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Q9NRX2

- RM17_HUMAN

UniProt

Q9NRX2 - RM17_HUMAN

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Protein

39S ribosomal protein L17, mitochondrial

Gene

MRPL17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein domain specific binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L17, mitochondrial
Short name:
L17mt
Short name:
MRP-L17
Alternative name(s):
LYST-interacting protein 2
Gene namesi
Name:MRPL17
Synonyms:LIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14053. MRPL17.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 88MitochondrionBy similarity
Chaini9 – 17516739S ribosomal protein L17, mitochondrialPRO_0000237331Add
BLAST

Proteomic databases

MaxQBiQ9NRX2.
PaxDbiQ9NRX2.
PeptideAtlasiQ9NRX2.
PRIDEiQ9NRX2.

PTM databases

PhosphoSiteiQ9NRX2.

Expressioni

Tissue specificityi

Detected in adrenal gland, mammary gland and adipose tissue.1 Publication

Gene expression databases

BgeeiQ9NRX2.
CleanExiHS_MRPL17.
ExpressionAtlasiQ9NRX2. baseline and differential.
GenevestigatoriQ9NRX2.

Organism-specific databases

HPAiHPA043666.
HPA050552.

Interactioni

Protein-protein interaction databases

BioGridi121968. 21 interactions.
IntActiQ9NRX2. 2 interactions.
MINTiMINT-3064942.
STRINGi9606.ENSP00000288937.

Structurei

Secondary structure

1
175
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 3811
Beta strandi41 – 455
Helixi46 – 6520
Helixi70 – 7910
Helixi85 – 906
Helixi93 – 997
Beta strandi105 – 1106
Beta strandi114 – 1163
Beta strandi120 – 1278

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQMNMR-A28-136[»]
ProteinModelPortaliQ9NRX2.
SMRiQ9NRX2. Positions 28-129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRX2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L17P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0203.
GeneTreeiENSGT00390000010698.
HOGENOMiHOG000019780.
HOVERGENiHBG056029.
InParanoidiQ9NRX2.
KOiK02879.
OMAiRYEDRQG.
OrthoDBiEOG74TX11.
PhylomeDBiQ9NRX2.
TreeFamiTF105844.

Family and domain databases

Gene3Di3.90.1030.10. 1 hit.
InterProiIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERiPTHR14413. PTHR14413. 1 hit.
PfamiPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMiSSF64263. SSF64263. 1 hit.
TIGRFAMsiTIGR00059. L17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD
60 70 80 90 100
EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ
110 120 130 140 150
TGGYTRMLQI PNRSLDRAKM AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ
160 170
GLRQDLRQSQ EASNHSSHTA QTPGI
Length:175
Mass (Da):20,050
Last modified:October 1, 2000 - v1
Checksum:i48C73425104200EA
GO

Sequence cautioni

The sequence AAG49441.1 differs from that shown. Reason: Frameshift at position 8.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051T → A in CAG33458. (PubMed:11984006)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164797 mRNA. Translation: AAF80761.1.
AF141338 mRNA. Translation: AAG49441.1. Frameshift.
AK026857 mRNA. Translation: BAB15575.1.
CR457177 mRNA. Translation: CAG33458.1.
CH471064 Genomic DNA. Translation: EAW68681.1.
CH471064 Genomic DNA. Translation: EAW68682.1.
BC012306 mRNA. Translation: AAH12306.1.
AB051620 Genomic DNA. Translation: BAB54948.1.
CCDSiCCDS31412.1.
RefSeqiNP_071344.1. NM_022061.3.
UniGeneiHs.523456.
Hs.708782.

Genome annotation databases

EnsembliENST00000288937; ENSP00000288937; ENSG00000158042.
GeneIDi63875.
KEGGihsa:63875.
UCSCiuc001men.2. human.

Polymorphism databases

DMDMi74752931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF164797 mRNA. Translation: AAF80761.1 .
AF141338 mRNA. Translation: AAG49441.1 . Frameshift.
AK026857 mRNA. Translation: BAB15575.1 .
CR457177 mRNA. Translation: CAG33458.1 .
CH471064 Genomic DNA. Translation: EAW68681.1 .
CH471064 Genomic DNA. Translation: EAW68682.1 .
BC012306 mRNA. Translation: AAH12306.1 .
AB051620 Genomic DNA. Translation: BAB54948.1 .
CCDSi CCDS31412.1.
RefSeqi NP_071344.1. NM_022061.3.
UniGenei Hs.523456.
Hs.708782.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CQM NMR - A 28-136 [» ]
ProteinModelPortali Q9NRX2.
SMRi Q9NRX2. Positions 28-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121968. 21 interactions.
IntActi Q9NRX2. 2 interactions.
MINTi MINT-3064942.
STRINGi 9606.ENSP00000288937.

PTM databases

PhosphoSitei Q9NRX2.

Polymorphism databases

DMDMi 74752931.

Proteomic databases

MaxQBi Q9NRX2.
PaxDbi Q9NRX2.
PeptideAtlasi Q9NRX2.
PRIDEi Q9NRX2.

Protocols and materials databases

DNASUi 63875.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288937 ; ENSP00000288937 ; ENSG00000158042 .
GeneIDi 63875.
KEGGi hsa:63875.
UCSCi uc001men.2. human.

Organism-specific databases

CTDi 63875.
GeneCardsi GC11M006659.
HGNCi HGNC:14053. MRPL17.
HPAi HPA043666.
HPA050552.
MIMi 611830. gene.
neXtProti NX_Q9NRX2.
PharmGKBi PA30946.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0203.
GeneTreei ENSGT00390000010698.
HOGENOMi HOG000019780.
HOVERGENi HBG056029.
InParanoidi Q9NRX2.
KOi K02879.
OMAi RYEDRQG.
OrthoDBi EOG74TX11.
PhylomeDBi Q9NRX2.
TreeFami TF105844.

Miscellaneous databases

EvolutionaryTracei Q9NRX2.
GeneWikii MRPL17.
GenomeRNAii 63875.
NextBioi 65556.
PROi Q9NRX2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRX2.
CleanExi HS_MRPL17.
ExpressionAtlasi Q9NRX2. baseline and differential.
Genevestigatori Q9NRX2.

Family and domain databases

Gene3Di 3.90.1030.10. 1 hit.
InterProi IPR000456. Ribosomal_L17.
[Graphical view ]
PANTHERi PTHR14413. PTHR14413. 1 hit.
Pfami PF01196. Ribosomal_L17. 1 hit.
[Graphical view ]
SUPFAMi SSF64263. SSF64263. 1 hit.
TIGRFAMsi TIGR00059. L17. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Tissue: Adrenal gland.
  2. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
    Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
    Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-175.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the mitochondrial ribosomal protein L17 isolog."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 28-136.

Entry informationi

Entry nameiRM17_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX2
Secondary accession number(s): D3DQU3
, Q6IAH8, Q96Q53, Q9C066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3