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Q9NS82

- AAA1_HUMAN

UniProt

Q9NS82 - AAA1_HUMAN

Protein

Asc-type amino acid transporter 1

Gene

SLC7A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

    GO - Molecular functioni

    1. L-serine transmembrane transporter activity Source: ProtInc
    2. neutral amino acid transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. blood coagulation Source: Reactome
    3. D-alanine transport Source: Ensembl
    4. D-serine transport Source: Ensembl
    5. ion transport Source: Reactome
    6. leukocyte migration Source: Reactome
    7. L-serine transport Source: GOC
    8. neutral amino acid transport Source: UniProtKB
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_12560. Basigin interactions.
    REACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.3.8.21. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Asc-type amino acid transporter 1
    Short name:
    Asc-1
    Alternative name(s):
    Solute carrier family 7 member 10
    Gene namesi
    Name:SLC7A10
    Synonyms:ASC1
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11058. SLC7A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35918.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Asc-type amino acid transporter 1PRO_0000054276Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9NS82.

    PTM databases

    PhosphoSiteiQ9NS82.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9NS82.
    BgeeiQ9NS82.
    CleanExiHS_SLC7A10.
    GenevestigatoriQ9NS82.

    Organism-specific databases

    HPAiHPA041884.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000253188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS82.
    SMRiQ9NS82. Positions 39-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei448 – 46821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ9NS82.
    KOiK13782.
    OMAiVPPYMAT.
    OrthoDBiEOG73BVCR.
    PhylomeDBiQ9NS82.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NS82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGHTQQPSG RGNPRPAPSP SPVPGTVPGA SERVALKKEI GLLSACTIII    50
    GNIIGSGIFI SPKGVLEHSG SVGLALFVWV LGGGVTALGS LCYAELGVAI 100
    PKSGGDYAYV TEIFGGLAGF LLLWSAVLIM YPTSLAVISM TFSNYVLQPV 150
    FPNCIPPTTA SRVLSMACLM LLTWVNSSSV RWATRIQDMF TGGKLLALSL 200
    IIGVGLLQIF QGHFEELRPS NAFAFWMTPS VGHLALAFLQ GSFAFSGWNF 250
    LNYVTEEMVD ARKNLPRAIF ISIPLVTFVY TFTNIAYFTA MSPQELLSSN 300
    AVAVTFGEKL LGYFSWVMPV SVALSTFGGI NGYLFTYSRL CFSGAREGHL 350
    PSLLAMIHVR HCTPIPALLV CCGATAVIML VGDTYTLINY VSFINYLCYG 400
    VTILGLLLLR WRRPALHRPI KVNLLIPVAY LVFWAFLLVF SFISEPMVCG 450
    VGVIIILTGV PIFFLGVFWR SKPKCVHRLT ESMTHWGQEL CFVVYPQDAP 500
    EEEENGPCPP SLLPATDKPS KPQ 523
    Length:523
    Mass (Da):56,798
    Last modified:October 1, 2000 - v1
    Checksum:i24BA0B36521AC2D4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121E → D in a family with cystinuria. 1 Publication
    Corresponds to variant rs79717007 [ dbSNP | Ensembl ].
    VAR_014282
    Natural varianti413 – 4131R → Q.
    Corresponds to variant rs34663170 [ dbSNP | Ensembl ].
    VAR_048158

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037670 mRNA. Translation: BAB03213.1.
    AF340165
    , AF340155, AF340156, AF340157, AF340158, AF340159, AF340160, AF340161, AF340162, AF340163, AF340164 Genomic DNA. Translation: AAK93960.1.
    AJ277731 mRNA. Translation: CAC81900.1.
    AK316594 mRNA. Translation: BAG38181.1.
    BC035627 mRNA. Translation: AAH35627.1.
    CCDSiCCDS12431.1.
    RefSeqiNP_062823.1. NM_019849.2.
    UniGeneiHs.58679.

    Genome annotation databases

    EnsembliENST00000253188; ENSP00000253188; ENSG00000130876.
    GeneIDi56301.
    KEGGihsa:56301.
    UCSCiuc002num.2. human.

    Polymorphism databases

    DMDMi25089504.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037670 mRNA. Translation: BAB03213.1 .
    AF340165
    , AF340155 , AF340156 , AF340157 , AF340158 , AF340159 , AF340160 , AF340161 , AF340162 , AF340163 , AF340164 Genomic DNA. Translation: AAK93960.1 .
    AJ277731 mRNA. Translation: CAC81900.1 .
    AK316594 mRNA. Translation: BAG38181.1 .
    BC035627 mRNA. Translation: AAH35627.1 .
    CCDSi CCDS12431.1.
    RefSeqi NP_062823.1. NM_019849.2.
    UniGenei Hs.58679.

    3D structure databases

    ProteinModelPortali Q9NS82.
    SMRi Q9NS82. Positions 39-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000253188.

    Protein family/group databases

    TCDBi 2.A.3.8.21. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei Q9NS82.

    Polymorphism databases

    DMDMi 25089504.

    Proteomic databases

    PRIDEi Q9NS82.

    Protocols and materials databases

    DNASUi 56301.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253188 ; ENSP00000253188 ; ENSG00000130876 .
    GeneIDi 56301.
    KEGGi hsa:56301.
    UCSCi uc002num.2. human.

    Organism-specific databases

    CTDi 56301.
    GeneCardsi GC19M033699.
    HGNCi HGNC:11058. SLC7A10.
    HPAi HPA041884.
    MIMi 607959. gene.
    neXtProti NX_Q9NS82.
    PharmGKBi PA35918.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q9NS82.
    KOi K13782.
    OMAi VPPYMAT.
    OrthoDBi EOG73BVCR.
    PhylomeDBi Q9NS82.
    TreeFami TF313355.

    Enzyme and pathway databases

    Reactomei REACT_12560. Basigin interactions.
    REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    GeneWikii SLC7A10.
    GenomeRNAii 56301.
    NextBioi 61967.
    PROi Q9NS82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NS82.
    Bgeei Q9NS82.
    CleanExi HS_SLC7A10.
    Genevestigatori Q9NS82.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity."
      Nakauchi J., Matsuo H., Kim D.K., Goto A., Chairoungdua A., Cha S.H., Inatomi J., Shiokawa Y., Yamaguchi K., Saito I., Endou H., Kanai Y.
      Neurosci. Lett. 287:231-235(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?"
      Leclerc D., Wu Q., Ellis J.R., Goodyer P., Rozen R.
      Mol. Genet. Metab. 73:333-339(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-112.
    3. Bassi M.T., Borsani G., Nunes V., Palacin M.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAAA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS82
    Secondary accession number(s): B2RE84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3