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Q9NRY5

- F1142_HUMAN

UniProt

Q9NRY5 - F1142_HUMAN

Protein

Protein FAM114A2

Gene

FAM114A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. purine nucleotide binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM114A2
    Gene namesi
    Name:FAM114A2
    Synonyms:C5orf3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1333. FAM114A2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162385716.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Protein FAM114A2PRO_0000274564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei146 – 1461Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NRY5.
    PaxDbiQ9NRY5.
    PRIDEiQ9NRY5.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00329662.

    PTM databases

    PhosphoSiteiQ9NRY5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NRY5.
    BgeeiQ9NRY5.
    CleanExiHS_FAM114A2.
    GenevestigatoriQ9NRY5.

    Organism-specific databases

    HPAiHPA035869.
    HPA035870.

    Interactioni

    Protein-protein interaction databases

    BioGridi116040. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili268 – 29528Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi297 – 3026Poly-Glu

    Sequence similaritiesi

    Belongs to the FAM114 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG131151.
    HOGENOMiHOG000059573.
    HOVERGENiHBG056879.
    InParanoidiQ9NRY5.
    OMAiDVPQTGW.
    OrthoDBiEOG7P5T0T.
    PhylomeDBiQ9NRY5.
    TreeFamiTF324360.

    Family and domain databases

    InterProiIPR007998. DUF719.
    [Graphical view]
    PANTHERiPTHR12842. PTHR12842. 1 hit.
    PfamiPF05334. DUF719. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NRY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR    50
    KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV 100
    ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG 150
    AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG 200
    LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL 250
    EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE 300
    EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE 350
    NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV 400
    LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV 450
    LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK 500
    PLLEH 505
    Length:505
    Mass (Da):55,468
    Last modified:May 18, 2010 - v4
    Checksum:iE3991C42F8DCF606
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681P → S in AAF76523. (PubMed:10843801)Curated
    Sequence conflicti122 – 1221G → S in AAF76523. (PubMed:10843801)Curated
    Sequence conflicti122 – 1221G → S in BAB14952. (PubMed:14702039)Curated
    Sequence conflicti122 – 1221G → S in AAH11414. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159700 mRNA. Translation: AAF76523.1.
    AK024664 mRNA. Translation: BAB14952.1.
    AK313331 mRNA. Translation: BAG36135.1.
    AC010232 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61646.1.
    CH471062 Genomic DNA. Translation: EAW61647.1.
    CH471062 Genomic DNA. Translation: EAW61648.1.
    BC011414 mRNA. Translation: AAH11414.1.
    CCDSiCCDS4323.1.
    RefSeqiNP_061161.2. NM_018691.2.
    XP_005268417.1. XM_005268360.2.
    XP_005268418.1. XM_005268361.2.
    UniGeneiHs.166551.

    Genome annotation databases

    EnsembliENST00000351797; ENSP00000341597; ENSG00000055147.
    ENST00000520667; ENSP00000430384; ENSG00000055147.
    ENST00000522858; ENSP00000430489; ENSG00000055147.
    GeneIDi10827.
    KEGGihsa:10827.
    UCSCiuc003lvb.3. human.

    Polymorphism databases

    DMDMi296439475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159700 mRNA. Translation: AAF76523.1 .
    AK024664 mRNA. Translation: BAB14952.1 .
    AK313331 mRNA. Translation: BAG36135.1 .
    AC010232 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61646.1 .
    CH471062 Genomic DNA. Translation: EAW61647.1 .
    CH471062 Genomic DNA. Translation: EAW61648.1 .
    BC011414 mRNA. Translation: AAH11414.1 .
    CCDSi CCDS4323.1.
    RefSeqi NP_061161.2. NM_018691.2.
    XP_005268417.1. XM_005268360.2.
    XP_005268418.1. XM_005268361.2.
    UniGenei Hs.166551.

    3D structure databases

    ProteinModelPortali Q9NRY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116040. 4 interactions.

    PTM databases

    PhosphoSitei Q9NRY5.

    Polymorphism databases

    DMDMi 296439475.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00329662.

    Proteomic databases

    MaxQBi Q9NRY5.
    PaxDbi Q9NRY5.
    PRIDEi Q9NRY5.

    Protocols and materials databases

    DNASUi 10827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000351797 ; ENSP00000341597 ; ENSG00000055147 .
    ENST00000520667 ; ENSP00000430384 ; ENSG00000055147 .
    ENST00000522858 ; ENSP00000430489 ; ENSG00000055147 .
    GeneIDi 10827.
    KEGGi hsa:10827.
    UCSCi uc003lvb.3. human.

    Organism-specific databases

    CTDi 10827.
    GeneCardsi GC05M153352.
    H-InvDB HIX0005337.
    HGNCi HGNC:1333. FAM114A2.
    HPAi HPA035869.
    HPA035870.
    neXtProti NX_Q9NRY5.
    PharmGKBi PA162385716.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131151.
    HOGENOMi HOG000059573.
    HOVERGENi HBG056879.
    InParanoidi Q9NRY5.
    OMAi DVPQTGW.
    OrthoDBi EOG7P5T0T.
    PhylomeDBi Q9NRY5.
    TreeFami TF324360.

    Miscellaneous databases

    ChiTaRSi FAM114A2. human.
    GeneWikii C5orf3.
    GenomeRNAii 10827.
    NextBioi 41126.
    PROi Q9NRY5.

    Gene expression databases

    ArrayExpressi Q9NRY5.
    Bgeei Q9NRY5.
    CleanExi HS_FAM114A2.
    Genevestigatori Q9NRY5.

    Family and domain databases

    InterProi IPR007998. DUF719.
    [Graphical view ]
    PANTHERi PTHR12842. PTHR12842. 1 hit.
    Pfami PF05334. DUF719. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs."
      Boultwood J., Fidler C., Strickson A.J., Watkins F., Kostrzewa M., Jaju R.J., Muller U., Wainscoat J.S.
      Genomics 66:26-34(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF1142_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRY5
    Secondary accession number(s): B2R8D8, Q9H7E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 89 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3