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Q9NRZ9 (HELLS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lymphoid-specific helicase

EC=3.6.4.-
Alternative name(s):
Proliferation-associated SNF2-like protein
SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Gene names
Name:HELLS
Synonyms:PASG, SMARCA6
ORF Names:Nbla10143
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis By similarity. UniProtKB Q60848

Subcellular location

Nucleus By similarity. Note: Closely associated with pericentric heterochromatin By similarity.

Tissue specificity

Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. Ref.1

Induction

By concanavalin-A in peripheral blood leukocytes. Ref.1

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence AAG01987.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH29381.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH30963.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH31004.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Helicase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentromeric heterochromatin assembly

Inferred from sequence or structural similarity. Source: UniProtKB

lymphocyte proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

maintenance of DNA methylation

Inferred from sequence or structural similarity. Source: UniProtKB

methylation-dependent chromatin silencing

Inferred from sequence or structural similarity. Source: UniProtKB

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

urogenital system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcentromeric heterochromatin

Inferred from sequence or structural similarity. Source: UniProtKB

chromosome, centromeric region

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: InterPro

chromatin binding

Inferred from electronic annotation. Source: Ensembl

helicase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

E2F3O007162EBI-1056215,EBI-765551

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q9NRZ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: Q9NRZ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
Note: No experimental confirmation available.
Isoform 3 Ref.2 (identifier: Q9NRZ9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     313-344: Missing.
Isoform 4 Ref.2 (identifier: Q9NRZ9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     783-838: Missing.
Isoform 5 Ref.2 (identifier: Q9NRZ9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     345-442: Missing.
Isoform 6 Ref.2 (identifier: Q9NRZ9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     313-442: Missing.
Isoform 7 Ref.2 (identifier: Q9NRZ9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     345-345: H → L
     346-838: Missing.
Isoform 8 Ref.2 (identifier: Q9NRZ9-8)

The sequence of this isoform differs from the canonical sequence as follows:
     313-315: VRN → IYL
     316-838: Missing.
Isoform 9 Ref.2 (identifier: Q9NRZ9-9)

The sequence of this isoform differs from the canonical sequence as follows:
     124-129: VMRKKR → GNFVCG
     130-838: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 838838Lymphoid-specific helicase
PRO_0000260051

Regions

Domain235 – 403169Helicase ATP-binding
Domain603 – 767165Helicase C-terminal
Nucleotide binding248 – 2558ATP By similarity
Coiled coil30 – 11586 Potential
Motif354 – 3574DEAH box

Natural variations

Alternative sequence1 – 1616Missing in isoform 2. Ref.3
VSP_052224
Alternative sequence124 – 1296VMRKKR → GNFVCG in isoform 9. Ref.2
VSP_052225
Alternative sequence130 – 838709Missing in isoform 9. Ref.2
VSP_052226
Alternative sequence313 – 442130Missing in isoform 6. Ref.2
VSP_052227
Alternative sequence313 – 34432Missing in isoform 3. Ref.2
VSP_052228
Alternative sequence313 – 3153VRN → IYL in isoform 8. Ref.2
VSP_052229
Alternative sequence316 – 838523Missing in isoform 8. Ref.2
VSP_052230
Alternative sequence345 – 44298Missing in isoform 5. Ref.2
VSP_052231
Alternative sequence3451H → L in isoform 7. Ref.2
VSP_052232
Alternative sequence346 – 838493Missing in isoform 7. Ref.2
VSP_052233
Alternative sequence783 – 83856Missing in isoform 4. Ref.2
VSP_052234
Natural variant6161H → R Found in a renal cell carcinoma sample; somatic mutation. Ref.14
VAR_064720

Experimental info

Sequence conflict1361Y → F in CAD97978. Ref.4
Sequence conflict6461D → N in CAD97978. Ref.4
Sequence conflict6961W → C in AAH29381. Ref.7
Sequence conflict7021L → P in BAE45737. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FE8C644C23F2526E

FASTA83897,074
        10         20         30         40         50         60 
MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE KARMSWDRES 

        70         80         90        100        110        120 
TEIRYRRLQH LLEKSNIYSK FLLTKMEQQQ LEEQKKKEKL ERKKESLKVK KGKNSIDASE 

       130        140        150        160        170        180 
EKPVMRKKRG REDESYNISE VMSKEEILSV AKKNKKENED ENSSSTNLCV EDLQKNKDSN 

       190        200        210        220        230        240 
SIIKDRLSET VRQNTKFFFD PVRKCNGQPV PFQQPKHFTG GVMRWYQVEG MEWLRMLWEN 

       250        260        270        280        290        300 
GINGILADEM GLGKTVQCIA TIALMIQRGV PGPFLVCGPL STLPNWMAEF KRFTPDIPTM 

       310        320        330        340        350        360 
LYHGTQEERQ KLVRNIYKRK GTLQIHPVVI TSFEIAMRDR NALQHCYWKY LIVDEGHRIK 

       370        380        390        400        410        420 
NMKCRLIREL KRFNADNKLL LTGTPLQNNL SELWSLLNFL LPDVFDDLKS FESWFDITSL 

       430        440        450        460        470        480 
SETAEDIIAK EREQNVLHML HQILTPFLLR RLKSDVALEV PPKREVVVYA PLSKKQEIFY 

       490        500        510        520        530        540 
TAIVNRTIAN MFGSSEKETI ELSPTGRPKR RTRKSINYSK IDDFPNELEK LISQIQPEVD 

       550        560        570        580        590        600 
RERAVVEVNI PVESEVNLKL QNIMMLLRKC CNHPYLIEYP IDPVTQEFKI DEELVTNSGK 

       610        620        630        640        650        660 
FLILDRMLPE LKKRGHKVLL FSQMTSMLDI LMDYCHLRDF NFSRLDGSMS YSEREKNMHS 

       670        680        690        700        710        720 
FNTDPEVFIF LVSTRAGGLG INLTAADTVI IYDSDWNPQS DLQAQDRCHR IGQTKPVVVY 

       730        740        750        760        770        780 
RLVTANTIDQ KIVERAAAKR KLEKLIIHKN HFKGGQSGLN LSKNFLDPKE LMELLKSRDY 

       790        800        810        820        830 
EREIKGSREK VISDKDLELL LDRSDLIDQM NASGPIKEKM GIFKILENSE DSSPECLF 

« Hide

Isoform 2 [UniParc].

Checksum: A309C9A880B6097D
Show »

FASTA82295,607
Isoform 3 [UniParc].

Checksum: 8CA3BA80E4D0A8BF
Show »

FASTA80693,323
Isoform 4 [UniParc].

Checksum: FB649163E59684AA
Show »

FASTA78290,766
Isoform 5 [UniParc].

Checksum: 8DB53162055D1DFC
Show »

FASTA74085,387
Isoform 6 [UniParc].

Checksum: 2D3377EDAB5399EE
Show »

FASTA70881,637
Isoform 7 [UniParc].

Checksum: 0171AA8F1508500B
Show »

FASTA34539,881
Isoform 8 [UniParc].

Checksum: 3CC4A3B96843B5F6
Show »

FASTA31536,407
Isoform 9 [UniParc].

Checksum: 27119BC8DDB6D496
Show »

FASTA12914,838

References

« Hide 'large scale' references
[1]"Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia."
Lee D.W., Zhang K., Ning Z.-Q., Raabe E.H., Tintner S., Wieland R., Wilkins B.J., Kim J.M., Blough R.I., Arceci R.J.
Cancer Res. 60:3612-3622(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
[2]"Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer."
Yano M., Ouchida M., Shigematsu H., Tanaka N., Ichimura K., Kobayashi K., Inaki Y., Toyooka S., Tsukuda K., Shimizu N., Shimizu K.
Int. J. Cancer 112:8-13(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8 AND 9).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Endometrial tumor.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 415-838 (ISOFORMS 1/2/3).
Tissue: Bone marrow, Prostate and Uterus.
[8]Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-838 (ISOFORMS 1/2/3/5/6).
Tissue: Brain.
[9]"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 467-838 (ISOFORMS 1/2/3/5/6).
Tissue: Neuroblastoma.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARG-616.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF155827 mRNA. Translation: AAF82262.1.
AB102717 mRNA. Translation: BAD10845.1.
AB102718 mRNA. Translation: BAD10846.1.
AB102719 mRNA. Translation: BAD10847.1.
AB102720 mRNA. Translation: BAD10848.1.
AB102721 mRNA. Translation: BAD10849.1.
AB102722 mRNA. Translation: BAD10850.1.
AK314485 mRNA. Translation: BAG37088.1.
AB113249 mRNA. Translation: BAD24805.1.
BX538033 mRNA. Translation: CAD97978.1.
AL138759 Genomic DNA. Translation: CAD13191.1.
CH471066 Genomic DNA. Translation: EAW50035.1.
BC015477 mRNA. Translation: AAH15477.1.
BC029381 mRNA. Translation: AAH29381.1. Different initiation.
BC030963 mRNA. Translation: AAH30963.1. Different initiation.
BC031004 mRNA. Translation: AAH31004.1. Different initiation.
AY007108 mRNA. Translation: AAG01987.1. Different initiation.
AB074174 mRNA. Translation: BAE45737.1.
RefSeqNP_060533.2. NM_018063.4.
UniGeneHs.655830.

3D structure databases

ProteinModelPortalQ9NRZ9.
SMRQ9NRZ9. Positions 212-805.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109320. 13 interactions.
IntActQ9NRZ9. 5 interactions.
MINTMINT-2819086.

PTM databases

PhosphoSiteQ9NRZ9.

Polymorphism databases

DMDM74761670.

Proteomic databases

PaxDbQ9NRZ9.
PRIDEQ9NRZ9.

Protocols and materials databases

DNASU3070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000348459; ENSP00000239027; ENSG00000119969. [Q9NRZ9-1]
ENST00000394036; ENSP00000377601; ENSG00000119969. [Q9NRZ9-9]
ENST00000394044; ENSP00000377608; ENSG00000119969. [Q9NRZ9-8]
ENST00000394045; ENSP00000377609; ENSG00000119969. [Q9NRZ9-5]
GeneID3070.
KEGGhsa:3070.
UCSCuc001kjs.3. human. [Q9NRZ9-1]
uc009xul.3. human. [Q9NRZ9-5]
uc009xum.3. human. [Q9NRZ9-6]

Organism-specific databases

CTD3070.
GeneCardsGC10P096305.
H-InvDBHIX0017337.
HGNCHGNC:4861. HELLS.
HPACAB004491.
MIM603946. gene.
neXtProtNX_Q9NRZ9.
PharmGKBPA35054.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0553.
HOVERGENHBG060049.
OrthoDBEOG7TXKG5.
PhylomeDBQ9NRZ9.
TreeFamTF329077.

Gene expression databases

ArrayExpressQ9NRZ9.
BgeeQ9NRZ9.
GenevestigatorQ9NRZ9.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHELLS. human.
GeneWikiHELLS.
GenomeRNAi3070.
NextBio12147.
PROQ9NRZ9.
SOURCESearch...

Entry information

Entry nameHELLS_HUMAN
AccessionPrimary (citable) accession number: Q9NRZ9
Secondary accession number(s): B2RB41 expand/collapse secondary AC list , Q3LID1, Q6I7N7, Q76H76, Q76H77, Q76H78, Q76H79, Q76H80, Q76H81, Q7Z397, Q7Z5X2, Q8N6P4, Q9H4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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