ID F1142_HUMAN Reviewed; 505 AA. AC Q9NRY5; B2R8D8; Q9H7E0; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 4. DT 27-MAR-2024, entry version 144. DE RecName: Full=Protein FAM114A2; GN Name=FAM114A2; Synonyms=C5orf3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Liver; RX PubMed=10843801; DOI=10.1006/geno.2000.6193; RA Boultwood J., Fidler C., Strickson A.J., Watkins F., Kostrzewa M., RA Jaju R.J., Muller U., Wainscoat J.S.; RT "Transcription mapping of the 5q- syndrome critical region: cloning of two RT novel genes and sequencing, expression, and mapping of a further six novel RT cDNAs."; RL Genomics 66:26-34(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-209, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- INTERACTION: CC Q9NRY5; Q05329: GAD2; NbExp=3; IntAct=EBI-10973142, EBI-9304251; CC Q9NRY5; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-10973142, EBI-11988931; CC Q9NRY5; P19404: NDUFV2; NbExp=3; IntAct=EBI-10973142, EBI-713665; CC Q9NRY5; C9JJ79: PILRA; NbExp=3; IntAct=EBI-10973142, EBI-12117156; CC Q9NRY5; P43378: PTPN9; NbExp=3; IntAct=EBI-10973142, EBI-742898; CC Q9NRY5; P61019: RAB2A; NbExp=3; IntAct=EBI-10973142, EBI-752037; CC Q9NRY5; Q8WUD1: RAB2B; NbExp=3; IntAct=EBI-10973142, EBI-5542466; CC Q9NRY5; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10973142, EBI-2623095; CC Q9NRY5; Q969Z0: TBRG4; NbExp=4; IntAct=EBI-10973142, EBI-702328; CC Q9NRY5; P49638: TTPA; NbExp=3; IntAct=EBI-10973142, EBI-10210710; CC -!- SIMILARITY: Belongs to the FAM114 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF159700; AAF76523.1; -; mRNA. DR EMBL; AK024664; BAB14952.1; -; mRNA. DR EMBL; AK313331; BAG36135.1; -; mRNA. DR EMBL; AC010232; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471062; EAW61646.1; -; Genomic_DNA. DR EMBL; CH471062; EAW61647.1; -; Genomic_DNA. DR EMBL; CH471062; EAW61648.1; -; Genomic_DNA. DR EMBL; BC011414; AAH11414.1; -; mRNA. DR CCDS; CCDS4323.1; -. DR RefSeq; NP_001304922.1; NM_001317993.1. DR RefSeq; NP_001304923.1; NM_001317994.1. DR RefSeq; NP_001304924.1; NM_001317995.1. DR RefSeq; NP_061161.2; NM_018691.3. DR RefSeq; XP_005268417.1; XM_005268360.4. DR RefSeq; XP_005268418.1; XM_005268361.4. DR RefSeq; XP_011535842.1; XM_011537540.2. DR RefSeq; XP_011535843.1; XM_011537541.2. DR RefSeq; XP_011535844.1; XM_011537542.2. DR RefSeq; XP_016864456.1; XM_017008967.1. DR RefSeq; XP_016864457.1; XM_017008968.1. DR AlphaFoldDB; Q9NRY5; -. DR SMR; Q9NRY5; -. DR BioGRID; 116040; 86. DR IntAct; Q9NRY5; 29. DR MINT; Q9NRY5; -. DR STRING; 9606.ENSP00000341597; -. DR GlyGen; Q9NRY5; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9NRY5; -. DR PhosphoSitePlus; Q9NRY5; -. DR SwissPalm; Q9NRY5; -. DR BioMuta; FAM114A2; -. DR DMDM; 296439475; -. DR REPRODUCTION-2DPAGE; IPI00329662; -. DR EPD; Q9NRY5; -. DR jPOST; Q9NRY5; -. DR MassIVE; Q9NRY5; -. DR MaxQB; Q9NRY5; -. DR PaxDb; 9606-ENSP00000341597; -. DR PeptideAtlas; Q9NRY5; -. DR ProteomicsDB; 82443; -. DR Pumba; Q9NRY5; -. DR Antibodypedia; 48470; 86 antibodies from 16 providers. DR DNASU; 10827; -. DR Ensembl; ENST00000351797.9; ENSP00000341597.4; ENSG00000055147.19. DR Ensembl; ENST00000520667.5; ENSP00000430384.1; ENSG00000055147.19. DR Ensembl; ENST00000522858.5; ENSP00000430489.1; ENSG00000055147.19. DR GeneID; 10827; -. DR KEGG; hsa:10827; -. DR MANE-Select; ENST00000351797.9; ENSP00000341597.4; NM_018691.4; NP_061161.2. DR UCSC; uc003lvb.5; human. DR AGR; HGNC:1333; -. DR CTD; 10827; -. DR DisGeNET; 10827; -. DR GeneCards; FAM114A2; -. DR HGNC; HGNC:1333; FAM114A2. DR HPA; ENSG00000055147; Low tissue specificity. DR neXtProt; NX_Q9NRY5; -. DR OpenTargets; ENSG00000055147; -. DR PharmGKB; PA162385716; -. DR VEuPathDB; HostDB:ENSG00000055147; -. DR eggNOG; ENOG502QS74; Eukaryota. DR GeneTree; ENSGT00390000010054; -. DR InParanoid; Q9NRY5; -. DR OMA; VLFENYC; -. DR OrthoDB; 5401701at2759; -. DR PhylomeDB; Q9NRY5; -. DR TreeFam; TF324360; -. DR PathwayCommons; Q9NRY5; -. DR Reactome; R-HSA-6802952; Signaling by BRAF and RAF1 fusions. DR SignaLink; Q9NRY5; -. DR BioGRID-ORCS; 10827; 8 hits in 1162 CRISPR screens. DR ChiTaRS; FAM114A2; human. DR GeneWiki; C5orf3; -. DR GenomeRNAi; 10827; -. DR Pharos; Q9NRY5; Tdark. DR PRO; PR:Q9NRY5; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; Q9NRY5; Protein. DR Bgee; ENSG00000055147; Expressed in colonic epithelium and 190 other cell types or tissues. DR ExpressionAtlas; Q9NRY5; baseline and differential. DR GO; GO:0017076; F:purine nucleotide binding; NAS:UniProtKB. DR InterPro; IPR007998; DUF719. DR PANTHER; PTHR12842; FI01459P; 1. DR PANTHER; PTHR12842:SF3; PROTEIN FAM114A2; 1. DR Pfam; PF05334; DUF719; 1. DR Genevisible; Q9NRY5; HS. PE 1: Evidence at protein level; KW Coiled coil; Phosphoprotein; Reference proteome. FT CHAIN 1..505 FT /note="Protein FAM114A2" FT /id="PRO_0000274564" FT REGION 1..65 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 342..366 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 268..295 FT /evidence="ECO:0000255" FT COMPBIAS 44..59 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 87 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 146 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332" FT MOD_RES 209 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT CONFLICT 68 FT /note="P -> S (in Ref. 1; AAF76523)" FT /evidence="ECO:0000305" FT CONFLICT 122 FT /note="G -> S (in Ref. 1; AAF76523, 2; BAB14952 and 5; FT AAH11414)" FT /evidence="ECO:0000305" SQ SEQUENCE 505 AA; 55468 MW; E3991C42F8DCF606 CRC64; MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK PLLEH //