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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Gene

NDUFA4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Alternative name(s):
NADH-ubiquinone oxidoreductase MLRQ subunit homolog
Short name:
NUOMS
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29836. NDUFA4L2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596402.

Chemistry

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFA4L2.
DMDMi23396790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2PRO_0000118825Add
BLAST

Proteomic databases

MaxQBiQ9NRX3.
PaxDbiQ9NRX3.
PeptideAtlasiQ9NRX3.
PRIDEiQ9NRX3.

PTM databases

iPTMnetiQ9NRX3.
PhosphoSiteiQ9NRX3.

Expressioni

Gene expression databases

BgeeiQ9NRX3.
CleanExiHS_NDUFA4L2.
ExpressionAtlasiQ9NRX3. baseline and differential.
GenevisibleiQ9NRX3. HS.

Organism-specific databases

HPAiHPA055323.

Interactioni

Protein-protein interaction databases

BioGridi121231. 14 interactions.
IntActiQ9NRX3. 14 interactions.
MINTiMINT-1369565.
STRINGi9606.ENSP00000377411.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J463. Eukaryota.
ENOG410XWHY. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ9NRX3.
KOiK03948.
OMAiMQGMSLA.
OrthoDBiEOG71P2DD.
PhylomeDBiQ9NRX3.
TreeFamiTF106383.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASLGARF YRQIKRHPGI IPMIGLICLG MGSAALYLLR LALRSPDVCW
60 70 80
DRKNNPEPWN RLSPNDQYKF LAVSTDYKKL KKDRPDF
Length:87
Mass (Da):9,966
Last modified:October 1, 2000 - v1
Checksum:iA08D7182A0A3CA87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164796 mRNA. Translation: AAF80760.1.
CR457176 mRNA. Translation: CAG33457.1.
BC011910 mRNA. Translation: AAH11910.1.
CCDSiCCDS8935.1.
RefSeqiNP_064527.1. NM_020142.3.
UniGeneiHs.75069.

Genome annotation databases

EnsembliENST00000393825; ENSP00000377411; ENSG00000185633.
ENST00000554503; ENSP00000450664; ENSG00000185633.
GeneIDi56901.
KEGGihsa:56901.
UCSCiuc001sno.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164796 mRNA. Translation: AAF80760.1.
CR457176 mRNA. Translation: CAG33457.1.
BC011910 mRNA. Translation: AAH11910.1.
CCDSiCCDS8935.1.
RefSeqiNP_064527.1. NM_020142.3.
UniGeneiHs.75069.

3D structure databases

ProteinModelPortaliQ9NRX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121231. 14 interactions.
IntActiQ9NRX3. 14 interactions.
MINTiMINT-1369565.
STRINGi9606.ENSP00000377411.

Chemistry

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiQ9NRX3.
PhosphoSiteiQ9NRX3.

Polymorphism and mutation databases

BioMutaiNDUFA4L2.
DMDMi23396790.

Proteomic databases

MaxQBiQ9NRX3.
PaxDbiQ9NRX3.
PeptideAtlasiQ9NRX3.
PRIDEiQ9NRX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393825; ENSP00000377411; ENSG00000185633.
ENST00000554503; ENSP00000450664; ENSG00000185633.
GeneIDi56901.
KEGGihsa:56901.
UCSCiuc001sno.4. human.

Organism-specific databases

CTDi56901.
GeneCardsiNDUFA4L2.
HGNCiHGNC:29836. NDUFA4L2.
HPAiHPA055323.
neXtProtiNX_Q9NRX3.
PharmGKBiPA144596402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J463. Eukaryota.
ENOG410XWHY. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ9NRX3.
KOiK03948.
OMAiMQGMSLA.
OrthoDBiEOG71P2DD.
PhylomeDBiQ9NRX3.
TreeFamiTF106383.

Miscellaneous databases

GenomeRNAii56901.
PROiQ9NRX3.

Gene expression databases

BgeeiQ9NRX3.
CleanExiHS_NDUFA4L2.
ExpressionAtlasiQ9NRX3. baseline and differential.
GenevisibleiQ9NRX3. HS.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiNUA4L_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX3
Secondary accession number(s): Q6IAH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.