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Protein

LanC-like protein 2

Gene

LANCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • catalytic activity Source: InterPro
  • GTP binding Source: UniProtKB
  • phosphatidylinositol-3-phosphate binding Source: UniProtKB
  • phosphatidylinositol-4-phosphate binding Source: UniProtKB
  • phosphatidylinositol-5-phosphate binding Source: UniProtKB

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of abscisic acid-activated signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 2
Alternative name(s):
Testis-specific adriamycin sensitivity protein
Gene namesi
Name:LANCL2
Synonyms:GPR69B, TASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6509. LANCL2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication
  • Cell membrane 2 Publications

  • Note: Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).1 Publication

GO - Cellular componenti

  • cortical actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21G → A: Loss of membrane localization and results in localization to the nucleus, particularly to the nucleoli. 1 Publication

Organism-specific databases

PharmGKBiPA30294.

Chemistry

ChEMBLiCHEMBL3351212.

Polymorphism and mutation databases

BioMutaiLANCL2.
DMDMi47116933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 450449LanC-like protein 2PRO_0000191272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei198 – 1981PhosphotyrosineBy similarity

Post-translational modificationi

Myristoylated. Essential for membrane association.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9NS86.
MaxQBiQ9NS86.
PaxDbiQ9NS86.
PeptideAtlasiQ9NS86.
PRIDEiQ9NS86.

PTM databases

iPTMnetiQ9NS86.
PhosphoSiteiQ9NS86.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000132434.
CleanExiHS_LANCL2.
ExpressionAtlasiQ9NS86. baseline and differential.
GenevisibleiQ9NS86. HS.

Organism-specific databases

HPAiHPA019711.
HPA029535.

Interactioni

Subunit structurei

Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-2510837,EBI-743771
TERF2IPQ9NYB02EBI-2510837,EBI-750109

Protein-protein interaction databases

BioGridi120998. 22 interactions.
IntActiQ9NS86. 5 interactions.
MINTiMINT-3073494.
STRINGi9606.ENSP00000254770.

Structurei

3D structure databases

ProteinModelPortaliQ9NS86.
SMRiQ9NS86. Positions 19-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1514Interaction with inositol phospholipidsAdd
BLAST

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9NS86.
OMAiNPFPDYE.
OrthoDBiEOG091G02TS.
PhylomeDBiQ9NS86.
TreeFamiTF300068.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETMSKRLK LHLGGEAEME ERAFVNPFPD YEAAAGALLA SGAAEETGCV
60 70 80 90 100
RPPATTDEPG LPFHQDGKII HNFIRRIQTK IKDLLQQMEE GLKTADPHDC
110 120 130 140 150
SAYTGWTGIA LLYLQLYRVT CDQTYLLRSL DYVKRTLRNL NGRRVTFLCG
160 170 180 190 200
DAGPLAVGAV IYHKLRSDCE SQECVTKLLQ LQRSVVCQES DLPDELLYGR
210 220 230 240 250
AGYLYALLYL NTEIGPGTVC ESAIKEVVNA IIESGKTLSR EERKTERCPL
260 270 280 290 300
LYQWHRKQYV GAAHGMAGIY YMLMQPAAKV DQETLTEMVK PSIDYVRHKK
310 320 330 340 350
FRSGNYPSSL SNETDRLVHW CHGAPGVIHM LMQAYKVFKE EKYLKEAMEC
360 370 380 390 400
SDVIWQRGLL RKGYGICHGT AGNGYSFLSL YRLTQDKKYL YRACKFAEWC
410 420 430 440 450
LDYGAHGCRI PDRPYSLFEG MAGAIHFLSD VLGPETSRFP AFELDSSKRD
Length:450
Mass (Da):50,854
Last modified:October 1, 2000 - v1
Checksum:i8FD27E11BB91C05D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561T → P.3 Publications
Corresponds to variant rs2272263 [ dbSNP | Ensembl ].
VAR_060064
Natural varianti74 – 741I → V.
Corresponds to variant rs6961412 [ dbSNP | Ensembl ].
VAR_053480

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278245 mRNA. Translation: CAC21715.1.
AB035966 mRNA. Translation: BAA96800.1.
AF353942 mRNA. Translation: AAK83286.1.
AK313326 mRNA. Translation: BAG36131.1.
AC073347 Genomic DNA. Translation: AAQ93360.1.
CH236957 Genomic DNA. Translation: EAL23810.1.
CH471201 Genomic DNA. Translation: EAW50968.1.
BC004887 mRNA. Translation: AAH04887.2.
BC070049 mRNA. Translation: AAH70049.1.
AL713665 mRNA. Translation: CAD28471.1.
CCDSiCCDS5517.1.
RefSeqiNP_061167.1. NM_018697.3.
UniGeneiHs.595384.
Hs.706612.

Genome annotation databases

EnsembliENST00000254770; ENSP00000254770; ENSG00000132434.
GeneIDi55915.
KEGGihsa:55915.
UCSCiuc003tqp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278245 mRNA. Translation: CAC21715.1.
AB035966 mRNA. Translation: BAA96800.1.
AF353942 mRNA. Translation: AAK83286.1.
AK313326 mRNA. Translation: BAG36131.1.
AC073347 Genomic DNA. Translation: AAQ93360.1.
CH236957 Genomic DNA. Translation: EAL23810.1.
CH471201 Genomic DNA. Translation: EAW50968.1.
BC004887 mRNA. Translation: AAH04887.2.
BC070049 mRNA. Translation: AAH70049.1.
AL713665 mRNA. Translation: CAD28471.1.
CCDSiCCDS5517.1.
RefSeqiNP_061167.1. NM_018697.3.
UniGeneiHs.595384.
Hs.706612.

3D structure databases

ProteinModelPortaliQ9NS86.
SMRiQ9NS86. Positions 19-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120998. 22 interactions.
IntActiQ9NS86. 5 interactions.
MINTiMINT-3073494.
STRINGi9606.ENSP00000254770.

Chemistry

ChEMBLiCHEMBL3351212.

PTM databases

iPTMnetiQ9NS86.
PhosphoSiteiQ9NS86.

Polymorphism and mutation databases

BioMutaiLANCL2.
DMDMi47116933.

Proteomic databases

EPDiQ9NS86.
MaxQBiQ9NS86.
PaxDbiQ9NS86.
PeptideAtlasiQ9NS86.
PRIDEiQ9NS86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254770; ENSP00000254770; ENSG00000132434.
GeneIDi55915.
KEGGihsa:55915.
UCSCiuc003tqp.3. human.

Organism-specific databases

CTDi55915.
GeneCardsiLANCL2.
HGNCiHGNC:6509. LANCL2.
HPAiHPA019711.
HPA029535.
MIMi612919. gene.
neXtProtiNX_Q9NS86.
PharmGKBiPA30294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9NS86.
OMAiNPFPDYE.
OrthoDBiEOG091G02TS.
PhylomeDBiQ9NS86.
TreeFamiTF300068.

Miscellaneous databases

ChiTaRSiLANCL2. human.
GeneWikiiLANCL2.
GenomeRNAii55915.
PROiQ9NS86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132434.
CleanExiHS_LANCL2.
ExpressionAtlasiQ9NS86. baseline and differential.
GenevisibleiQ9NS86. HS.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLANC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS86
Secondary accession number(s): B2R8D4
, Q6NSL4, Q8TCQ3, Q9BSR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P-glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.