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Protein

Sperm protein associated with the nucleus on the X chromosome A

Gene

SPANXA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • spermatogenesis Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome ACurated
Alternative name(s):
Cancer/testis antigen 11.1
Short name:
CT11.1Imported
Nuclear-associated protein SPAN-XaImported
Short name:
SPAN-X
Short name:
SPANX-A
SPANX family member A
Gene namesi
Name:SPANXA1Imported
Synonyms:SPANXA
AND
Name:SPANXA2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198021.6
HostDB:ENSG00000203926.4
HGNCiHGNC:11218 SPANXA1
HGNC:14328 SPANXA2
MIMi300305 gene
300493 gene
neXtProtiNX_Q9NS26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30014
64663
728712
OpenTargetsiENSG00000198021
PharmGKBiPA37870

Polymorphism and mutation databases

BioMutaiSPANXA1
DMDMi77416663

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895491 – 97Sperm protein associated with the nucleus on the X chromosome AAdd BLAST97

Proteomic databases

MaxQBiQ9NS26
PaxDbiQ9NS26
PeptideAtlasiQ9NS26
PRIDEiQ9NS26
ProteomicsDBi82474

PTM databases

iPTMnetiQ9NS26
PhosphoSitePlusiQ9NS26

Expressioni

Tissue specificityi

Detected in testis and sperm.2 Publications

Developmental stagei

Detected in round and elongating spermatids.2 Publications

Gene expression databases

BgeeiENSG00000198021
CleanExiHS_SPANXA1
HS_SPANXA2
GenevisibleiQ9NS26 HS

Organism-specific databases

HPAiHPA046423
HPA073647

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SETBP1Q9Y6X03EBI-10313181,EBI-2548259

Protein-protein interaction databases

BioGridi119032, 5 interactors
609133, 2 interactors
IntActiQ9NS26, 1 interactor
STRINGi9606.ENSP00000359550

Structurei

3D structure databases

ProteinModelPortaliQ9NS26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 86Poly-Glu4

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410KCE0 Eukaryota
ENOG4110P2D LUCA
GeneTreeiENSGT00730000111796
HOGENOMiHOG000015252
HOVERGENiHBG059401
InParanoidiQ9NS26
OMAiNETMPET
OrthoDBiEOG091G0PSU
PhylomeDBiQ9NS26
TreeFamiTF341404

Family and domain databases

InterProiView protein in InterPro
IPR010007 SPAN-X_fam
PANTHERiPTHR23425 PTHR23425, 1 hit
PfamiView protein in Pfam
PF07458 SPAN-X, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NS26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCDSNE ANEMMPETPT GDSDPQPAPK KMKTSESSTI
60 70 80 90
LVVRYRRNFK RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):11,038
Last modified:October 1, 2000 - v1
Checksum:i35DD0CEDF8A71376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098306 mRNA Translation: AAF28420.1
AJ457794 Genomic DNA Translation: CAD29843.1
AY920732 mRNA Translation: AAY16548.1
AY920733 mRNA Translation: AAY16549.1
AY920735 mRNA Translation: AAY16551.1
AY920736 mRNA Translation: AAY16552.1
AY920738 mRNA Translation: AAY16554.1
AY920739 mRNA Translation: AAY16555.1
AY920741 mRNA Translation: AAY16557.1
AY920742 mRNA Translation: AAY16558.1
AY920743 mRNA Translation: AAY16559.1
AY920744 mRNA Translation: AAY16560.1
AY920745 mRNA Translation: AAY16561.1
AY920746 mRNA Translation: AAY16562.1
DQ994201 Genomic DNA Translation: ABN68940.1
DQ994202 Genomic DNA Translation: ABN68941.1
DQ994203 Genomic DNA Translation: ABN68942.1
DQ994204 Genomic DNA Translation: ABN68943.1
DQ994205 Genomic DNA Translation: ABN68944.1
DQ994206 Genomic DNA Translation: ABN68945.1
DQ994207 Genomic DNA Translation: ABN68946.1
DQ994208 Genomic DNA Translation: ABN68947.1
DQ994209 Genomic DNA Translation: ABN68948.1
DQ994210 Genomic DNA Translation: ABN68949.1
AL121881 Genomic DNA Translation: CAD19068.1
AL121881 Genomic DNA Translation: CAI42369.1
BC069393 mRNA Translation: AAH69393.1
BC069816 mRNA Translation: AAH69816.1
CCDSiCCDS14674.1
CCDS44007.1
RefSeqiNP_038481.2, NM_013453.3
NP_663695.1, NM_145662.3
UniGeneiHs.334464
Hs.558533
Hs.711784

Genome annotation databases

EnsembliENST00000370518; ENSP00000359549; ENSG00000203926
ENST00000370519; ENSP00000359550; ENSG00000198021
GeneIDi30014
728712
KEGGihsa:30014
hsa:728712
UCSCiuc004fbn.4 human

Similar proteinsi

Entry informationi

Entry nameiSPNXA_HUMAN
AccessioniPrimary (citable) accession number: Q9NS26
Secondary accession number(s): Q5JWI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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