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Q9NS87

- KIF15_HUMAN

UniProt

Q9NS87 - KIF15_HUMAN

Protein

Kinesin-like protein KIF15

Gene

KIF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 1168ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: ProtInc
    3. microtubule motor activity Source: InterPro
    4. motor activity Source: ProtInc

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. blood coagulation Source: Reactome
    3. cell proliferation Source: ProtInc
    4. metabolic process Source: GOC
    5. microtubule-based movement Source: Reactome
    6. mitotic nuclear division Source: ProtInc

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF15
    Alternative name(s):
    Kinesin-like protein 2
    Short name:
    hKLP2
    Kinesin-like protein 7
    Serologically defined breast cancer antigen NY-BR-62
    Gene namesi
    Name:KIF15
    Synonyms:KLP2, KNSL7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17273. KIF15.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeletonspindle
    Note: Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase By similarity. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells By similarity. Colocalizes with actin in interphase By similarity. Colocalizes in dendrites and in growth cone of axons with microtubules By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: ProtInc
    2. cytosol Source: Reactome
    3. membrane Source: UniProtKB
    4. microtubule Source: UniProtKB-KW
    5. plus-end kinesin complex Source: ProtInc
    6. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30183.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13881388Kinesin-like protein KIF15PRO_0000328684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei568 – 5681Phosphoserine1 Publication
    Modified residuei1009 – 10091N6-acetyllysine1 Publication
    Modified residuei1141 – 11411Phosphoserine1 Publication
    Modified residuei1144 – 11441Phosphothreonine1 Publication
    Modified residuei1169 – 11691Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NS87.
    PaxDbiQ9NS87.
    PRIDEiQ9NS87.

    PTM databases

    PhosphoSiteiQ9NS87.

    Expressioni

    Tissue specificityi

    Expressed in testis, colon, thymus and in breast cancer.1 Publication

    Gene expression databases

    ArrayExpressiQ9NS87.
    BgeeiQ9NS87.
    CleanExiHS_KIF15.
    GenevestigatoriQ9NS87.

    Organism-specific databases

    HPAiHPA035516.
    HPA035517.

    Interactioni

    Subunit structurei

    Interacts with MKI67 and TPX2.2 Publications

    Protein-protein interaction databases

    BioGridi121307. 11 interactions.
    DIPiDIP-28133N.
    IntActiQ9NS87. 4 interactions.
    MINTiMINT-138026.
    STRINGi9606.ENSP00000324020.

    Structurei

    Secondary structure

    1
    1388
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 336
    Beta strandi50 – 556
    Beta strandi58 – 614
    Beta strandi64 – 663
    Beta strandi68 – 714
    Beta strandi73 – 764
    Helixi82 – 9817
    Beta strandi103 – 1086
    Helixi115 – 1195
    Helixi135 – 15016
    Beta strandi158 – 17215
    Beta strandi174 – 1763
    Beta strandi186 – 1894
    Beta strandi195 – 1984
    Helixi208 – 22619
    Beta strandi228 – 2314
    Beta strandi236 – 25015
    Beta strandi253 – 26513
    Helixi290 – 30617
    Beta strandi307 – 3093
    Helixi315 – 3173
    Helixi319 – 3235
    Helixi325 – 3273
    Beta strandi330 – 34011
    Helixi344 – 3463
    Helixi347 – 36014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BN2X-ray2.70A/B/C19-375[»]
    ProteinModelPortaliQ9NS87.
    SMRiQ9NS87. Positions 24-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 363338Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili368 – 13881021Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000113225.
    HOVERGENiHBG062662.
    InParanoidiQ9NS87.
    KOiK10400.
    OMAiEHHSAQM.
    OrthoDBiEOG7M0NQQ.
    PhylomeDBiQ9NS87.
    TreeFamiTF320478.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR024658. Kinesin-like_KLP2.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    PF12711. Kinesin-relat_1. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NS87-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPGCKTELR SVTNGQSNQP SNEGDAIKVF VRIRPPAERS GSADGEQNLC     50
    LSVLSSTSLR LHSNPEPKTF TFDHVADVDT TQESVFATVA KSIVESCMSG 100
    YNGTIFAYGQ TGSGKTFTMM GPSESDNFSH NLRGVIPRSF EYLFSLIDRE 150
    KEKAGAGKSF LCKCSFIEIY NEQIYDLLDS ASAGLYLREH IKKGVFVVGA 200
    VEQVVTSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF TITIESMEKS 250
    NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT 300
    ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET 350
    LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LAELASGQTP 400
    PESFLTRDKK KTNYMEYFQE AMLFFKKSEQ EKKSLIEKVT QLEDLTLKKE 450
    KFIQSNKMIV KFREDQIIRL EKLHKESRGG FLPEEQDRLL SELRNEIQTL 500
    REQIEHHPRV AKYAMENHSL REENRRLRLL EPVKRAQEMD AQTIAKLEKA 550
    FSEISGMEKS DKNQQGFSPK AQKEPCLFAN TEKLKAQLLQ IQTELNNSKQ 600
    EYEEFKELTR KRQLELESEL QSLQKANLNL ENLLEATKAC KRQEVSQLNK 650
    IHAETLKIIT TPTKAYQLHS RPVPKLSPEM GSFGSLYTQN SSILDNDILN 700
    EPVPPEMNEQ AFEAISEELR TVQEQMSALQ AKLDEEEHKN LKLQQHVDKL 750
    EHHSTQMQEL FSSERIDWTK QQEELLSQLN VLEKQLQETQ TKNDFLKSEV 800
    HDLRVVLHSA DKELSSVKLE YSSFKTNQEK EFNKLSERHM HVQLQLDNLR 850
    LENEKLLESK ACLQDSYDNL QEIMKFEIDQ LSRNLQNFKK ENETLKSDLN 900
    NLMELLEAEK ERNNKLSLQF EEDKENSSKE ILKVLEAVRQ EKQKETAKCE 950
    QQMAKVQKLE ESLLATEKVI SSLEKSRDSD KKVVADLMNQ IQELRTSVCE 1000
    KTETIDTLKQ ELKDINCKYN SALVDREESR VLIKKQEVDI LDLKETLRLR 1050
    ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTKKEALI 1100
    QELQHKLNQK KEEVEQKKNE YNFKMRQLEH VMDSAAEDPQ SPKTPPHFQT 1150
    HLAKLLETQE QEIEDGRASK TSLEHLVTKL NEDREVKNAE ILRMKEQLRE 1200
    MENLRLESQQ LIEKNWLLQG QLDDIKRQKE NSDQNHPDNQ QLKNEQEESI 1250
    KERLAKSKIV EEMLKMKADL EEVQSALYNK EMECLRMTDE VERTQTLESK 1300
    AFQEKEQLRS KLEEMYEERE RTSQEMEMLR KQVECLAEEN GKLVGHQNLH 1350
    QKIQYVVRLK KENVRLAEET EKLRAENVFL KEKKRSES 1388
    Length:1,388
    Mass (Da):160,160
    Last modified:October 1, 2000 - v1
    Checksum:iE127EB4B991CA83A
    GO
    Isoform 2 (identifier: Q9NS87-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: Missing.

    Show »
    Length:1,291
    Mass (Da):149,784
    Checksum:i86EABBD49A76151B
    GO
    Isoform 3 (identifier: Q9NS87-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-952: Missing.

    Show »
    Length:436
    Mass (Da):51,433
    Checksum:i3BE3ABBDB7A7821D
    GO
    Isoform 4 (identifier: Q9NS87-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1092-1119: ELTKKEALIQELQHKLNQKKEEVEQKKN → RTDQERSPDSGTSAQAKPKERGSRTEEE
         1200-1388: Missing.

    Show »
    Length:1,199
    Mass (Da):137,169
    Checksum:i18176A5A924EFB95
    GO

    Sequence cautioni

    The sequence AAG48261.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1057 – 10571E → K in AAG48261. (PubMed:12747765)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti211 – 2111A → V.
    Corresponds to variant rs34862960 [ dbSNP | Ensembl ].
    VAR_042464
    Natural varianti996 – 9961T → S.2 Publications
    Corresponds to variant rs11710339 [ dbSNP | Ensembl ].
    VAR_042465
    Natural varianti1206 – 12061L → M.
    Corresponds to variant rs3804583 [ dbSNP | Ensembl ].
    VAR_042466
    Natural varianti1272 – 12721E → D.
    Corresponds to variant rs17076986 [ dbSNP | Ensembl ].
    VAR_042467

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 952952Missing in isoform 3. 1 PublicationVSP_032752Add
    BLAST
    Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_032753Add
    BLAST
    Alternative sequencei1092 – 111928ELTKK…EQKKN → RTDQERSPDSGTSAQAKPKE RGSRTEEE in isoform 4. 1 PublicationVSP_032754Add
    BLAST
    Alternative sequencei1200 – 1388189Missing in isoform 4. 1 PublicationVSP_032755Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035898 mRNA. Translation: BAB03309.1.
    AK027816 mRNA. Translation: BAB55389.1.
    BC117174 mRNA. Translation: AAI17175.1.
    AL832908 mRNA. Translation: CAH10635.1.
    AF308294 mRNA. Translation: AAG48261.1. Frameshift.
    CCDSiCCDS33744.1. [Q9NS87-1]
    RefSeqiNP_064627.1. NM_020242.2. [Q9NS87-1]
    XP_005265385.1. XM_005265328.1. [Q9NS87-2]
    UniGeneiHs.658939.

    Genome annotation databases

    EnsembliENST00000326047; ENSP00000324020; ENSG00000163808. [Q9NS87-1]
    GeneIDi56992.
    KEGGihsa:56992.
    UCSCiuc003cnx.4. human. [Q9NS87-1]
    uc010hir.3. human. [Q9NS87-3]

    Polymorphism databases

    DMDMi74752937.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035898 mRNA. Translation: BAB03309.1 .
    AK027816 mRNA. Translation: BAB55389.1 .
    BC117174 mRNA. Translation: AAI17175.1 .
    AL832908 mRNA. Translation: CAH10635.1 .
    AF308294 mRNA. Translation: AAG48261.1 . Frameshift.
    CCDSi CCDS33744.1. [Q9NS87-1 ]
    RefSeqi NP_064627.1. NM_020242.2. [Q9NS87-1 ]
    XP_005265385.1. XM_005265328.1. [Q9NS87-2 ]
    UniGenei Hs.658939.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BN2 X-ray 2.70 A/B/C 19-375 [» ]
    ProteinModelPortali Q9NS87.
    SMRi Q9NS87. Positions 24-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121307. 11 interactions.
    DIPi DIP-28133N.
    IntActi Q9NS87. 4 interactions.
    MINTi MINT-138026.
    STRINGi 9606.ENSP00000324020.

    PTM databases

    PhosphoSitei Q9NS87.

    Polymorphism databases

    DMDMi 74752937.

    Proteomic databases

    MaxQBi Q9NS87.
    PaxDbi Q9NS87.
    PRIDEi Q9NS87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326047 ; ENSP00000324020 ; ENSG00000163808 . [Q9NS87-1 ]
    GeneIDi 56992.
    KEGGi hsa:56992.
    UCSCi uc003cnx.4. human. [Q9NS87-1 ]
    uc010hir.3. human. [Q9NS87-3 ]

    Organism-specific databases

    CTDi 56992.
    GeneCardsi GC03P044803.
    HGNCi HGNC:17273. KIF15.
    HPAi HPA035516.
    HPA035517.
    neXtProti NX_Q9NS87.
    PharmGKBi PA30183.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000113225.
    HOVERGENi HBG062662.
    InParanoidi Q9NS87.
    KOi K10400.
    OMAi EHHSAQM.
    OrthoDBi EOG7M0NQQ.
    PhylomeDBi Q9NS87.
    TreeFami TF320478.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Miscellaneous databases

    GeneWikii KIF15.
    GenomeRNAii 56992.
    NextBioi 62689.
    PROi Q9NS87.

    Gene expression databases

    ArrayExpressi Q9NS87.
    Bgeei Q9NS87.
    CleanExi HS_KIF15.
    Genevestigatori Q9NS87.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR024658. Kinesin-like_KLP2.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    PF12711. Kinesin-relat_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2."
      Sueishi M., Takagi M., Yoneda Y.
      J. Biol. Chem. 275:28888-28892(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MKI67, SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 339-1388 (ISOFORMS 1/2), VARIANT SER-996.
      Tissue: Melanoma.
    5. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
      Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
      Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 786-1388 (ISOFORM 4), TISSUE SPECIFICITY, VARIANT SER-996.
      Tissue: Mammary gland.
    6. "repp86: a human protein associated in the progression of mitosis."
      Heidebrecht H.-J., Adam-Klages S., Szczepanowski M., Pollmann M., Buck F., Endl E., Kruse M.-L., Rudolph P., Parwaresch R.
      Mol. Cancer Res. 1:271-279(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TPX2, SUBCELLULAR LOCATION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1009, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1141; THR-1144 AND SER-1169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKIF15_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS87
    Secondary accession number(s): Q17RV9
    , Q69YL6, Q96JX7, Q9H280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3