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Q9NS67 (GPR27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene names
Name:GPR27
Synonyms:SREB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Probable G-protein coupled receptor 27
PRO_0000069548

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 5511Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9721Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13921Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 18121Extracellular Potential
Transmembrane182 – 20221Helical; Name=5; Potential
Topological domain203 – 28583Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=6; Potential
Topological domain307 – 32014Extracellular Potential
Transmembrane321 – 34121Helical; Name=7; Potential
Topological domain342 – 37534Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 171 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9NS67 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: E17AF3D86FD47204

FASTA37539,818
        10         20         30         40         50         60 
MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL 

        70         80         90        100        110        120 
CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR 

       130        140        150        160        170        180 
YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA 

       190        200        210        220        230        240 
PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA 

       250        260        270        280        290        300 
NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY 

       310        320        330        340        350        360 
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR 

       370 
TTQATHPCDL KGIGL 

« Hide

References

[1]"An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040799 mRNA. Translation: BAA96645.1.
CCDSCCDS2915.1.
PIRJC7287.
RefSeqNP_061844.1. NM_018971.1.
UniGeneHs.591653.

3D structure databases

ProteinModelPortalQ9NS67.
SMRQ9NS67. Positions 20-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303149.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM15214047.

Proteomic databases

PaxDbQ9NS67.
PRIDEQ9NS67.

Protocols and materials databases

DNASU2850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304411; ENSP00000303149; ENSG00000170837.
GeneID2850.
KEGGhsa:2850.
UCSCuc011bge.2. human.

Organism-specific databases

CTD2850.
GeneCardsGC03P071803.
HGNCHGNC:4482. GPR27.
HPAHPA029395.
MIM605187. gene.
neXtProtNX_Q9NS67.
PharmGKBPA28870.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237432.
HOGENOMHOG000231471.
HOVERGENHBG051805.
InParanoidQ9NS67.
KOK04301.
OMAQATLPCD.
OrthoDBEOG73NG3K.
PhylomeDBQ9NS67.
TreeFamTF331163.

Gene expression databases

ArrayExpressQ9NS67.
BgeeQ9NS67.
CleanExHS_GPR27.
GenevestigatorQ9NS67.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR27.
GenomeRNAi2850.
NextBio11243.
PROQ9NS67.
SOURCESearch...

Entry information

Entry nameGPR27_HUMAN
AccessionPrimary (citable) accession number: Q9NS67
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries