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Protein

Tumor necrosis factor receptor superfamily member 19

Gene

TNFRSF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

GO - Molecular functioni

  • receptor activity Source: GO_Central
  • tumor necrosis factor-activated receptor activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • hair follicle development Source: Ensembl
  • JNK cascade Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • positive regulation of JNK cascade Source: GO_Central
  • tissue development Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127863-MONOMER.
SignaLinkiQ9NS68.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
TRADE
Toxicity and JNK inducer
Gene namesi
Name:TNFRSF19
Synonyms:TAJ, TROY
ORF Names:UNQ1888/PRO4333
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11915. TNFRSF19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 170ExtracellularSequence analysisAdd BLAST141
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 423CytoplasmicSequence analysisAdd BLAST232

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55504.
OpenTargetsiENSG00000127863.
PharmGKBiPA36608.

Polymorphism and mutation databases

BioMutaiTNFRSF19.
DMDMi21264102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000003459730 – 423Tumor necrosis factor receptor superfamily member 19Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation
Disulfide bondi52 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi92 ↔ 106PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi117 ↔ 135PROSITE-ProRule annotation
Disulfide bondi138 ↔ 149PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9NS68.
PaxDbiQ9NS68.
PeptideAtlasiQ9NS68.
PRIDEiQ9NS68.

PTM databases

iPTMnetiQ9NS68.
PhosphoSitePlusiQ9NS68.

Expressioni

Tissue specificityi

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000127863.
CleanExiHS_TNFRSF19.
ExpressionAtlasiQ9NS68. baseline and differential.
GenevisibleiQ9NS68. HS.

Organism-specific databases

HPAiHPA010135.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.2 Publications

Protein-protein interaction databases

BioGridi120684. 42 interactors.
IntActiQ9NS68. 4 interactors.
STRINGi9606.ENSP00000371693.

Structurei

3D structure databases

ProteinModelPortaliQ9NS68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 72TNFR-Cys 1Add BLAST40
Repeati74 – 114TNFR-Cys 2Add BLAST41
Repeati116 – 149TNFR-Cys 3Add BLAST34

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRK. Eukaryota.
ENOG410ZU96. LUCA.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000049070.
HOVERGENiHBG069143.
InParanoidiQ9NS68.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG091G0ADI.
PhylomeDBiQ9NS68.
TreeFamiTF331385.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PANTHERiPTHR12120:SF1. PTHR12120:SF1. 1 hit.
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS68-1) [UniParc]FASTAAdd to basket
Also known as: TAJ-alpha, TRADEalpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN
60 70 80 90 100
QCGPGMELSK ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR
110 120 130 140 150
FQKANCSATS DAICGDCLPG FYRKTKLVGF QDMECVPCGD PPPPYEPHCA
160 170 180 190 200
SKVNLVKIAS TASSPRDTAL AAVICSALAT VLLALLILCV IYCKRQFMEK
210 220 230 240 250
KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD SVQTCGPVRL
260 270 280 290 300
LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI
310 320 330 340 350
CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN
360 370 380 390 400
SSQDLVGGAV PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ
410 420
ESGAVIHPAT QTSLQVRQRL GSL
Length:423
Mass (Da):46,015
Last modified:October 1, 2000 - v1
Checksum:iB5891CEA9ED45361
GO
Isoform 2 (identifier: Q9NS68-2) [UniParc]FASTAAdd to basket
Also known as: TRADEbeta

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA

Show »
Length:417
Mass (Da):45,305
Checksum:i3AA85D783F0835C4
GO
Isoform 3 (identifier: Q9NS68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     416-423: VRQRLGSL → EA

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,542
Checksum:i4798BE078A891985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74T → A in AAF71828 (PubMed:10809768).Curated1
Sequence conflicti215 – 216GS → ET in AAF71828 (PubMed:10809768).Curated2
Sequence conflicti221F → L in AAK28396 (Ref. 3) Curated1
Sequence conflicti330T → A in AAK28396 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02427831S → T.1 PublicationCorresponds to variant rs9550987dbSNPEnsembl.1
Natural variantiVAR_070812159A → V.1 PublicationCorresponds to variant rs61756242dbSNPEnsembl.1
Natural variantiVAR_024279405V → I.2 PublicationsCorresponds to variant rs3751362dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448861 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_006512416 – 423VRQRLGSL → EA in isoform 2 and isoform 3. 4 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA. Translation: AAF71828.1.
AB040434 mRNA. Translation: BAB03269.1.
AF246998 mRNA. Translation: AAK28395.1.
AF246999 mRNA. Translation: AAK28396.1.
AY358888 mRNA. Translation: AAQ89247.1.
AK292874 mRNA. Translation: BAF85563.1.
AK292891 mRNA. Translation: BAF85580.1.
AK304290 mRNA. Translation: BAG65148.1.
AL161422 Genomic DNA. Translation: CAH70837.2.
AL161422 Genomic DNA. Translation: CAH70838.1.
AL354815 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08326.1.
BC047321 mRNA. Translation: AAH47321.1.
CCDSiCCDS55893.1. [Q9NS68-3]
CCDS9301.1. [Q9NS68-2]
CCDS9302.1. [Q9NS68-1]
RefSeqiNP_001191387.1. NM_001204458.1. [Q9NS68-2]
NP_001191388.1. NM_001204459.1. [Q9NS68-3]
NP_061117.2. NM_018647.3. [Q9NS68-1]
NP_683760.1. NM_148957.3. [Q9NS68-2]
XP_005266502.1. XM_005266445.2. [Q9NS68-1]
XP_011533448.1. XM_011535146.1. [Q9NS68-1]
XP_016876140.1. XM_017020651.1. [Q9NS68-1]
UniGeneiHs.149168.
Hs.730848.

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863. [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863. [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863. [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863. [Q9NS68-3]
GeneIDi55504.
KEGGihsa:55504.
UCSCiuc001uot.4. human. [Q9NS68-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167555 mRNA. Translation: AAF71828.1.
AB040434 mRNA. Translation: BAB03269.1.
AF246998 mRNA. Translation: AAK28395.1.
AF246999 mRNA. Translation: AAK28396.1.
AY358888 mRNA. Translation: AAQ89247.1.
AK292874 mRNA. Translation: BAF85563.1.
AK292891 mRNA. Translation: BAF85580.1.
AK304290 mRNA. Translation: BAG65148.1.
AL161422 Genomic DNA. Translation: CAH70837.2.
AL161422 Genomic DNA. Translation: CAH70838.1.
AL354815 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08326.1.
BC047321 mRNA. Translation: AAH47321.1.
CCDSiCCDS55893.1. [Q9NS68-3]
CCDS9301.1. [Q9NS68-2]
CCDS9302.1. [Q9NS68-1]
RefSeqiNP_001191387.1. NM_001204458.1. [Q9NS68-2]
NP_001191388.1. NM_001204459.1. [Q9NS68-3]
NP_061117.2. NM_018647.3. [Q9NS68-1]
NP_683760.1. NM_148957.3. [Q9NS68-2]
XP_005266502.1. XM_005266445.2. [Q9NS68-1]
XP_011533448.1. XM_011535146.1. [Q9NS68-1]
XP_016876140.1. XM_017020651.1. [Q9NS68-1]
UniGeneiHs.149168.
Hs.730848.

3D structure databases

ProteinModelPortaliQ9NS68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120684. 42 interactors.
IntActiQ9NS68. 4 interactors.
STRINGi9606.ENSP00000371693.

PTM databases

iPTMnetiQ9NS68.
PhosphoSitePlusiQ9NS68.

Polymorphism and mutation databases

BioMutaiTNFRSF19.
DMDMi21264102.

Proteomic databases

MaxQBiQ9NS68.
PaxDbiQ9NS68.
PeptideAtlasiQ9NS68.
PRIDEiQ9NS68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248484; ENSP00000248484; ENSG00000127863. [Q9NS68-2]
ENST00000382258; ENSP00000371693; ENSG00000127863. [Q9NS68-1]
ENST00000382263; ENSP00000371698; ENSG00000127863. [Q9NS68-2]
ENST00000403372; ENSP00000385408; ENSG00000127863. [Q9NS68-3]
GeneIDi55504.
KEGGihsa:55504.
UCSCiuc001uot.4. human. [Q9NS68-1]

Organism-specific databases

CTDi55504.
DisGeNETi55504.
GeneCardsiTNFRSF19.
HGNCiHGNC:11915. TNFRSF19.
HPAiHPA010135.
MIMi606122. gene.
neXtProtiNX_Q9NS68.
OpenTargetsiENSG00000127863.
PharmGKBiPA36608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFRK. Eukaryota.
ENOG410ZU96. LUCA.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000049070.
HOVERGENiHBG069143.
InParanoidiQ9NS68.
KOiK05155.
OMAiICGEFSD.
OrthoDBiEOG091G0ADI.
PhylomeDBiQ9NS68.
TreeFamiTF331385.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127863-MONOMER.
SignaLinkiQ9NS68.

Miscellaneous databases

GeneWikiiTNFRSF19.
GenomeRNAii55504.
PROiQ9NS68.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127863.
CleanExiHS_TNFRSF19.
ExpressionAtlasiQ9NS68. baseline and differential.
GenevisibleiQ9NS68. HS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022342. TNFR_19.
[Graphical view]
PANTHERiPTHR12120:SF1. PTHR12120:SF1. 1 hit.
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01969. TNFACTORR19.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR19_HUMAN
AccessioniPrimary (citable) accession number: Q9NS68
Secondary accession number(s): A8KA09
, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NZV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.