Q9NS67 (GPR27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 27

Alternative name(s):
Super conserved receptor expressed in brain 1

Gene names

Name:	GPR27
Synonyms:	SREB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Probable G-protein coupled receptor 27		PRO_0000069548
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 55	11	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 97	21	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 139	21	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 181	21	Extracellular Potential
	Transmembrane	182 – 202	21	Helical; Name=5; Potential
	Topological domain	203 – 285	83	Cytoplasmic Potential
	Transmembrane	286 – 306	21	Helical; Name=6; Potential
	Topological domain	307 – 320	14	Extracellular Potential
	Transmembrane	321 – 341	21	Helical; Name=7; Potential
	Topological domain	342 – 375	34	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 171		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NS67 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E17AF3D86FD47204	FASTA	375	39,818
	10 20 30 40 50 60 MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL 70 80 90 100 110 120 CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR 130 140 150 160 170 180 YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA 190 200 210 220 230 240 PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA 250 260 270 280 290 300 NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY 310 320 330 340 350 360 VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR 370 TTQATHPCDL KGIGL

References

[1]

"An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system." Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K. Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040799 mRNA. Translation: BAA96645.1.
IPI	IPI00016902.
PIR	JC7287.
RefSeq	NP_061844.1. NM_018971.1.
UniGene	Hs.591653.
3D structure databases
ProteinModelPortal	Q9NS67.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303149.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	15214047.
Proteomic databases
PaxDb	Q9NS67.
PRIDE	Q9NS67.
Protocols and materials databases
DNASU	2850.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304411; ENSP00000303149; ENSG00000170837.
GeneID	2850.
KEGG	hsa:2850.
UCSC	uc011bge.2. human.
Organism-specific databases
CTD	2850.
GeneCards	GC03P071803.
HGNC	HGNC:4482. GPR27.
HPA	HPA029395.
MIM	605187. gene.
neXtProt	NX_Q9NS67.
PharmGKB	PA28870.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG237432.
HOGENOM	HOG000231471.
HOVERGEN	HBG051805.
InParanoid	Q9NS67.
KO	K04301.
OMA	ATQATLP.
OrthoDB	EOG4P2Q34.
Gene expression databases
ArrayExpress	Q9NS67.
Bgee	Q9NS67.
CleanEx	HS_GPR27.
Genevestigator	Q9NS67.
GermOnline	ENSG00000170837. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2850.
NextBio	11243.
SOURCE	Search...

Entry information

Entry name

GPR27_HUMAN

Accession

Primary (citable) accession number: Q9NS67

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.