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Protein

Probable G-protein coupled receptor 173

Gene

GPR173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • gonadotropin-releasing hormone receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • negative regulation of neuron migration Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 173
Alternative name(s):
Super conserved receptor expressed in brain 3
Gene namesi
Name:GPR173
Synonyms:SREB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18186. GPR173.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 59CytoplasmicSequence analysisAdd BLAST12
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 97ExtracellularSequence analysisAdd BLAST17
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 188ExtracellularSequence analysisAdd BLAST28
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 287CytoplasmicSequence analysisAdd BLAST78
Transmembranei288 – 308Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini309 – 322ExtracellularSequence analysisAdd BLAST14
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 373CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184194.
PharmGKBiPA134896710.

Polymorphism and mutation databases

BioMutaiGPR173.
DMDMi15214315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696501 – 373Probable G-protein coupled receptor 173Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 174PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS66.
PRIDEiQ9NS66.

PTM databases

iPTMnetiQ9NS66.
PhosphoSitePlusiQ9NS66.

Expressioni

Tissue specificityi

Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

Gene expression databases

BgeeiENSG00000184194.
CleanExiHS_GPR173.
ExpressionAtlasiQ9NS66. baseline and differential.
GenevisibleiQ9NS66. HS.

Organism-specific databases

HPAiHPA003905.

Interactioni

Protein-protein interaction databases

BioGridi119931. 1 interactor.
STRINGi9606.ENSP00000331600.

Structurei

3D structure databases

ProteinModelPortaliQ9NS66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS66.
KOiK04300.
OMAiKRMTFWT.
OrthoDBiEOG091G0AOZ.
PhylomeDBiQ9NS66.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE
60 70 80 90 100
RALHKAPYYF LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA
110 120 130 140 150
FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL
160 170 180 190 200
SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT
210 220 230 240 250
HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG
260 270 280 290 300
RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
310 320 330 340 350
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC
360 370
LRTHAPCWGT GGAPAPREPY CVM
Length:373
Mass (Da):41,481
Last modified:October 1, 2000 - v1
Checksum:i8A227F914C9D8358
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040801 mRNA. Translation: BAA96647.1.
BX322635 Genomic DNA. Translation: CAI42530.1.
CH471154 Genomic DNA. Translation: EAW93142.1.
BC009861 mRNA. Translation: AAH09861.1.
CCDSiCCDS14349.1.
PIRiJC7289.
RefSeqiNP_061842.1. NM_018969.5.
XP_011529100.1. XM_011530798.2.
UniGeneiHs.193011.

Genome annotation databases

EnsembliENST00000332582; ENSP00000331600; ENSG00000184194.
GeneIDi54328.
KEGGihsa:54328.
UCSCiuc004dru.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040801 mRNA. Translation: BAA96647.1.
BX322635 Genomic DNA. Translation: CAI42530.1.
CH471154 Genomic DNA. Translation: EAW93142.1.
BC009861 mRNA. Translation: AAH09861.1.
CCDSiCCDS14349.1.
PIRiJC7289.
RefSeqiNP_061842.1. NM_018969.5.
XP_011529100.1. XM_011530798.2.
UniGeneiHs.193011.

3D structure databases

ProteinModelPortaliQ9NS66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119931. 1 interactor.
STRINGi9606.ENSP00000331600.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NS66.
PhosphoSitePlusiQ9NS66.

Polymorphism and mutation databases

BioMutaiGPR173.
DMDMi15214315.

Proteomic databases

PaxDbiQ9NS66.
PRIDEiQ9NS66.

Protocols and materials databases

DNASUi54328.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332582; ENSP00000331600; ENSG00000184194.
GeneIDi54328.
KEGGihsa:54328.
UCSCiuc004dru.4. human.

Organism-specific databases

CTDi54328.
GeneCardsiGPR173.
HGNCiHGNC:18186. GPR173.
HPAiHPA003905.
MIMi300253. gene.
neXtProtiNX_Q9NS66.
OpenTargetsiENSG00000184194.
PharmGKBiPA134896710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS66.
KOiK04300.
OMAiKRMTFWT.
OrthoDBiEOG091G0AOZ.
PhylomeDBiQ9NS66.
TreeFamiTF331163.

Enzyme and pathway databases

BioCyciZFISH:G66-33886-MONOMER.

Miscellaneous databases

ChiTaRSiGPR173. human.
GeneWikiiGPR173.
GenomeRNAii54328.
PROiQ9NS66.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184194.
CleanExiHS_GPR173.
ExpressionAtlasiQ9NS66. baseline and differential.
GenevisibleiQ9NS66. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP173_HUMAN
AccessioniPrimary (citable) accession number: Q9NS66
Secondary accession number(s): B1B0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.