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Protein

Protein reprimo

Gene

RPRM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).By similarity

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • regulation of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein reprimo
Gene namesi
Name:RPRM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24201. RPRM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56475.
OpenTargetsiENSG00000177519.
PharmGKBiPA134937494.

Polymorphism and mutation databases

BioMutaiRPRM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127521 – 109Protein reprimoAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Modified residuei98PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NS64.
PaxDbiQ9NS64.
PRIDEiQ9NS64.

PTM databases

PhosphoSitePlusiQ9NS64.

Expressioni

Inductioni

By p53/TP53, following X-ray irradiation.1 Publication

Gene expression databases

BgeeiENSG00000177519.
CleanExiHS_RPRM.
GenevisibleiQ9NS64. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F05EBI-1052363,EBI-743099
TMEM79Q9BSE25EBI-1052363,EBI-8649725

Protein-protein interaction databases

BioGridi121145. 8 interactors.
IntActiQ9NS64. 5 interactors.
STRINGi9606.ENSP00000314946.

Structurei

3D structure databases

ProteinModelPortaliQ9NS64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the reprimo family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYSF. Eukaryota.
ENOG4111U46. LUCA.
GeneTreeiENSGT00390000010523.
HOGENOMiHOG000059532.
HOVERGENiHBG105220.
InParanoidiQ9NS64.
KOiK10128.
OMAiCCNFSSV.
OrthoDBiEOG091G0YGP.
PhylomeDBiQ9NS64.
TreeFamiTF332720.

Family and domain databases

InterProiIPR033356. Reprimo.
[Graphical view]
PANTHERiPTHR28649:SF2. PTHR28649:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NS64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPALGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS
60 70 80 90 100
LYIMRVVQIA VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE

VEAVVVGPY
Length:109
Mass (Da):11,774
Last modified:October 1, 2000 - v1
Checksum:i7026A0AB1FB6BE62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043585 mRNA. Translation: BAB01513.1.
AK311958 mRNA. Translation: BAG34898.1.
AK074808 mRNA. Translation: BAG52007.1.
AC012501 Genomic DNA. Translation: AAY14783.1.
CH471058 Genomic DNA. Translation: EAX11467.1.
BC002908 mRNA. Translation: AAH02908.1.
CCDSiCCDS2198.1.
RefSeqiNP_062819.1. NM_019845.2.
UniGeneiHs.100890.

Genome annotation databases

EnsembliENST00000325926; ENSP00000314946; ENSG00000177519.
GeneIDi56475.
KEGGihsa:56475.
UCSCiuc002tyq.1. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043585 mRNA. Translation: BAB01513.1.
AK311958 mRNA. Translation: BAG34898.1.
AK074808 mRNA. Translation: BAG52007.1.
AC012501 Genomic DNA. Translation: AAY14783.1.
CH471058 Genomic DNA. Translation: EAX11467.1.
BC002908 mRNA. Translation: AAH02908.1.
CCDSiCCDS2198.1.
RefSeqiNP_062819.1. NM_019845.2.
UniGeneiHs.100890.

3D structure databases

ProteinModelPortaliQ9NS64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121145. 8 interactors.
IntActiQ9NS64. 5 interactors.
STRINGi9606.ENSP00000314946.

PTM databases

PhosphoSitePlusiQ9NS64.

Polymorphism and mutation databases

BioMutaiRPRM.

Proteomic databases

EPDiQ9NS64.
PaxDbiQ9NS64.
PRIDEiQ9NS64.

Protocols and materials databases

DNASUi56475.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325926; ENSP00000314946; ENSG00000177519.
GeneIDi56475.
KEGGihsa:56475.
UCSCiuc002tyq.1. human.

Organism-specific databases

CTDi56475.
DisGeNETi56475.
GeneCardsiRPRM.
HGNCiHGNC:24201. RPRM.
MIMi612171. gene.
neXtProtiNX_Q9NS64.
OpenTargetsiENSG00000177519.
PharmGKBiPA134937494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYSF. Eukaryota.
ENOG4111U46. LUCA.
GeneTreeiENSGT00390000010523.
HOGENOMiHOG000059532.
HOVERGENiHBG105220.
InParanoidiQ9NS64.
KOiK10128.
OMAiCCNFSSV.
OrthoDBiEOG091G0YGP.
PhylomeDBiQ9NS64.
TreeFamiTF332720.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177519-MONOMER.

Miscellaneous databases

GenomeRNAii56475.
PROiQ9NS64.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177519.
CleanExiHS_RPRM.
GenevisibleiQ9NS64. HS.

Family and domain databases

InterProiIPR033356. Reprimo.
[Graphical view]
PANTHERiPTHR28649:SF2. PTHR28649:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPRM_HUMAN
AccessioniPrimary (citable) accession number: Q9NS64
Secondary accession number(s): B2R4V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Reprimo' signifies stop/repress.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.