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Protein

Cysteinyl leukotriene receptor 2

Gene

CYSLTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152207-MONOMER.
ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.

Chemistry databases

SwissLipidsiSLP:000001584.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
G-protein coupled receptor GPCR21
Short name:
hGPCR21
G-protein coupled receptor HG57
HPN321
Gene namesi
Name:CYSLTR2
Synonyms:CYSLT2, CYSLT2R
ORF Names:PSEC0146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:18274. CYSLTR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 123ExtracellularSequence analysisAdd BLAST30
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 153CytoplasmicSequence analysis9
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 204ExtracellularSequence analysisAdd BLAST30
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 245CytoplasmicSequence analysisAdd BLAST20
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 346CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57105.
OpenTargetsiENSG00000152207.
PharmGKBiPA38518.

Chemistry databases

ChEMBLiCHEMBL4330.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi270.

Polymorphism and mutation databases

BioMutaiCYSLTR2.
DMDMi20138034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693031 – 346Cysteinyl leukotriene receptor 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 187PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS75.
PRIDEiQ9NS75.

PTM databases

PhosphoSitePlusiQ9NS75.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Gene expression databases

BgeeiENSG00000152207.
CleanExiHS_CYSLTR2.
ExpressionAtlasiQ9NS75. baseline and differential.
GenevisibleiQ9NS75. HS.

Organism-specific databases

HPAiHPA046528.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CYSLTR1Q9Y2712EBI-3843579,EBI-9347754

Protein-protein interaction databases

BioGridi121371. 1 interactor.
IntActiQ9NS75. 5 interactors.
STRINGi9606.ENSP00000282018.

Chemistry databases

BindingDBiQ9NS75.

Structurei

3D structure databases

ProteinModelPortaliQ9NS75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGJM. Eukaryota.
ENOG410YDV0. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ9NS75.
KOiK04323.
OMAiAANSCFN.
OrthoDBiEOG091G0EA7.
PhylomeDBiQ9NS75.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF
60 70 80 90 100
WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR
110 120 130 140 150
GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT
160 170 180 190 200
SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT
210 220 230 240 250
MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII
260 270 280 290 300
ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF
310 320 330 340
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV
Length:346
Mass (Da):39,635
Last modified:October 1, 2000 - v1
Checksum:iEB54A4A2DDCE5EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038269 mRNA. Translation: BAB03601.1.
AF254664 Genomic DNA. Translation: AAG17281.1.
AF279611 Genomic DNA. Translation: AAK69485.1.
AB083603 Genomic DNA. Translation: BAB89316.1.
AY389504 Genomic DNA. Translation: AAQ91330.1.
AL137118 Genomic DNA. Translation: CAC29102.1.
BC069160 mRNA. Translation: AAH69160.1.
AB041644 Genomic DNA. Translation: BAB16379.1.
CCDSiCCDS9412.1.
RefSeqiNP_001295394.1. NM_001308465.2.
NP_001295396.1. NM_001308467.2.
NP_001295397.1. NM_001308468.2.
NP_001295398.1. NM_001308469.2.
NP_001295399.1. NM_001308470.2.
NP_001295400.1. NM_001308471.2.
NP_001295405.1. NM_001308476.2.
NP_065110.1. NM_020377.4.
UniGeneiHs.253706.
Hs.614318.

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207.
ENST00000614739; ENSP00000477930; ENSG00000152207.
GeneIDi57105.
KEGGihsa:57105.
UCSCiuc010ada.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038269 mRNA. Translation: BAB03601.1.
AF254664 Genomic DNA. Translation: AAG17281.1.
AF279611 Genomic DNA. Translation: AAK69485.1.
AB083603 Genomic DNA. Translation: BAB89316.1.
AY389504 Genomic DNA. Translation: AAQ91330.1.
AL137118 Genomic DNA. Translation: CAC29102.1.
BC069160 mRNA. Translation: AAH69160.1.
AB041644 Genomic DNA. Translation: BAB16379.1.
CCDSiCCDS9412.1.
RefSeqiNP_001295394.1. NM_001308465.2.
NP_001295396.1. NM_001308467.2.
NP_001295397.1. NM_001308468.2.
NP_001295398.1. NM_001308469.2.
NP_001295399.1. NM_001308470.2.
NP_001295400.1. NM_001308471.2.
NP_001295405.1. NM_001308476.2.
NP_065110.1. NM_020377.4.
UniGeneiHs.253706.
Hs.614318.

3D structure databases

ProteinModelPortaliQ9NS75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121371. 1 interactor.
IntActiQ9NS75. 5 interactors.
STRINGi9606.ENSP00000282018.

Chemistry databases

BindingDBiQ9NS75.
ChEMBLiCHEMBL4330.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi270.
SwissLipidsiSLP:000001584.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9NS75.

Polymorphism and mutation databases

BioMutaiCYSLTR2.
DMDMi20138034.

Proteomic databases

PaxDbiQ9NS75.
PRIDEiQ9NS75.

Protocols and materials databases

DNASUi57105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207.
ENST00000614739; ENSP00000477930; ENSG00000152207.
GeneIDi57105.
KEGGihsa:57105.
UCSCiuc010ada.2. human.

Organism-specific databases

CTDi57105.
DisGeNETi57105.
GeneCardsiCYSLTR2.
HGNCiHGNC:18274. CYSLTR2.
HPAiHPA046528.
MIMi605666. gene.
neXtProtiNX_Q9NS75.
OpenTargetsiENSG00000152207.
PharmGKBiPA38518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJM. Eukaryota.
ENOG410YDV0. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ9NS75.
KOiK04323.
OMAiAANSCFN.
OrthoDBiEOG091G0EA7.
PhylomeDBiQ9NS75.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152207-MONOMER.
ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiCysteinyl_leukotriene_receptor_2.
GenomeRNAii57105.
PROiQ9NS75.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152207.
CleanExiHS_CYSLTR2.
ExpressionAtlasiQ9NS75. baseline and differential.
GenevisibleiQ9NS75. HS.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLTR2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS75
Secondary accession number(s): Q9HCQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.