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Protein

Serine incorporator 1

Gene

SERINC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 1
Alternative name(s):
Tumor differentially expressed protein 1-like
Tumor differentially expressed protein 2
Gene namesi
Name:SERINC1
Synonyms:KIAA1253, TDE1L, TDE2
ORF Names:UNQ396/PRO732
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13464. SERINC1.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3938CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Topological domaini61 – 8828LumenalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 12314CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 1517LumenalSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 19725CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 23113LumenalSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Topological domaini253 – 2597CytoplasmicSequence analysis
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Topological domaini281 – 30929LumenalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Topological domaini331 – 38757CytoplasmicSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 42618LumenalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST
Topological domaini448 – 4536CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973249.

Polymorphism and mutation databases

BioMutaiSERINC1.
DMDMi25453298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 453452Serine incorporator 1PRO_0000218966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Glycosylationi298 – 2981N-linked (GlcNAc...)1 Publication
Modified residuei351 – 3511PhosphoserineCombined sources
Modified residuei352 – 3521PhosphothreonineCombined sources
Modified residuei361 – 3611PhosphoserineCombined sources
Modified residuei364 – 3641PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9NRX5.
MaxQBiQ9NRX5.
PaxDbiQ9NRX5.
PeptideAtlasiQ9NRX5.
PRIDEiQ9NRX5.

PTM databases

iPTMnetiQ9NRX5.
PhosphoSiteiQ9NRX5.
SwissPalmiQ9NRX5.

Expressioni

Gene expression databases

BgeeiENSG00000111897.
CleanExiHS_SERINC1.
GenevisibleiQ9NRX5. HS.

Organism-specific databases

HPAiHPA035738.
HPA035739.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PAX8Q067102EBI-2683145,EBI-2683132

Protein-protein interaction databases

BioGridi121579. 33 interactions.
IntActiQ9NRX5. 14 interactions.
MINTiMINT-5005668.
STRINGi9606.ENSP00000342962.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOVERGENiHBG025699.
InParanoidiQ9NRX5.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9NRX5.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV
60 70 80 90 100
CVACVMLIPG MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF
110 120 130 140 150
YLLLSLLMIK VKSSSDPRAA VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT
160 170 180 190 200
VWFYVGMAGA FCFILIQLVL LIDFAHSWNE SWVEKMEEGN SRCWYAALLS
210 220 230 240 250
ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC VGASVMSILP
260 270 280 290 300
KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT
310 320 330 340 350
STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE
360 370 380 390 400
STLIEDGGAR SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI
410 420 430 440 450
MMTLTNWYRY EPSREMKSQW TAVWVKISSS WIGIVLYVWT LVAPLVLTNR

DFD
Length:453
Mass (Da):50,495
Last modified:October 1, 2000 - v1
Checksum:i3868DBF38165B78C
GO

Sequence cautioni

The sequence BAA86567 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891A → S in AAH28607 (PubMed:15489334).Curated
Sequence conflicti247 – 2471S → F in AAP97200 (Ref. 1) Curated
Sequence conflicti247 – 2471S → F in AAP97211 (Ref. 1) Curated
Sequence conflicti408 – 4081Y → S in AAQ88795 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991L → V.
Corresponds to variant rs13210569 [ dbSNP | Ensembl ].
VAR_052275
Natural varianti216 – 2161F → V.
Corresponds to variant rs13210446 [ dbSNP | Ensembl ].
VAR_052276
Natural varianti225 – 2251S → G.
Corresponds to variant rs17260829 [ dbSNP | Ensembl ].
VAR_052277

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA. Translation: AAP97200.1.
AF092436 Genomic DNA. Translation: AAP97211.1.
AB033079 mRNA. Translation: BAA86567.1. Different initiation.
AL137261 mRNA. Translation: CAB70662.2.
AF164794 mRNA. Translation: AAF80758.1.
AY358429 mRNA. Translation: AAQ88795.1.
AK128781 mRNA. Translation: BAG54731.1.
Z99129 Genomic DNA. Translation: CAD92585.1.
CH471051 Genomic DNA. Translation: EAW48172.1.
CH471051 Genomic DNA. Translation: EAW48173.1.
BC028607 mRNA. Translation: AAH28607.1.
BC033029 mRNA. Translation: AAH33029.1.
CCDSiCCDS5125.1.
RefSeqiNP_065806.1. NM_020755.3.
UniGeneiHs.146668.

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897.
GeneIDi57515.
KEGGihsa:57515.
UCSCiuc003pyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087902 mRNA. Translation: AAP97200.1.
AF092436 Genomic DNA. Translation: AAP97211.1.
AB033079 mRNA. Translation: BAA86567.1. Different initiation.
AL137261 mRNA. Translation: CAB70662.2.
AF164794 mRNA. Translation: AAF80758.1.
AY358429 mRNA. Translation: AAQ88795.1.
AK128781 mRNA. Translation: BAG54731.1.
Z99129 Genomic DNA. Translation: CAD92585.1.
CH471051 Genomic DNA. Translation: EAW48172.1.
CH471051 Genomic DNA. Translation: EAW48173.1.
BC028607 mRNA. Translation: AAH28607.1.
BC033029 mRNA. Translation: AAH33029.1.
CCDSiCCDS5125.1.
RefSeqiNP_065806.1. NM_020755.3.
UniGeneiHs.146668.

3D structure databases

ProteinModelPortaliQ9NRX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121579. 33 interactions.
IntActiQ9NRX5. 14 interactions.
MINTiMINT-5005668.
STRINGi9606.ENSP00000342962.

PTM databases

iPTMnetiQ9NRX5.
PhosphoSiteiQ9NRX5.
SwissPalmiQ9NRX5.

Polymorphism and mutation databases

BioMutaiSERINC1.
DMDMi25453298.

Proteomic databases

EPDiQ9NRX5.
MaxQBiQ9NRX5.
PaxDbiQ9NRX5.
PeptideAtlasiQ9NRX5.
PRIDEiQ9NRX5.

Protocols and materials databases

DNASUi57515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339697; ENSP00000342962; ENSG00000111897.
GeneIDi57515.
KEGGihsa:57515.
UCSCiuc003pyy.2. human.

Organism-specific databases

CTDi57515.
GeneCardsiSERINC1.
HGNCiHGNC:13464. SERINC1.
HPAiHPA035738.
HPA035739.
MIMi614548. gene.
neXtProtiNX_Q9NRX5.
PharmGKBiPA134973249.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOVERGENiHBG025699.
InParanoidiQ9NRX5.
OMAiSSSWICI.
OrthoDBiEOG091G07WS.
PhylomeDBiQ9NRX5.
TreeFamiTF312881.

Miscellaneous databases

ChiTaRSiSERINC1. human.
GeneWikiiSERINC1.
GenomeRNAii57515.
PROiQ9NRX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111897.
CleanExiHS_SERINC1.
GenevisibleiQ9NRX5. HS.

Family and domain databases

InterProiIPR029552. SERINC1.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF15. PTHR10383:SF15. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX5
Secondary accession number(s): B3KY69
, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NTH8, Q9ULG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.