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Protein

Protein FAM114A2

Gene

FAM114A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. purine nucleotide binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM114A2
Gene namesi
Name:FAM114A2
Synonyms:C5orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1333. FAM114A2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Protein FAM114A2PRO_0000274564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461Phosphoserine1 Publication
Modified residuei209 – 2091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NRY5.
PaxDbiQ9NRY5.
PRIDEiQ9NRY5.

2D gel databases

REPRODUCTION-2DPAGEIPI00329662.

PTM databases

PhosphoSiteiQ9NRY5.

Expressioni

Gene expression databases

BgeeiQ9NRY5.
CleanExiHS_FAM114A2.
ExpressionAtlasiQ9NRY5. baseline and differential.
GenevestigatoriQ9NRY5.

Organism-specific databases

HPAiHPA035869.
HPA035870.

Interactioni

Protein-protein interaction databases

BioGridi116040. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NRY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili268 – 29528Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi297 – 3026Poly-Glu

Sequence similaritiesi

Belongs to the FAM114 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG131151.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ9NRY5.
OMAiSKDVPQT.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ9NRY5.
TreeFamiTF324360.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR
60 70 80 90 100
KRPETKPSSD LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV
110 120 130 140 150
ATVGQGISNV IEKAETSLGI PGPSEISTEV KYVAGETNAK ENENSSPVAG
160 170 180 190 200
AFGVFSTIST AVQSTGKSVI SGGLDALEFI GKKTMDVIAE GDPGFKRTKG
210 220 230 240 250
LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL FDEFQGLSHL
260 270 280 290 300
EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE
310 320 330 340 350
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE
360 370 380 390 400
NEEGEKQSEA ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV
410 420 430 440 450
LHGRKQEVTA IERSQTLSQM TIVLCKELSS LSKEFTTCLT TAGVKEMADV
460 470 480 490 500
LNPLITAVFL EASNSASYIQ DAFQLLLPVL EISLIENKIE SHRHELQGQK

PLLEH
Length:505
Mass (Da):55,468
Last modified:May 18, 2010 - v4
Checksum:iE3991C42F8DCF606
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681P → S in AAF76523 (PubMed:10843801).Curated
Sequence conflicti122 – 1221G → S in AAF76523 (PubMed:10843801).Curated
Sequence conflicti122 – 1221G → S in BAB14952 (PubMed:14702039).Curated
Sequence conflicti122 – 1221G → S in AAH11414 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159700 mRNA. Translation: AAF76523.1.
AK024664 mRNA. Translation: BAB14952.1.
AK313331 mRNA. Translation: BAG36135.1.
AC010232 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61646.1.
CH471062 Genomic DNA. Translation: EAW61647.1.
CH471062 Genomic DNA. Translation: EAW61648.1.
BC011414 mRNA. Translation: AAH11414.1.
CCDSiCCDS4323.1.
RefSeqiNP_061161.2. NM_018691.2.
XP_005268417.1. XM_005268360.2.
XP_005268418.1. XM_005268361.2.
UniGeneiHs.166551.

Genome annotation databases

EnsembliENST00000351797; ENSP00000341597; ENSG00000055147.
ENST00000520667; ENSP00000430384; ENSG00000055147.
ENST00000522858; ENSP00000430489; ENSG00000055147.
GeneIDi10827.
KEGGihsa:10827.
UCSCiuc003lvb.3. human.

Polymorphism databases

DMDMi296439475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159700 mRNA. Translation: AAF76523.1.
AK024664 mRNA. Translation: BAB14952.1.
AK313331 mRNA. Translation: BAG36135.1.
AC010232 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61646.1.
CH471062 Genomic DNA. Translation: EAW61647.1.
CH471062 Genomic DNA. Translation: EAW61648.1.
BC011414 mRNA. Translation: AAH11414.1.
CCDSiCCDS4323.1.
RefSeqiNP_061161.2. NM_018691.2.
XP_005268417.1. XM_005268360.2.
XP_005268418.1. XM_005268361.2.
UniGeneiHs.166551.

3D structure databases

ProteinModelPortaliQ9NRY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116040. 8 interactions.

PTM databases

PhosphoSiteiQ9NRY5.

Polymorphism databases

DMDMi296439475.

2D gel databases

REPRODUCTION-2DPAGEIPI00329662.

Proteomic databases

MaxQBiQ9NRY5.
PaxDbiQ9NRY5.
PRIDEiQ9NRY5.

Protocols and materials databases

DNASUi10827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351797; ENSP00000341597; ENSG00000055147.
ENST00000520667; ENSP00000430384; ENSG00000055147.
ENST00000522858; ENSP00000430489; ENSG00000055147.
GeneIDi10827.
KEGGihsa:10827.
UCSCiuc003lvb.3. human.

Organism-specific databases

CTDi10827.
GeneCardsiGC05M153352.
H-InvDBHIX0005337.
HGNCiHGNC:1333. FAM114A2.
HPAiHPA035869.
HPA035870.
neXtProtiNX_Q9NRY5.
PharmGKBiPA162385716.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG131151.
GeneTreeiENSGT00390000010054.
HOGENOMiHOG000059573.
HOVERGENiHBG056879.
InParanoidiQ9NRY5.
OMAiSKDVPQT.
OrthoDBiEOG7P5T0T.
PhylomeDBiQ9NRY5.
TreeFamiTF324360.

Miscellaneous databases

ChiTaRSiFAM114A2. human.
GeneWikiiC5orf3.
GenomeRNAii10827.
NextBioi41126.
PROiQ9NRY5.

Gene expression databases

BgeeiQ9NRY5.
CleanExiHS_FAM114A2.
ExpressionAtlasiQ9NRY5. baseline and differential.
GenevestigatoriQ9NRY5.

Family and domain databases

InterProiIPR007998. DUF719.
[Graphical view]
PANTHERiPTHR12842. PTHR12842. 1 hit.
PfamiPF05334. DUF719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs."
    Boultwood J., Fidler C., Strickson A.J., Watkins F., Kostrzewa M., Jaju R.J., Muller U., Wainscoat J.S.
    Genomics 66:26-34(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiF1142_HUMAN
AccessioniPrimary (citable) accession number: Q9NRY5
Secondary accession number(s): B2R8D8, Q9H7E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.