TMDN-SCA6-001 EMBL BAA94765.1. Tissue: Cerebellum EMBL BAA94765.1.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB035726 mRNA. Translation: BAA94765.1.
IPI	IPI00217498.
UniGene	Hs.501632
3D structure databases
SMR	Q9NS89. Positions 1242-1318, 1559-1815.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NS89.
Genome annotation databases
Ensembl	ENST00000360228; ENSP00000353362; ENSG00000141837; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:1388. CACNA1A.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NS89.
Gene expression databases
ArrayExpress	Q9NS89.
Bgee	Q9NS89.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005448. VDCC_P/Q_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF59. PQVDCCAlpha1. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01632. PQVDCCALPHA1.
ProtoNet	Search...

Hide | Top

Entry information

Entry name

Q9NS89_HUMAN

Accession

Primary (citable) accession number: Q9NS89

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information