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Q9NS66 (GP173_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 173
Alternative name(s):
Super conserved receptor expressed in brain 3
Gene names
Name:GPR173
Synonyms:SREB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Probable G-protein coupled receptor 173
PRO_0000069650

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 5912Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 9717Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13921Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 18828Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 28778Cytoplasmic Potential
Transmembrane288 – 30821Helical; Name=6; Potential
Topological domain309 – 32214Extracellular Potential
Transmembrane323 – 34321Helical; Name=7; Potential
Topological domain344 – 37330Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 174 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9NS66 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8A227F914C9D8358

FASTA37341,481
        10         20         30         40         50         60 
MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE RALHKAPYYF 

        70         80         90        100        110        120 
LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA FMAVLFCFHA AFMLFCISVT 

       130        140        150        160        170        180 
RYMAIAHHRF YAKRMTLWTC AAVICMAWTL SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY 

       190        200        210        220        230        240 
FKANDTLGFM LMLAVLMAAT HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ 

       250        260        270        280        290        300 
AAANWIAGFG RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS 

       310        320        330        340        350        360 
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC LRTHAPCWGT 

       370 
GGAPAPREPY CVM 

« Hide

References

« Hide 'large scale' references
[1]"An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB040801 mRNA. Translation: BAA96647.1.
BX322635 Genomic DNA. Translation: CAI42530.1.
CH471154 Genomic DNA. Translation: EAW93142.1.
BC009861 mRNA. Translation: AAH09861.1.
CCDSCCDS14349.1.
PIRJC7289.
RefSeqNP_061842.1. NM_018969.5.
UniGeneHs.193011.

3D structure databases

ProteinModelPortalQ9NS66.
SMRQ9NS66. Positions 26-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000331600.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9NS66.

Polymorphism databases

DMDM15214315.

Proteomic databases

PaxDbQ9NS66.
PRIDEQ9NS66.

Protocols and materials databases

DNASU54328.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332582; ENSP00000331600; ENSG00000184194.
ENST00000596393; ENSP00000470859; ENSG00000268476.
GeneID54328.
KEGGhsa:54328.
UCSCuc004dru.3. human.

Organism-specific databases

CTD54328.
GeneCardsGC0XP053095.
HGNCHGNC:18186. GPR173.
HPAHPA003905.
MIM300253. gene.
neXtProtNX_Q9NS66.
PharmGKBPA134896710.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237432.
HOGENOMHOG000231471.
HOVERGENHBG051805.
InParanoidQ9NS66.
KOK04300.
OMAKRMTFWT.
PhylomeDBQ9NS66.
TreeFamTF331163.

Gene expression databases

ArrayExpressQ9NS66.
BgeeQ9NS66.
CleanExHS_GPR173.
GenevestigatorQ9NS66.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR173. human.
GeneWikiGPR173.
GenomeRNAi54328.
NextBio56561.
PROQ9NS66.
SOURCESearch...

Entry information

Entry nameGP173_HUMAN
AccessionPrimary (citable) accession number: Q9NS66
Secondary accession number(s): B1B0A5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries