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Q9NS68 (TNR19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene names
Name:TNFRSF19
Synonyms:TAJ, TROY
ORF Names:UNQ1888/PRO4333
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Subunit structure

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1. Ref.1 Ref.10

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Sequence similarities

Contains 3 TNFR-Cys repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NS68-1)

Also known as: TAJ-alpha; TRADEalpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NS68-2)

Also known as: TRADEbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA
Isoform 3 (identifier: Q9NS68-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     416-423: VRQRLGSL → EA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.9
Chain30 – 423394Tumor necrosis factor receptor superfamily member 19
PRO_0000034597

Regions

Topological domain30 – 170141Extracellular Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 423232Cytoplasmic Potential
Repeat33 – 7240TNFR-Cys 1
Repeat74 – 11441TNFR-Cys 2
Repeat116 – 14934TNFR-Cys 3

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 46 By similarity
Disulfide bond49 ↔ 62 By similarity
Disulfide bond52 ↔ 72 By similarity
Disulfide bond75 ↔ 89 By similarity
Disulfide bond92 ↔ 106 By similarity
Disulfide bond95 ↔ 114 By similarity
Disulfide bond117 ↔ 135 By similarity
Disulfide bond138 ↔ 149 By similarity

Natural variations

Alternative sequence1 – 132132Missing in isoform 3.
VSP_044886
Alternative sequence416 – 4238VRQRLGSL → EA in isoform 2 and isoform 3.
VSP_006512
Natural variant311S → T. Ref.3
Corresponds to variant rs9550987 [ dbSNP | Ensembl ].
VAR_024278
Natural variant1591A → V. Ref.5
Corresponds to variant rs61756242 [ dbSNP | Ensembl ].
VAR_070812
Natural variant4051V → I. Ref.3 Ref.5
Corresponds to variant rs3751362 [ dbSNP | Ensembl ].
VAR_024279

Experimental info

Sequence conflict741T → A in AAF71828. Ref.1
Sequence conflict215 – 2162GS → ET in AAF71828. Ref.1
Sequence conflict2211F → L in AAK28396. Ref.3
Sequence conflict3301T → A in AAK28396. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (TAJ-alpha) (TRADEalpha) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B5891CEA9ED45361

FASTA42346,015
        10         20         30         40         50         60 
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK 

        70         80         90        100        110        120 
ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG 

       130        140        150        160        170        180 
FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT 

       190        200        210        220        230        240 
VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD 

       250        260        270        280        290        300 
SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI 

       310        320        330        340        350        360 
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV 

       370        380        390        400        410        420 
PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQVRQRL 


GSL 

« Hide

Isoform 2 (TRADEbeta) [UniParc].

Checksum: 3AA85D783F0835C4
Show »

FASTA41745,305
Isoform 3 [UniParc].

Checksum: 4798BE078A891985
Show »

FASTA28530,542

References

« Hide 'large scale' references
[1]"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRAF1; TRAF2; TRAF3 AND TRAF5.
Tissue: Fetal spleen.
[2]"TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
J. Biol. Chem. 275:20742-20747(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Glial tumor.
[3]"TRADE, a novel TNF receptor family member associated with death signaling."
Chaudhary D., Long A.J.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-31 AND ILE-405.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS VAL-159 AND ILE-405.
Tissue: Trachea.
[6]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[9]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-44.
[10]"A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors."
Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z.
Neuron 45:345-351(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LINGO1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF167555 mRNA. Translation: AAF71828.1.
AB040434 mRNA. Translation: BAB03269.1.
AF246998 mRNA. Translation: AAK28395.1.
AF246999 mRNA. Translation: AAK28396.1.
AY358888 mRNA. Translation: AAQ89247.1.
AK292874 mRNA. Translation: BAF85563.1.
AK292891 mRNA. Translation: BAF85580.1.
AK304290 mRNA. Translation: BAG65148.1.
AL161422 Genomic DNA. Translation: CAH70837.2.
AL161422 Genomic DNA. Translation: CAH70838.1.
AL354815 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08326.1.
BC047321 mRNA. Translation: AAH47321.1.
CCDSCCDS55893.1. [Q9NS68-3]
CCDS9301.1. [Q9NS68-2]
CCDS9302.1. [Q9NS68-1]
RefSeqNP_001191387.1. NM_001204458.1. [Q9NS68-2]
NP_001191388.1. NM_001204459.1. [Q9NS68-3]
NP_061117.2. NM_018647.3. [Q9NS68-1]
NP_683760.1. NM_148957.3. [Q9NS68-2]
XP_005266502.1. XM_005266445.1. [Q9NS68-1]
UniGeneHs.149168.
Hs.730848.

3D structure databases

ProteinModelPortalQ9NS68.
SMRQ9NS68. Positions 33-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120684. 4 interactions.
IntActQ9NS68. 3 interactions.
STRING9606.ENSP00000371693.

PTM databases

PhosphoSiteQ9NS68.

Polymorphism databases

DMDM21264102.

Proteomic databases

MaxQBQ9NS68.
PaxDbQ9NS68.
PRIDEQ9NS68.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248484; ENSP00000248484; ENSG00000127863. [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863. [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863. [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863. [Q9NS68-3]
GeneID55504.
KEGGhsa:55504.
UCSCuc001uot.3. human. [Q9NS68-2]
uc001uov.2. human. [Q9NS68-1]

Organism-specific databases

CTD55504.
GeneCardsGC13P024144.
HGNCHGNC:11915. TNFRSF19.
HPAHPA010135.
MIM606122. gene.
neXtProtNX_Q9NS68.
PharmGKBPA36608.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47237.
HOGENOMHOG000049070.
HOVERGENHBG069143.
InParanoidQ9NS68.
KOK05155.
OMAICGEFSD.
OrthoDBEOG7Z3F4G.
PhylomeDBQ9NS68.
TreeFamTF331385.

Enzyme and pathway databases

SignaLinkQ9NS68.

Gene expression databases

BgeeQ9NS68.
CleanExHS_TNFRSF19.
GenevestigatorQ9NS68.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSPR01969. TNFACTORR19.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTNFRSF19.
GenomeRNAi55504.
NextBio35464702.
PROQ9NS68.
SOURCESearch...

Entry information

Entry nameTNR19_HUMAN
AccessionPrimary (citable) accession number: Q9NS68
Secondary accession number(s): A8KA09 expand/collapse secondary AC list , A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NZV2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM