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Protein

Double-stranded RNA-specific editase B2

Gene

ADARB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi432ZincPROSITE-ProRule annotation1
Active sitei434Proton donorPROSITE-ProRule annotation1
Metal bindingi490ZincPROSITE-ProRule annotation1
Metal bindingi555ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • adenosine deaminase activity Source: ProtInc
  • double-stranded RNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processmRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-specific editase B2 (EC:3.5.-.-)
Alternative name(s):
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
dsRNA adenosine deaminase B2
Gene namesi
Name:ADARB2
Synonyms:ADAR3, RED2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000185736.15.
HGNCiHGNC:227. ADARB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi105.
OpenTargetsiENSG00000185736.
PharmGKBiPA24557.

Polymorphism and mutation databases

BioMutaiADARB2.
DMDMi33112436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717821 – 739Double-stranded RNA-specific editase B2Add BLAST739

Proteomic databases

EPDiQ9NS39.
PaxDbiQ9NS39.
PeptideAtlasiQ9NS39.
PRIDEiQ9NS39.

2D gel databases

SWISS-2DPAGEiQ9NS39.

PTM databases

iPTMnetiQ9NS39.
PhosphoSitePlusiQ9NS39.

Expressioni

Tissue specificityi

Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue.2 Publications

Gene expression databases

BgeeiENSG00000185736.
CleanExiHS_ADARB2.
ExpressionAtlasiQ9NS39. baseline and differential.
GenevisibleiQ9NS39. HS.

Organism-specific databases

HPAiHPA031333.

Interactioni

Protein-protein interaction databases

BioGridi106619. 9 interactors.
IntActiQ9NS39. 5 interactors.
MINTiMINT-4728108.
STRINGi9606.ENSP00000370713.

Structurei

3D structure databases

ProteinModelPortaliQ9NS39.
SMRiQ9NS39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 191DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini274 – 341DRBM 2PROSITE-ProRule annotationAdd BLAST68
Domaini408 – 735A to I editasePROSITE-ProRule annotationAdd BLAST328

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 35R-domain (ssRNA-binding)Add BLAST13

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiQ9NS39.
KOiK13194.
OMAiCKLQLIW.
OrthoDBiEOG091G0MZP.
PhylomeDBiQ9NS39.
TreeFamiTF315806.

Family and domain databases

InterProiView protein in InterPro
IPR002466. A_deamin.
IPR014720. dsRBD_dom.
PfamiView protein in Pfam
PF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
SMARTiView protein in SMART
SM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
PROSITEiView protein in PROSITE
PS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NS39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS
60 70 80 90 100
PGITNTEDDD TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR
110 120 130 140 150
PLEEGNGGHL CKLQLVWKKL SWSVAPKNAL VQLHELRPGL QYRTVSQTGP
160 170 180 190 200
VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR AAELALRSFV QFPNACQAHL
210 220 230 240 250
AMGGGPGPGT DFTSDQADFP DTLFQEFEPP APRPGLAGGR PGDAALLSAA
260 270 280 290 300
YGRRRLLCRA LDLVGPTPAT PAAPGERNPV VLLNRLRAGL RYVCLAEPAE
310 320 330 340 350
RRARSFVMAV SVDGRTFEGS GRSKKLARGQ AAQAALQELF DIQMPGHAPG
360 370 380 390 400
RARRTPMPQE FADSISQLVT QKFREVTTDL TPMHARHKAL AGIVMTKGLD
410 420 430 440 450
ARQAQVVALS SGTKCISGEH LSDQGLVVND CHAEVVARRA FLHFLYTQLE
460 470 480 490 500
LHLSKRREDS ERSIFVRLKE GGYRLRENIL FHLYVSTSPC GDARLHSPYE
510 520 530 540 550
ITTDLHSSKH LVRKFRGHLR TKIESGEGTV PVRGPSAVQT WDGVLLGEQL
560 570 580 590 600
ITMSCTDKIA RWNVLGLQGA LLSHFVEPVY LQSIVVGSLH HTGHLARVMS
610 620 630 640 650
HRMEGVGQLP ASYRHNRPLL SGVSDAEARQ PGKSPPFSMN WVVGSADLEI
660 670 680 690 700
INATTGRRSC GGPSRLCKHV LSARWARLYG RLSTRTPSPG DTPSMYCEAK
710 720 730
LGAHTYQSVK QQLFKAFQKA GLGTWVRKPP EQQQFLLTL
Length:739
Mass (Da):80,621
Last modified:October 1, 2000 - v1
Checksum:iA158A81D35894F79
GO
Isoform 2 (identifier: Q9NS39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MASVLGSGRG...DTLSTSSAEV → MGLWSPVPGN...GAPLTAGSPH
     70-560: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):26,723
Checksum:i370AD0A469831419
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02043844A → T. Corresponds to variant dbSNP:rs3793733Ensembl.1
Natural variantiVAR_035806210T → M in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035807512V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138734198Ensembl.1
Natural variantiVAR_048726626A → T1 PublicationCorresponds to variant dbSNP:rs2271275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569261 – 69MASVL…SSAEV → MGLWSPVPGNSVPRAPVMAG LGLGHSQGAPQGPHDGKTDR SSGPGRRRTERTRLPGLLGG APLTAGSPH in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_05692770 – 560Missing in isoform 2. 1 PublicationAdd BLAST491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034837 mRNA. Translation: AAF78094.1.
AK055107 mRNA. Translation: BAG51468.1.
AL442069 Genomic DNA. No translation available.
AL450386 Genomic DNA. No translation available.
AL513304, AC026224, AL392083 Genomic DNA. Translation: CAH73405.1.
AL392083, AC026224, AL513304 Genomic DNA. Translation: CAH72171.1.
BC137477 mRNA. Translation: AAI37478.1.
BC140852 mRNA. Translation: AAI40853.1.
CCDSiCCDS7058.1. [Q9NS39-1]
RefSeqiNP_061172.1. NM_018702.3. [Q9NS39-1]
UniGeneiHs.586663.

Genome annotation databases

EnsembliENST00000381310; ENSP00000370711; ENSG00000185736. [Q9NS39-2]
ENST00000381312; ENSP00000370713; ENSG00000185736. [Q9NS39-1]
GeneIDi105.
KEGGihsa:105.
UCSCiuc001igm.5. human. [Q9NS39-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRED2_HUMAN
AccessioniPrimary (citable) accession number: Q9NS39
Secondary accession number(s): B2RPJ5, Q5VUT6, Q5VW42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot