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Protein

Sperm protein associated with the nucleus on the X chromosome A

Gene

SPANXA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • spermatogenesis Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome ACurated
Alternative name(s):
Cancer/testis antigen 11.1
Short name:
CT11.1Imported
Nuclear-associated protein SPAN-XaImported
Short name:
SPAN-X
Short name:
SPANX-A
SPANX family member A
Gene namesi
Name:SPANXA1Imported
Synonyms:SPANXA
AND
Name:SPANXA2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11218. SPANXA1.
HGNC:14328. SPANXA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30014.
728712.
OpenTargetsiENSG00000198021.
ENSG00000203926.
PharmGKBiPA37870.

Polymorphism and mutation databases

BioMutaiSPANXA1.
DMDMi77416663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895491 – 97Sperm protein associated with the nucleus on the X chromosome AAdd BLAST97

Proteomic databases

MaxQBiQ9NS26.
PaxDbiQ9NS26.
PeptideAtlasiQ9NS26.
PRIDEiQ9NS26.

PTM databases

iPTMnetiQ9NS26.
PhosphoSitePlusiQ9NS26.

Expressioni

Tissue specificityi

Detected in testis and sperm.2 Publications

Developmental stagei

Detected in round and elongating spermatids.2 Publications

Gene expression databases

BgeeiENSG00000198021.
CleanExiHS_SPANXA1.
HS_SPANXA2.
GenevisibleiQ9NS26. HS.

Organism-specific databases

HPAiHPA046423.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SETBP1Q9Y6X03EBI-10313181,EBI-2548259

Protein-protein interaction databases

BioGridi119032. 5 interactors.
609133. 1 interactor.
IntActiQ9NS26. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9NS26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 86Poly-Glu4

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

eggNOGiENOG410KCE0. Eukaryota.
ENOG4110P2D. LUCA.
GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NS26.
OMAiNETMPET.
OrthoDBiEOG091G0PSU.
PhylomeDBiQ9NS26.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQSSAGGV KRSVPCDSNE ANEMMPETPT GDSDPQPAPK KMKTSESSTI
60 70 80 90
LVVRYRRNFK RTSPEELLND HARENRINPL QMEEEEFMEI MVEIPAK
Length:97
Mass (Da):11,038
Last modified:October 1, 2000 - v1
Checksum:i35DD0CEDF8A71376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098306 mRNA. Translation: AAF28420.1.
AJ457794 Genomic DNA. Translation: CAD29843.1.
AY920732 mRNA. Translation: AAY16548.1.
AY920733 mRNA. Translation: AAY16549.1.
AY920735 mRNA. Translation: AAY16551.1.
AY920736 mRNA. Translation: AAY16552.1.
AY920738 mRNA. Translation: AAY16554.1.
AY920739 mRNA. Translation: AAY16555.1.
AY920741 mRNA. Translation: AAY16557.1.
AY920742 mRNA. Translation: AAY16558.1.
AY920743 mRNA. Translation: AAY16559.1.
AY920744 mRNA. Translation: AAY16560.1.
AY920745 mRNA. Translation: AAY16561.1.
AY920746 mRNA. Translation: AAY16562.1.
DQ994201 Genomic DNA. Translation: ABN68940.1.
DQ994202 Genomic DNA. Translation: ABN68941.1.
DQ994203 Genomic DNA. Translation: ABN68942.1.
DQ994204 Genomic DNA. Translation: ABN68943.1.
DQ994205 Genomic DNA. Translation: ABN68944.1.
DQ994206 Genomic DNA. Translation: ABN68945.1.
DQ994207 Genomic DNA. Translation: ABN68946.1.
DQ994208 Genomic DNA. Translation: ABN68947.1.
DQ994209 Genomic DNA. Translation: ABN68948.1.
DQ994210 Genomic DNA. Translation: ABN68949.1.
AL121881 Genomic DNA. Translation: CAD19068.1.
AL121881 Genomic DNA. Translation: CAI42369.1.
BC069393 mRNA. Translation: AAH69393.1.
BC069816 mRNA. Translation: AAH69816.1.
CCDSiCCDS14674.1.
CCDS44007.1.
RefSeqiNP_038481.2. NM_013453.3.
NP_663695.1. NM_145662.3.
UniGeneiHs.334464.
Hs.558533.
Hs.711784.

Genome annotation databases

EnsembliENST00000370518; ENSP00000359549; ENSG00000203926.
ENST00000370519; ENSP00000359550; ENSG00000198021.
GeneIDi30014.
728712.
KEGGihsa:30014.
hsa:728712.
UCSCiuc004fbn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098306 mRNA. Translation: AAF28420.1.
AJ457794 Genomic DNA. Translation: CAD29843.1.
AY920732 mRNA. Translation: AAY16548.1.
AY920733 mRNA. Translation: AAY16549.1.
AY920735 mRNA. Translation: AAY16551.1.
AY920736 mRNA. Translation: AAY16552.1.
AY920738 mRNA. Translation: AAY16554.1.
AY920739 mRNA. Translation: AAY16555.1.
AY920741 mRNA. Translation: AAY16557.1.
AY920742 mRNA. Translation: AAY16558.1.
AY920743 mRNA. Translation: AAY16559.1.
AY920744 mRNA. Translation: AAY16560.1.
AY920745 mRNA. Translation: AAY16561.1.
AY920746 mRNA. Translation: AAY16562.1.
DQ994201 Genomic DNA. Translation: ABN68940.1.
DQ994202 Genomic DNA. Translation: ABN68941.1.
DQ994203 Genomic DNA. Translation: ABN68942.1.
DQ994204 Genomic DNA. Translation: ABN68943.1.
DQ994205 Genomic DNA. Translation: ABN68944.1.
DQ994206 Genomic DNA. Translation: ABN68945.1.
DQ994207 Genomic DNA. Translation: ABN68946.1.
DQ994208 Genomic DNA. Translation: ABN68947.1.
DQ994209 Genomic DNA. Translation: ABN68948.1.
DQ994210 Genomic DNA. Translation: ABN68949.1.
AL121881 Genomic DNA. Translation: CAD19068.1.
AL121881 Genomic DNA. Translation: CAI42369.1.
BC069393 mRNA. Translation: AAH69393.1.
BC069816 mRNA. Translation: AAH69816.1.
CCDSiCCDS14674.1.
CCDS44007.1.
RefSeqiNP_038481.2. NM_013453.3.
NP_663695.1. NM_145662.3.
UniGeneiHs.334464.
Hs.558533.
Hs.711784.

3D structure databases

ProteinModelPortaliQ9NS26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119032. 5 interactors.
609133. 1 interactor.
IntActiQ9NS26. 1 interactor.

PTM databases

iPTMnetiQ9NS26.
PhosphoSitePlusiQ9NS26.

Polymorphism and mutation databases

BioMutaiSPANXA1.
DMDMi77416663.

Proteomic databases

MaxQBiQ9NS26.
PaxDbiQ9NS26.
PeptideAtlasiQ9NS26.
PRIDEiQ9NS26.

Protocols and materials databases

DNASUi30014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370518; ENSP00000359549; ENSG00000203926.
ENST00000370519; ENSP00000359550; ENSG00000198021.
GeneIDi30014.
728712.
KEGGihsa:30014.
hsa:728712.
UCSCiuc004fbn.4. human.

Organism-specific databases

CTDi30014.
728712.
DisGeNETi30014.
728712.
GeneCardsiSPANXA1.
SPANXA2.
HGNCiHGNC:11218. SPANXA1.
HGNC:14328. SPANXA2.
HPAiHPA046423.
MIMi300305. gene.
300493. gene.
neXtProtiNX_Q9NS26.
OpenTargetsiENSG00000198021.
ENSG00000203926.
PharmGKBiPA37870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCE0. Eukaryota.
ENOG4110P2D. LUCA.
GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NS26.
OMAiNETMPET.
OrthoDBiEOG091G0PSU.
PhylomeDBiQ9NS26.
TreeFamiTF341404.

Miscellaneous databases

PROiQ9NS26.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198021.
CleanExiHS_SPANXA1.
HS_SPANXA2.
GenevisibleiQ9NS26. HS.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PANTHERiPTHR23425. PTHR23425. 1 hit.
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPNXA_HUMAN
AccessioniPrimary (citable) accession number: Q9NS26
Secondary accession number(s): Q5JWI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.