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Q9NRX6

- KISHB_HUMAN

UniProt

Q9NRX6 - KISHB_HUMAN

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Protein

Protein kish-B

Gene

TMEM167B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the early part of the secretory pathway.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kish-B
Alternative name(s):
Transmembrane protein 167B
Gene namesi
Name:TMEM167B
Synonyms:C1orf119
ORF Names:AD-020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30187. TMEM167B.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 7452Protein kish-BPRO_0000265081Add
BLAST

Proteomic databases

PRIDEiQ9NRX6.

Expressioni

Gene expression databases

BgeeiQ9NRX6.
CleanExiHS_TMEM167B.
GenevestigatoriQ9NRX6.

Interactioni

Protein-protein interaction databases

BioGridi121230. 2 interactions.
STRINGi9606.ENSP00000342148.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 5230ExtracellularSequence AnalysisAdd
BLAST
Topological domaini74 – 741CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the KISH family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305758.
GeneTreeiENSGT00730000111341.
HOGENOMiHOG000231410.
HOVERGENiHBG080265.
InParanoidiQ9NRX6.
OMAiCAYLKKV.
OrthoDBiEOG7VMP7X.
PhylomeDBiQ9NRX6.
TreeFamiTF300138.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV
60 70
IGTRLHAAVA IACVVMAFYV LFIK
Length:74
Mass (Da):8,294
Last modified:October 1, 2000 - v1
Checksum:i3ADBFA3B0DF48C29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164793 mRNA. Translation: AAF80757.1.
AK291293 mRNA. Translation: BAF83982.1.
AL356488 Genomic DNA. Translation: CAI19043.1.
CH471122 Genomic DNA. Translation: EAW56356.1.
BC008739 mRNA. Translation: AAH08739.1.
BC065186 mRNA. Translation: AAH65186.1.
BC066918 mRNA. Translation: AAH66918.1.
BC067116 mRNA. Translation: AAH67116.1.
BC146873 mRNA. Translation: AAI46874.1.
BC146879 mRNA. Translation: AAI46880.1.
BC171849 mRNA. Translation: AAI71849.1.
CCDSiCCDS30789.1.
RefSeqiNP_064526.1. NM_020141.3.
UniGeneiHs.82933.

Genome annotation databases

EnsembliENST00000338272; ENSP00000342148; ENSG00000215717.
GeneIDi56900.
KEGGihsa:56900.
UCSCiuc001dwn.3. human.

Polymorphism databases

DMDMi74752932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164793 mRNA. Translation: AAF80757.1 .
AK291293 mRNA. Translation: BAF83982.1 .
AL356488 Genomic DNA. Translation: CAI19043.1 .
CH471122 Genomic DNA. Translation: EAW56356.1 .
BC008739 mRNA. Translation: AAH08739.1 .
BC065186 mRNA. Translation: AAH65186.1 .
BC066918 mRNA. Translation: AAH66918.1 .
BC067116 mRNA. Translation: AAH67116.1 .
BC146873 mRNA. Translation: AAI46874.1 .
BC146879 mRNA. Translation: AAI46880.1 .
BC171849 mRNA. Translation: AAI71849.1 .
CCDSi CCDS30789.1.
RefSeqi NP_064526.1. NM_020141.3.
UniGenei Hs.82933.

3D structure databases

ProteinModelPortali Q9NRX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121230. 2 interactions.
STRINGi 9606.ENSP00000342148.

Polymorphism databases

DMDMi 74752932.

Proteomic databases

PRIDEi Q9NRX6.

Protocols and materials databases

DNASUi 56900.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338272 ; ENSP00000342148 ; ENSG00000215717 .
GeneIDi 56900.
KEGGi hsa:56900.
UCSCi uc001dwn.3. human.

Organism-specific databases

CTDi 56900.
GeneCardsi GC01P109630.
HGNCi HGNC:30187. TMEM167B.
neXtProti NX_Q9NRX6.
PharmGKBi PA162405910.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305758.
GeneTreei ENSGT00730000111341.
HOGENOMi HOG000231410.
HOVERGENi HBG080265.
InParanoidi Q9NRX6.
OMAi CAYLKKV.
OrthoDBi EOG7VMP7X.
PhylomeDBi Q9NRX6.
TreeFami TF300138.

Miscellaneous databases

GenomeRNAii 56900.
NextBioi 62351.
PROi Q9NRX6.

Gene expression databases

Bgeei Q9NRX6.
CleanExi HS_TMEM167B.
Genevestigatori Q9NRX6.

Family and domain databases

InterProi IPR009653. DUF1242.
[Graphical view ]
PANTHERi PTHR13229. PTHR13229. 1 hit.
Pfami PF06842. DUF1242. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Skin, Testis and Uterus.
  6. "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
    Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
    EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiKISHB_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX6
Secondary accession number(s): B2RUU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3