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Q9NS66

- GP173_HUMAN

UniProt

Q9NS66 - GP173_HUMAN

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Protein

Probable G-protein coupled receptor 173

Gene

GPR173

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. gonadotropin-releasing hormone receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. negative regulation of neuron migration Source: Ensembl
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 173
Alternative name(s):
Super conserved receptor expressed in brain 3
Gene namesi
Name:GPR173
Synonyms:SREB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:18186. GPR173.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Probable G-protein coupled receptor 173PRO_0000069650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 174PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NS66.
PRIDEiQ9NS66.

PTM databases

PhosphoSiteiQ9NS66.

Expressioni

Tissue specificityi

Expressed at high levels in brain and ovary. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

Gene expression databases

BgeeiQ9NS66.
CleanExiHS_GPR173.
ExpressionAtlasiQ9NS66. baseline and differential.
GenevestigatoriQ9NS66.

Organism-specific databases

HPAiHPA003905.

Interactioni

Protein-protein interaction databases

BioGridi119931. 1 interaction.
STRINGi9606.ENSP00000331600.

Structurei

3D structure databases

ProteinModelPortaliQ9NS66.
SMRiQ9NS66. Positions 26-352.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 5912CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini81 – 9717ExtracellularSequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
BLAST
Topological domaini210 – 28778CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini309 – 32214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini344 – 37330CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237432.
GeneTreeiENSGT00760000119257.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiQ9NS66.
KOiK04300.
OMAiKRMTFWT.
PhylomeDBiQ9NS66.
TreeFamiTF331163.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS66-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE
60 70 80 90 100
RALHKAPYYF LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA
110 120 130 140 150
FMAVLFCFHA AFMLFCISVT RYMAIAHHRF YAKRMTLWTC AAVICMAWTL
160 170 180 190 200
SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY FKANDTLGFM LMLAVLMAAT
210 220 230 240 250
HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ AAANWIAGFG
260 270 280 290 300
RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
310 320 330 340 350
PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC
360 370
LRTHAPCWGT GGAPAPREPY CVM
Length:373
Mass (Da):41,481
Last modified:October 1, 2000 - v1
Checksum:i8A227F914C9D8358
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040801 mRNA. Translation: BAA96647.1.
BX322635 Genomic DNA. Translation: CAI42530.1.
CH471154 Genomic DNA. Translation: EAW93142.1.
BC009861 mRNA. Translation: AAH09861.1.
CCDSiCCDS14349.1.
PIRiJC7289.
RefSeqiNP_061842.1. NM_018969.5.
UniGeneiHs.193011.

Genome annotation databases

EnsembliENST00000332582; ENSP00000331600; ENSG00000184194.
GeneIDi54328.
KEGGihsa:54328.
UCSCiuc004dru.3. human.

Polymorphism databases

DMDMi15214315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040801 mRNA. Translation: BAA96647.1 .
BX322635 Genomic DNA. Translation: CAI42530.1 .
CH471154 Genomic DNA. Translation: EAW93142.1 .
BC009861 mRNA. Translation: AAH09861.1 .
CCDSi CCDS14349.1.
PIRi JC7289.
RefSeqi NP_061842.1. NM_018969.5.
UniGenei Hs.193011.

3D structure databases

ProteinModelPortali Q9NS66.
SMRi Q9NS66. Positions 26-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119931. 1 interaction.
STRINGi 9606.ENSP00000331600.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9NS66.

Polymorphism databases

DMDMi 15214315.

Proteomic databases

PaxDbi Q9NS66.
PRIDEi Q9NS66.

Protocols and materials databases

DNASUi 54328.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332582 ; ENSP00000331600 ; ENSG00000184194 .
GeneIDi 54328.
KEGGi hsa:54328.
UCSCi uc004dru.3. human.

Organism-specific databases

CTDi 54328.
GeneCardsi GC0XP053095.
HGNCi HGNC:18186. GPR173.
HPAi HPA003905.
MIMi 300253. gene.
neXtProti NX_Q9NS66.
PharmGKBi PA134896710.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237432.
GeneTreei ENSGT00760000119257.
HOGENOMi HOG000231471.
HOVERGENi HBG051805.
InParanoidi Q9NS66.
KOi K04300.
OMAi KRMTFWT.
PhylomeDBi Q9NS66.
TreeFami TF331163.

Miscellaneous databases

ChiTaRSi GPR173. human.
GeneWikii GPR173.
GenomeRNAii 54328.
NextBioi 56561.
PROi Q9NS66.
SOURCEi Search...

Gene expression databases

Bgeei Q9NS66.
CleanExi HS_GPR173.
ExpressionAtlasi Q9NS66. baseline and differential.
Genevestigatori Q9NS66.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system."
    Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T., Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.
    Biochem. Biophys. Res. Commun. 272:576-582(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiGP173_HUMAN
AccessioniPrimary (citable) accession number: Q9NS66
Secondary accession number(s): B1B0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3