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Protein

Protein reprimo

Gene

RPRM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).By similarity

Miscellaneous

'Reprimo' signifies stop/repress.

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • regulation of mitotic cell cycle Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Protein reprimo
Gene namesi
Name:RPRM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000177519.3
HGNCiHGNC:24201 RPRM
MIMi612171 gene
neXtProtiNX_Q9NS64

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56475
OpenTargetsiENSG00000177519
PharmGKBiPA134937494

Polymorphism and mutation databases

BioMutaiRPRM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127521 – 109Protein reprimoAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei98PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NS64
PRIDEiQ9NS64

PTM databases

PhosphoSitePlusiQ9NS64

Expressioni

Inductioni

By p53/TP53, following X-ray irradiation.1 Publication

Gene expression databases

BgeeiENSG00000177519
CleanExiHS_RPRM
GenevisibleiQ9NS64 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121145, 24 interactors
IntActiQ9NS64, 46 interactors
MINTiQ9NS64
STRINGi9606.ENSP00000314946

Structurei

3D structure databases

ProteinModelPortaliQ9NS64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the reprimo family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYSF Eukaryota
ENOG4111U46 LUCA
GeneTreeiENSGT00390000010523
HOGENOMiHOG000059532
HOVERGENiHBG105220
InParanoidiQ9NS64
KOiK10128
OMAiFFCCNFS
OrthoDBiEOG091G0YGP
PhylomeDBiQ9NS64
TreeFamiTF332720

Family and domain databases

InterProiView protein in InterPro
IPR033356 Reprimo
PANTHERiPTHR28649:SF2 PTHR28649:SF2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NS64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPALGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS
60 70 80 90 100
LYIMRVVQIA VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE

VEAVVVGPY
Length:109
Mass (Da):11,774
Last modified:October 1, 2000 - v1
Checksum:i7026A0AB1FB6BE62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043585 mRNA Translation: BAB01513.1
AK311958 mRNA Translation: BAG34898.1
AK074808 mRNA Translation: BAG52007.1
AC012501 Genomic DNA Translation: AAY14783.1
CH471058 Genomic DNA Translation: EAX11467.1
BC002908 mRNA Translation: AAH02908.1
CCDSiCCDS2198.1
RefSeqiNP_062819.1, NM_019845.2
UniGeneiHs.100890

Genome annotation databases

EnsembliENST00000325926; ENSP00000314946; ENSG00000177519
GeneIDi56475
KEGGihsa:56475
UCSCiuc002tyq.1 human

Similar proteinsi

Entry informationi

Entry nameiRPRM_HUMAN
AccessioniPrimary (citable) accession number: Q9NS64
Secondary accession number(s): B2R4V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health