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Q9NRZ9

- HELLS_HUMAN

UniProt

Q9NRZ9 - HELLS_HUMAN

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Protein

Lymphoid-specific helicase

Gene

HELLS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi248 – 2558ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. chromatin binding Source: Ensembl
  3. DNA binding Source: InterPro
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA methylation Source: Ensembl
  2. lymphocyte proliferation Source: UniProtKB
  3. maintenance of DNA methylation Source: UniProtKB
  4. methylation-dependent chromatin silencing Source: UniProtKB
  5. mitotic nuclear division Source: UniProtKB-KW
  6. multicellular organismal development Source: UniProtKB
  7. negative regulation of apoptotic process Source: Ensembl
  8. negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  9. pericentric heterochromatin assembly Source: UniProtKB
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. urogenital system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Helicase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphoid-specific helicase (EC:3.6.4.-)
Alternative name(s):
Proliferation-associated SNF2-like protein
SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Gene namesi
Name:HELLSImported
Synonyms:PASG1 Publication, SMARCA6Imported
ORF Names:Nbla10143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:4861. HELLS.

Subcellular locationi

Nucleus By similarity
Note: Closely associated with pericentric heterochromatin.By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
  3. pericentric heterochromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838Lymphoid-specific helicasePRO_0000260051Add
BLAST

Proteomic databases

MaxQBiQ9NRZ9.
PaxDbiQ9NRZ9.
PRIDEiQ9NRZ9.

PTM databases

PhosphoSiteiQ9NRZ9.

Expressioni

Tissue specificityi

Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.1 Publication

Inductioni

By concanavalin-A in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiQ9NRZ9.
ExpressionAtlasiQ9NRZ9. baseline and differential.
GenevestigatoriQ9NRZ9.

Organism-specific databases

HPAiCAB004491.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E2F3O007162EBI-1056215,EBI-765551

Protein-protein interaction databases

BioGridi109320. 17 interactions.
IntActiQ9NRZ9. 6 interactions.
MINTiMINT-2819086.

Structurei

3D structure databases

ProteinModelPortaliQ9NRZ9.
SMRiQ9NRZ9. Positions 214-486, 510-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 403169Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 767165Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili30 – 11586Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi354 – 3574DEAH boxSequence Analysis

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00740000115593.
HOVERGENiHBG060049.
InParanoidiQ9NRZ9.
OrthoDBiEOG7TXKG5.
PhylomeDBiQ9NRZ9.
TreeFamiTF329077.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q9NRZ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE
60 70 80 90 100
KARMSWDRES TEIRYRRLQH LLEKSNIYSK FLLTKMEQQQ LEEQKKKEKL
110 120 130 140 150
ERKKESLKVK KGKNSIDASE EKPVMRKKRG REDESYNISE VMSKEEILSV
160 170 180 190 200
AKKNKKENED ENSSSTNLCV EDLQKNKDSN SIIKDRLSET VRQNTKFFFD
210 220 230 240 250
PVRKCNGQPV PFQQPKHFTG GVMRWYQVEG MEWLRMLWEN GINGILADEM
260 270 280 290 300
GLGKTVQCIA TIALMIQRGV PGPFLVCGPL STLPNWMAEF KRFTPDIPTM
310 320 330 340 350
LYHGTQEERQ KLVRNIYKRK GTLQIHPVVI TSFEIAMRDR NALQHCYWKY
360 370 380 390 400
LIVDEGHRIK NMKCRLIREL KRFNADNKLL LTGTPLQNNL SELWSLLNFL
410 420 430 440 450
LPDVFDDLKS FESWFDITSL SETAEDIIAK EREQNVLHML HQILTPFLLR
460 470 480 490 500
RLKSDVALEV PPKREVVVYA PLSKKQEIFY TAIVNRTIAN MFGSSEKETI
510 520 530 540 550
ELSPTGRPKR RTRKSINYSK IDDFPNELEK LISQIQPEVD RERAVVEVNI
560 570 580 590 600
PVESEVNLKL QNIMMLLRKC CNHPYLIEYP IDPVTQEFKI DEELVTNSGK
610 620 630 640 650
FLILDRMLPE LKKRGHKVLL FSQMTSMLDI LMDYCHLRDF NFSRLDGSMS
660 670 680 690 700
YSEREKNMHS FNTDPEVFIF LVSTRAGGLG INLTAADTVI IYDSDWNPQS
710 720 730 740 750
DLQAQDRCHR IGQTKPVVVY RLVTANTIDQ KIVERAAAKR KLEKLIIHKN
760 770 780 790 800
HFKGGQSGLN LSKNFLDPKE LMELLKSRDY EREIKGSREK VISDKDLELL
810 820 830
LDRSDLIDQM NASGPIKEKM GIFKILENSE DSSPECLF
Length:838
Mass (Da):97,074
Last modified:October 1, 2000 - v1
Checksum:iFE8C644C23F2526E
GO
Isoform 2 (identifier: Q9NRZ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:822
Mass (Da):95,607
Checksum:iA309C9A880B6097D
GO
Isoform 31 Publication (identifier: Q9NRZ9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-344: Missing.

Show »
Length:806
Mass (Da):93,323
Checksum:i8CA3BA80E4D0A8BF
GO
Isoform 41 Publication (identifier: Q9NRZ9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     783-838: Missing.

Show »
Length:782
Mass (Da):90,766
Checksum:iFB649163E59684AA
GO
Isoform 51 Publication (identifier: Q9NRZ9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-442: Missing.

Show »
Length:740
Mass (Da):85,387
Checksum:i8DB53162055D1DFC
GO
Isoform 61 Publication (identifier: Q9NRZ9-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-442: Missing.

Show »
Length:708
Mass (Da):81,637
Checksum:i2D3377EDAB5399EE
GO
Isoform 71 Publication (identifier: Q9NRZ9-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-345: H → L
     346-838: Missing.

Show »
Length:345
Mass (Da):39,881
Checksum:i0171AA8F1508500B
GO
Isoform 81 Publication (identifier: Q9NRZ9-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-315: VRN → IYL
     316-838: Missing.

Show »
Length:315
Mass (Da):36,407
Checksum:i3CC4A3B96843B5F6
GO
Isoform 91 Publication (identifier: Q9NRZ9-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-129: VMRKKR → GNFVCG
     130-838: Missing.

Show »
Length:129
Mass (Da):14,838
Checksum:i27119BC8DDB6D496
GO

Sequence cautioni

The sequence AAG01987.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH29381.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH30963.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH31004.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361Y → F in CAD97978. (PubMed:17974005)Curated
Sequence conflicti646 – 6461D → N in CAD97978. (PubMed:17974005)Curated
Sequence conflicti696 – 6961W → C in AAH29381. (PubMed:15489334)Curated
Sequence conflicti702 – 7021L → P in BAE45737. (PubMed:12880961)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti616 – 6161H → R Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064720

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616Missing in isoform 2. 1 PublicationVSP_052224Add
BLAST
Alternative sequencei124 – 1296VMRKKR → GNFVCG in isoform 9. 1 PublicationVSP_052225
Alternative sequencei130 – 838709Missing in isoform 9. 1 PublicationVSP_052226Add
BLAST
Alternative sequencei313 – 442130Missing in isoform 6. 1 PublicationVSP_052227Add
BLAST
Alternative sequencei313 – 34432Missing in isoform 3. 1 PublicationVSP_052228Add
BLAST
Alternative sequencei313 – 3153VRN → IYL in isoform 8. 1 PublicationVSP_052229
Alternative sequencei316 – 838523Missing in isoform 8. 1 PublicationVSP_052230Add
BLAST
Alternative sequencei345 – 44298Missing in isoform 5. 1 PublicationVSP_052231Add
BLAST
Alternative sequencei345 – 3451H → L in isoform 7. 1 PublicationVSP_052232
Alternative sequencei346 – 838493Missing in isoform 7. 1 PublicationVSP_052233Add
BLAST
Alternative sequencei783 – 83856Missing in isoform 4. 1 PublicationVSP_052234Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155827 mRNA. Translation: AAF82262.1.
AB102717 mRNA. Translation: BAD10845.1.
AB102718 mRNA. Translation: BAD10846.1.
AB102719 mRNA. Translation: BAD10847.1.
AB102720 mRNA. Translation: BAD10848.1.
AB102721 mRNA. Translation: BAD10849.1.
AB102722 mRNA. Translation: BAD10850.1.
AK314485 mRNA. Translation: BAG37088.1.
AB113249 mRNA. Translation: BAD24805.1.
BX538033 mRNA. Translation: CAD97978.1.
AL138759 Genomic DNA. Translation: CAD13191.1.
CH471066 Genomic DNA. Translation: EAW50035.1.
BC015477 mRNA. Translation: AAH15477.1.
BC029381 mRNA. Translation: AAH29381.1. Different initiation.
BC030963 mRNA. Translation: AAH30963.1. Different initiation.
BC031004 mRNA. Translation: AAH31004.1. Different initiation.
AY007108 mRNA. Translation: AAG01987.1. Different initiation.
AB074174 mRNA. Translation: BAE45737.1.
CCDSiCCDS73163.1. [Q9NRZ9-5]
CCDS7434.1. [Q9NRZ9-1]
RefSeqiNP_001275996.1. NM_001289067.1.
NP_001275997.1. NM_001289068.1. [Q9NRZ9-2]
NP_001275998.1. NM_001289069.1. [Q9NRZ9-3]
NP_001275999.1. NM_001289070.1. [Q9NRZ9-5]
NP_001276000.1. NM_001289071.1.
NP_001276001.1. NM_001289072.1. [Q9NRZ9-6]
NP_001276002.1. NM_001289073.1.
NP_001276003.1. NM_001289074.1.
NP_001276004.1. NM_001289075.1.
NP_060533.2. NM_018063.4. [Q9NRZ9-1]
UniGeneiHs.655830.

Genome annotation databases

EnsembliENST00000348459; ENSP00000239027; ENSG00000119969. [Q9NRZ9-1]
ENST00000394045; ENSP00000377609; ENSG00000119969. [Q9NRZ9-5]
GeneIDi3070.
KEGGihsa:3070.
UCSCiuc001kjs.3. human. [Q9NRZ9-1]
uc009xul.3. human. [Q9NRZ9-5]
uc009xum.3. human. [Q9NRZ9-6]

Polymorphism databases

DMDMi74761670.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155827 mRNA. Translation: AAF82262.1 .
AB102717 mRNA. Translation: BAD10845.1 .
AB102718 mRNA. Translation: BAD10846.1 .
AB102719 mRNA. Translation: BAD10847.1 .
AB102720 mRNA. Translation: BAD10848.1 .
AB102721 mRNA. Translation: BAD10849.1 .
AB102722 mRNA. Translation: BAD10850.1 .
AK314485 mRNA. Translation: BAG37088.1 .
AB113249 mRNA. Translation: BAD24805.1 .
BX538033 mRNA. Translation: CAD97978.1 .
AL138759 Genomic DNA. Translation: CAD13191.1 .
CH471066 Genomic DNA. Translation: EAW50035.1 .
BC015477 mRNA. Translation: AAH15477.1 .
BC029381 mRNA. Translation: AAH29381.1 . Different initiation.
BC030963 mRNA. Translation: AAH30963.1 . Different initiation.
BC031004 mRNA. Translation: AAH31004.1 . Different initiation.
AY007108 mRNA. Translation: AAG01987.1 . Different initiation.
AB074174 mRNA. Translation: BAE45737.1 .
CCDSi CCDS73163.1. [Q9NRZ9-5 ]
CCDS7434.1. [Q9NRZ9-1 ]
RefSeqi NP_001275996.1. NM_001289067.1.
NP_001275997.1. NM_001289068.1. [Q9NRZ9-2 ]
NP_001275998.1. NM_001289069.1. [Q9NRZ9-3 ]
NP_001275999.1. NM_001289070.1. [Q9NRZ9-5 ]
NP_001276000.1. NM_001289071.1.
NP_001276001.1. NM_001289072.1. [Q9NRZ9-6 ]
NP_001276002.1. NM_001289073.1.
NP_001276003.1. NM_001289074.1.
NP_001276004.1. NM_001289075.1.
NP_060533.2. NM_018063.4. [Q9NRZ9-1 ]
UniGenei Hs.655830.

3D structure databases

ProteinModelPortali Q9NRZ9.
SMRi Q9NRZ9. Positions 214-486, 510-743.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109320. 17 interactions.
IntActi Q9NRZ9. 6 interactions.
MINTi MINT-2819086.

PTM databases

PhosphoSitei Q9NRZ9.

Polymorphism databases

DMDMi 74761670.

Proteomic databases

MaxQBi Q9NRZ9.
PaxDbi Q9NRZ9.
PRIDEi Q9NRZ9.

Protocols and materials databases

DNASUi 3070.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000348459 ; ENSP00000239027 ; ENSG00000119969 . [Q9NRZ9-1 ]
ENST00000394045 ; ENSP00000377609 ; ENSG00000119969 . [Q9NRZ9-5 ]
GeneIDi 3070.
KEGGi hsa:3070.
UCSCi uc001kjs.3. human. [Q9NRZ9-1 ]
uc009xul.3. human. [Q9NRZ9-5 ]
uc009xum.3. human. [Q9NRZ9-6 ]

Organism-specific databases

CTDi 3070.
GeneCardsi GC10P096305.
H-InvDB HIX0017337.
HGNCi HGNC:4861. HELLS.
HPAi CAB004491.
MIMi 603946. gene.
neXtProti NX_Q9NRZ9.
PharmGKBi PA35054.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00740000115593.
HOVERGENi HBG060049.
InParanoidi Q9NRZ9.
OrthoDBi EOG7TXKG5.
PhylomeDBi Q9NRZ9.
TreeFami TF329077.

Miscellaneous databases

ChiTaRSi HELLS. human.
GeneWikii HELLS.
GenomeRNAii 3070.
NextBioi 12147.
PROi Q9NRZ9.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRZ9.
ExpressionAtlasi Q9NRZ9. baseline and differential.
Genevestigatori Q9NRZ9.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia."
    Lee D.W., Zhang K., Ning Z.-Q., Raabe E.H., Tintner S., Wieland R., Wilkins B.J., Kim J.M., Blough R.I., Arceci R.J.
    Cancer Res. 60:3612-3622(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
  2. "Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer."
    Yano M., Ouchida M., Shigematsu H., Tanaka N., Ichimura K., Kobayashi K., Inaki Y., Toyooka S., Tsukuda K., Shimizu N., Shimizu K.
    Int. J. Cancer 112:8-13(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6; 7; 8 AND 9).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrial tumor.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 415-838 (ISOFORMS 1/2/3).
    Tissue: Bone marrowImported, ProstateImported and UterusImported.
  8. Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-838 (ISOFORMS 1/2/3/5/6).
    Tissue: Brain.
  9. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 467-838 (ISOFORMS 1/2/3/5/6).
    Tissue: Neuroblastoma1 Publication.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: VARIANT ARG-616.

Entry informationi

Entry nameiHELLS_HUMAN
AccessioniPrimary (citable) accession number: Q9NRZ9
Secondary accession number(s): B2RB41
, Q3LID1, Q6I7N7, Q76H76, Q76H77, Q76H78, Q76H79, Q76H80, Q76H81, Q7Z397, Q7Z5X2, Q8N6P4, Q9H4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3