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Protein

Kv channel-interacting protein 2

Gene

KCNIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).By similarity6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi189 – 200121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi237 – 248122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • A-type (transient outward) potassium channel activity Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • ER retention sequence binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • potassium channel regulator activity Source: BHF-UCL
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • cardiac conduction Source: Reactome
  • chemical synaptic transmission Source: UniProtKB
  • clustering of voltage-gated potassium channels Source: UniProtKB
  • detection of calcium ion Source: ProtInc
  • membrane repolarization Source: BHF-UCL
  • muscle contraction Source: UniProtKB
  • potassium ion export Source: BHF-UCL
  • potassium ion transmembrane transport Source: BHF-UCL
  • potassium ion transport Source: UniProtKB
  • regulation of cation channel activity Source: BHF-UCL
  • regulation of heart contraction Source: UniProtKB
  • regulation of potassium ion transmembrane transport Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calcium, Metal-binding, Potassium

Enzyme and pathway databases

ReactomeiR-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Kv channel-interacting protein 2
Short name:
KChIP21 Publication
Alternative name(s):
A-type potassium channel modulatory protein 2
Cardiac voltage-gated potassium channel modulatory subunit
Potassium channel-interacting protein 2
Gene namesi
Name:KCNIP2
Synonyms:KCHIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:15522. KCNIP2.

Subcellular locationi

Isoform 1 :
  • Cell membrane By similarity; Lipid-anchor By similarity

  • Note: Detected on lipid rafts (By similarity).By similarity
Isoform 2 :
  • Cell membrane By similarity; Lipid-anchor By similarity
Isoform 6 :
  • Cell membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30042.

Polymorphism and mutation databases

BioMutaiKCNIP2.
DMDMi338817979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Kv channel-interacting protein 2PRO_0000073821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Lipidationi45 – 451S-palmitoyl cysteineBy similarity
Lipidationi46 – 461S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylated. Palmitoylation enhances association with the plasma membrane.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9NS61.
PeptideAtlasiQ9NS61.
PRIDEiQ9NS61.

PTM databases

iPTMnetiQ9NS61.
PhosphoSiteiQ9NS61.

Expressioni

Tissue specificityi

Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.3 Publications

Gene expression databases

BgeeiENSG00000120049.
ExpressionAtlasiQ9NS61. baseline and differential.
GenevisibleiQ9NS61. HS.

Interactioni

Subunit structurei

Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits (PubMed:14623880, PubMed:14980201). Interacts with KCND2 (PubMed:10676964, PubMed:14623880, PubMed:14980201). Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KCND2Q9NZV83EBI-1052975,EBI-1646745
KCNIP1Q9NZI24EBI-1053010,EBI-2120635

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119043. 11 interactions.
IntActiQ9NS61. 2 interactions.
MINTiMINT-4712078.

Structurei

3D structure databases

ProteinModelPortaliQ9NS61.
SMRiQ9NS61. Positions 90-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 13757EF-hand 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Domaini140 – 17536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 21136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 25936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 27014Interaction with KCND2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiQ9NS61.
OMAiMNRCPRR.
OrthoDBiEOG091G11T4.
TreeFamiTF318560.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029532. KCNIP2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF65. PTHR23055:SF65. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS61-1) [UniParc]FASTAAdd to basket
Also known as: KChIP2a, KChIP2b, KCHIP2.4, KCHIP2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGQGRKESL SDSRDLDGSY DQLTGHPPGP TKKALKQRFL KLLPCCGPQA
60 70 80 90 100
LPSVSETLAA PASLRPHRPR LLDPDSVDDE FELSTVCHRP EGLEQLQEQT
110 120 130 140 150
KFTRKELQVL YRGFKNECPS GIVNEENFKQ IYSQFFPQGD SSTYATFLFN
160 170 180 190 200
AFDTNHDGSV SFEDFVAGLS VILRGTVDDR LNWAFNLYDL NKDGCITKEE
210 220 230 240 250
MLDIMKSIYD MMGKYTYPAL REEAPREHVE SFFQKMDRNK DGVVTIEEFI
260 270
ESCQKDENIM RSMQLFDNVI
Length:270
Mass (Da):30,907
Last modified:June 28, 2011 - v3
Checksum:iB75AD02B9E273243
GO
Isoform 2 (identifier: Q9NS61-2) [UniParc]FASTAAdd to basket
Also known as: 3, KChIP2.1, KChIP2b

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: TLAAPASLRPHRPRLLDPD → N

Show »
Length:252
Mass (Da):28,943
Checksum:i7502F0C69D2B35FE
GO
Isoform 3 (identifier: Q9NS61-3) [UniParc]FASTAAdd to basket
Also known as: 2, KChIP2.2, KChIP2c, KCHIP2S

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.

Show »
Length:220
Mass (Da):25,562
Checksum:i52FD8C601356338F
GO
Isoform 4 (identifier: Q9NS61-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MRGQGRKESL...LRPHRPRLLD → MNRCPRRCRSPLGQAARSLYQLVTGSLS

Show »
Length:225
Mass (Da):26,066
Checksum:i7919AFDD3A5FACF1
GO
Isoform 5 (identifier: Q9NS61-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     160-163: Missing.

Show »
Length:216
Mass (Da):25,100
Checksum:iEDDF7A3B16108F08
GO
Isoform 6 (identifier: Q9NS61-6) [UniParc]FASTAAdd to basket
Also known as: KCHIP4.2

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: T → IGRVFRFLGDSSLPSA

Show »
Length:285
Mass (Da):32,510
Checksum:i38A62414577BCF49
GO
Isoform 7 (identifier: Q9NS61-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     116-116: N → NPGALSFQ

Show »
Length:227
Mass (Da):26,263
Checksum:i7F1D2B8E7F85D8B9
GO
Isoform 8 (identifier: Q9NS61-8) [UniParc]FASTAAdd to basket
Also known as: KCHIP2.6

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: Missing.
     94-162: EQLQEQTKFT...DTNHDGSVSF → MWLSWTAWTM...SRFTPSSFLK

Show »
Length:177
Mass (Da):20,482
Checksum:i8CF26C549F293353
GO
Isoform 9 (identifier: Q9NS61-9) [UniParc]FASTAAdd to basket
Also known as: KCHIP2.5

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: Missing.
     163-198: Missing.
     256-270: DENIMRSMQLFDNVI → VQLPALYITLTWTQA

Show »
Length:184
Mass (Da):21,401
Checksum:i4B810CA98F45A052
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501A → V in BAA96740 (PubMed:11263977).Curated
Sequence conflicti71 – 711L → P in BAA96740 (PubMed:11263977).Curated
Sequence conflicti75 – 751D → V in BAA96741 (PubMed:11263977).Curated
Sequence conflicti76 – 761S → R in BAB55052 (PubMed:14702039).Curated
Sequence conflicti78 – 781D → E in BAA96740 (PubMed:11263977).Curated
Sequence conflicti83 – 831L → S in CAB66656 (PubMed:11230166).Curated
Sequence conflicti224 – 2241A → P in BAA96740 (PubMed:11263977).Curated
Sequence conflicti224 – 2241A → P in BAA96741 (PubMed:11263977).Curated
Sequence conflicti239 – 2391N → S in AAP57633 (Ref. 9) Curated
Sequence conflicti246 – 2461I → N in CAB66656 (PubMed:11230166).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9393Missing in isoform 8. 1 PublicationVSP_015049Add
BLAST
Alternative sequencei1 – 7373MRGQG…PRLLD → MNRCPRRCRSPLGQAARSLY QLVTGSLS in isoform 4. 3 PublicationsVSP_015050Add
BLAST
Alternative sequencei25 – 7450Missing in isoform 3, isoform 5, isoform 7 and isoform 9. 10 PublicationsVSP_015051Add
BLAST
Alternative sequencei57 – 7519TLAAP…LLDPD → N in isoform 2. 8 PublicationsVSP_015052Add
BLAST
Alternative sequencei57 – 571T → IGRVFRFLGDSSLPSA in isoform 6. 1 PublicationVSP_015053
Alternative sequencei94 – 16269EQLQE…GSVSF → MWLSWTAWTMNLNCPPCVTG LRVWSSCRSKPNSRARSCRS CTGASRTNVPAELSMRRTSS RFTPSSFLK in isoform 8. 1 PublicationVSP_015054Add
BLAST
Alternative sequencei116 – 1161N → NPGALSFQ in isoform 7. 1 PublicationVSP_015055
Alternative sequencei160 – 1634Missing in isoform 5. 1 PublicationVSP_015056
Alternative sequencei163 – 19836Missing in isoform 9. 1 PublicationVSP_015057Add
BLAST
Alternative sequencei256 – 27015DENIM…FDNVI → VQLPALYITLTWTQA in isoform 9. 1 PublicationVSP_015058Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199598 mRNA. Translation: AAF33683.1.
AB044584 mRNA. Translation: BAA96740.1.
AB044585 mRNA. Translation: BAA96741.1.
AY026328 mRNA. Translation: AAK07674.1.
AY026331, AY026329, AY026330 Genomic DNA. Translation: AAK21972.1.
AF347114 mRNA. Translation: AAK70356.1.
AF295076 mRNA. Translation: AAG02120.1.
AF295530 mRNA. Translation: AAG02121.1.
AF367018 mRNA. Translation: AAK53707.1.
AF367019 mRNA. Translation: AAK53708.1.
AF367020 mRNA. Translation: AAK53709.1.
AF367021 mRNA. Translation: AAK53710.1.
DQ148480 mRNA. Translation: AAZ77797.1.
DQ148481 mRNA. Translation: AAZ77798.1.
DQ148483 mRNA. Translation: AAZ77800.1.
AL136722 mRNA. Translation: CAB66656.1.
AY302141 mRNA. Translation: AAP57633.1.
AK027347 mRNA. Translation: BAB55052.1.
AK315042 mRNA. Translation: BAG37523.1.
AC010789 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49733.1.
BC034685 mRNA. Translation: AAH34685.1.
AJ276317 mRNA. Translation: CAB77054.1.
CCDSiCCDS41562.1. [Q9NS61-2]
CCDS7521.1. [Q9NS61-6]
CCDS7522.1. [Q9NS61-1]
CCDS7523.1. [Q9NS61-7]
CCDS7524.1. [Q9NS61-3]
CCDS7525.1. [Q9NS61-4]
CCDS7526.1. [Q9NS61-9]
RefSeqiNP_055406.2. NM_014591.4. [Q9NS61-6]
NP_775283.1. NM_173191.2. [Q9NS61-1]
NP_775284.1. NM_173192.2. [Q9NS61-2]
NP_775285.1. NM_173193.2. [Q9NS61-7]
NP_775286.1. NM_173194.2. [Q9NS61-4]
NP_775287.1. NM_173195.2. [Q9NS61-3]
NP_775289.1. NM_173197.2. [Q9NS61-9]
UniGeneiHs.97044.

Genome annotation databases

EnsembliENST00000239117; ENSP00000239117; ENSG00000120049. [Q9NS61-9]
ENST00000343195; ENSP00000344169; ENSG00000120049. [Q9NS61-3]
ENST00000348850; ENSP00000239118; ENSG00000120049. [Q9NS61-4]
ENST00000353068; ENSP00000341624; ENSG00000120049. [Q9NS61-7]
ENST00000356640; ENSP00000349055; ENSG00000120049. [Q9NS61-1]
ENST00000358038; ENSP00000350733; ENSG00000120049. [Q9NS61-2]
ENST00000434163; ENSP00000411679; ENSG00000120049. [Q9NS61-8]
ENST00000461105; ENSP00000420040; ENSG00000120049. [Q9NS61-6]
GeneIDi30819.
KEGGihsa:30819.
UCSCiuc001ktz.4. human. [Q9NS61-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199598 mRNA. Translation: AAF33683.1.
AB044584 mRNA. Translation: BAA96740.1.
AB044585 mRNA. Translation: BAA96741.1.
AY026328 mRNA. Translation: AAK07674.1.
AY026331, AY026329, AY026330 Genomic DNA. Translation: AAK21972.1.
AF347114 mRNA. Translation: AAK70356.1.
AF295076 mRNA. Translation: AAG02120.1.
AF295530 mRNA. Translation: AAG02121.1.
AF367018 mRNA. Translation: AAK53707.1.
AF367019 mRNA. Translation: AAK53708.1.
AF367020 mRNA. Translation: AAK53709.1.
AF367021 mRNA. Translation: AAK53710.1.
DQ148480 mRNA. Translation: AAZ77797.1.
DQ148481 mRNA. Translation: AAZ77798.1.
DQ148483 mRNA. Translation: AAZ77800.1.
AL136722 mRNA. Translation: CAB66656.1.
AY302141 mRNA. Translation: AAP57633.1.
AK027347 mRNA. Translation: BAB55052.1.
AK315042 mRNA. Translation: BAG37523.1.
AC010789 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49733.1.
BC034685 mRNA. Translation: AAH34685.1.
AJ276317 mRNA. Translation: CAB77054.1.
CCDSiCCDS41562.1. [Q9NS61-2]
CCDS7521.1. [Q9NS61-6]
CCDS7522.1. [Q9NS61-1]
CCDS7523.1. [Q9NS61-7]
CCDS7524.1. [Q9NS61-3]
CCDS7525.1. [Q9NS61-4]
CCDS7526.1. [Q9NS61-9]
RefSeqiNP_055406.2. NM_014591.4. [Q9NS61-6]
NP_775283.1. NM_173191.2. [Q9NS61-1]
NP_775284.1. NM_173192.2. [Q9NS61-2]
NP_775285.1. NM_173193.2. [Q9NS61-7]
NP_775286.1. NM_173194.2. [Q9NS61-4]
NP_775287.1. NM_173195.2. [Q9NS61-3]
NP_775289.1. NM_173197.2. [Q9NS61-9]
UniGeneiHs.97044.

3D structure databases

ProteinModelPortaliQ9NS61.
SMRiQ9NS61. Positions 90-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119043. 11 interactions.
IntActiQ9NS61. 2 interactions.
MINTiMINT-4712078.

PTM databases

iPTMnetiQ9NS61.
PhosphoSiteiQ9NS61.

Polymorphism and mutation databases

BioMutaiKCNIP2.
DMDMi338817979.

Proteomic databases

MaxQBiQ9NS61.
PeptideAtlasiQ9NS61.
PRIDEiQ9NS61.

Protocols and materials databases

DNASUi30819.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239117; ENSP00000239117; ENSG00000120049. [Q9NS61-9]
ENST00000343195; ENSP00000344169; ENSG00000120049. [Q9NS61-3]
ENST00000348850; ENSP00000239118; ENSG00000120049. [Q9NS61-4]
ENST00000353068; ENSP00000341624; ENSG00000120049. [Q9NS61-7]
ENST00000356640; ENSP00000349055; ENSG00000120049. [Q9NS61-1]
ENST00000358038; ENSP00000350733; ENSG00000120049. [Q9NS61-2]
ENST00000434163; ENSP00000411679; ENSG00000120049. [Q9NS61-8]
ENST00000461105; ENSP00000420040; ENSG00000120049. [Q9NS61-6]
GeneIDi30819.
KEGGihsa:30819.
UCSCiuc001ktz.4. human. [Q9NS61-1]

Organism-specific databases

CTDi30819.
GeneCardsiKCNIP2.
HGNCiHGNC:15522. KCNIP2.
MIMi604661. gene.
neXtProtiNX_Q9NS61.
PharmGKBiPA30042.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiQ9NS61.
OMAiMNRCPRR.
OrthoDBiEOG091G11T4.
TreeFamiTF318560.

Enzyme and pathway databases

ReactomeiR-HSA-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

ChiTaRSiKCNIP2. human.
GeneWikiiKCNIP2.
GenomeRNAii30819.
PROiQ9NS61.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120049.
ExpressionAtlasiQ9NS61. baseline and differential.
GenevisibleiQ9NS61. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR029532. KCNIP2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF65. PTHR23055:SF65. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS61
Secondary accession number(s): A6NJE5
, A8MQ75, Q3YAC6, Q3YAC8, Q3YAC9, Q7Z6F1, Q96K86, Q96T41, Q96T42, Q96T43, Q96T44, Q9H0N4, Q9HD10, Q9HD11, Q9NS60, Q9NY10, Q9NZI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.