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Protein

Sperm protein associated with the nucleus on the X chromosome B1

Gene

SPANXB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • spermatid development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130017-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protein associated with the nucleus on the X chromosome B1Curated
Alternative name(s):
Cancer/testis antigen 11.2Curated
Short name:
CT11.2Imported
Nuclear-associated protein SPAN-XbImported
Short name:
SPANX-BImported
SPANX family member B1Imported
SPANX family member F1Imported
Gene namesi
Name:SPANXB1Imported
Synonyms:SPANXB, SPANXB2Imported, SPANXF1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14329. SPANXB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi728695.
OpenTargetsiENSG00000227234.
PharmGKBiPA37871.

Polymorphism and mutation databases

DMDMi85700153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895501 – 103Sperm protein associated with the nucleus on the X chromosome B1Add BLAST103

Proteomic databases

EPDiQ9NS25.
MaxQBiQ9NS25.
PaxDbiQ9NS25.
PeptideAtlasiQ9NS25.
PRIDEiQ9NS25.

PTM databases

iPTMnetiQ9NS25.
PhosphoSitePlusiQ9NS25.

Expressioni

Tissue specificityi

Detected in testis and sperm.2 Publications

Developmental stagei

Detected in round and elongating spermatids.2 Publications

Gene expression databases

BgeeiENSG00000227234.
CleanExiHS_SPANXB1.
HS_SPANXB2.

Organism-specific databases

HPAiHPA046423.

Structurei

3D structure databases

ProteinModelPortaliQ9NS25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 92Poly-Glu4

Sequence similaritiesi

Belongs to the SPAN-X family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NS25.
OrthoDBiEOG091G0PSU.
TreeFamiTF341404.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NS25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQSSVRRL KRSVPCESNE ANEANEANKT MPETPTGDSD PQPAPKKMKT
60 70 80 90 100
SESSTILVVR YRRNVKRTSP EELLNDHARE NRINPDQMEE EEFIEITTER

PKK
Length:103
Mass (Da):11,840
Last modified:July 22, 2015 - v2
Checksum:iCABB0D7B5993266D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02116374L → V.5 PublicationsCorresponds to variant rs3208371dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098307 mRNA. Translation: AAF28421.1.
AJ457789 Genomic DNA. Translation: CAD29838.1.
AJ457793 Genomic DNA. Translation: CAD29842.1.
AJ457796 mRNA. Translation: CAD29845.1.
AY787057 Genomic DNA. Translation: AAW47348.1.
AY787058 Genomic DNA. Translation: AAW47349.1.
AY787059 Genomic DNA. Translation: AAW47350.1.
AY787060 Genomic DNA. Translation: AAW47351.1.
AY787061 Genomic DNA. Translation: AAW47352.1.
AY787062 Genomic DNA. Translation: AAW47353.1.
AY787063 Genomic DNA. Translation: AAW47354.1.
AY787064 Genomic DNA. Translation: AAW47355.1.
AY787065 Genomic DNA. Translation: AAW47356.1.
AY787066 Genomic DNA. Translation: AAW47357.1.
AY787067 Genomic DNA. Translation: AAW47358.1.
AY787068 Genomic DNA. Translation: AAW47359.1.
AY787069 Genomic DNA. Translation: AAW47360.1.
AY787070 Genomic DNA. Translation: AAW47361.1.
AY787071 Genomic DNA. Translation: AAW47362.1.
AY787072 Genomic DNA. Translation: AAW47363.1.
AY787073 Genomic DNA. Translation: AAW47364.1.
AY787074 Genomic DNA. Translation: AAW47365.1.
AY787075 Genomic DNA. Translation: AAW47366.1.
AY787076 Genomic DNA. Translation: AAW47367.1.
AY787077 Genomic DNA. Translation: AAW47368.1.
AY787078 Genomic DNA. Translation: AAW47369.1.
AY787079 Genomic DNA. Translation: AAW47370.1.
AY787080 Genomic DNA. Translation: AAW47371.1.
AY787081 Genomic DNA. Translation: AAW47372.1.
AY787082 Genomic DNA. Translation: AAW47373.1.
AY787083 Genomic DNA. Translation: AAW47374.1.
AY787090 Genomic DNA. Translation: AAW47376.1.
AY787092 Genomic DNA. Translation: AAW47377.1.
AY787127 Genomic DNA. Translation: AAW47380.1.
AY787130 Genomic DNA. Translation: AAW47382.1.
AY787632 Genomic DNA. Translation: AAW47383.1.
AL031078 Genomic DNA. Translation: CAI42717.1.
AL031078 Genomic DNA. Translation: CAI42718.1.
AL451048 Genomic DNA. No translation available.
BC034472 mRNA. Translation: AAH34472.1.
BC137533 mRNA. Translation: AAI37534.1.
BC137536 mRNA. Translation: AAI37537.1.
CCDSiCCDS44006.1.
RefSeqiNP_115850.2. NM_032461.3.
UniGeneiHs.434105.
Hs.711489.

Genome annotation databases

EnsembliENST00000449283; ENSP00000405202; ENSG00000227234.
GeneIDi728695.
KEGGihsa:728695.
UCSCiuc004fbi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098307 mRNA. Translation: AAF28421.1.
AJ457789 Genomic DNA. Translation: CAD29838.1.
AJ457793 Genomic DNA. Translation: CAD29842.1.
AJ457796 mRNA. Translation: CAD29845.1.
AY787057 Genomic DNA. Translation: AAW47348.1.
AY787058 Genomic DNA. Translation: AAW47349.1.
AY787059 Genomic DNA. Translation: AAW47350.1.
AY787060 Genomic DNA. Translation: AAW47351.1.
AY787061 Genomic DNA. Translation: AAW47352.1.
AY787062 Genomic DNA. Translation: AAW47353.1.
AY787063 Genomic DNA. Translation: AAW47354.1.
AY787064 Genomic DNA. Translation: AAW47355.1.
AY787065 Genomic DNA. Translation: AAW47356.1.
AY787066 Genomic DNA. Translation: AAW47357.1.
AY787067 Genomic DNA. Translation: AAW47358.1.
AY787068 Genomic DNA. Translation: AAW47359.1.
AY787069 Genomic DNA. Translation: AAW47360.1.
AY787070 Genomic DNA. Translation: AAW47361.1.
AY787071 Genomic DNA. Translation: AAW47362.1.
AY787072 Genomic DNA. Translation: AAW47363.1.
AY787073 Genomic DNA. Translation: AAW47364.1.
AY787074 Genomic DNA. Translation: AAW47365.1.
AY787075 Genomic DNA. Translation: AAW47366.1.
AY787076 Genomic DNA. Translation: AAW47367.1.
AY787077 Genomic DNA. Translation: AAW47368.1.
AY787078 Genomic DNA. Translation: AAW47369.1.
AY787079 Genomic DNA. Translation: AAW47370.1.
AY787080 Genomic DNA. Translation: AAW47371.1.
AY787081 Genomic DNA. Translation: AAW47372.1.
AY787082 Genomic DNA. Translation: AAW47373.1.
AY787083 Genomic DNA. Translation: AAW47374.1.
AY787090 Genomic DNA. Translation: AAW47376.1.
AY787092 Genomic DNA. Translation: AAW47377.1.
AY787127 Genomic DNA. Translation: AAW47380.1.
AY787130 Genomic DNA. Translation: AAW47382.1.
AY787632 Genomic DNA. Translation: AAW47383.1.
AL031078 Genomic DNA. Translation: CAI42717.1.
AL031078 Genomic DNA. Translation: CAI42718.1.
AL451048 Genomic DNA. No translation available.
BC034472 mRNA. Translation: AAH34472.1.
BC137533 mRNA. Translation: AAI37534.1.
BC137536 mRNA. Translation: AAI37537.1.
CCDSiCCDS44006.1.
RefSeqiNP_115850.2. NM_032461.3.
UniGeneiHs.434105.
Hs.711489.

3D structure databases

ProteinModelPortaliQ9NS25.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9NS25.
PhosphoSitePlusiQ9NS25.

Polymorphism and mutation databases

DMDMi85700153.

Proteomic databases

EPDiQ9NS25.
MaxQBiQ9NS25.
PaxDbiQ9NS25.
PeptideAtlasiQ9NS25.
PRIDEiQ9NS25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449283; ENSP00000405202; ENSG00000227234.
GeneIDi728695.
KEGGihsa:728695.
UCSCiuc004fbi.3. human.

Organism-specific databases

CTDi728695.
DisGeNETi728695.
GeneCardsiSPANXB1.
SPANXF1.
HGNCiHGNC:14329. SPANXB1.
HPAiHPA046423.
MIMi300669. gene.
neXtProtiNX_Q9NS25.
OpenTargetsiENSG00000227234.
PharmGKBiPA37871.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111796.
HOGENOMiHOG000015252.
HOVERGENiHBG059401.
InParanoidiQ9NS25.
OrthoDBiEOG091G0PSU.
TreeFamiTF341404.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130017-MONOMER.

Miscellaneous databases

PROiQ9NS25.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000227234.
CleanExiHS_SPANXB1.
HS_SPANXB2.

Family and domain databases

InterProiIPR010007. SPAN-X_fam.
[Graphical view]
PfamiPF07458. SPAN-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPNXB_HUMAN
AccessioniPrimary (citable) accession number: Q9NS25
Secondary accession number(s): A0A0G2JJ56
, B2RPP2, Q32WQ7, Q5JYZ7, Q8TAD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 22, 2015
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.