Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NS67

- GPR27_HUMAN

UniProt

Q9NS67 - GPR27_HUMAN

Protein

Probable G-protein coupled receptor 27

Gene

GPR27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 27
    Alternative name(s):
    Super conserved receptor expressed in brain 1
    Gene namesi
    Name:GPR27
    Synonyms:SREB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4482. GPR27.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28870.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Probable G-protein coupled receptor 27PRO_0000069548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NS67.
    PRIDEiQ9NS67.

    Expressioni

    Tissue specificityi

    Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

    Gene expression databases

    ArrayExpressiQ9NS67.
    BgeeiQ9NS67.
    CleanExiHS_GPR27.
    GenevestigatoriQ9NS67.

    Organism-specific databases

    HPAiHPA029395.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303149.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS67.
    SMRiQ9NS67. Positions 20-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 5511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 18121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 28583CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 32014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 37534CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237432.
    HOGENOMiHOG000231471.
    HOVERGENiHBG051805.
    InParanoidiQ9NS67.
    KOiK04301.
    OMAiQATLPCD.
    OrthoDBiEOG73NG3K.
    PhylomeDBiQ9NS67.
    TreeFamiTF331163.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NS67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH    50
    RAPYYLLLDL CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF 100
    LAALFCFHAA FLLLGVGVTR YLAIAHHRFY AERLAGWPCA AMLVCAAWAL 150
    ALAAAFPPVL DGGGDDEDAP CALEQRPDGA PGALGFLLLL AVVVGATHLV 200
    YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA NWTAGFGRGP 250
    TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY 300
    VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR 350
    AQFPCCQSPR TTQATHPCDL KGIGL 375
    Length:375
    Mass (Da):39,818
    Last modified:October 1, 2000 - v1
    Checksum:iE17AF3D86FD47204
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040799 mRNA. Translation: BAA96645.1.
    CCDSiCCDS2915.1.
    PIRiJC7287.
    RefSeqiNP_061844.1. NM_018971.1.
    UniGeneiHs.591653.

    Genome annotation databases

    EnsembliENST00000304411; ENSP00000303149; ENSG00000170837.
    GeneIDi2850.
    KEGGihsa:2850.
    UCSCiuc011bge.2. human.

    Polymorphism databases

    DMDMi15214047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040799 mRNA. Translation: BAA96645.1 .
    CCDSi CCDS2915.1.
    PIRi JC7287.
    RefSeqi NP_061844.1. NM_018971.1.
    UniGenei Hs.591653.

    3D structure databases

    ProteinModelPortali Q9NS67.
    SMRi Q9NS67. Positions 20-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303149.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 15214047.

    Proteomic databases

    PaxDbi Q9NS67.
    PRIDEi Q9NS67.

    Protocols and materials databases

    DNASUi 2850.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304411 ; ENSP00000303149 ; ENSG00000170837 .
    GeneIDi 2850.
    KEGGi hsa:2850.
    UCSCi uc011bge.2. human.

    Organism-specific databases

    CTDi 2850.
    GeneCardsi GC03P071803.
    HGNCi HGNC:4482. GPR27.
    HPAi HPA029395.
    MIMi 605187. gene.
    neXtProti NX_Q9NS67.
    PharmGKBi PA28870.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237432.
    HOGENOMi HOG000231471.
    HOVERGENi HBG051805.
    InParanoidi Q9NS67.
    KOi K04301.
    OMAi QATLPCD.
    OrthoDBi EOG73NG3K.
    PhylomeDBi Q9NS67.
    TreeFami TF331163.

    Miscellaneous databases

    GeneWikii GPR27.
    GenomeRNAii 2850.
    NextBioi 11243.
    PROi Q9NS67.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NS67.
    Bgeei Q9NS67.
    CleanExi HS_GPR27.
    Genevestigatori Q9NS67.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
      Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
      Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGPR27_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3