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Q9NS37

- ZHANG_HUMAN

UniProt

Q9NS37 - ZHANG_HUMAN

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Protein
CREB/ATF bZIP transcription factor
Gene
CREBZF, ZF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. negative regulation of gene expression, epigenetic Source: UniProtKB
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. response to virus Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB/ATF bZIP transcription factor
Alternative name(s):
Host cell factor-binding transcription factor Zhangfei
Short name:
HCF-binding transcription factor Zhangfei
Gene namesi
Name:CREBZF
Synonyms:ZF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:24905. CREBZF.

Subcellular locationi

Nucleus
Note: Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi303 – 3031D → A: Significantly reduced binding to HCFC1. 1 Publication
Mutagenesisi304 – 3041H → A: Significantly reduced binding to HCFC1. 1 Publication
Mutagenesisi306 – 3061Y → A: Does not interact with HCFC1 and is inefficient at inhibiting CREB3 transcriptional activity. Does not colocalize with CREB3 in promyelocytic leukemia protein nuclear bodies (PML-NB). 2 Publications

Organism-specific databases

PharmGKBiPA162382821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354CREB/ATF bZIP transcription factor
PRO_0000076645Add
BLAST

Proteomic databases

PaxDbiQ9NS37.
PRIDEiQ9NS37.

PTM databases

PhosphoSiteiQ9NS37.

Expressioni

Tissue specificityi

In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.1 Publication

Gene expression databases

ArrayExpressiQ9NS37.
BgeeiQ9NS37.
CleanExiHS_CREBZF.
GenevestigatoriQ9NS37.

Organism-specific databases

HPAiHPA021526.

Interactioni

Subunit structurei

Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-632965,EBI-632965
ATF4P188485EBI-632965,EBI-492498
EsrrgP625093EBI-632965,EBI-5274019From a different organism.
HCFC1P516108EBI-632965,EBI-396176
SIRT1Q96EB63EBI-632965,EBI-1802965

Protein-protein interaction databases

BioGridi121817. 12 interactions.
IntActiQ9NS37. 7 interactions.
MINTiMINT-1200350.
STRINGi9606.ENSP00000260058.

Structurei

3D structure databases

ProteinModelPortaliQ9NS37.
SMRiQ9NS37. Positions 214-255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26764bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2268Basic motif By similarity
Regioni232 – 26736Leucine-zipper By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi303 – 3064HCFC1-binding motif (HBM)

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Phylogenomic databases

eggNOGiNOG46652.
HOGENOMiHOG000285965.
HOVERGENiHBG099107.
InParanoidiQ9NS37.
OrthoDBiEOG7FZ00Q.
PhylomeDBiQ9NS37.
TreeFamiTF336153.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS37-1 [UniParc]FASTAAdd to Basket

« Hide

MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS    50
PGRKQQFGDE GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD 100
FLSGLELADL LDPRQPDWHL DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE 150
AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG SAEKRRRKSP GGGGGGGSGN 200
DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA AENQELRAEN 250
RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP 300
AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS 350
SLKM 354
Length:354
Mass (Da):37,134
Last modified:July 7, 2009 - v2
Checksum:iBE3AC77203216155
GO

Sequence cautioni

The sequence AAD28325.1 differs from that shown. Reason: Frameshift at positions 5 and 49.
The sequence BAG36256.1 differs from that shown. Reason: Frameshift at position 59.
The sequence AAD28325.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAZ42189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG36256.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161S → F in AAH60807. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039942 mRNA. Translation: AAD28325.1. Sequence problems.
AP000642 Genomic DNA. No translation available.
BC060807 mRNA. Translation: AAH60807.1.
BC093796 mRNA. Translation: AAH93796.2.
BC093798 mRNA. Translation: AAH93798.2.
AK313471 mRNA. Translation: BAG36256.1. Sequence problems.
DQ128105 mRNA. Translation: AAZ42189.1. Different initiation.
CCDSiCCDS41697.1.
RefSeqiNP_001034707.1. NM_001039618.2.
XP_006718708.1. XM_006718645.1.
UniGeneiHs.535319.
Hs.714910.

Genome annotation databases

EnsembliENST00000398294; ENSP00000381342; ENSG00000137504.
ENST00000490820; ENSP00000434281; ENSG00000137504.
ENST00000527447; ENSP00000433459; ENSG00000137504.
GeneIDi58487.
KEGGihsa:58487.
UCSCiuc001pas.2. human.

Polymorphism databases

DMDMi251757415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039942 mRNA. Translation: AAD28325.1 . Sequence problems.
AP000642 Genomic DNA. No translation available.
BC060807 mRNA. Translation: AAH60807.1 .
BC093796 mRNA. Translation: AAH93796.2 .
BC093798 mRNA. Translation: AAH93798.2 .
AK313471 mRNA. Translation: BAG36256.1 . Sequence problems.
DQ128105 mRNA. Translation: AAZ42189.1 . Different initiation.
CCDSi CCDS41697.1.
RefSeqi NP_001034707.1. NM_001039618.2.
XP_006718708.1. XM_006718645.1.
UniGenei Hs.535319.
Hs.714910.

3D structure databases

ProteinModelPortali Q9NS37.
SMRi Q9NS37. Positions 214-255.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121817. 12 interactions.
IntActi Q9NS37. 7 interactions.
MINTi MINT-1200350.
STRINGi 9606.ENSP00000260058.

PTM databases

PhosphoSitei Q9NS37.

Polymorphism databases

DMDMi 251757415.

Proteomic databases

PaxDbi Q9NS37.
PRIDEi Q9NS37.

Protocols and materials databases

DNASUi 58487.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398294 ; ENSP00000381342 ; ENSG00000137504 .
ENST00000490820 ; ENSP00000434281 ; ENSG00000137504 .
ENST00000527447 ; ENSP00000433459 ; ENSG00000137504 .
GeneIDi 58487.
KEGGi hsa:58487.
UCSCi uc001pas.2. human.

Organism-specific databases

CTDi 58487.
GeneCardsi GC11M085368.
HGNCi HGNC:24905. CREBZF.
HPAi HPA021526.
MIMi 606444. gene.
neXtProti NX_Q9NS37.
PharmGKBi PA162382821.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46652.
HOGENOMi HOG000285965.
HOVERGENi HBG099107.
InParanoidi Q9NS37.
OrthoDBi EOG7FZ00Q.
PhylomeDBi Q9NS37.
TreeFami TF336153.

Miscellaneous databases

GenomeRNAii 58487.
NextBioi 64946.
PROi Q9NS37.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NS37.
Bgeei Q9NS37.
CleanExi HS_CREBZF.
Genevestigatori Q9NS37.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16."
    Lu R., Misra V.
    Nucleic Acids Res. 28:2446-2454(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HCFC1, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-303; HIS-304 AND TYR-306.
    Tissue: Cervix carcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-354.
    Tissue: Hippocampus.
  5. Zhang J.W., Zhang X., Ma Y.N.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-354.
    Tissue: Bone marrow.
  6. "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman."
    Misra V., Rapin N., Akhova O., Bainbridge M., Korchinski P.
    J. Biol. Chem. 280:15257-15266(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A SUPPRESSOR OF CREB3 TRANSCRIPTIONAL ACTIVITY, INTERACTION WITH HCFC1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-306.

Entry informationi

Entry nameiZHANG_HUMAN
AccessioniPrimary (citable) accession number: Q9NS37
Secondary accession number(s): B2R8Q9, Q0P5U9, Q52LT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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