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Protein

Tumor necrosis factor receptor superfamily member 19

Gene

TNFRSF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

GO - Molecular functioni

  1. tumor necrosis factor-activated receptor activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB
  2. hair follicle development Source: Ensembl
  3. JNK cascade Source: UniProtKB
  4. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  5. tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ9NS68.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:TNFRSF19
Synonyms:TAJ, TROY
ORF Names:UNQ1888/PRO4333
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11915. TNFRSF19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 170141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 423232CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 423394Tumor necrosis factor receptor superfamily member 19PRO_0000034597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NS68.
PaxDbiQ9NS68.
PRIDEiQ9NS68.

PTM databases

PhosphoSiteiQ9NS68.

Expressioni

Tissue specificityi

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

BgeeiQ9NS68.
CleanExiHS_TNFRSF19.
ExpressionAtlasiQ9NS68. baseline and differential.
GenevestigatoriQ9NS68.

Organism-specific databases

HPAiHPA010135.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.2 Publications

Protein-protein interaction databases

BioGridi120684. 4 interactions.
IntActiQ9NS68. 3 interactions.
STRINGi9606.ENSP00000371693.

Structurei

3D structure databases

ProteinModelPortaliQ9NS68.
SMRiQ9NS68. Positions 33-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati33 – 7240TNFR-Cys 1Add
BLAST
Repeati74 – 11441TNFR-Cys 2Add
BLAST
Repeati116 – 14934TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47237.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000049070.
HOVERGENiHBG069143.
InParanoidiQ9NS68.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG7Z3F4G.
PhylomeDBiQ9NS68.
TreeFamiTF331385.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS68-1) [UniParc]FASTAAdd to basket

Also known as: TAJ-alpha, TRADEalpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR
110 120 130 140 150
FQKANCSATS DAICGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCA
160 170 180 190 200
SKVNLVKIAS TASSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD SVQTCGPVRL
260 270 280 290 300
LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
310 320 330 340 350
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN
360 370 380 390 400
SSQDLVGGAV PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ
410 420
ESGAVIHPAT QTSLQVRQRL GSL
Length:423
Mass (Da):46,015
Last modified:October 1, 2000 - v1
Checksum:iB5891CEA9ED45361
GO
Isoform 2 (identifier: Q9NS68-2) [UniParc]FASTAAdd to basket

Also known as: TRADEbeta

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA

Show »
Length:417
Mass (Da):45,305
Checksum:i3AA85D783F0835C4
GO
Isoform 3 (identifier: Q9NS68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     416-423: VRQRLGSL → EA

Note: No experimental confirmation available.

Show »
Length:285
Mass (Da):30,542
Checksum:i4798BE078A891985
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741T → A in AAF71828 (PubMed:10809768).Curated
Sequence conflicti215 – 2162GS → ET in AAF71828 (PubMed:10809768).Curated
Sequence conflicti221 – 2211F → L in AAK28396 (Ref. 3) Curated
Sequence conflicti330 – 3301T → A in AAK28396 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311S → T.1 Publication
Corresponds to variant rs9550987 [ dbSNP | Ensembl ].
VAR_024278
Natural varianti159 – 1591A → V.1 Publication
Corresponds to variant rs61756242 [ dbSNP | Ensembl ].
VAR_070812
Natural varianti405 – 4051V → I.2 Publications
Corresponds to variant rs3751362 [ dbSNP | Ensembl ].
VAR_024279

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 132132Missing in isoform 3. 1 PublicationVSP_044886Add
BLAST
Alternative sequencei416 – 4238VRQRLGSL → EA in isoform 2 and isoform 3. 4 PublicationsVSP_006512

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA. Translation: AAF71828.1.
AB040434 mRNA. Translation: BAB03269.1.
AF246998 mRNA. Translation: AAK28395.1.
AF246999 mRNA. Translation: AAK28396.1.
AY358888 mRNA. Translation: AAQ89247.1.
AK292874 mRNA. Translation: BAF85563.1.
AK292891 mRNA. Translation: BAF85580.1.
AK304290 mRNA. Translation: BAG65148.1.
AL161422 Genomic DNA. Translation: CAH70837.2.
AL161422 Genomic DNA. Translation: CAH70838.1.
AL354815 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08326.1.
BC047321 mRNA. Translation: AAH47321.1.
CCDSiCCDS55893.1. [Q9NS68-3]
CCDS9301.1. [Q9NS68-2]
CCDS9302.1. [Q9NS68-1]
RefSeqiNP_001191387.1. NM_001204458.1. [Q9NS68-2]
NP_001191388.1. NM_001204459.1. [Q9NS68-3]
NP_061117.2. NM_018647.3. [Q9NS68-1]
NP_683760.1. NM_148957.3. [Q9NS68-2]
XP_005266502.1. XM_005266445.1. [Q9NS68-1]
UniGeneiHs.149168.
Hs.730848.

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863. [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863. [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863. [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863. [Q9NS68-3]
GeneIDi55504.
KEGGihsa:55504.
UCSCiuc001uot.3. human. [Q9NS68-2]
uc001uov.2. human. [Q9NS68-1]

Polymorphism databases

DMDMi21264102.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA. Translation: AAF71828.1.
AB040434 mRNA. Translation: BAB03269.1.
AF246998 mRNA. Translation: AAK28395.1.
AF246999 mRNA. Translation: AAK28396.1.
AY358888 mRNA. Translation: AAQ89247.1.
AK292874 mRNA. Translation: BAF85563.1.
AK292891 mRNA. Translation: BAF85580.1.
AK304290 mRNA. Translation: BAG65148.1.
AL161422 Genomic DNA. Translation: CAH70837.2.
AL161422 Genomic DNA. Translation: CAH70838.1.
AL354815 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08326.1.
BC047321 mRNA. Translation: AAH47321.1.
CCDSiCCDS55893.1. [Q9NS68-3]
CCDS9301.1. [Q9NS68-2]
CCDS9302.1. [Q9NS68-1]
RefSeqiNP_001191387.1. NM_001204458.1. [Q9NS68-2]
NP_001191388.1. NM_001204459.1. [Q9NS68-3]
NP_061117.2. NM_018647.3. [Q9NS68-1]
NP_683760.1. NM_148957.3. [Q9NS68-2]
XP_005266502.1. XM_005266445.1. [Q9NS68-1]
UniGeneiHs.149168.
Hs.730848.

3D structure databases

ProteinModelPortaliQ9NS68.
SMRiQ9NS68. Positions 33-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120684. 4 interactions.
IntActiQ9NS68. 3 interactions.
STRINGi9606.ENSP00000371693.

PTM databases

PhosphoSiteiQ9NS68.

Polymorphism databases

DMDMi21264102.

Proteomic databases

MaxQBiQ9NS68.
PaxDbiQ9NS68.
PRIDEiQ9NS68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863. [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863. [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863. [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863. [Q9NS68-3]
GeneIDi55504.
KEGGihsa:55504.
UCSCiuc001uot.3. human. [Q9NS68-2]
uc001uov.2. human. [Q9NS68-1]

Organism-specific databases

CTDi55504.
GeneCardsiGC13P024144.
HGNCiHGNC:11915. TNFRSF19.
HPAiHPA010135.
MIMi606122. gene.
neXtProtiNX_Q9NS68.
PharmGKBiPA36608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47237.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000049070.
HOVERGENiHBG069143.
InParanoidiQ9NS68.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG7Z3F4G.
PhylomeDBiQ9NS68.
TreeFamiTF331385.

Enzyme and pathway databases

SignaLinkiQ9NS68.

Miscellaneous databases

GeneWikiiTNFRSF19.
GenomeRNAii55504.
NextBioi35464702.
PROiQ9NS68.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NS68.
CleanExiHS_TNFRSF19.
ExpressionAtlasiQ9NS68. baseline and differential.
GenevestigatoriQ9NS68.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."
    Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M.
    J. Biol. Chem. 275:15336-15342(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRAF1; TRAF2; TRAF3 AND TRAF5.
    Tissue: Fetal spleen.
  2. "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles."
    Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T.
    J. Biol. Chem. 275:20742-20747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Glial tumor.
  3. "TRADE, a novel TNF receptor family member associated with death signaling."
    Chaudhary D., Long A.J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-31 AND ILE-405.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS VAL-159 AND ILE-405.
    Tissue: Trachea.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-44.
  10. "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors."
    Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z.
    Neuron 45:345-351(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LINGO1.

Entry informationi

Entry nameiTNR19_HUMAN
AccessioniPrimary (citable) accession number: Q9NS68
Secondary accession number(s): A8KA09
, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NZV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.