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Q9NS66

- GP173_HUMAN

UniProt

Q9NS66 - GP173_HUMAN

Protein

Probable G-protein coupled receptor 173

Gene

GPR173

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. gonadotropin-releasing hormone receptor activity Source: Ensembl
    2. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of neuron migration Source: Ensembl
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 173
    Alternative name(s):
    Super conserved receptor expressed in brain 3
    Gene namesi
    Name:GPR173
    Synonyms:SREB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:18186. GPR173.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896710.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Probable G-protein coupled receptor 173PRO_0000069650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 174PROSITE-ProRule annotation
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NS66.
    PRIDEiQ9NS66.

    PTM databases

    PhosphoSiteiQ9NS66.

    Expressioni

    Tissue specificityi

    Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

    Gene expression databases

    ArrayExpressiQ9NS66.
    BgeeiQ9NS66.
    CleanExiHS_GPR173.
    GenevestigatoriQ9NS66.

    Organism-specific databases

    HPAiHPA003905.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS66.
    SMRiQ9NS66. Positions 26-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 5912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 28778CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 37330CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237432.
    HOGENOMiHOG000231471.
    HOVERGENiHBG051805.
    InParanoidiQ9NS66.
    KOiK04300.
    OMAiKRMTFWT.
    PhylomeDBiQ9NS66.
    TreeFamiTF331163.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NS66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE    50
    RALHKAPYYF LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA 100
    FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL 150
    SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT 200
    HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG 250
    RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS 300
    PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC 350
    LRTHAPCWGT GGAPAPREPY CVM 373
    Length:373
    Mass (Da):41,481
    Last modified:October 1, 2000 - v1
    Checksum:i8A227F914C9D8358
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040801 mRNA. Translation: BAA96647.1.
    BX322635 Genomic DNA. Translation: CAI42530.1.
    CH471154 Genomic DNA. Translation: EAW93142.1.
    BC009861 mRNA. Translation: AAH09861.1.
    CCDSiCCDS14349.1.
    PIRiJC7289.
    RefSeqiNP_061842.1. NM_018969.5.
    UniGeneiHs.193011.

    Genome annotation databases

    EnsembliENST00000332582; ENSP00000331600; ENSG00000184194.
    GeneIDi54328.
    KEGGihsa:54328.
    UCSCiuc004dru.3. human.

    Polymorphism databases

    DMDMi15214315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040801 mRNA. Translation: BAA96647.1 .
    BX322635 Genomic DNA. Translation: CAI42530.1 .
    CH471154 Genomic DNA. Translation: EAW93142.1 .
    BC009861 mRNA. Translation: AAH09861.1 .
    CCDSi CCDS14349.1.
    PIRi JC7289.
    RefSeqi NP_061842.1. NM_018969.5.
    UniGenei Hs.193011.

    3D structure databases

    ProteinModelPortali Q9NS66.
    SMRi Q9NS66. Positions 26-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331600.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9NS66.

    Polymorphism databases

    DMDMi 15214315.

    Proteomic databases

    PaxDbi Q9NS66.
    PRIDEi Q9NS66.

    Protocols and materials databases

    DNASUi 54328.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332582 ; ENSP00000331600 ; ENSG00000184194 .
    GeneIDi 54328.
    KEGGi hsa:54328.
    UCSCi uc004dru.3. human.

    Organism-specific databases

    CTDi 54328.
    GeneCardsi GC0XP053095.
    HGNCi HGNC:18186. GPR173.
    HPAi HPA003905.
    MIMi 300253. gene.
    neXtProti NX_Q9NS66.
    PharmGKBi PA134896710.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237432.
    HOGENOMi HOG000231471.
    HOVERGENi HBG051805.
    InParanoidi Q9NS66.
    KOi K04300.
    OMAi KRMTFWT.
    PhylomeDBi Q9NS66.
    TreeFami TF331163.

    Miscellaneous databases

    ChiTaRSi GPR173. human.
    GeneWikii GPR173.
    GenomeRNAii 54328.
    NextBioi 56561.
    PROi Q9NS66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NS66.
    Bgeei Q9NS66.
    CleanExi HS_GPR173.
    Genevestigatori Q9NS66.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
      Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
      Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiGP173_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS66
    Secondary accession number(s): B1B0A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3