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Protein

Mitochondrial import receptor subunit TOM22 homolog

Gene

TOMM22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.1 Publication

GO - Molecular functioni

GO - Biological processi

  • macroautophagy Source: Reactome
  • protein import into mitochondrial matrix Source: GO_Central
  • protein import into mitochondrial outer membrane Source: BHF-UCL
  • protein targeting to mitochondrion Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100216-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM22 homolog
Short name:
hTom22
Alternative name(s):
1C9-2
Translocase of outer membrane 22 kDa subunit homolog
Gene namesi
Name:TOMM22
Synonyms:TOM22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18002. TOMM22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 83CytoplasmicSequence analysisAdd BLAST82
Transmembranei84 – 103HelicalSequence analysisAdd BLAST20
Topological domaini104 – 142Mitochondrial intermembraneSequence analysisAdd BLAST39

GO - Cellular componenti

  • integral component of membrane Source: BHF-UCL
  • integral component of mitochondrial outer membrane Source: GO_Central
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: Ensembl
  • mitochondrial outer membrane Source: Reactome
  • mitochondrial outer membrane translocase complex Source: BHF-UCL
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56993.
OpenTargetsiENSG00000100216.
PharmGKBiPA38275.

Polymorphism and mutation databases

BioMutaiTOMM22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000761062 – 142Mitochondrial import receptor subunit TOM22 homologAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei15PhosphoserineCombined sources1
Modified residuei43PhosphothreonineCombined sources1
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NS69.
MaxQBiQ9NS69.
PaxDbiQ9NS69.
PeptideAtlasiQ9NS69.
PRIDEiQ9NS69.
TopDownProteomicsiQ9NS69.

PTM databases

iPTMnetiQ9NS69.
PhosphoSitePlusiQ9NS69.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100216.
CleanExiHS_TOMM22.
ExpressionAtlasiQ9NS69. baseline and differential.
GenevisibleiQ9NS69. HS.

Organism-specific databases

HPAiHPA003037.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MP034192EBI-1047508,EBI-10042882From a different organism.
TOMM7Q9P0U12EBI-1047508,EBI-1180558

Protein-protein interaction databases

BioGridi121308. 70 interactors.
IntActiQ9NS69. 14 interactors.
STRINGi9606.ENSP00000216034.

Structurei

3D structure databases

ProteinModelPortaliQ9NS69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 50Import sequence; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarity10
Regioni83 – 103TMD; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST21
Regioni123 – 142C-tail signal; necessary for mitochondrion outer membrane localization and integration in the TOM complexBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 118Poly-Gln9

Domaini

Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.By similarity

Sequence similaritiesi

Belongs to the Tom22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4111. Eukaryota.
ENOG41122K3. LUCA.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
HOVERGENiHBG061819.
InParanoidiQ9NS69.
KOiK17769.
OMAiFYTFSCN.
OrthoDBiEOG091G0XN1.
PhylomeDBiQ9NS69.
TreeFamiTF106201.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NS69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG
60 70 80 90 100
LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRAALWIGTT SFMILVLPVV
110 120 130 140
FETEKLQMEQ QQQLQQRQIL LGPNTGLSGG MPGALPSLPG KI
Length:142
Mass (Da):15,522
Last modified:January 23, 2007 - v3
Checksum:iC957232F8420F34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040119 mRNA. Translation: BAB03306.1.
AB041906 mRNA. Translation: BAB16408.1.
AK024731 mRNA. Translation: BAB14979.1.
CR456475 mRNA. Translation: CAG30361.1.
BC009363 mRNA. Translation: AAH09363.1.
CCDSiCCDS13975.1.
RefSeqiNP_064628.1. NM_020243.4.
UniGeneiHs.595072.

Genome annotation databases

EnsembliENST00000216034; ENSP00000216034; ENSG00000100216.
GeneIDi56993.
KEGGihsa:56993.
UCSCiuc003awe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040119 mRNA. Translation: BAB03306.1.
AB041906 mRNA. Translation: BAB16408.1.
AK024731 mRNA. Translation: BAB14979.1.
CR456475 mRNA. Translation: CAG30361.1.
BC009363 mRNA. Translation: AAH09363.1.
CCDSiCCDS13975.1.
RefSeqiNP_064628.1. NM_020243.4.
UniGeneiHs.595072.

3D structure databases

ProteinModelPortaliQ9NS69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121308. 70 interactors.
IntActiQ9NS69. 14 interactors.
STRINGi9606.ENSP00000216034.

PTM databases

iPTMnetiQ9NS69.
PhosphoSitePlusiQ9NS69.

Polymorphism and mutation databases

BioMutaiTOMM22.

Proteomic databases

EPDiQ9NS69.
MaxQBiQ9NS69.
PaxDbiQ9NS69.
PeptideAtlasiQ9NS69.
PRIDEiQ9NS69.
TopDownProteomicsiQ9NS69.

Protocols and materials databases

DNASUi56993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216034; ENSP00000216034; ENSG00000100216.
GeneIDi56993.
KEGGihsa:56993.
UCSCiuc003awe.4. human.

Organism-specific databases

CTDi56993.
DisGeNETi56993.
GeneCardsiTOMM22.
HGNCiHGNC:18002. TOMM22.
HPAiHPA003037.
MIMi607046. gene.
neXtProtiNX_Q9NS69.
OpenTargetsiENSG00000100216.
PharmGKBiPA38275.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4111. Eukaryota.
ENOG41122K3. LUCA.
GeneTreeiENSGT00390000016475.
HOGENOMiHOG000067816.
HOVERGENiHBG061819.
InParanoidiQ9NS69.
KOiK17769.
OMAiFYTFSCN.
OrthoDBiEOG091G0XN1.
PhylomeDBiQ9NS69.
TreeFamiTF106201.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100216-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

ChiTaRSiTOMM22. human.
GeneWikiiTOMM22.
GenomeRNAii56993.
PROiQ9NS69.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100216.
CleanExiHS_TOMM22.
ExpressionAtlasiQ9NS69. baseline and differential.
GenevisibleiQ9NS69. HS.

Family and domain databases

InterProiIPR005683. Tom22.
[Graphical view]
PfamiPF04281. Tom22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NS69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.