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Q9NS82

- AAA1_HUMAN

UniProt

Q9NS82 - AAA1_HUMAN

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Protein
Asc-type amino acid transporter 1
Gene
SLC7A10, ASC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: ProtInc
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. D-alanine transport Source: Ensembl
  2. D-serine transport Source: Ensembl
  3. L-serine transport Source: GOC
  4. amino acid transport Source: Reactome
  5. blood coagulation Source: Reactome
  6. ion transport Source: Reactome
  7. leukocyte migration Source: Reactome
  8. neutral amino acid transport Source: UniProtKB
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.21. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Asc-type amino acid transporter 1
Short name:
Asc-1
Alternative name(s):
Solute carrier family 7 member 10
Gene namesi
Name:SLC7A10
Synonyms:ASC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11058. SLC7A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Transmembranei424 – 44421Helical; Reviewed prediction
Add
BLAST
Transmembranei448 – 46821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Asc-type amino acid transporter 1
PRO_0000054276Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9NS82.

PTM databases

PhosphoSiteiQ9NS82.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ9NS82.
BgeeiQ9NS82.
CleanExiHS_SLC7A10.
GenevestigatoriQ9NS82.

Organism-specific databases

HPAiHPA041884.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc By similarity.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000253188.

Structurei

3D structure databases

ProteinModelPortaliQ9NS82.
SMRiQ9NS82. Positions 39-370.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9NS82.
KOiK13782.
OMAiVPPYMAT.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9NS82.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NS82-1 [UniParc]FASTAAdd to Basket

« Hide

MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII    50
GNIIGSGIFI SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI 100
PKSGGDYAYV TEIFGGLAGF LLLWSAVLIM YPTSLAVISM TFSNYVLQPV 150
FPNCIPPTTA SRVLSMACLM LLTWVNSSSV RWATRIQDMF TGGKLLALSL 200
IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ GSFAFSGWNF 250
LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN 300
AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL 350
PSLLAMIHVR HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG 400
VTILGLLLLR WRRPALHRPI KVNLLIPVAY LVFWAFLLVF SFISEPMVCG 450
VGVIIILTGV PIFFLGVFWR SKPKCVHRLT ESMTHWGQEL CFVVYPQDAP 500
EEEENGPCPP SLLPATDKPS KPQ 523
Length:523
Mass (Da):56,798
Last modified:October 1, 2000 - v1
Checksum:i24BA0B36521AC2D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121E → D in a family with cystinuria. 1 Publication
Corresponds to variant rs79717007 [ dbSNP | Ensembl ].
VAR_014282
Natural varianti413 – 4131R → Q.
Corresponds to variant rs34663170 [ dbSNP | Ensembl ].
VAR_048158

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037670 mRNA. Translation: BAB03213.1.
AF340165
, AF340155, AF340156, AF340157, AF340158, AF340159, AF340160, AF340161, AF340162, AF340163, AF340164 Genomic DNA. Translation: AAK93960.1.
AJ277731 mRNA. Translation: CAC81900.1.
AK316594 mRNA. Translation: BAG38181.1.
BC035627 mRNA. Translation: AAH35627.1.
CCDSiCCDS12431.1.
RefSeqiNP_062823.1. NM_019849.2.
UniGeneiHs.58679.

Genome annotation databases

EnsembliENST00000253188; ENSP00000253188; ENSG00000130876.
GeneIDi56301.
KEGGihsa:56301.
UCSCiuc002num.2. human.

Polymorphism databases

DMDMi25089504.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037670 mRNA. Translation: BAB03213.1 .
AF340165
, AF340155 , AF340156 , AF340157 , AF340158 , AF340159 , AF340160 , AF340161 , AF340162 , AF340163 , AF340164 Genomic DNA. Translation: AAK93960.1 .
AJ277731 mRNA. Translation: CAC81900.1 .
AK316594 mRNA. Translation: BAG38181.1 .
BC035627 mRNA. Translation: AAH35627.1 .
CCDSi CCDS12431.1.
RefSeqi NP_062823.1. NM_019849.2.
UniGenei Hs.58679.

3D structure databases

ProteinModelPortali Q9NS82.
SMRi Q9NS82. Positions 39-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000253188.

Protein family/group databases

TCDBi 2.A.3.8.21. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei Q9NS82.

Polymorphism databases

DMDMi 25089504.

Proteomic databases

PRIDEi Q9NS82.

Protocols and materials databases

DNASUi 56301.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253188 ; ENSP00000253188 ; ENSG00000130876 .
GeneIDi 56301.
KEGGi hsa:56301.
UCSCi uc002num.2. human.

Organism-specific databases

CTDi 56301.
GeneCardsi GC19M033699.
HGNCi HGNC:11058. SLC7A10.
HPAi HPA041884.
MIMi 607959. gene.
neXtProti NX_Q9NS82.
PharmGKBi PA35918.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi Q9NS82.
KOi K13782.
OMAi VPPYMAT.
OrthoDBi EOG73BVCR.
PhylomeDBi Q9NS82.
TreeFami TF313355.

Enzyme and pathway databases

Reactomei REACT_12560. Basigin interactions.
REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikii SLC7A10.
GenomeRNAii 56301.
NextBioi 61967.
PROi Q9NS82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NS82.
Bgeei Q9NS82.
CleanExi HS_SLC7A10.
Genevestigatori Q9NS82.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity."
    Nakauchi J., Matsuo H., Kim D.K., Goto A., Chairoungdua A., Cha S.H., Inatomi J., Shiokawa Y., Yamaguchi K., Saito I., Endou H., Kanai Y.
    Neurosci. Lett. 287:231-235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?"
    Leclerc D., Wu Q., Ellis J.R., Goodyer P., Rozen R.
    Mol. Genet. Metab. 73:333-339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-112.
  3. Bassi M.T., Borsani G., Nunes V., Palacin M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAAA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NS82
Secondary accession number(s): B2RE84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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