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Protein

Kinesin-like protein KIF15

Gene

KIF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1168ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: ProtInc
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  • blood coagulation Source: Reactome
  • cell proliferation Source: ProtInc
  • metabolic process Source: GOC
  • microtubule-based movement Source: GO_Central
  • mitotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Short name:
hKLP2
Kinesin-like protein 7
Serologically defined breast cancer antigen NY-BR-62
Gene namesi
Name:KIF15
Synonyms:KLP2, KNSL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17273. KIF15.

Subcellular locationi

  • Cytoplasm
  • Cytoplasmcytoskeletonspindle

  • Note: Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity).By similarity

GO - Cellular componenti

  • centrosome Source: ProtInc
  • cytosol Source: Reactome
  • kinesin complex Source: GO_Central
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • plus-end kinesin complex Source: ProtInc
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30183.

Polymorphism and mutation databases

BioMutaiKIF15.
DMDMi74752937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Kinesin-like protein KIF15PRO_0000328684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681Phosphoserine1 Publication
Modified residuei1009 – 10091N6-acetyllysine1 Publication
Modified residuei1169 – 11691Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NS87.
PaxDbiQ9NS87.
PRIDEiQ9NS87.

PTM databases

PhosphoSiteiQ9NS87.

Expressioni

Tissue specificityi

Expressed in testis, colon, thymus and in breast cancer.1 Publication

Gene expression databases

BgeeiQ9NS87.
CleanExiHS_KIF15.
ExpressionAtlasiQ9NS87. baseline and differential.
GenevestigatoriQ9NS87.

Organism-specific databases

HPAiHPA035516.
HPA035517.

Interactioni

Subunit structurei

Interacts with MKI67 and TPX2.2 Publications

Protein-protein interaction databases

BioGridi121307. 13 interactions.
DIPiDIP-28133N.
IntActiQ9NS87. 4 interactions.
MINTiMINT-138026.
STRINGi9606.ENSP00000324020.

Structurei

Secondary structure

1
1388
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 336Combined sources
Beta strandi50 – 556Combined sources
Beta strandi58 – 614Combined sources
Beta strandi64 – 663Combined sources
Beta strandi68 – 714Combined sources
Beta strandi73 – 764Combined sources
Helixi82 – 9817Combined sources
Beta strandi103 – 1086Combined sources
Helixi115 – 1195Combined sources
Helixi135 – 15016Combined sources
Beta strandi158 – 17215Combined sources
Beta strandi174 – 1763Combined sources
Beta strandi186 – 1894Combined sources
Beta strandi195 – 1984Combined sources
Helixi208 – 22619Combined sources
Beta strandi228 – 2314Combined sources
Beta strandi236 – 25015Combined sources
Beta strandi253 – 26513Combined sources
Helixi290 – 30617Combined sources
Beta strandi307 – 3093Combined sources
Helixi315 – 3173Combined sources
Helixi319 – 3235Combined sources
Helixi325 – 3273Combined sources
Beta strandi330 – 34011Combined sources
Helixi344 – 3463Combined sources
Helixi347 – 36014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BN2X-ray2.70A/B/C19-375[»]
ProteinModelPortaliQ9NS87.
SMRiQ9NS87. Positions 24-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 363338Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili368 – 13881021Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000113225.
HOVERGENiHBG062662.
InParanoidiQ9NS87.
KOiK10400.
OMAiEHHSAQM.
OrthoDBiEOG7M0NQQ.
PhylomeDBiQ9NS87.
TreeFamiTF320478.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS87-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGCKTELR SVTNGQSNQP SNEGDAIKVF VRIRPPAERS GSADGEQNLC
60 70 80 90 100
LSVLSSTSLR LHSNPEPKTF TFDHVADVDT TQESVFATVA KSIVESCMSG
110 120 130 140 150
YNGTIFAYGQ TGSGKTFTMM GPSESDNFSH NLRGVIPRSF EYLFSLIDRE
160 170 180 190 200
KEKAGAGKSF LCKCSFIEIY NEQIYDLLDS ASAGLYLREH IKKGVFVVGA
210 220 230 240 250
VEQVVTSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF TITIESMEKS
260 270 280 290 300
NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
310 320 330 340 350
ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET
360 370 380 390 400
LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LAELASGQTP
410 420 430 440 450
PESFLTRDKK KTNYMEYFQE AMLFFKKSEQ EKKSLIEKVT QLEDLTLKKE
460 470 480 490 500
KFIQSNKMIV KFREDQIIRL EKLHKESRGG FLPEEQDRLL SELRNEIQTL
510 520 530 540 550
REQIEHHPRV AKYAMENHSL REENRRLRLL EPVKRAQEMD AQTIAKLEKA
560 570 580 590 600
FSEISGMEKS DKNQQGFSPK AQKEPCLFAN TEKLKAQLLQ IQTELNNSKQ
610 620 630 640 650
EYEEFKELTR KRQLELESEL QSLQKANLNL ENLLEATKAC KRQEVSQLNK
660 670 680 690 700
IHAETLKIIT TPTKAYQLHS RPVPKLSPEM GSFGSLYTQN SSILDNDILN
710 720 730 740 750
EPVPPEMNEQ AFEAISEELR TVQEQMSALQ AKLDEEEHKN LKLQQHVDKL
760 770 780 790 800
EHHSTQMQEL FSSERIDWTK QQEELLSQLN VLEKQLQETQ TKNDFLKSEV
810 820 830 840 850
HDLRVVLHSA DKELSSVKLE YSSFKTNQEK EFNKLSERHM HVQLQLDNLR
860 870 880 890 900
LENEKLLESK ACLQDSYDNL QEIMKFEIDQ LSRNLQNFKK ENETLKSDLN
910 920 930 940 950
NLMELLEAEK ERNNKLSLQF EEDKENSSKE ILKVLEAVRQ EKQKETAKCE
960 970 980 990 1000
QQMAKVQKLE ESLLATEKVI SSLEKSRDSD KKVVADLMNQ IQELRTSVCE
1010 1020 1030 1040 1050
KTETIDTLKQ ELKDINCKYN SALVDREESR VLIKKQEVDI LDLKETLRLR
1060 1070 1080 1090 1100
ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTKKEALI
1110 1120 1130 1140 1150
QELQHKLNQK KEEVEQKKNE YNFKMRQLEH VMDSAAEDPQ SPKTPPHFQT
1160 1170 1180 1190 1200
HLAKLLETQE QEIEDGRASK TSLEHLVTKL NEDREVKNAE ILRMKEQLRE
1210 1220 1230 1240 1250
MENLRLESQQ LIEKNWLLQG QLDDIKRQKE NSDQNHPDNQ QLKNEQEESI
1260 1270 1280 1290 1300
KERLAKSKIV EEMLKMKADL EEVQSALYNK EMECLRMTDE VERTQTLESK
1310 1320 1330 1340 1350
AFQEKEQLRS KLEEMYEERE RTSQEMEMLR KQVECLAEEN GKLVGHQNLH
1360 1370 1380
QKIQYVVRLK KENVRLAEET EKLRAENVFL KEKKRSES
Length:1,388
Mass (Da):160,160
Last modified:October 1, 2000 - v1
Checksum:iE127EB4B991CA83A
GO
Isoform 2 (identifier: Q9NS87-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:1,291
Mass (Da):149,784
Checksum:i86EABBD49A76151B
GO
Isoform 3 (identifier: Q9NS87-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-952: Missing.

Show »
Length:436
Mass (Da):51,433
Checksum:i3BE3ABBDB7A7821D
GO
Isoform 4 (identifier: Q9NS87-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1092-1119: ELTKKEALIQELQHKLNQKKEEVEQKKN → RTDQERSPDSGTSAQAKPKERGSRTEEE
     1200-1388: Missing.

Show »
Length:1,199
Mass (Da):137,169
Checksum:i18176A5A924EFB95
GO

Sequence cautioni

The sequence AAG48261.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1057 – 10571E → K in AAG48261 (PubMed:12747765).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti211 – 2111A → V.
Corresponds to variant rs34862960 [ dbSNP | Ensembl ].
VAR_042464
Natural varianti996 – 9961T → S.2 Publications
Corresponds to variant rs11710339 [ dbSNP | Ensembl ].
VAR_042465
Natural varianti1206 – 12061L → M.
Corresponds to variant rs3804583 [ dbSNP | Ensembl ].
VAR_042466
Natural varianti1272 – 12721E → D.
Corresponds to variant rs17076986 [ dbSNP | Ensembl ].
VAR_042467

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 952952Missing in isoform 3. 1 PublicationVSP_032752Add
BLAST
Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_032753Add
BLAST
Alternative sequencei1092 – 111928ELTKK…EQKKN → RTDQERSPDSGTSAQAKPKE RGSRTEEE in isoform 4. 1 PublicationVSP_032754Add
BLAST
Alternative sequencei1200 – 1388189Missing in isoform 4. 1 PublicationVSP_032755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035898 mRNA. Translation: BAB03309.1.
AK027816 mRNA. Translation: BAB55389.1.
BC117174 mRNA. Translation: AAI17175.1.
AL832908 mRNA. Translation: CAH10635.1.
AF308294 mRNA. Translation: AAG48261.1. Frameshift.
CCDSiCCDS33744.1. [Q9NS87-1]
RefSeqiNP_064627.1. NM_020242.2. [Q9NS87-1]
UniGeneiHs.658939.

Genome annotation databases

EnsembliENST00000326047; ENSP00000324020; ENSG00000163808. [Q9NS87-1]
ENST00000627272; ENSP00000486004; ENSG00000280610. [Q9NS87-1]
GeneIDi56992.
KEGGihsa:56992.
UCSCiuc003cnx.4. human. [Q9NS87-1]
uc010hir.3. human. [Q9NS87-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035898 mRNA. Translation: BAB03309.1.
AK027816 mRNA. Translation: BAB55389.1.
BC117174 mRNA. Translation: AAI17175.1.
AL832908 mRNA. Translation: CAH10635.1.
AF308294 mRNA. Translation: AAG48261.1. Frameshift.
CCDSiCCDS33744.1. [Q9NS87-1]
RefSeqiNP_064627.1. NM_020242.2. [Q9NS87-1]
UniGeneiHs.658939.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BN2X-ray2.70A/B/C19-375[»]
ProteinModelPortaliQ9NS87.
SMRiQ9NS87. Positions 24-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121307. 13 interactions.
DIPiDIP-28133N.
IntActiQ9NS87. 4 interactions.
MINTiMINT-138026.
STRINGi9606.ENSP00000324020.

PTM databases

PhosphoSiteiQ9NS87.

Polymorphism and mutation databases

BioMutaiKIF15.
DMDMi74752937.

Proteomic databases

MaxQBiQ9NS87.
PaxDbiQ9NS87.
PRIDEiQ9NS87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326047; ENSP00000324020; ENSG00000163808. [Q9NS87-1]
ENST00000627272; ENSP00000486004; ENSG00000280610. [Q9NS87-1]
GeneIDi56992.
KEGGihsa:56992.
UCSCiuc003cnx.4. human. [Q9NS87-1]
uc010hir.3. human. [Q9NS87-3]

Organism-specific databases

CTDi56992.
GeneCardsiGC03P044803.
HGNCiHGNC:17273. KIF15.
HPAiHPA035516.
HPA035517.
neXtProtiNX_Q9NS87.
PharmGKBiPA30183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000113225.
HOVERGENiHBG062662.
InParanoidiQ9NS87.
KOiK10400.
OMAiEHHSAQM.
OrthoDBiEOG7M0NQQ.
PhylomeDBiQ9NS87.
TreeFamiTF320478.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.

Miscellaneous databases

GeneWikiiKIF15.
GenomeRNAii56992.
NextBioi62689.
PROiQ9NS87.

Gene expression databases

BgeeiQ9NS87.
CleanExiHS_KIF15.
ExpressionAtlasiQ9NS87. baseline and differential.
GenevestigatoriQ9NS87.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2."
    Sueishi M., Takagi M., Yoneda Y.
    J. Biol. Chem. 275:28888-28892(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MKI67, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 339-1388 (ISOFORMS 1/2), VARIANT SER-996.
    Tissue: Melanoma.
  5. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
    Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
    Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 786-1388 (ISOFORM 4), TISSUE SPECIFICITY, VARIANT SER-996.
    Tissue: Mammary gland.
  6. "repp86: a human protein associated in the progression of mitosis."
    Heidebrecht H.-J., Adam-Klages S., Szczepanowski M., Pollmann M., Buck F., Endl E., Kruse M.-L., Rudolph P., Parwaresch R.
    Mol. Cancer Res. 1:271-279(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TPX2, SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1009, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKIF15_HUMAN
AccessioniPrimary (citable) accession number: Q9NS87
Secondary accession number(s): Q17RV9
, Q69YL6, Q96JX7, Q9H280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.