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Q9NS67

- GPR27_HUMAN

UniProt

Q9NS67 - GPR27_HUMAN

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Protein

Probable G-protein coupled receptor 27

Gene

GPR27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene namesi
Name:GPR27
Synonyms:SREB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:4482. GPR27.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 5511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 9721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 18121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini203 – 28583CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini307 – 32014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei321 – 34121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini342 – 37534CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Probable G-protein coupled receptor 27PRO_0000069548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS67.
PRIDEiQ9NS67.

Expressioni

Tissue specificityi

Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Gene expression databases

BgeeiQ9NS67.
CleanExiHS_GPR27.
ExpressionAtlasiQ9NS67. baseline and differential.
GenevestigatoriQ9NS67.

Organism-specific databases

HPAiHPA029395.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303149.

Structurei

3D structure databases

ProteinModelPortaliQ9NS67.
SMRiQ9NS67. Positions 20-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00770000120588.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS67.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG73NG3K.
PhylomeDBiQ9NS67.
TreeFamiTF331163.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH
60 70 80 90 100
RAPYYLLLDL CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF
110 120 130 140 150
LAALFCFHAA FLLLGVGVTR YLAIAHHRFY AERLAGWPCA AMLVCAAWAL
160 170 180 190 200
ALAAAFPPVL DGGGDDEDAP CALEQRPDGA PGALGFLLLL AVVVGATHLV
210 220 230 240 250
YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA NWTAGFGRGP
260 270 280 290 300
TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY
310 320 330 340 350
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR
360 370
AQFPCCQSPR TTQATHPCDL KGIGL
Length:375
Mass (Da):39,818
Last modified:October 1, 2000 - v1
Checksum:iE17AF3D86FD47204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040799 mRNA. Translation: BAA96645.1.
CCDSiCCDS2915.1.
PIRiJC7287.
RefSeqiNP_061844.1. NM_018971.1.
UniGeneiHs.591653.

Genome annotation databases

EnsembliENST00000304411; ENSP00000303149; ENSG00000170837.
GeneIDi2850.
KEGGihsa:2850.
UCSCiuc011bge.2. human.

Polymorphism databases

DMDMi15214047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040799 mRNA. Translation: BAA96645.1 .
CCDSi CCDS2915.1.
PIRi JC7287.
RefSeqi NP_061844.1. NM_018971.1.
UniGenei Hs.591653.

3D structure databases

ProteinModelPortali Q9NS67.
SMRi Q9NS67. Positions 20-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000303149.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 15214047.

Proteomic databases

PaxDbi Q9NS67.
PRIDEi Q9NS67.

Protocols and materials databases

DNASUi 2850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304411 ; ENSP00000303149 ; ENSG00000170837 .
GeneIDi 2850.
KEGGi hsa:2850.
UCSCi uc011bge.2. human.

Organism-specific databases

CTDi 2850.
GeneCardsi GC03P071803.
HGNCi HGNC:4482. GPR27.
HPAi HPA029395.
MIMi 605187. gene.
neXtProti NX_Q9NS67.
PharmGKBi PA28870.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237432.
GeneTreei ENSGT00770000120588.
HOGENOMi HOG000231471.
HOVERGENi HBG051805.
InParanoidi Q9NS67.
KOi K04301.
OMAi QATLPCD.
OrthoDBi EOG73NG3K.
PhylomeDBi Q9NS67.
TreeFami TF331163.

Miscellaneous databases

GeneWikii GPR27.
GenomeRNAii 2850.
NextBioi 11243.
PROi Q9NS67.
SOURCEi Search...

Gene expression databases

Bgeei Q9NS67.
CleanExi HS_GPR27.
ExpressionAtlasi Q9NS67. baseline and differential.
Genevestigatori Q9NS67.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
    Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
    Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGPR27_HUMAN
AccessioniPrimary (citable) accession number: Q9NS67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3