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Q9NS28

- RGS18_HUMAN

UniProt

Q9NS28 - RGS18_HUMAN

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Protein
Regulator of G-protein signaling 18
Gene
RGS18, RGS13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.2 Publications

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 18
Short name:
RGS18
Gene namesi
Name:RGS18
Synonyms:RGS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14261. RGS18.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Regulator of G-protein signaling 18
PRO_0000204227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NS28.
PRIDEiQ9NS28.

2D gel databases

OGPiQ9NS28.

PTM databases

PhosphoSiteiQ9NS28.

Expressioni

Tissue specificityi

Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.2 Publications

Gene expression databases

BgeeiQ9NS28.
CleanExiHS_RGS13.
HS_RGS18.
GenevestigatoriQ9NS28.

Organism-specific databases

HPAiHPA045780.

Interactioni

Protein-protein interaction databases

BioGridi122160. 5 interactions.
DIPiDIP-59096N.
STRINGi9606.ENSP00000356430.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi77 – 837
Helixi87 – 926
Helixi94 – 10613
Helixi111 – 12212
Helixi127 – 14115
Beta strandi144 – 1474
Helixi155 – 1639
Helixi164 – 1663
Turni170 – 1734
Helixi174 – 18613
Helixi188 – 1936
Helixi196 – 2027

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLVNMR-A76-202[»]
2JM5NMR-A75-223[»]
2OWINMR-A75-223[»]
ProteinModelPortaliQ9NS28.
SMRiQ9NS28. Positions 77-204.

Miscellaneous databases

EvolutionaryTraceiQ9NS28.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 202117RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG278594.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ9NS28.
KOiK16449.
OMAiLDFHTKE.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ9NS28.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS28-1 [UniParc]FASTAAdd to Basket

« Hide

METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL    50
LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF 100
TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE 150
VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD 200
LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL 235
Length:235
Mass (Da):27,582
Last modified:October 1, 2000 - v1
Checksum:i973ABDE8EC7DE3D5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2272DV → ML1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076642 mRNA. Translation: AAF80227.1.
AF268036 mRNA. Translation: AAK58589.1.
AL596342, AL513175 Genomic DNA. Translation: CAH71160.1.
AK315377 mRNA. Translation: BAG37770.1.
AL513175, AL596342 Genomic DNA. Translation: CAH70529.1.
CH471067 Genomic DNA. Translation: EAW91223.1.
BC020632 mRNA. Translation: AAH20632.1.
CCDSiCCDS1374.1.
RefSeqiNP_570138.1. NM_130782.2.
UniGeneiHs.440890.

Genome annotation databases

EnsembliENST00000367460; ENSP00000356430; ENSG00000150681.
GeneIDi64407.
KEGGihsa:64407.
UCSCiuc001gsg.3. human.

Polymorphism databases

DMDMi15214228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076642 mRNA. Translation: AAF80227.1 .
AF268036 mRNA. Translation: AAK58589.1 .
AL596342 , AL513175 Genomic DNA. Translation: CAH71160.1 .
AK315377 mRNA. Translation: BAG37770.1 .
AL513175 , AL596342 Genomic DNA. Translation: CAH70529.1 .
CH471067 Genomic DNA. Translation: EAW91223.1 .
BC020632 mRNA. Translation: AAH20632.1 .
CCDSi CCDS1374.1.
RefSeqi NP_570138.1. NM_130782.2.
UniGenei Hs.440890.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DLV NMR - A 76-202 [» ]
2JM5 NMR - A 75-223 [» ]
2OWI NMR - A 75-223 [» ]
ProteinModelPortali Q9NS28.
SMRi Q9NS28. Positions 77-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122160. 5 interactions.
DIPi DIP-59096N.
STRINGi 9606.ENSP00000356430.

PTM databases

PhosphoSitei Q9NS28.

Polymorphism databases

DMDMi 15214228.

2D gel databases

OGPi Q9NS28.

Proteomic databases

PaxDbi Q9NS28.
PRIDEi Q9NS28.

Protocols and materials databases

DNASUi 64407.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367460 ; ENSP00000356430 ; ENSG00000150681 .
GeneIDi 64407.
KEGGi hsa:64407.
UCSCi uc001gsg.3. human.

Organism-specific databases

CTDi 64407.
GeneCardsi GC01P192127.
HGNCi HGNC:14261. RGS18.
HPAi HPA045780.
MIMi 607192. gene.
neXtProti NX_Q9NS28.
PharmGKBi PA34369.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278594.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q9NS28.
KOi K16449.
OMAi LDFHTKE.
OrthoDBi EOG7VHSZ5.
PhylomeDBi Q9NS28.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei Q9NS28.
GeneWikii RGS18.
GenomeRNAii 64407.
NextBioi 66362.
PROi Q9NS28.
SOURCEi Search...

Gene expression databases

Bgeei Q9NS28.
CleanExi HS_RGS13.
HS_RGS18.
Genevestigatori Q9NS28.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel regulator of G-protein signaling."
    Zhang W., Wan T., Yuan Z., He L., Cao X.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells."
    Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R., Hood L., Weissman I.L., Clarke M.F.
    J. Biol. Chem. 276:915-923(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "Cloning and characterization of a novel regulator of G protein signalling in human platelets."
    Gagnon A.W., Murray D.L., Leadley R.J. Jr.
    Cell. Signal. 14:595-606(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Platelet.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  8. "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins."
    Garcia A., Prabhakar S., Hughan S., Anderson T.W., Brock C.J., Pearce A.C., Dwek R.A., Watson S.P., Hebestreit H.F., Zitzmann N.
    Blood 103:2088-2095(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-49.
  9. "Solution structure of the RGS domain of human regulator of G-protein signaling 18."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 76-204.

Entry informationi

Entry nameiRGS18_HUMAN
AccessioniPrimary (citable) accession number: Q9NS28
Secondary accession number(s): B2RD23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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