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Protein

39S ribosomal protein L17, mitochondrial

Gene

MRPL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158042-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L17, mitochondrial
Short name:
L17mt
Short name:
MRP-L17
Alternative name(s):
LYST-interacting protein 2
Gene namesi
Name:MRPL17
Synonyms:LIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14053. MRPL17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi63875.
OpenTargetsiENSG00000158042.
PharmGKBiPA30946.

Polymorphism and mutation databases

BioMutaiMRPL17.
DMDMi74752931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00002373319 – 17539S ribosomal protein L17, mitochondrialAdd BLAST167

Proteomic databases

EPDiQ9NRX2.
MaxQBiQ9NRX2.
PaxDbiQ9NRX2.
PeptideAtlasiQ9NRX2.
PRIDEiQ9NRX2.
TopDownProteomicsiQ9NRX2.

PTM databases

iPTMnetiQ9NRX2.
PhosphoSitePlusiQ9NRX2.

Expressioni

Tissue specificityi

Detected in adrenal gland, mammary gland and adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000158042.
CleanExiHS_MRPL17.
ExpressionAtlasiQ9NRX2. baseline and differential.
GenevisibleiQ9NRX2. HS.

Organism-specific databases

HPAiHPA043666.
HPA050552.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121968. 41 interactors.
IntActiQ9NRX2. 8 interactors.
MINTiMINT-3064942.
STRINGi9606.ENSP00000288937.

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 38Combined sources11
Beta strandi41 – 45Combined sources5
Helixi46 – 65Combined sources20
Helixi70 – 79Combined sources10
Helixi85 – 90Combined sources6
Helixi93 – 99Combined sources7
Beta strandi105 – 110Combined sources6
Beta strandi114 – 116Combined sources3
Beta strandi120 – 127Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQMNMR-A28-136[»]
3J7Yelectron microscopy3.40O1-175[»]
3J9Melectron microscopy3.50O1-175[»]
ProteinModelPortaliQ9NRX2.
SMRiQ9NRX2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRX2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L17P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3280. Eukaryota.
COG0203. LUCA.
GeneTreeiENSGT00390000010698.
HOGENOMiHOG000019780.
HOVERGENiHBG056029.
InParanoidiQ9NRX2.
KOiK02879.
OMAiAPRYKDQ.
OrthoDBiEOG091G0PQG.
PhylomeDBiQ9NRX2.
TreeFamiTF105844.

Family and domain databases

Gene3Di3.90.1030.10. 1 hit.
InterProiIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERiPTHR14413. PTHR14413. 1 hit.
PfamiPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMiSSF64263. SSF64263. 1 hit.
TIGRFAMsiTIGR00059. L17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD
60 70 80 90 100
EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ
110 120 130 140 150
TGGYTRMLQI PNRSLDRAKM AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ
160 170
GLRQDLRQSQ EASNHSSHTA QTPGI
Length:175
Mass (Da):20,050
Last modified:October 1, 2000 - v1
Checksum:i48C73425104200EA
GO

Sequence cautioni

The sequence AAG49441 differs from that shown. Reason: Frameshift at position 8.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105T → A in CAG33458 (PubMed:11984006).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164797 mRNA. Translation: AAF80761.1.
AF141338 mRNA. Translation: AAG49441.1. Frameshift.
AK026857 mRNA. Translation: BAB15575.1.
CR457177 mRNA. Translation: CAG33458.1.
CH471064 Genomic DNA. Translation: EAW68681.1.
CH471064 Genomic DNA. Translation: EAW68682.1.
BC012306 mRNA. Translation: AAH12306.1.
AB051620 Genomic DNA. Translation: BAB54948.1.
CCDSiCCDS31412.1.
RefSeqiNP_071344.1. NM_022061.3.
UniGeneiHs.523456.
Hs.708782.

Genome annotation databases

EnsembliENST00000288937; ENSP00000288937; ENSG00000158042.
GeneIDi63875.
KEGGihsa:63875.
UCSCiuc001men.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164797 mRNA. Translation: AAF80761.1.
AF141338 mRNA. Translation: AAG49441.1. Frameshift.
AK026857 mRNA. Translation: BAB15575.1.
CR457177 mRNA. Translation: CAG33458.1.
CH471064 Genomic DNA. Translation: EAW68681.1.
CH471064 Genomic DNA. Translation: EAW68682.1.
BC012306 mRNA. Translation: AAH12306.1.
AB051620 Genomic DNA. Translation: BAB54948.1.
CCDSiCCDS31412.1.
RefSeqiNP_071344.1. NM_022061.3.
UniGeneiHs.523456.
Hs.708782.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQMNMR-A28-136[»]
3J7Yelectron microscopy3.40O1-175[»]
3J9Melectron microscopy3.50O1-175[»]
ProteinModelPortaliQ9NRX2.
SMRiQ9NRX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121968. 41 interactors.
IntActiQ9NRX2. 8 interactors.
MINTiMINT-3064942.
STRINGi9606.ENSP00000288937.

PTM databases

iPTMnetiQ9NRX2.
PhosphoSitePlusiQ9NRX2.

Polymorphism and mutation databases

BioMutaiMRPL17.
DMDMi74752931.

Proteomic databases

EPDiQ9NRX2.
MaxQBiQ9NRX2.
PaxDbiQ9NRX2.
PeptideAtlasiQ9NRX2.
PRIDEiQ9NRX2.
TopDownProteomicsiQ9NRX2.

Protocols and materials databases

DNASUi63875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288937; ENSP00000288937; ENSG00000158042.
GeneIDi63875.
KEGGihsa:63875.
UCSCiuc001men.3. human.

Organism-specific databases

CTDi63875.
DisGeNETi63875.
GeneCardsiMRPL17.
HGNCiHGNC:14053. MRPL17.
HPAiHPA043666.
HPA050552.
MIMi611830. gene.
neXtProtiNX_Q9NRX2.
OpenTargetsiENSG00000158042.
PharmGKBiPA30946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3280. Eukaryota.
COG0203. LUCA.
GeneTreeiENSGT00390000010698.
HOGENOMiHOG000019780.
HOVERGENiHBG056029.
InParanoidiQ9NRX2.
KOiK02879.
OMAiAPRYKDQ.
OrthoDBiEOG091G0PQG.
PhylomeDBiQ9NRX2.
TreeFamiTF105844.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158042-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

EvolutionaryTraceiQ9NRX2.
GeneWikiiMRPL17.
GenomeRNAii63875.
PROiQ9NRX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158042.
CleanExiHS_MRPL17.
ExpressionAtlasiQ9NRX2. baseline and differential.
GenevisibleiQ9NRX2. HS.

Family and domain databases

Gene3Di3.90.1030.10. 1 hit.
InterProiIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERiPTHR14413. PTHR14413. 1 hit.
PfamiPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMiSSF64263. SSF64263. 1 hit.
TIGRFAMsiTIGR00059. L17. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM17_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX2
Secondary accession number(s): D3DQU3
, Q6IAH8, Q96Q53, Q9C066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.