Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NRY5 (F1142_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM114A2
Gene names
Name:FAM114A2
Synonyms:C5orf3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM114 family.

Ontologies

Keywords
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpurine nucleotide binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Protein FAM114A2
PRO_0000274564

Regions

Coiled coil268 – 29528 Potential
Compositional bias297 – 3026Poly-Glu

Amino acid modifications

Modified residue1461Phosphoserine Ref.6

Experimental info

Sequence conflict681P → S in AAF76523. Ref.1
Sequence conflict1221G → S in AAF76523. Ref.1
Sequence conflict1221G → S in BAB14952. Ref.2
Sequence conflict1221G → S in AAH11414. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9NRY5 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: E3991C42F8DCF606

FASTA50555,468
        10         20         30         40         50         60 
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR KRPETKPSSD 

        70         80         90        100        110        120 
LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV ATVGQGISNV IEKAETSLGI 

       130        140        150        160        170        180 
PGPSEISTEV KYVAGETNAK ENENSSPVAG AFGVFSTIST AVQSTGKSVI SGGLDALEFI 

       190        200        210        220        230        240 
GKKTMDVIAE GDPGFKRTKG LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL 

       250        260        270        280        290        300 
FDEFQGLSHL EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE 

       310        320        330        340        350        360 
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE NEEGEKQSEA 

       370        380        390        400        410        420 
ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV LHGRKQEVTA IERSQTLSQM 

       430        440        450        460        470        480 
TIVLCKELSS LSKEFTTCLT TAGVKEMADV LNPLITAVFL EASNSASYIQ DAFQLLLPVL 

       490        500 
EISLIENKIE SHRHELQGQK PLLEH 

« Hide

References

« Hide 'large scale' references
[1]"Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs."
Boultwood J., Fidler C., Strickson A.J., Watkins F., Kostrzewa M., Jaju R.J., Muller U., Wainscoat J.S.
Genomics 66:26-34(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF159700 mRNA. Translation: AAF76523.1.
AK024664 mRNA. Translation: BAB14952.1.
AK313331 mRNA. Translation: BAG36135.1.
AC010232 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61646.1.
CH471062 Genomic DNA. Translation: EAW61647.1.
CH471062 Genomic DNA. Translation: EAW61648.1.
BC011414 mRNA. Translation: AAH11414.1.
CCDSCCDS4323.1.
RefSeqNP_061161.2. NM_018691.2.
XP_005268417.1. XM_005268360.2.
XP_005268418.1. XM_005268361.2.
UniGeneHs.166551.

3D structure databases

ProteinModelPortalQ9NRY5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116040. 4 interactions.

PTM databases

PhosphoSiteQ9NRY5.

Polymorphism databases

DMDM296439475.

2D gel databases

REPRODUCTION-2DPAGEIPI00329662.

Proteomic databases

MaxQBQ9NRY5.
PaxDbQ9NRY5.
PRIDEQ9NRY5.

Protocols and materials databases

DNASU10827.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351797; ENSP00000341597; ENSG00000055147.
ENST00000520667; ENSP00000430384; ENSG00000055147.
ENST00000522858; ENSP00000430489; ENSG00000055147.
GeneID10827.
KEGGhsa:10827.
UCSCuc003lvb.3. human.

Organism-specific databases

CTD10827.
GeneCardsGC05M153352.
H-InvDBHIX0005337.
HGNCHGNC:1333. FAM114A2.
HPAHPA035869.
HPA035870.
neXtProtNX_Q9NRY5.
PharmGKBPA162385716.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG131151.
HOGENOMHOG000059573.
HOVERGENHBG056879.
InParanoidQ9NRY5.
OMADVPQTGW.
OrthoDBEOG7P5T0T.
PhylomeDBQ9NRY5.
TreeFamTF324360.

Gene expression databases

ArrayExpressQ9NRY5.
BgeeQ9NRY5.
CleanExHS_FAM114A2.
GenevestigatorQ9NRY5.

Family and domain databases

InterProIPR007998. DUF719.
[Graphical view]
PANTHERPTHR12842. PTHR12842. 1 hit.
PfamPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM114A2. human.
GeneWikiC5orf3.
GenomeRNAi10827.
NextBio41126.
PROQ9NRY5.

Entry information

Entry nameF1142_HUMAN
AccessionPrimary (citable) accession number: Q9NRY5
Secondary accession number(s): B2R8D8, Q9H7E0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM