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Q9NRX6

- KISHB_HUMAN

UniProt

Q9NRX6 - KISHB_HUMAN

Protein

Protein kish-B

Gene

TMEM167B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in the early part of the secretory pathway.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kish-B
    Alternative name(s):
    Transmembrane protein 167B
    Gene namesi
    Name:TMEM167B
    Synonyms:C1orf119
    ORF Names:AD-020
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30187. TMEM167B.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405910.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 7452Protein kish-BPRO_0000265081Add
    BLAST

    Proteomic databases

    PRIDEiQ9NRX6.

    Expressioni

    Gene expression databases

    BgeeiQ9NRX6.
    CleanExiHS_TMEM167B.
    GenevestigatoriQ9NRX6.

    Interactioni

    Protein-protein interaction databases

    BioGridi121230. 2 interactions.
    STRINGi9606.ENSP00000342148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 5230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 741CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KISH family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305758.
    HOGENOMiHOG000231410.
    HOVERGENiHBG080265.
    OMAiCAYLKKV.
    OrthoDBiEOG7VMP7X.
    PhylomeDBiQ9NRX6.
    TreeFamiTF300138.

    Family and domain databases

    InterProiIPR009653. DUF1242.
    [Graphical view]
    PANTHERiPTHR13229. PTHR13229. 1 hit.
    PfamiPF06842. DUF1242. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NRX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV   50
    IGTRLHAAVA IACVVMAFYV LFIK 74
    Length:74
    Mass (Da):8,294
    Last modified:October 1, 2000 - v1
    Checksum:i3ADBFA3B0DF48C29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164793 mRNA. Translation: AAF80757.1.
    AK291293 mRNA. Translation: BAF83982.1.
    AL356488 Genomic DNA. Translation: CAI19043.1.
    CH471122 Genomic DNA. Translation: EAW56356.1.
    BC008739 mRNA. Translation: AAH08739.1.
    BC065186 mRNA. Translation: AAH65186.1.
    BC066918 mRNA. Translation: AAH66918.1.
    BC067116 mRNA. Translation: AAH67116.1.
    BC146873 mRNA. Translation: AAI46874.1.
    BC146879 mRNA. Translation: AAI46880.1.
    BC171849 mRNA. Translation: AAI71849.1.
    CCDSiCCDS30789.1.
    RefSeqiNP_064526.1. NM_020141.3.
    UniGeneiHs.82933.

    Genome annotation databases

    EnsembliENST00000338272; ENSP00000342148; ENSG00000215717.
    GeneIDi56900.
    KEGGihsa:56900.
    UCSCiuc001dwn.3. human.

    Polymorphism databases

    DMDMi74752932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164793 mRNA. Translation: AAF80757.1 .
    AK291293 mRNA. Translation: BAF83982.1 .
    AL356488 Genomic DNA. Translation: CAI19043.1 .
    CH471122 Genomic DNA. Translation: EAW56356.1 .
    BC008739 mRNA. Translation: AAH08739.1 .
    BC065186 mRNA. Translation: AAH65186.1 .
    BC066918 mRNA. Translation: AAH66918.1 .
    BC067116 mRNA. Translation: AAH67116.1 .
    BC146873 mRNA. Translation: AAI46874.1 .
    BC146879 mRNA. Translation: AAI46880.1 .
    BC171849 mRNA. Translation: AAI71849.1 .
    CCDSi CCDS30789.1.
    RefSeqi NP_064526.1. NM_020141.3.
    UniGenei Hs.82933.

    3D structure databases

    ProteinModelPortali Q9NRX6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121230. 2 interactions.
    STRINGi 9606.ENSP00000342148.

    Polymorphism databases

    DMDMi 74752932.

    Proteomic databases

    PRIDEi Q9NRX6.

    Protocols and materials databases

    DNASUi 56900.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338272 ; ENSP00000342148 ; ENSG00000215717 .
    GeneIDi 56900.
    KEGGi hsa:56900.
    UCSCi uc001dwn.3. human.

    Organism-specific databases

    CTDi 56900.
    GeneCardsi GC01P109630.
    HGNCi HGNC:30187. TMEM167B.
    neXtProti NX_Q9NRX6.
    PharmGKBi PA162405910.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305758.
    HOGENOMi HOG000231410.
    HOVERGENi HBG080265.
    OMAi CAYLKKV.
    OrthoDBi EOG7VMP7X.
    PhylomeDBi Q9NRX6.
    TreeFami TF300138.

    Miscellaneous databases

    GenomeRNAii 56900.
    NextBioi 62351.
    PROi Q9NRX6.

    Gene expression databases

    Bgeei Q9NRX6.
    CleanExi HS_TMEM167B.
    Genevestigatori Q9NRX6.

    Family and domain databases

    InterProi IPR009653. DUF1242.
    [Graphical view ]
    PANTHERi PTHR13229. PTHR13229. 1 hit.
    Pfami PF06842. DUF1242. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Skin, Testis and Uterus.
    6. "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
      Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
      EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKISHB_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRX6
    Secondary accession number(s): B2RUU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3