Alpha1A-voltage-dependent calcium channel

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Unreviewed, UniProtKB/TrEMBL Q9NS88 (Q9NS88_HUMAN)

Last modified January 19, 2010. Version 56. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
Alpha1A-voltage-dependent calcium channel EMBL BAA94766.2

Gene names

Name:

CACNA1A EMBL BAA94766.2

Organism

Homo sapiens (Human) EMBL BAA94766.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	2506 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	adult walking behavior Inferred from electronic annotation. Source: Compara behavioral response to pain Inferred from electronic annotation. Source: Compara calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara calcium ion-dependent exocytosis of neurotransmitter Inferred from electronic annotation. Source: Compara cell growth Inferred from electronic annotation. Source: Compara cellular chloride ion homeostasis Inferred from electronic annotation. Source: Compara central nervous system neuron differentiation Inferred from electronic annotation. Source: Compara cerebellar Purkinje cell differentiation Inferred from electronic annotation. Source: Compara cerebellar molecular layer development Inferred from electronic annotation. Source: Compara cerebellum maturation Inferred from electronic annotation. Source: Compara dendrite morphogenesis Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Ref.1 Inferred from direct assay. Source: UniProtKB gamma-aminobutyric acid secretion Inferred from electronic annotation. Source: Compara gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara membrane depolarization Inferred from electronic annotation. Source: Compara musculoskeletal movement, spinal reflex action Inferred from electronic annotation. Source: Compara negative regulation of hormone biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from electronic annotation. Source: Compara neurotransmitter metabolic process Inferred from electronic annotation. Source: Compara receptor clustering Inferred from electronic annotation. Source: Compara regulation of acetylcholine secretion Inferred from electronic annotation. Source: Compara regulation of axonogenesis Inferred from electronic annotation. Source: Compara regulation of calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara rhythmic synaptic transmission Inferred from electronic annotation. Source: Compara spinal cord motor neuron differentiation Inferred from electronic annotation. Source: Compara sulfur amino acid metabolic process Inferred from electronic annotation. Source: Compara synapse assembly Inferred from electronic annotation. Source: Compara synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara thyroid hormone metabolic process Inferred from electronic annotation. Source: Compara transmembrane transport Inferred from electronic annotation. Source: InterPro vestibular nucleus development Inferred from electronic annotation. Source: Compara
Cellular component	dendrite Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Inferred from electronic annotation. Source: Compara
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: Compara high voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9NS88-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D64A6C75284A1B53
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FASTA

2,506

282,582

        10         20         30         40         50         60 
MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA 

        70         80         90        100        110        120 
LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH 

       130        140        150        160        170        180 
LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG 

       190        200        210        220        230        240 
ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF 

       250        260        270        280        290        300 
AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ 

       310        320        330        340        350        360 
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS 

       370        380        390        400        410        420 
GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDETD GEQRHPFDAL 

       430        440        450        460        470        480 
RRTTIKKSKT DLLNPEEAED QLADIASVGS PFARASIKSA KLENSTFFHK KERRMRFYIR 

       490        500        510        520        530        540 
RMVKTQAFYW TVLSLVALNT LCVAIVHYNQ PEWLSDFLYY AEFIFLGLFM SEMFIKMYGL 

       550        560        570        580        590        600 
GTRPYFHSSF NCFDCGVIIG SIFEVIWAVI KPGTSFGISV LRALRLLRIF KVTKYWASLR 

       610        620        630        640        650        660 
NLVVSLLNSM KSIISLLFLL FLFIVVFALL GMQLFGGQFN FDEGTPPTNF DTFPAAIMTV 

       670        680        690        700        710        720 
FQILTGEDWN EVMYDGIKSQ GGVQGGMVFS IYFIVLTLFG NYTLLNVFLA IAVDNLANAQ 

       730        740        750        760        770        780 
ELTKDEQEEE EAANQKLALQ KAKEVAEVSP LSAANMSIAV KEQQKNQKPA KSVWEQRTSE 

       790        800        810        820        830        840 
MRKQNLLASR EALYNEMDPD ERWKAAYTRH LRPDMKTHLD RPLVVDPQEN RNNNTNKSRA 

       850        860        870        880        890        900 
AEPTVDQRLG QQRAEDFLRK QARYHDRARD PSGSAGLDAR RPWAGSQEAE LSREDPYGRE 

       910        920        930        940        950        960 
SDHHAREGSL EQPGFWEGEA ERGKAGDPHR RHVHRQGGSR ESRSGSPRTG ANGEHRRHRA 

       970        980        990       1000       1010       1020 
HRSPGEEGPE DKAERRARHR EGSRPARGGE GEGEGPDGGE RRRRHRHGAP ATYEGDARRE 

      1030       1040       1050       1060       1070       1080 
DKERRHRRRK ENQGSGVPVS GPNLSTTRPI QQDLGRQDPP LAEDIDNMKN NKLATAESAA 

      1090       1100       1110       1120       1130       1140 
PHGSLGHAGL PQSPAKMGNS TDPSPMLAIP AMATNPQNAA SRRTPNNPGN PSNPGPPKTP 

      1150       1160       1170       1180       1190       1200 
ENSLIVTNPS GTQTNSAKTA RKPDHTTVDI PPACPPPLNH TVVQVNKNAN PDPLPKKEEE 

      1210       1220       1230       1240       1250       1260 
KKEEEEDDRG EDGPKPMPPY SSMFILSTTN PLRRLCHYIL NLRYFEMCIL MVIAMSSIAL 

      1270       1280       1290       1300       1310       1320 
AAEDPVQPNA PRNNVLRYFD YVFTGVFTFE MVIKMIDLGL VLHQGAYFRD LWNILDFIVV 

      1330       1340       1350       1360       1370       1380 
SGALVAFAFT GNSKGKDINT IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV NSLKNVFNIL 

      1390       1400       1410       1420       1430       1440 
IVYMLFMFIF AVVAVQLFKG KFFHCTDESK EFEKDCRGKY LLYEKNEVKA RDREWKKYEF 

      1450       1460       1470       1480       1490       1500 
HYDNVLWALL TLFTVSTGEG WPQVLKHSVD ATFENQGPSP GYRMEMSIFY VVYFVVFPFF 

      1510       1520       1530       1540       1550       1560 
FVNIFVALII ITFQEQGDKM MEEYSLEKNE RACIDFAISA KPLTRHMPQN KQSFQYRMWQ 

      1570       1580       1590       1600       1610       1620 
FVVSPPFEYT IMAMIALNTI VLMMKFYGAS VAYENALRVF NIVFTSLFSL ECVLKVMAFG 

      1630       1640       1650       1660       1670       1680 
ILNYFRDAWN IFDFVTVLGS ITDILVTEFG NNFINLSFLR LFRAARLIKL LRQGYTIRIL 

      1690       1700       1710       1720       1730       1740 
LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QVFGNIGIDV EDEDSDEDEF QITEHNNFRT 

      1750       1760       1770       1780       1790       1800 
FFQALMLLFR SATGEAWHNI MLSCLSGKPC DKNSGILTRE CGNEFAYFYF VSFIFLCSFL 

      1810       1820       1830       1840       1850       1860 
MLNLFVAVIM DNFEYLTRDS SILGPHHLDE YVRVWAEYDP AAWGRMPYLD MYQMLRHMSP 

      1870       1880       1890       1900       1910       1920 
PLGLGKKCPA RVAYKRLLRM DLPVADDNTV HFNSTLMALI RTALDIKIAK GGADKQQMDA 

      1930       1940       1950       1960       1970       1980 
ELRKEMMAIW PNLSQKTLDL LVTPHKSTDL TVGKIYAAMM IMEYYRQSKA KKLQAMREEQ 

      1990       2000       2010       2020       2030       2040 
DRTPLMFQRM EPPSPTQEGG PGQNALPSTQ LDPGGALMAH ESGLKESPSW VTQRAQEMFQ 

      2050       2060       2070       2080       2090       2100 
KTGTWSPEQG PPTDMPNSQP NSQSVEMREM GRDGYSDSEH YLPMEGQGRA ASMPRLPAEN 

      2110       2120       2130       2140       2150       2160 
QRRRGRPRGN NLSTISDTSP MKRSASVLGP KARRLDDYSL ERVPPEENQR HHQRRRDRSH 

      2170       2180       2190       2200       2210       2220 
RASERSLGRY TDVDTGLGTD LSMTTQSGDL PSKERDQERG RPKDRKHRQH HHHHHHHHHP 

      2230       2240       2250       2260       2270       2280 
PPPDKDRYAQ ERPDHGRARA RDQRWSRSPS EGREHMAHRQ GSSSVSGSPA PSTSGTSTPR 

      2290       2300       2310       2320       2330       2340 
RGRRQLPQTP STPRPHVSYS PVIRKAGGSG PPQQQQQQQQ QQQQQAVARP GRAATSGPRR 

      2350       2360       2370       2380       2390       2400 
YPGPTAEPLA GDRPPTGGHS SGRSPRMERR VPGPARSESP RACRHGGARW PASGPHVSEG 

      2410       2420       2430       2440       2450       2460 
PPGPRHHGYY RGSDYDEADG PGSGGGEEAM AGAYDAPPPV RHASSGATGR SPRTPRASGP 

      2470       2480       2490       2500 
ACASPSRHGR RLPNGYYPAH GLARPRGPGS RKGLHEPYSE SDDDWC

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References

[1]	"Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function." Toru S., Murakoshi T., Ishikawa K., Saegusa H., Fujigasaki H., Uchihara T., Nagayama S., Osanai M., Mizusawa H., Tanabe T. J. Biol. Chem. 275:10893-10898(2000) [PubMed: 10753886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: TMDN-CNT-001 EMBL BAA94766.2. Tissue: Cerebellum EMBL BAA94766.2.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AB035727 mRNA. Translation: BAA94766.2.
IPI	IPI00291347.
RefSeq	NP_001120694.1.
UniGene	Hs.501632
3D structure databases
SMR	Q9NS88. Positions 1241-1317, 1558-1689.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NS88.
Proteomic databases
PRIDE	Q9NS88.
Genome annotation databases
Ensembl	ENST00000360228; ENSP00000353362; ENSG00000141837; Homo sapiens. [Genome view]
GeneID	773.
Organism-specific databases
CTD	773.
HGNC	HGNC:1388. CACNA1A.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG713873.
HOVERGEN	Q9NS88.
Gene expression databases
ArrayExpress	Q9NS88.
Bgee	Q9NS88.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005448. VDCC_P/Q_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF59. PQVDCCAlpha1. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01632. PQVDCCALPHA1.
ProtoNet	Search...

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Entry information

Entry name

Q9NS88_HUMAN

Accession

Primary (citable) accession number: Q9NS88

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information