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Protein

Gastrokine-1

Gene

GKN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.1 Publication

GO - Biological processi

  • digestion Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-1
Alternative name(s):
18 kDa antrum mucosa protein
Short name:
AMP-18
Protein CA11
Gene namesi
Name:GKN1
Synonyms:AMP18, CA11
ORF Names:UNQ489/PRO1005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23217. GKN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898851.

Polymorphism and mutation databases

BioMutaiGKN1.
DMDMi223590223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434By similarityAdd
BLAST
Chaini35 – 199165Gastrokine-1PRO_0000021332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 156By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NS71.
PRIDEiQ9NS71.

PTM databases

PhosphoSiteiQ9NS71.

Expressioni

Tissue specificityi

Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.2 Publications

Gene expression databases

BgeeiQ9NS71.
CleanExiHS_CA11.
HS_GKN1.
GenevisibleiQ9NS71. HS.

Organism-specific databases

HPAiHPA047684.

Interactioni

Protein-protein interaction databases

BioGridi121133. 10 interactions.
IntActiQ9NS71. 1 interaction.
STRINGi9606.ENSP00000367172.

Structurei

3D structure databases

ProteinModelPortaliQ9NS71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 16497BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the gastrokine family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVWS. Eukaryota.
ENOG410YN1G. LUCA.
GeneTreeiENSGT00530000063697.
HOGENOMiHOG000112728.
HOVERGENiHBG009322.
InParanoidiQ9NS71.
OMAiCIVHKMN.
OrthoDBiEOG7BKCW4.
PhylomeDBiQ9NS71.
TreeFamiTF335950.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAYSSVHCF REDKMKFTIV FAGLLGVFLA PALANYNINV NDDNNNAGSG
60 70 80 90 100
QQSVSVNNEH NVANVDNNNG WDSWNSIWDY GNGFAATRLF QKKTCIVHKM
110 120 130 140 150
NKEVMPSIQS LDALVKEKKL QGKGPGGPPP KGLMYSVNPN KVDDLSKFGK
160 170 180 190
NIANMCRGIP TYMAEEMQEA SLFFYSGTCY TTSVLWIVDI SFCGDTVEN
Length:199
Mass (Da):21,999
Last modified:February 10, 2009 - v3
Checksum:iC099B8B9A1338D7A
GO

Sequence cautioni

The sequence AAN75447.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAN75449.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ89409.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181K → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_035923

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039886 mRNA. Translation: BAA92433.1.
AY139182 Genomic DNA. Translation: AAN75447.1. Different initiation.
AY139184 mRNA. Translation: AAN75449.1. Different initiation.
AC114802 Genomic DNA. No translation available.
BC059778 mRNA. Translation: AAH59778.2.
AY359050 mRNA. Translation: AAQ89409.1. Different initiation.
CCDSiCCDS1891.2.
RefSeqiNP_062563.3. NM_019617.3.
UniGeneiHs.69319.

Genome annotation databases

EnsembliENST00000377938; ENSP00000367172; ENSG00000169605.
GeneIDi56287.
KEGGihsa:56287.
UCSCiuc002sfc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039886 mRNA. Translation: BAA92433.1.
AY139182 Genomic DNA. Translation: AAN75447.1. Different initiation.
AY139184 mRNA. Translation: AAN75449.1. Different initiation.
AC114802 Genomic DNA. No translation available.
BC059778 mRNA. Translation: AAH59778.2.
AY359050 mRNA. Translation: AAQ89409.1. Different initiation.
CCDSiCCDS1891.2.
RefSeqiNP_062563.3. NM_019617.3.
UniGeneiHs.69319.

3D structure databases

ProteinModelPortaliQ9NS71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121133. 10 interactions.
IntActiQ9NS71. 1 interaction.
STRINGi9606.ENSP00000367172.

PTM databases

PhosphoSiteiQ9NS71.

Polymorphism and mutation databases

BioMutaiGKN1.
DMDMi223590223.

Proteomic databases

PaxDbiQ9NS71.
PRIDEiQ9NS71.

Protocols and materials databases

DNASUi56287.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377938; ENSP00000367172; ENSG00000169605.
GeneIDi56287.
KEGGihsa:56287.
UCSCiuc002sfc.4. human.

Organism-specific databases

CTDi56287.
GeneCardsiGKN1.
HGNCiHGNC:23217. GKN1.
HPAiHPA047684.
MIMi606402. gene.
neXtProtiNX_Q9NS71.
PharmGKBiPA134898851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVWS. Eukaryota.
ENOG410YN1G. LUCA.
GeneTreeiENSGT00530000063697.
HOGENOMiHOG000112728.
HOVERGENiHBG009322.
InParanoidiQ9NS71.
OMAiCIVHKMN.
OrthoDBiEOG7BKCW4.
PhylomeDBiQ9NS71.
TreeFamiTF335950.

Miscellaneous databases

GenomeRNAii56287.
NextBioi61955.
PROiQ9NS71.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NS71.
CleanExiHS_CA11.
HS_GKN1.
GenevisibleiQ9NS71. HS.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of two novel genes, down-regulated in gastric cancer."
    Yoshikawa Y., Mukai H., Hino F., Asada K., Kato I.
    Jpn. J. Cancer Res. 91:459-463(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Stomach.
  2. "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa."
    Martin T.E., Powell C.T., Wang Z., Bhattacharyya S., Walsh-Reitz M.M., Agarwal K., Toback F.G.
    Am. J. Physiol. 285:G332-G343(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Stomach.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-199.
    Tissue: Colon.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-199.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-118.

Entry informationi

Entry nameiGKN1_HUMAN
AccessioniPrimary (citable) accession number: Q9NS71
Secondary accession number(s): Q8IUA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: March 16, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.