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Q9NRZ5 (PLCD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

EC=2.3.1.51
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 4
Short name=1-AGP acyltransferase 4
Short name=1-AGPAT 4
Lysophosphatidic acid acyltransferase delta
Short name=LPAAT-delta
Gene names
Name:AGPAT4
ORF Names:UNQ499/PRO1016
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.

Catalytic activity

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus. Ref.5

Domain

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similarities

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CRKP461081EBI-1754287,EBI-886

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3783781-acyl-sn-glycerol-3-phosphate acyltransferase delta
PRO_0000208197

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane307 – 32721Helical; Potential
Transmembrane338 – 35821Helical; Potential
Motif96 – 1016HXXXXD motif

Sequences

Sequence LengthMass (Da)Tools
Q9NRZ5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3EFC13D196F8CDC5

FASTA37844,021
        10         20         30         40         50         60 
MDLAGLLKSQ FLCHLVFCYV FIASGLIINT IQLFTLLLWP INKQLFRKIN CRLSYCISSQ 

        70         80         90        100        110        120 
LVMLLEWWSG TECTIFTDPR AYLKYGKENA IVVLNHKFEI DFLCGWSLSE RFGLLGGSKV 

       130        140        150        160        170        180 
LAKKELAYVP IIGWMWYFTE MVFCSRKWEQ DRKTVATSLQ HLRDYPEKYF FLIHCEGTRF 

       190        200        210        220        230        240 
TEKKHEISMQ VARAKGLPRL KHHLLPRTKG FAITVRSLRN VVSAVYDCTL NFRNNENPTL 

       250        260        270        280        290        300 
LGVLNGKKYH ADLYVRRIPL EDIPEDDDEC SAWLHKLYQE KDAFQEEYYR TGTFPETPMV 

       310        320        330        340        350        360 
PPRRPWTLVN WLFWASLVLY PFFQFLVSMI RSGSSLTLAS FILVFFVASV GVRWMIGVTE 

       370 
IDKGSAYGNS DSKQKLND 

« Hide

References

« Hide 'large scale' references
[1]"The structure and functions of human lysophosphatidic acid acyltransferases."
Leung D.W.
Front. Biosci. 6:D944-D953(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[5]"Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria."
Prasad S.S., Garg A., Agarwal A.K.
J. Lipid Res. 52:451-462(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF156776 mRNA. Translation: AAF80338.1.
AY358506 mRNA. Translation: AAQ88870.1.
AL109942 Genomic DNA. Translation: CAI21478.1.
BC020209 mRNA. Translation: AAH20209.1.
RefSeqNP_064518.1. NM_020133.2.
UniGeneHs.353175.

3D structure databases

ProteinModelPortalQ9NRZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121225. 1 interaction.
IntActQ9NRZ5. 1 interaction.
STRING9606.ENSP00000314036.

PTM databases

PhosphoSiteQ9NRZ5.

Polymorphism databases

DMDM12230468.

Proteomic databases

PaxDbQ9NRZ5.
PRIDEQ9NRZ5.

Protocols and materials databases

DNASU56895.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320285; ENSP00000314036; ENSG00000026652.
GeneID56895.
KEGGhsa:56895.
UCSCuc003qtr.1. human.

Organism-specific databases

CTD56895.
GeneCardsGC06M161471.
HGNCHGNC:20885. AGPAT4.
HPAHPA053287.
MIM614795. gene.
neXtProtNX_Q9NRZ5.
PharmGKBPA134961047.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0204.
HOGENOMHOG000006110.
HOVERGENHBG008205.
InParanoidQ9NRZ5.
KOK13523.
OMAPEKYFFL.
OrthoDBEOG7H7928.
PhylomeDBQ9NRZ5.
TreeFamTF314065.

Enzyme and pathway databases

BioCycMetaCyc:HS00452-MONOMER.
ReactomeREACT_111217. Metabolism.
UniPathwayUPA00557; UER00613.

Gene expression databases

ArrayExpressQ9NRZ5.
BgeeQ9NRZ5.
CleanExHS_AGPAT4.
GenevestigatorQ9NRZ5.

Family and domain databases

InterProIPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamPF01553. Acyltransferase. 1 hit.
[Graphical view]
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGPAT4. human.
GenomeRNAi56895.
NextBio62325.
PROQ9NRZ5.
SOURCESearch...

Entry information

Entry namePLCD_HUMAN
AccessionPrimary (citable) accession number: Q9NRZ5
Secondary accession number(s): Q5TEF0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM