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Protein

Protein kish-B

Gene

TMEM167B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the early part of the secretory pathway.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kish-B
Alternative name(s):
Transmembrane protein 167B
Gene namesi
Name:TMEM167B
Synonyms:C1orf119
ORF Names:AD-020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30187. TMEM167B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 5230ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 741CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405910.

Polymorphism and mutation databases

BioMutaiTMEM167B.
DMDMi74752932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 7452Protein kish-BPRO_0000265081Add
BLAST

Proteomic databases

PRIDEiQ9NRX6.

Expressioni

Gene expression databases

BgeeiQ9NRX6.
CleanExiHS_TMEM167B.
ExpressionAtlasiQ9NRX6. baseline and differential.
GenevestigatoriQ9NRX6.

Interactioni

Protein-protein interaction databases

BioGridi121230. 2 interactions.
STRINGi9606.ENSP00000342148.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KISH family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305758.
GeneTreeiENSGT00730000111341.
HOGENOMiHOG000231410.
HOVERGENiHBG080265.
InParanoidiQ9NRX6.
OMAiCAYLKKV.
OrthoDBiEOG7VMP7X.
PhylomeDBiQ9NRX6.
TreeFamiTF300138.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV
60 70
IGTRLHAAVA IACVVMAFYV LFIK
Length:74
Mass (Da):8,294
Last modified:October 1, 2000 - v1
Checksum:i3ADBFA3B0DF48C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164793 mRNA. Translation: AAF80757.1.
AK291293 mRNA. Translation: BAF83982.1.
AL356488 Genomic DNA. Translation: CAI19043.1.
CH471122 Genomic DNA. Translation: EAW56356.1.
BC008739 mRNA. Translation: AAH08739.1.
BC065186 mRNA. Translation: AAH65186.1.
BC066918 mRNA. Translation: AAH66918.1.
BC067116 mRNA. Translation: AAH67116.1.
BC146873 mRNA. Translation: AAI46874.1.
BC146879 mRNA. Translation: AAI46880.1.
BC171849 mRNA. Translation: AAI71849.1.
CCDSiCCDS30789.1.
RefSeqiNP_064526.1. NM_020141.3.
UniGeneiHs.82933.

Genome annotation databases

EnsembliENST00000338272; ENSP00000342148; ENSG00000215717.
GeneIDi56900.
KEGGihsa:56900.
UCSCiuc001dwn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164793 mRNA. Translation: AAF80757.1.
AK291293 mRNA. Translation: BAF83982.1.
AL356488 Genomic DNA. Translation: CAI19043.1.
CH471122 Genomic DNA. Translation: EAW56356.1.
BC008739 mRNA. Translation: AAH08739.1.
BC065186 mRNA. Translation: AAH65186.1.
BC066918 mRNA. Translation: AAH66918.1.
BC067116 mRNA. Translation: AAH67116.1.
BC146873 mRNA. Translation: AAI46874.1.
BC146879 mRNA. Translation: AAI46880.1.
BC171849 mRNA. Translation: AAI71849.1.
CCDSiCCDS30789.1.
RefSeqiNP_064526.1. NM_020141.3.
UniGeneiHs.82933.

3D structure databases

ProteinModelPortaliQ9NRX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121230. 2 interactions.
STRINGi9606.ENSP00000342148.

Polymorphism and mutation databases

BioMutaiTMEM167B.
DMDMi74752932.

Proteomic databases

PRIDEiQ9NRX6.

Protocols and materials databases

DNASUi56900.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338272; ENSP00000342148; ENSG00000215717.
GeneIDi56900.
KEGGihsa:56900.
UCSCiuc001dwn.3. human.

Organism-specific databases

CTDi56900.
GeneCardsiGC01P109630.
HGNCiHGNC:30187. TMEM167B.
neXtProtiNX_Q9NRX6.
PharmGKBiPA162405910.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305758.
GeneTreeiENSGT00730000111341.
HOGENOMiHOG000231410.
HOVERGENiHBG080265.
InParanoidiQ9NRX6.
OMAiCAYLKKV.
OrthoDBiEOG7VMP7X.
PhylomeDBiQ9NRX6.
TreeFamiTF300138.

Miscellaneous databases

GenomeRNAii56900.
NextBioi62351.
PROiQ9NRX6.

Gene expression databases

BgeeiQ9NRX6.
CleanExiHS_TMEM167B.
ExpressionAtlasiQ9NRX6. baseline and differential.
GenevestigatoriQ9NRX6.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Skin, Testis and Uterus.
  6. "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
    Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
    EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKISHB_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX6
Secondary accession number(s): B2RUU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.