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Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Gene

AGPAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.By similarity

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), Lysocardiolipin acyltransferase 1 (LCLAT1)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS00452-MONOMER
ReactomeiR-HSA-1483166 Synthesis of PA
UniPathwayiUPA00557; UER00613

Names & Taxonomyi

Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC:2.3.1.51)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 4
Short name:
1-AGP acyltransferase 4
Short name:
1-AGPAT 4
Lysophosphatidic acid acyltransferase delta
Short name:
LPAAT-delta
Gene namesi
Name:AGPAT4
ORF Names:UNQ499/PRO1016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000026652.13
HGNCiHGNC:20885 AGPAT4
MIMi614795 gene
neXtProtiNX_Q9NRZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56895
OpenTargetsiENSG00000026652
PharmGKBiPA134961047

Polymorphism and mutation databases

BioMutaiAGPAT4
DMDMi12230468

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002081971 – 3781-acyl-sn-glycerol-3-phosphate acyltransferase deltaAdd BLAST378

Proteomic databases

EPDiQ9NRZ5
MaxQBiQ9NRZ5
PaxDbiQ9NRZ5
PeptideAtlasiQ9NRZ5
PRIDEiQ9NRZ5

PTM databases

iPTMnetiQ9NRZ5
PhosphoSitePlusiQ9NRZ5

Expressioni

Tissue specificityi

Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus.1 Publication

Gene expression databases

BgeeiENSG00000026652
CleanExiHS_AGPAT4
ExpressionAtlasiQ9NRZ5 baseline and differential
GenevisibleiQ9NRZ5 HS

Organism-specific databases

HPAiHPA053287
HPA060525

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-1754287,EBI-307352

Protein-protein interaction databases

BioGridi121225, 10 interactors
IntActiQ9NRZ5, 4 interactors
STRINGi9606.ENSP00000314036

Structurei

3D structure databases

ProteinModelPortaliQ9NRZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 101HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1505 Eukaryota
COG0204 LUCA
GeneTreeiENSGT00890000139404
HOGENOMiHOG000006110
HOVERGENiHBG008205
InParanoidiQ9NRZ5
KOiK13523
OMAiAYCISSQ
OrthoDBiEOG091G0C4Z
PhylomeDBiQ9NRZ5
TreeFamiTF314065

Family and domain databases

InterProiView protein in InterPro
IPR032098 Acyltransf_C
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF16076 Acyltransf_C, 1 hit
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLAGLLKSQ FLCHLVFCYV FIASGLIINT IQLFTLLLWP INKQLFRKIN
60 70 80 90 100
CRLSYCISSQ LVMLLEWWSG TECTIFTDPR AYLKYGKENA IVVLNHKFEI
110 120 130 140 150
DFLCGWSLSE RFGLLGGSKV LAKKELAYVP IIGWMWYFTE MVFCSRKWEQ
160 170 180 190 200
DRKTVATSLQ HLRDYPEKYF FLIHCEGTRF TEKKHEISMQ VARAKGLPRL
210 220 230 240 250
KHHLLPRTKG FAITVRSLRN VVSAVYDCTL NFRNNENPTL LGVLNGKKYH
260 270 280 290 300
ADLYVRRIPL EDIPEDDDEC SAWLHKLYQE KDAFQEEYYR TGTFPETPMV
310 320 330 340 350
PPRRPWTLVN WLFWASLVLY PFFQFLVSMI RSGSSLTLAS FILVFFVASV
360 370
GVRWMIGVTE IDKGSAYGNS DSKQKLND
Length:378
Mass (Da):44,021
Last modified:October 1, 2000 - v1
Checksum:i3EFC13D196F8CDC5
GO
Isoform 2 (identifier: Q9NRZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: Q → L
     61-222: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,951
Checksum:i829C71A3B08C71CD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05692860Q → L in isoform 2. 1 Publication1
Alternative sequenceiVSP_05692961 – 222Missing in isoform 2. 1 PublicationAdd BLAST162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156776 mRNA Translation: AAF80338.1
AY358506 mRNA Translation: AAQ88870.1
AK299721 mRNA Translation: BAG61621.1
AL109942 Genomic DNA No translation available.
BC020209 mRNA Translation: AAH20209.1
CCDSiCCDS5280.1 [Q9NRZ5-1]
RefSeqiNP_064518.1, NM_020133.2 [Q9NRZ5-1]
UniGeneiHs.353175

Genome annotation databases

EnsembliENST00000320285; ENSP00000314036; ENSG00000026652 [Q9NRZ5-1]
GeneIDi56895
KEGGihsa:56895
UCSCiuc003qtr.2 human [Q9NRZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPLCD_HUMAN
AccessioniPrimary (citable) accession number: Q9NRZ5
Secondary accession number(s): B4DSF9, Q5TEF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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