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Protein

Probable G-protein coupled receptor 27

Gene

GPR27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene namesi
Name:GPR27
Synonyms:SREB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4482. GPR27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 5511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 9721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 18121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini203 – 28583CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini307 – 32014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei321 – 34121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini342 – 37534CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28870.

Polymorphism and mutation databases

BioMutaiGPR27.
DMDMi15214047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Probable G-protein coupled receptor 27PRO_0000069548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS67.
PRIDEiQ9NS67.

Expressioni

Tissue specificityi

Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Gene expression databases

BgeeiQ9NS67.
CleanExiHS_GPR27.
ExpressionAtlasiQ9NS67. baseline and differential.
GenevisibleiQ9NS67. HS.

Organism-specific databases

HPAiHPA029395.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303149.

Structurei

3D structure databases

ProteinModelPortaliQ9NS67.
SMRiQ9NS67. Positions 20-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS67.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG73NG3K.
PhylomeDBiQ9NS67.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH
60 70 80 90 100
RAPYYLLLDL CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF
110 120 130 140 150
LAALFCFHAA FLLLGVGVTR YLAIAHHRFY AERLAGWPCA AMLVCAAWAL
160 170 180 190 200
ALAAAFPPVL DGGGDDEDAP CALEQRPDGA PGALGFLLLL AVVVGATHLV
210 220 230 240 250
YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA NWTAGFGRGP
260 270 280 290 300
TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY
310 320 330 340 350
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR
360 370
AQFPCCQSPR TTQATHPCDL KGIGL
Length:375
Mass (Da):39,818
Last modified:October 1, 2000 - v1
Checksum:iE17AF3D86FD47204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040799 mRNA. Translation: BAA96645.1.
CCDSiCCDS2915.1.
PIRiJC7287.
RefSeqiNP_061844.1. NM_018971.1.
UniGeneiHs.591653.

Genome annotation databases

EnsembliENST00000304411; ENSP00000303149; ENSG00000170837.
GeneIDi2850.
KEGGihsa:2850.
UCSCiuc011bge.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040799 mRNA. Translation: BAA96645.1.
CCDSiCCDS2915.1.
PIRiJC7287.
RefSeqiNP_061844.1. NM_018971.1.
UniGeneiHs.591653.

3D structure databases

ProteinModelPortaliQ9NS67.
SMRiQ9NS67. Positions 20-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303149.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR27.
DMDMi15214047.

Proteomic databases

PaxDbiQ9NS67.
PRIDEiQ9NS67.

Protocols and materials databases

DNASUi2850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304411; ENSP00000303149; ENSG00000170837.
GeneIDi2850.
KEGGihsa:2850.
UCSCiuc011bge.2. human.

Organism-specific databases

CTDi2850.
GeneCardsiGC03P071803.
HGNCiHGNC:4482. GPR27.
HPAiHPA029395.
MIMi605187. gene.
neXtProtiNX_Q9NS67.
PharmGKBiPA28870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS67.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG73NG3K.
PhylomeDBiQ9NS67.
TreeFamiTF331163.

Miscellaneous databases

GeneWikiiGPR27.
GenomeRNAii2850.
NextBioi11243.
PROiQ9NS67.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NS67.
CleanExiHS_GPR27.
ExpressionAtlasiQ9NS67. baseline and differential.
GenevisibleiQ9NS67. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
    Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
    Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGPR27_HUMAN
AccessioniPrimary (citable) accession number: Q9NS67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.