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Q9NS75 (CLTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 2

Short name=CysLTR2
Alternative name(s):
G-protein coupled receptor GPCR21
Short name=hGPCR21
G-protein coupled receptor HG57
HPN321
Gene names
Name:CYSLTR2
Synonyms:CYSLT2, CYSLT2R
ORF Names:PSEC0146
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Cysteinyl leukotriene receptor 2
PRO_0000069303

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 6321Helical; Name=1; Potential
Topological domain64 – 729Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 12330Extracellular Potential
Transmembrane124 – 14421Helical; Name=3; Potential
Topological domain145 – 1539Cytoplasmic Potential
Transmembrane154 – 17421Helical; Name=4; Potential
Topological domain175 – 20430Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 24520Cytoplasmic Potential
Transmembrane246 – 26621Helical; Name=6; Potential
Topological domain267 – 28620Extracellular Potential
Transmembrane287 – 30721Helical; Name=7; Potential
Topological domain308 – 34639Cytoplasmic Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9NS75 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: EB54A4A2DDCE5EE4

FASTA34639,635
        10         20         30         40         50         60 
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF WGVLGNGLSI 

        70         80         90        100        110        120 
YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR GSNWIFGDLA CRIMSYSLYV 

       130        140        150        160        170        180 
NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT SIRSAWILCG IIWILIMASS IMLLDSGSEQ 

       190        200        210        220        230        240 
NGSVTSCLEL NLYKIAKLQT MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV 

       250        260        270        280        290        300 
SHRKALTTII ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF 

       310        320        330        340 
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV 

« Hide

References

« Hide 'large scale' references
[1]"The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor."
Takasaki J., Kamohara M., Matsumoto M., Saito T., Sugimoto T., Ota T., Nishikawa T., Kawai Y., Masuho Y., Isogai T., Suzuki Y., Sugano S., Furuichi K.
Biochem. Biophys. Res. Commun. 274:316-322(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Characterization of the human cysteinyl leukotriene 2 receptor."
Heise C.E., O'Dowd B.F., Figueroa D.J., Sawyer N., Nguyen T., Im D.-S., Stocco R., Bellefeuille J.N., Abramovitz M., Cheng R., Williams D.L. Jr., Zeng Z., Liu Q., Ma L., Clements M.K., Coulombe N., Liu Y., Austin C.P. expand/collapse author list , George S.R., O'Neill G.P., Metters K.M., Lynch K.R., Evans J.F.
J. Biol. Chem. 275:30531-30536(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist."
Nothacker H.-P., Wang Z., Zhu Y., Reinscheid R.K., Lin S.H.S., Civelli O.
Mol. Pharmacol. 58:1601-1608(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Homo sapiens cysteinyl leukotriene receptor 1 like receptor."
Suga H.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-346.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB038269 mRNA. Translation: BAB03601.1.
AF254664 Genomic DNA. Translation: AAG17281.1.
AF279611 Genomic DNA. Translation: AAK69485.1.
AB083603 Genomic DNA. Translation: BAB89316.1.
AY389504 Genomic DNA. Translation: AAQ91330.1.
AL137118 Genomic DNA. Translation: CAC29102.1.
BC069160 mRNA. Translation: AAH69160.1.
AB041644 Genomic DNA. Translation: BAB16379.1.
RefSeqNP_065110.1. NM_020377.2.
UniGeneHs.253706.
Hs.614318.

3D structure databases

ProteinModelPortalQ9NS75.
SMRQ9NS75. Positions 34-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9NS75. 1 interaction.
STRING9606.ENSP00000282018.

Chemistry

BindingDBQ9NS75.
ChEMBLCHEMBL2094254.
DrugBankDB00716. Nedocromil.
GuidetoPHARMACOLOGY270.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM20138034.

Proteomic databases

PaxDbQ9NS75.
PRIDEQ9NS75.

Protocols and materials databases

DNASU57105.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282018; ENSP00000282018; ENSG00000152207.
GeneID57105.
KEGGhsa:57105.
UCSCuc001vck.2. human.

Organism-specific databases

CTD57105.
GeneCardsGC13P049280.
HGNCHGNC:18274. CYSLTR2.
HPAHPA046528.
MIM605666. gene.
neXtProtNX_Q9NS75.
PharmGKBPA38518.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119185.
HOGENOMHOG000236328.
HOVERGENHBG099611.
InParanoidQ9NS75.
KOK04323.
OMAHPFRLLH.
OrthoDBEOG74FF1B.
PhylomeDBQ9NS75.
TreeFamTF350009.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NS75.
BgeeQ9NS75.
CleanExHS_CYSLTR2.
GenevestigatorQ9NS75.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCysteinyl_leukotriene_receptor_2.
GenomeRNAi57105.
NextBio62945.
PROQ9NS75.
SOURCESearch...

Entry information

Entry nameCLTR2_HUMAN
AccessionPrimary (citable) accession number: Q9NS75
Secondary accession number(s): Q9HCQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries