Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carbonic anhydrase-related protein 10

Gene

CA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Does not have a catalytic activity.

GO - Biological processi

  • brain development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase-related protein 10
Alternative name(s):
Carbonic anhydrase-related protein X
Short name:
CA-RP X
Short name:
CARP X
Cerebral protein 15
Gene namesi
Name:CA10
ORF Names:hucep-15, UNQ533/PRO1076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1369. CA10.

Pathology & Biotechi

Organism-specific databases

DisGeNETi56934.
OpenTargetsiENSG00000154975.
PharmGKBiPA25985.

Chemistry databases

DrugBankiDB00909. Zonisamide.

Polymorphism and mutation databases

BioMutaiCA10.
DMDMi18203320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774361 – 328Carbonic anhydrase-related protein 10Add BLAST328

Proteomic databases

PaxDbiQ9NS85.
PeptideAtlasiQ9NS85.
PRIDEiQ9NS85.

PTM databases

iPTMnetiQ9NS85.
PhosphoSitePlusiQ9NS85.

Expressioni

Tissue specificityi

Strong expression in brain and central nervous system.1 Publication

Developmental stagei

Not expressed in fetal brain.

Gene expression databases

BgeeiENSG00000154975.
CleanExiHS_CA10.
ExpressionAtlasiQ9NS85. baseline and differential.
GenevisibleiQ9NS85. HS.

Organism-specific databases

HPAiHPA054825.

Interactioni

Protein-protein interaction databases

BioGridi121259. 26 interactors.
STRINGi9606.ENSP00000285273.

Structurei

3D structure databases

ProteinModelPortaliQ9NS85.
SMRiQ9NS85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 301Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00740000115510.
HOGENOMiHOG000019899.
HOVERGENiHBG097666.
InParanoidiQ9NS85.
OMAiNLHHRTV.
OrthoDBiEOG091G0T4J.
PhylomeDBiQ9NS85.
TreeFamiTF352926.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018423. CA10.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF91. PTHR18952:SF91. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW
60 70 80 90 100
GLVNSAWNLC SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN
110 120 130 140 150
TGRHVSLRLD KEHLVNISGG PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ
160 170 180 190 200
AFSGEVQLIH YNHELYTNVT EAAKSPNGLV VVSIFIKVSD SSNPFLNRML
210 220 230 240 250
NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT IPPCYETASW
260 270 280 290 300
IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
310 320
INFSLQGKDC PNNRAQKLQY RVNEWLLK
Length:328
Mass (Da):37,563
Last modified:October 1, 2000 - v1
Checksum:iB20BFEC1800422B4
GO
Isoform 2 (identifier: Q9NS85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,049
Checksum:i14D1A23D092D3178
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569401 – 75Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036836 mRNA. Translation: BAB00615.1.
AF288385 mRNA. Translation: AAK11974.1.
AB001597 mRNA. Translation: BAB46928.1.
AF064854 mRNA. No translation available.
AL161812 mRNA. Translation: CAB82105.1.
AY358509 mRNA. Translation: AAQ88873.1.
AK294652 mRNA. Translation: BAG57827.1.
AK313001 mRNA. Translation: BAG35837.1.
AC002090 Genomic DNA. No translation available.
AC004108 Genomic DNA. No translation available.
AC005883 Genomic DNA. No translation available.
AC006083 Genomic DNA. No translation available.
AC016473 Genomic DNA. No translation available.
AC092713 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94558.1.
BC020577 mRNA. Translation: AAH20577.1.
BC047456 mRNA. Translation: AAH47456.1.
BC068462 mRNA. Translation: AAH68462.1.
CCDSiCCDS32684.1. [Q9NS85-1]
RefSeqiNP_001076002.1. NM_001082533.1. [Q9NS85-1]
NP_001076003.1. NM_001082534.1. [Q9NS85-1]
NP_064563.1. NM_020178.4. [Q9NS85-1]
UniGeneiHs.463466.

Genome annotation databases

EnsembliENST00000285273; ENSP00000285273; ENSG00000154975. [Q9NS85-1]
ENST00000442502; ENSP00000390666; ENSG00000154975. [Q9NS85-1]
ENST00000451037; ENSP00000405388; ENSG00000154975. [Q9NS85-1]
ENST00000570565; ENSP00000459619; ENSG00000154975. [Q9NS85-2]
GeneIDi56934.
KEGGihsa:56934.
UCSCiuc002itw.5. human. [Q9NS85-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036836 mRNA. Translation: BAB00615.1.
AF288385 mRNA. Translation: AAK11974.1.
AB001597 mRNA. Translation: BAB46928.1.
AF064854 mRNA. No translation available.
AL161812 mRNA. Translation: CAB82105.1.
AY358509 mRNA. Translation: AAQ88873.1.
AK294652 mRNA. Translation: BAG57827.1.
AK313001 mRNA. Translation: BAG35837.1.
AC002090 Genomic DNA. No translation available.
AC004108 Genomic DNA. No translation available.
AC005883 Genomic DNA. No translation available.
AC006083 Genomic DNA. No translation available.
AC016473 Genomic DNA. No translation available.
AC092713 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94558.1.
BC020577 mRNA. Translation: AAH20577.1.
BC047456 mRNA. Translation: AAH47456.1.
BC068462 mRNA. Translation: AAH68462.1.
CCDSiCCDS32684.1. [Q9NS85-1]
RefSeqiNP_001076002.1. NM_001082533.1. [Q9NS85-1]
NP_001076003.1. NM_001082534.1. [Q9NS85-1]
NP_064563.1. NM_020178.4. [Q9NS85-1]
UniGeneiHs.463466.

3D structure databases

ProteinModelPortaliQ9NS85.
SMRiQ9NS85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121259. 26 interactors.
STRINGi9606.ENSP00000285273.

Chemistry databases

DrugBankiDB00909. Zonisamide.

PTM databases

iPTMnetiQ9NS85.
PhosphoSitePlusiQ9NS85.

Polymorphism and mutation databases

BioMutaiCA10.
DMDMi18203320.

Proteomic databases

PaxDbiQ9NS85.
PeptideAtlasiQ9NS85.
PRIDEiQ9NS85.

Protocols and materials databases

DNASUi56934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285273; ENSP00000285273; ENSG00000154975. [Q9NS85-1]
ENST00000442502; ENSP00000390666; ENSG00000154975. [Q9NS85-1]
ENST00000451037; ENSP00000405388; ENSG00000154975. [Q9NS85-1]
ENST00000570565; ENSP00000459619; ENSG00000154975. [Q9NS85-2]
GeneIDi56934.
KEGGihsa:56934.
UCSCiuc002itw.5. human. [Q9NS85-1]

Organism-specific databases

CTDi56934.
DisGeNETi56934.
GeneCardsiCA10.
HGNCiHGNC:1369. CA10.
HPAiHPA054825.
MIMi604642. gene.
neXtProtiNX_Q9NS85.
OpenTargetsiENSG00000154975.
PharmGKBiPA25985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00740000115510.
HOGENOMiHOG000019899.
HOVERGENiHBG097666.
InParanoidiQ9NS85.
OMAiNLHHRTV.
OrthoDBiEOG091G0T4J.
PhylomeDBiQ9NS85.
TreeFamiTF352926.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154975-MONOMER.

Miscellaneous databases

ChiTaRSiCA10. human.
GeneWikiiCA10.
GenomeRNAii56934.
PROiQ9NS85.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154975.
CleanExiHS_CA10.
ExpressionAtlasiQ9NS85. baseline and differential.
GenevisibleiQ9NS85. HS.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR018423. CA10.
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF91. PTHR18952:SF91. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH10_HUMAN
AccessioniPrimary (citable) accession number: Q9NS85
Secondary accession number(s): B2R7J0, B4DGL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.