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Protein

Tumor necrosis factor receptor superfamily member 19

Gene

TNFRSF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • hair follicle development Source: Ensembl
  • JNK cascade Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • positive regulation of JNK cascade Source: GO_Central
  • tissue development Source: GO_Central

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

SignaLinkiQ9NS68

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:TNFRSF19
Synonyms:TAJ, TROY
ORF Names:UNQ1888/PRO4333
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000127863.15
HGNCiHGNC:11915 TNFRSF19
MIMi606122 gene
neXtProtiNX_Q9NS68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 170ExtracellularSequence analysisAdd BLAST141
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 423CytoplasmicSequence analysisAdd BLAST232

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55504
OpenTargetsiENSG00000127863
PharmGKBiPA36608

Polymorphism and mutation databases

BioMutaiTNFRSF19
DMDMi21264102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000003459730 – 423Tumor necrosis factor receptor superfamily member 19Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NS68
PaxDbiQ9NS68
PeptideAtlasiQ9NS68
PRIDEiQ9NS68

PTM databases

iPTMnetiQ9NS68
PhosphoSitePlusiQ9NS68

Expressioni

Tissue specificityi

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000127863
CleanExiHS_TNFRSF19
ExpressionAtlasiQ9NS68 baseline and differential
GenevisibleiQ9NS68 HS

Organism-specific databases

HPAiHPA010135

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.2 Publications

Protein-protein interaction databases

BioGridi120684, 45 interactors
CORUMiQ9NS68
IntActiQ9NS68, 5 interactors
STRINGi9606.ENSP00000371693

Structurei

3D structure databases

ProteinModelPortaliQ9NS68
SMRiQ9NS68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 72TNFR-Cys 1Add BLAST40
Repeati74 – 114TNFR-Cys 2Add BLAST41
Repeati116 – 149TNFR-Cys 3Add BLAST34

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRK Eukaryota
ENOG410ZU96 LUCA
GeneTreeiENSGT00730000110978
HOGENOMiHOG000049070
HOVERGENiHBG069143
InParanoidiQ9NS68
KOiK05155
OMAiAWPLMQN
OrthoDBiEOG091G0ADI
PhylomeDBiQ9NS68
TreeFamiTF331385

Family and domain databases

CDDicd13418 TNFRSF19, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022342 TNFR_19
IPR034047 TNFRSF19_N
PANTHERiPTHR12120:SF1 PTHR12120:SF1, 1 hit
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01969 TNFACTORR19
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS68-1) [UniParc]FASTAAdd to basket
Also known as: TAJ-alpha, TRADEalpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR
110 120 130 140 150
FQKANCSATS DAICGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCA
160 170 180 190 200
SKVNLVKIAS TASSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD SVQTCGPVRL
260 270 280 290 300
LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
310 320 330 340 350
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN
360 370 380 390 400
SSQDLVGGAV PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ
410 420
ESGAVIHPAT QTSLQVRQRL GSL
Length:423
Mass (Da):46,015
Last modified:October 1, 2000 - v1
Checksum:iB5891CEA9ED45361
GO
Isoform 2 (identifier: Q9NS68-2) [UniParc]FASTAAdd to basket
Also known as: TRADEbeta

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA

Show »
Length:417
Mass (Da):45,305
Checksum:i3AA85D783F0835C4
GO
Isoform 3 (identifier: Q9NS68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     416-423: VRQRLGSL → EA

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,542
Checksum:i4798BE078A891985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74T → A in AAF71828 (PubMed:10809768).Curated1
Sequence conflicti215 – 216GS → ET in AAF71828 (PubMed:10809768).Curated2
Sequence conflicti221F → L in AAK28396 (Ref. 3) Curated1
Sequence conflicti330T → A in AAK28396 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02427831S → T1 PublicationCorresponds to variant dbSNP:rs9550987Ensembl.1
Natural variantiVAR_070812159A → V1 PublicationCorresponds to variant dbSNP:rs61756242Ensembl.1
Natural variantiVAR_024279405V → I2 PublicationsCorresponds to variant dbSNP:rs3751362Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448861 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_006512416 – 423VRQRLGSL → EA in isoform 2 and isoform 3. 4 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA Translation: AAF71828.1
AB040434 mRNA Translation: BAB03269.1
AF246998 mRNA Translation: AAK28395.1
AF246999 mRNA Translation: AAK28396.1
AY358888 mRNA Translation: AAQ89247.1
AK292874 mRNA Translation: BAF85563.1
AK292891 mRNA Translation: BAF85580.1
AK304290 mRNA Translation: BAG65148.1
AL161422 Genomic DNA No translation available.
AL354815 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08326.1
BC047321 mRNA Translation: AAH47321.1
CCDSiCCDS55893.1 [Q9NS68-3]
CCDS9301.1 [Q9NS68-2]
CCDS9302.1 [Q9NS68-1]
RefSeqiNP_001191387.1, NM_001204458.1 [Q9NS68-2]
NP_001191388.1, NM_001204459.1 [Q9NS68-3]
NP_061117.2, NM_018647.3 [Q9NS68-1]
NP_683760.1, NM_148957.3 [Q9NS68-2]
XP_005266502.1, XM_005266445.2 [Q9NS68-1]
XP_011533448.1, XM_011535146.1 [Q9NS68-1]
XP_016876140.1, XM_017020651.1 [Q9NS68-1]
UniGeneiHs.149168
Hs.730848

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863 [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863 [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863 [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863 [Q9NS68-3]
GeneIDi55504
KEGGihsa:55504
UCSCiuc001uot.4 human [Q9NS68-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiTNR19_HUMAN
AccessioniPrimary (citable) accession number: Q9NS68
Secondary accession number(s): A8KA09
, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NZV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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