SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NS75

- CLTR2_HUMAN

UniProt

Q9NS75 - CLTR2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cysteinyl leukotriene receptor 2
Gene
CYSLTR2, CYSLT2, CYSLT2R, PSEC0146
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

GO - Molecular functioni

  1. cysteinyl leukotriene receptor activity Source: Ensembl
  2. leukotriene receptor activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. immune response Source: UniProtKB
  2. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  3. positive regulation of angiogenesis Source: Ensembl
  4. positive regulation of cell death Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
G-protein coupled receptor GPCR21
Short name:
hGPCR21
G-protein coupled receptor HG57
HPN321
Gene namesi
Name:CYSLTR2
Synonyms:CYSLT2, CYSLT2R
ORF Names:PSEC0146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:18274. CYSLTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Extracellular Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini64 – 729Cytoplasmic Reviewed prediction
Transmembranei73 – 9321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini94 – 12330Extracellular Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini145 – 1539Cytoplasmic Reviewed prediction
Transmembranei154 – 17421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini175 – 20430Extracellular Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini226 – 24520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini267 – 28620Extracellular Reviewed prediction
Add
BLAST
Transmembranei287 – 30721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini308 – 34639Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cysteinyl leukotriene receptor 2
PRO_0000069303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi30 – 301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 187 By similarity
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS75.
PRIDEiQ9NS75.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Gene expression databases

ArrayExpressiQ9NS75.
BgeeiQ9NS75.
CleanExiHS_CYSLTR2.
GenevestigatoriQ9NS75.

Organism-specific databases

HPAiHPA046528.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CYSLTR1Q9Y2712EBI-3843579,EBI-9347754

Protein-protein interaction databases

IntActiQ9NS75. 2 interactions.
STRINGi9606.ENSP00000282018.

Structurei

3D structure databases

ProteinModelPortaliQ9NS75.
SMRiQ9NS75. Positions 8-321.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ9NS75.
KOiK04323.
OMAiHPFRLLH.
OrthoDBiEOG74FF1B.
PhylomeDBiQ9NS75.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS75-1 [UniParc]FASTAAdd to Basket

« Hide

MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF    50
WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR 100
GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT 150
SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT 200
MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII 250
ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF 300
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV 346
Length:346
Mass (Da):39,635
Last modified:October 1, 2000 - v1
Checksum:iEB54A4A2DDCE5EE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038269 mRNA. Translation: BAB03601.1.
AF254664 Genomic DNA. Translation: AAG17281.1.
AF279611 Genomic DNA. Translation: AAK69485.1.
AB083603 Genomic DNA. Translation: BAB89316.1.
AY389504 Genomic DNA. Translation: AAQ91330.1.
AL137118 Genomic DNA. Translation: CAC29102.1.
BC069160 mRNA. Translation: AAH69160.1.
AB041644 Genomic DNA. Translation: BAB16379.1.
CCDSiCCDS9412.1.
RefSeqiNP_065110.1. NM_020377.2.
UniGeneiHs.253706.
Hs.614318.

Genome annotation databases

EnsembliENST00000282018; ENSP00000282018; ENSG00000152207.
GeneIDi57105.
KEGGihsa:57105.
UCSCiuc001vck.2. human.

Polymorphism databases

DMDMi20138034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038269 mRNA. Translation: BAB03601.1 .
AF254664 Genomic DNA. Translation: AAG17281.1 .
AF279611 Genomic DNA. Translation: AAK69485.1 .
AB083603 Genomic DNA. Translation: BAB89316.1 .
AY389504 Genomic DNA. Translation: AAQ91330.1 .
AL137118 Genomic DNA. Translation: CAC29102.1 .
BC069160 mRNA. Translation: AAH69160.1 .
AB041644 Genomic DNA. Translation: BAB16379.1 .
CCDSi CCDS9412.1.
RefSeqi NP_065110.1. NM_020377.2.
UniGenei Hs.253706.
Hs.614318.

3D structure databases

ProteinModelPortali Q9NS75.
SMRi Q9NS75. Positions 8-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9NS75. 2 interactions.
STRINGi 9606.ENSP00000282018.

Chemistry

BindingDBi Q9NS75.
ChEMBLi CHEMBL2094254.
DrugBanki DB00716. Nedocromil.
GuidetoPHARMACOLOGYi 270.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 20138034.

Proteomic databases

PaxDbi Q9NS75.
PRIDEi Q9NS75.

Protocols and materials databases

DNASUi 57105.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282018 ; ENSP00000282018 ; ENSG00000152207 .
GeneIDi 57105.
KEGGi hsa:57105.
UCSCi uc001vck.2. human.

Organism-specific databases

CTDi 57105.
GeneCardsi GC13P049280.
HGNCi HGNC:18274. CYSLTR2.
HPAi HPA046528.
MIMi 605666. gene.
neXtProti NX_Q9NS75.
PharmGKBi PA38518.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119185.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q9NS75.
KOi K04323.
OMAi HPFRLLH.
OrthoDBi EOG74FF1B.
PhylomeDBi Q9NS75.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18302. Leukotriene receptors.

Miscellaneous databases

GeneWikii Cysteinyl_leukotriene_receptor_2.
GenomeRNAii 57105.
NextBioi 62945.
PROi Q9NS75.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NS75.
Bgeei Q9NS75.
CleanExi HS_CYSLTR2.
Genevestigatori Q9NS75.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor."
    Takasaki J., Kamohara M., Matsumoto M., Saito T., Sugimoto T., Ota T., Nishikawa T., Kawai Y., Masuho Y., Isogai T., Suzuki Y., Sugano S., Furuichi K.
    Biochem. Biophys. Res. Commun. 274:316-322(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist."
    Nothacker H.-P., Wang Z., Zhu Y., Reinscheid R.K., Lin S.H.S., Civelli O.
    Mol. Pharmacol. 58:1601-1608(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Homo sapiens cysteinyl leukotriene receptor 1 like receptor."
    Suga H.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-346.

Entry informationi

Entry nameiCLTR2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS75
Secondary accession number(s): Q9HCQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi