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Q9NS75

- CLTR2_HUMAN

UniProt

Q9NS75 - CLTR2_HUMAN

Protein

Cysteinyl leukotriene receptor 2

Gene

CYSLTR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

    GO - Molecular functioni

    1. cysteinyl leukotriene receptor activity Source: Ensembl
    2. leukotriene receptor activity Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. positive regulation of angiogenesis Source: Ensembl
    3. positive regulation of cell death Source: Ensembl
    4. positive regulation of ERK1 and ERK2 cascade Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Short name:
    CysLTR2
    Alternative name(s):
    G-protein coupled receptor GPCR21
    Short name:
    hGPCR21
    G-protein coupled receptor HG57
    HPN321
    Gene namesi
    Name:CYSLTR2
    Synonyms:CYSLT2, CYSLT2R
    ORF Names:PSEC0146
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:18274. CYSLTR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Cysteinyl leukotriene receptor 2PRO_0000069303Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 187PROSITE-ProRule annotation
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NS75.
    PRIDEiQ9NS75.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

    Gene expression databases

    ArrayExpressiQ9NS75.
    BgeeiQ9NS75.
    CleanExiHS_CYSLTR2.
    GenevestigatoriQ9NS75.

    Organism-specific databases

    HPAiHPA046528.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CYSLTR1Q9Y2712EBI-3843579,EBI-9347754

    Protein-protein interaction databases

    IntActiQ9NS75. 2 interactions.
    STRINGi9606.ENSP00000282018.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS75.
    SMRiQ9NS75. Positions 8-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 729CytoplasmicSequence Analysis
    Topological domaini94 – 12330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 1539CytoplasmicSequence Analysis
    Topological domaini175 – 20430ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini308 – 34639CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiQ9NS75.
    KOiK04323.
    OMAiHPFRLLH.
    OrthoDBiEOG74FF1B.
    PhylomeDBiQ9NS75.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NS75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF    50
    WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR 100
    GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT 150
    SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT 200
    MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII 250
    ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF 300
    NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV 346
    Length:346
    Mass (Da):39,635
    Last modified:October 1, 2000 - v1
    Checksum:iEB54A4A2DDCE5EE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038269 mRNA. Translation: BAB03601.1.
    AF254664 Genomic DNA. Translation: AAG17281.1.
    AF279611 Genomic DNA. Translation: AAK69485.1.
    AB083603 Genomic DNA. Translation: BAB89316.1.
    AY389504 Genomic DNA. Translation: AAQ91330.1.
    AL137118 Genomic DNA. Translation: CAC29102.1.
    BC069160 mRNA. Translation: AAH69160.1.
    AB041644 Genomic DNA. Translation: BAB16379.1.
    CCDSiCCDS9412.1.
    RefSeqiNP_065110.1. NM_020377.2.
    UniGeneiHs.253706.
    Hs.614318.

    Genome annotation databases

    EnsembliENST00000282018; ENSP00000282018; ENSG00000152207.
    GeneIDi57105.
    KEGGihsa:57105.
    UCSCiuc001vck.2. human.

    Polymorphism databases

    DMDMi20138034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038269 mRNA. Translation: BAB03601.1 .
    AF254664 Genomic DNA. Translation: AAG17281.1 .
    AF279611 Genomic DNA. Translation: AAK69485.1 .
    AB083603 Genomic DNA. Translation: BAB89316.1 .
    AY389504 Genomic DNA. Translation: AAQ91330.1 .
    AL137118 Genomic DNA. Translation: CAC29102.1 .
    BC069160 mRNA. Translation: AAH69160.1 .
    AB041644 Genomic DNA. Translation: BAB16379.1 .
    CCDSi CCDS9412.1.
    RefSeqi NP_065110.1. NM_020377.2.
    UniGenei Hs.253706.
    Hs.614318.

    3D structure databases

    ProteinModelPortali Q9NS75.
    SMRi Q9NS75. Positions 8-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9NS75. 2 interactions.
    STRINGi 9606.ENSP00000282018.

    Chemistry

    BindingDBi Q9NS75.
    ChEMBLi CHEMBL2094254.
    DrugBanki DB00716. Nedocromil.
    GuidetoPHARMACOLOGYi 270.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 20138034.

    Proteomic databases

    PaxDbi Q9NS75.
    PRIDEi Q9NS75.

    Protocols and materials databases

    DNASUi 57105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282018 ; ENSP00000282018 ; ENSG00000152207 .
    GeneIDi 57105.
    KEGGi hsa:57105.
    UCSCi uc001vck.2. human.

    Organism-specific databases

    CTDi 57105.
    GeneCardsi GC13P049280.
    HGNCi HGNC:18274. CYSLTR2.
    HPAi HPA046528.
    MIMi 605666. gene.
    neXtProti NX_Q9NS75.
    PharmGKBi PA38518.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119185.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi Q9NS75.
    KOi K04323.
    OMAi HPFRLLH.
    OrthoDBi EOG74FF1B.
    PhylomeDBi Q9NS75.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18302. Leukotriene receptors.

    Miscellaneous databases

    GeneWikii Cysteinyl_leukotriene_receptor_2.
    GenomeRNAii 57105.
    NextBioi 62945.
    PROi Q9NS75.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NS75.
    Bgeei Q9NS75.
    CleanExi HS_CYSLTR2.
    Genevestigatori Q9NS75.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor."
      Takasaki J., Kamohara M., Matsumoto M., Saito T., Sugimoto T., Ota T., Nishikawa T., Kawai Y., Masuho Y., Isogai T., Suzuki Y., Sugano S., Furuichi K.
      Biochem. Biophys. Res. Commun. 274:316-322(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist."
      Nothacker H.-P., Wang Z., Zhu Y., Reinscheid R.K., Lin S.H.S., Civelli O.
      Mol. Pharmacol. 58:1601-1608(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Homo sapiens cysteinyl leukotriene receptor 1 like receptor."
      Suga H.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-346.

    Entry informationi

    Entry nameiCLTR2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS75
    Secondary accession number(s): Q9HCQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3