Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NS37

- ZHANG_HUMAN

UniProt

Q9NS37 - ZHANG_HUMAN

Protein

CREB/ATF bZIP transcription factor

Gene

CREBZF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (07 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. identical protein binding Source: IntAct
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of gene expression, epigenetic Source: UniProtKB
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    4. response to virus Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CREB/ATF bZIP transcription factor
    Alternative name(s):
    Host cell factor-binding transcription factor Zhangfei
    Short name:
    HCF-binding transcription factor Zhangfei
    Gene namesi
    Name:CREBZF
    Synonyms:ZF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:24905. CREBZF.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi303 – 3031D → A: Significantly reduced binding to HCFC1. 1 Publication
    Mutagenesisi304 – 3041H → A: Significantly reduced binding to HCFC1. 1 Publication
    Mutagenesisi306 – 3061Y → A: Does not interact with HCFC1 and is inefficient at inhibiting CREB3 transcriptional activity. Does not colocalize with CREB3 in promyelocytic leukemia protein nuclear bodies (PML-NB). 2 Publications

    Organism-specific databases

    PharmGKBiPA162382821.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354CREB/ATF bZIP transcription factorPRO_0000076645Add
    BLAST

    Proteomic databases

    PaxDbiQ9NS37.
    PRIDEiQ9NS37.

    PTM databases

    PhosphoSiteiQ9NS37.

    Expressioni

    Tissue specificityi

    In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9NS37.
    BgeeiQ9NS37.
    CleanExiHS_CREBZF.
    GenevestigatoriQ9NS37.

    Organism-specific databases

    HPAiHPA021526.

    Interactioni

    Subunit structurei

    Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-632965,EBI-632965
    ATF4P188485EBI-632965,EBI-492498
    EsrrgP625093EBI-632965,EBI-5274019From a different organism.
    HCFC1P516108EBI-632965,EBI-396176
    SIRT1Q96EB63EBI-632965,EBI-1802965

    Protein-protein interaction databases

    BioGridi121817. 12 interactions.
    DIPiDIP-33934N.
    IntActiQ9NS37. 7 interactions.
    MINTiMINT-1200350.
    STRINGi9606.ENSP00000260058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NS37.
    SMRiQ9NS37. Positions 214-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 26764bZIPAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2268Basic motifBy similarity
    Regioni232 – 26736Leucine-zipperBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi303 – 3064HCFC1-binding motif (HBM)

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Sequence Analysis

    Phylogenomic databases

    eggNOGiNOG46652.
    HOGENOMiHOG000285965.
    HOVERGENiHBG099107.
    InParanoidiQ9NS37.
    OrthoDBiEOG7FZ00Q.
    PhylomeDBiQ9NS37.
    TreeFamiTF336153.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NS37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHSLTKLLA ASGSNSPTRS ESPEPAATCS LPSDLTRAAA GEEETAAAGS    50
    PGRKQQFGDE GELEAGRGSR GGVAVRAPSP EEMEEEAIAS LPGEETEDMD 100
    FLSGLELADL LDPRQPDWHL DPGLSSPGPL SSSGGGSDSG GLWRGDDDDE 150
    AAAAEMQRFS DLLQRLLNGI GGCSSSSDSG SAEKRRRKSP GGGGGGGSGN 200
    DNNQAATKSP RKAAAAAARL NRLKKKEYVM GLESRVRGLA AENQELRAEN 250
    RELGKRVQAL QEESRYLRAV LANETGLARL LSRLSGVGLR LTTSLFRDSP 300
    AGDHDYALPV GKQKQDLLEE DDSAGGVCLH VDKDKVSVEF CSACARKASS 350
    SLKM 354
    Length:354
    Mass (Da):37,134
    Last modified:July 7, 2009 - v2
    Checksum:iBE3AC77203216155
    GO

    Sequence cautioni

    The sequence AAD28325.1 differs from that shown. Reason: Frameshift at positions 5 and 49.
    The sequence BAG36256.1 differs from that shown. Reason: Frameshift at position 59.
    The sequence AAD28325.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAZ42189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG36256.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161S → F in AAH60807. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039942 mRNA. Translation: AAD28325.1. Sequence problems.
    AP000642 Genomic DNA. No translation available.
    BC060807 mRNA. Translation: AAH60807.1.
    BC093796 mRNA. Translation: AAH93796.2.
    BC093798 mRNA. Translation: AAH93798.2.
    AK313471 mRNA. Translation: BAG36256.1. Sequence problems.
    DQ128105 mRNA. Translation: AAZ42189.1. Different initiation.
    CCDSiCCDS41697.1.
    RefSeqiNP_001034707.1. NM_001039618.2.
    XP_006718708.1. XM_006718645.1.
    UniGeneiHs.535319.
    Hs.714910.

    Genome annotation databases

    EnsembliENST00000490820; ENSP00000434281; ENSG00000137504.
    ENST00000527447; ENSP00000433459; ENSG00000137504.
    GeneIDi58487.
    KEGGihsa:58487.
    UCSCiuc001pas.2. human.

    Polymorphism databases

    DMDMi251757415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039942 mRNA. Translation: AAD28325.1 . Sequence problems.
    AP000642 Genomic DNA. No translation available.
    BC060807 mRNA. Translation: AAH60807.1 .
    BC093796 mRNA. Translation: AAH93796.2 .
    BC093798 mRNA. Translation: AAH93798.2 .
    AK313471 mRNA. Translation: BAG36256.1 . Sequence problems.
    DQ128105 mRNA. Translation: AAZ42189.1 . Different initiation.
    CCDSi CCDS41697.1.
    RefSeqi NP_001034707.1. NM_001039618.2.
    XP_006718708.1. XM_006718645.1.
    UniGenei Hs.535319.
    Hs.714910.

    3D structure databases

    ProteinModelPortali Q9NS37.
    SMRi Q9NS37. Positions 214-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121817. 12 interactions.
    DIPi DIP-33934N.
    IntActi Q9NS37. 7 interactions.
    MINTi MINT-1200350.
    STRINGi 9606.ENSP00000260058.

    PTM databases

    PhosphoSitei Q9NS37.

    Polymorphism databases

    DMDMi 251757415.

    Proteomic databases

    PaxDbi Q9NS37.
    PRIDEi Q9NS37.

    Protocols and materials databases

    DNASUi 58487.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000490820 ; ENSP00000434281 ; ENSG00000137504 .
    ENST00000527447 ; ENSP00000433459 ; ENSG00000137504 .
    GeneIDi 58487.
    KEGGi hsa:58487.
    UCSCi uc001pas.2. human.

    Organism-specific databases

    CTDi 58487.
    GeneCardsi GC11M085368.
    HGNCi HGNC:24905. CREBZF.
    HPAi HPA021526.
    MIMi 606444. gene.
    neXtProti NX_Q9NS37.
    PharmGKBi PA162382821.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46652.
    HOGENOMi HOG000285965.
    HOVERGENi HBG099107.
    InParanoidi Q9NS37.
    OrthoDBi EOG7FZ00Q.
    PhylomeDBi Q9NS37.
    TreeFami TF336153.

    Miscellaneous databases

    GenomeRNAii 58487.
    NextBioi 64946.
    PROi Q9NS37.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NS37.
    Bgeei Q9NS37.
    CleanExi HS_CREBZF.
    Genevestigatori Q9NS37.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16."
      Lu R., Misra V.
      Nucleic Acids Res. 28:2446-2454(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HCFC1, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-303; HIS-304 AND TYR-306.
      Tissue: Cervix carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-354.
      Tissue: Hippocampus.
    5. Zhang J.W., Zhang X., Ma Y.N.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-354.
      Tissue: Bone marrow.
    6. "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman."
      Misra V., Rapin N., Akhova O., Bainbridge M., Korchinski P.
      J. Biol. Chem. 280:15257-15266(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A SUPPRESSOR OF CREB3 TRANSCRIPTIONAL ACTIVITY, INTERACTION WITH HCFC1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-306.

    Entry informationi

    Entry nameiZHANG_HUMAN
    AccessioniPrimary (citable) accession number: Q9NS37
    Secondary accession number(s): B2R8Q9, Q0P5U9, Q52LT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3