ID   GPR27_HUMAN             Reviewed;         375 AA.
AC   Q9NS67;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Probable G-protein coupled receptor 27;
DE   AltName: Full=Super conserved receptor expressed in brain 1;
GN   Name=GPR27; Synonyms=SREB1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA   Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA   Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT   "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT   expressed in the central nervous system.";
RL   Biochem. Biophys. Res. Commun. 272:576-582(2000).
CC   -!- FUNCTION: Orphan receptor. Possible candidate for amine-like G-protein
CC       coupled receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed as a 3.0 kb transcript in brain,
CC       ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels
CC       in pancreas and small intestine. A 2.3 kb transcript was also found in
CC       peripheral Leukocytes. In brain regions, detected as a 3.0 kb
CC       transcript in all regions tested. Highest levels in the caudate
CC       nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in
CC       the cerebellum.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AB040799; BAA96645.1; -; mRNA.
DR   CCDS; CCDS2915.1; -.
DR   PIR; JC7287; JC7287.
DR   RefSeq; NP_061844.1; NM_018971.2.
DR   AlphaFoldDB; Q9NS67; -.
DR   SMR; Q9NS67; -.
DR   BioGRID; 109109; 20.
DR   IntAct; Q9NS67; 1.
DR   MINT; Q9NS67; -.
DR   STRING; 9606.ENSP00000303149; -.
DR   BindingDB; Q9NS67; -.
DR   ChEMBL; CHEMBL4523923; -.
DR   GlyCosmos; Q9NS67; 1 site, No reported glycans.
DR   GlyGen; Q9NS67; 1 site.
DR   PhosphoSitePlus; Q9NS67; -.
DR   BioMuta; GPR27; -.
DR   DMDM; 15214047; -.
DR   MassIVE; Q9NS67; -.
DR   PaxDb; 9606-ENSP00000303149; -.
DR   PeptideAtlas; Q9NS67; -.
DR   Antibodypedia; 15615; 331 antibodies from 28 providers.
DR   DNASU; 2850; -.
DR   Ensembl; ENST00000304411.3; ENSP00000303149.2; ENSG00000170837.3.
DR   GeneID; 2850; -.
DR   KEGG; hsa:2850; -.
DR   MANE-Select; ENST00000304411.3; ENSP00000303149.2; NM_018971.3; NP_061844.1.
DR   UCSC; uc011bge.3; human.
DR   AGR; HGNC:4482; -.
DR   CTD; 2850; -.
DR   DisGeNET; 2850; -.
DR   GeneCards; GPR27; -.
DR   HGNC; HGNC:4482; GPR27.
DR   HPA; ENSG00000170837; Tissue enhanced (brain).
DR   MIM; 605187; gene.
DR   neXtProt; NX_Q9NS67; -.
DR   OpenTargets; ENSG00000170837; -.
DR   PharmGKB; PA28870; -.
DR   VEuPathDB; HostDB:ENSG00000170837; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00890000139436; -.
DR   HOGENOM; CLU_055518_0_0_1; -.
DR   InParanoid; Q9NS67; -.
DR   OMA; CKMFYAI; -.
DR   OrthoDB; 2962814at2759; -.
DR   PhylomeDB; Q9NS67; -.
DR   TreeFam; TF331163; -.
DR   PathwayCommons; Q9NS67; -.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   SignaLink; Q9NS67; -.
DR   BioGRID-ORCS; 2850; 7 hits in 1137 CRISPR screens.
DR   GeneWiki; GPR27; -.
DR   GenomeRNAi; 2850; -.
DR   Pharos; Q9NS67; Tbio.
DR   PRO; PR:Q9NS67; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9NS67; Protein.
DR   Bgee; ENSG00000170837; Expressed in medial globus pallidus and 179 other cell types or tissues.
DR   ExpressionAtlas; Q9NS67; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   CDD; cd15216; 7tmA_SREB1_GPR27; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR19268; G PROTEIN-COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR19268:SF8; G-PROTEIN COUPLED RECEPTOR 27-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9NS67; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..375
FT                   /note="Probable G-protein coupled receptor 27"
FT                   /id="PRO_0000069548"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..181
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        203..285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        342..375
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..171
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   375 AA;  39818 MW;  E17AF3D86FD47204 CRC64;
     MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL
     CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR
     YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA
     PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA
     NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY
     VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR
     TTQATHPCDL KGIGL
//