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Protein

Serine incorporator 1

Gene

SERINC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111897-MONOMER.
ReactomeiR-HSA-977347. Serine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:SERINC1
Synonyms:KIAA1253, TDE1L, TDE2
ORF Names:UNQ396/PRO732
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13464. SERINC1.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 39CytoplasmicSequence analysisAdd BLAST38
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 88LumenalSequence analysisAdd BLAST28
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 123CytoplasmicSequence analysisAdd BLAST14
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 151LumenalSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 197CytoplasmicSequence analysisAdd BLAST25
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231LumenalSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 259CytoplasmicSequence analysis7
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Topological domaini281 – 309LumenalSequence analysisAdd BLAST29
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 387CytoplasmicSequence analysisAdd BLAST57
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 426LumenalSequence analysisAdd BLAST18
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 453CytoplasmicSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57515.
OpenTargetsiENSG00000111897.
PharmGKBiPA134973249.

Polymorphism and mutation databases

BioMutaiSERINC1.
DMDMi25453298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002189662 – 453Serine incorporator 1Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Glycosylationi298N-linked (GlcNAc...)1 Publication1
Modified residuei351PhosphoserineCombined sources1
Modified residuei352PhosphothreonineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9NRX5.
MaxQBiQ9NRX5.
PaxDbiQ9NRX5.
PeptideAtlasiQ9NRX5.
PRIDEiQ9NRX5.

PTM databases

iPTMnetiQ9NRX5.
PhosphoSitePlusiQ9NRX5.
SwissPalmiQ9NRX5.

Expressioni

Gene expression databases

BgeeiENSG00000111897.
CleanExiHS_SERINC1.
GenevisibleiQ9NRX5. HS.

Organism-specific databases

HPAiHPA035738.
HPA035739.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PAX8Q067102EBI-2683145,EBI-2683132

Protein-protein interaction databases

BioGridi121579. 33 interactors.
IntActiQ9NRX5. 14 interactors.
MINTiMINT-5005668.
STRINGi9606.ENSP00000342962.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOVERGENiHBG025699.
InParanoidiQ9NRX5.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9NRX5.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC VGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT
310 320 330 340 350
STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGGAR SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,495
Last modified:October 1, 2000 - v1
Checksum:i3868DBF38165B78C
GO

Sequence cautioni

The sequence BAA86567 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → S in AAH28607 (PubMed:15489334).Curated1
Sequence conflicti247S → F in AAP97200 (Ref. 1) Curated1
Sequence conflicti247S → F in AAP97211 (Ref. 1) Curated1
Sequence conflicti408Y → S in AAQ88795 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052275199L → V.Corresponds to variant rs13210569dbSNPEnsembl.1
Natural variantiVAR_052276216F → V.Corresponds to variant rs13210446dbSNPEnsembl.1
Natural variantiVAR_052277225S → G.Corresponds to variant rs17260829dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA. Translation: AAP97200.1.
AF092436 Genomic DNA. Translation: AAP97211.1.
AB033079 mRNA. Translation: BAA86567.1. Different initiation.
AL137261 mRNA. Translation: CAB70662.2.
AF164794 mRNA. Translation: AAF80758.1.
AY358429 mRNA. Translation: AAQ88795.1.
AK128781 mRNA. Translation: BAG54731.1.
Z99129 Genomic DNA. Translation: CAD92585.1.
CH471051 Genomic DNA. Translation: EAW48172.1.
CH471051 Genomic DNA. Translation: EAW48173.1.
BC028607 mRNA. Translation: AAH28607.1.
BC033029 mRNA. Translation: AAH33029.1.
CCDSiCCDS5125.1.
RefSeqiNP_065806.1. NM_020755.3.
UniGeneiHs.146668.

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897.
GeneIDi57515.
KEGGihsa:57515.
UCSCiuc003pyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA. Translation: AAP97200.1.
AF092436 Genomic DNA. Translation: AAP97211.1.
AB033079 mRNA. Translation: BAA86567.1. Different initiation.
AL137261 mRNA. Translation: CAB70662.2.
AF164794 mRNA. Translation: AAF80758.1.
AY358429 mRNA. Translation: AAQ88795.1.
AK128781 mRNA. Translation: BAG54731.1.
Z99129 Genomic DNA. Translation: CAD92585.1.
CH471051 Genomic DNA. Translation: EAW48172.1.
CH471051 Genomic DNA. Translation: EAW48173.1.
BC028607 mRNA. Translation: AAH28607.1.
BC033029 mRNA. Translation: AAH33029.1.
CCDSiCCDS5125.1.
RefSeqiNP_065806.1. NM_020755.3.
UniGeneiHs.146668.

3D structure databases

ProteinModelPortaliQ9NRX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121579. 33 interactors.
IntActiQ9NRX5. 14 interactors.
MINTiMINT-5005668.
STRINGi9606.ENSP00000342962.

PTM databases

iPTMnetiQ9NRX5.
PhosphoSitePlusiQ9NRX5.
SwissPalmiQ9NRX5.

Polymorphism and mutation databases

BioMutaiSERINC1.
DMDMi25453298.

Proteomic databases

EPDiQ9NRX5.
MaxQBiQ9NRX5.
PaxDbiQ9NRX5.
PeptideAtlasiQ9NRX5.
PRIDEiQ9NRX5.

Protocols and materials databases

DNASUi57515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897.
GeneIDi57515.
KEGGihsa:57515.
UCSCiuc003pyy.2. human.

Organism-specific databases

CTDi57515.
DisGeNETi57515.
GeneCardsiSERINC1.
HGNCiHGNC:13464. SERINC1.
HPAiHPA035738.
HPA035739.
MIMi614548. gene.
neXtProtiNX_Q9NRX5.
OpenTargetsiENSG00000111897.
PharmGKBiPA134973249.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOVERGENiHBG025699.
InParanoidiQ9NRX5.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9NRX5.
TreeFamiTF312881.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111897-MONOMER.
ReactomeiR-HSA-977347. Serine biosynthesis.

Miscellaneous databases

ChiTaRSiSERINC1. human.
GeneWikiiSERINC1.
GenomeRNAii57515.
PROiQ9NRX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111897.
CleanExiHS_SERINC1.
GenevisibleiQ9NRX5. HS.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX5
Secondary accession number(s): B3KY69
, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NTH8, Q9ULG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.