Q9NRX2 (RM17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L17, mitochondrial
Short name=L17mt
Short name=MRP-L17

Alternative name(s):
LYST-interacting protein 2

Gene names

Name:	MRPL17
Synonyms:	LIP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Potential.
Tissue specificity	Detected in adrenal gland, mammary gland and adipose tissue. Ref.1
Sequence similarities	Belongs to the ribosomal protein L17P family.
Sequence caution	The sequence AAG49441.1 differs from that shown. Reason: Frameshift at position 8.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: Compara ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 8

8

Mitochondrion By similarity

Chain

9 – 175

167

39S ribosomal protein L17, mitochondrial

PRO_0000237331

Experimental info

Sequence conflict

105

1

T → A in CAG33458. Ref.2

Secondary structure

1

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175

Helix Strand Turn

Details...

Helix

28 – 38

11

Beta strand

41 – 45

5

Helix

46 – 65

20

Helix

70 – 79

10

Helix

85 – 90

6

Helix

93 – 99

7

Beta strand

105 – 110

6

Beta strand

114 – 116

3

Beta strand

120 – 127

8

Sequences

	Sequence		Length	Mass (Da)
	Q9NRX2 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 48C73425104200EA	FASTA	175	20,050
	10 20 30 40 50 60 MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI 70 80 90 100 110 120 DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ TGGYTRMLQI PNRSLDRAKM 130 140 150 160 170 AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ GLRQDLRQSQ EASNHSSHTA QTPGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY. Tissue: Adrenal gland.
[2]	"The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins." Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F. Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adipose tissue.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[7]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-175.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Solution structure of the mitochondrial ribosomal protein L17 isolog." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 28-136.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF164797 mRNA. Translation: AAF80761.1.
AF141338 mRNA. Translation: AAG49441.1. Frameshift.
AK026857 mRNA. Translation: BAB15575.1.
CR457177 mRNA. Translation: CAG33458.1.
CH471064 Genomic DNA. Translation: EAW68681.1.
CH471064 Genomic DNA. Translation: EAW68682.1.
BC012306 mRNA. Translation: AAH12306.1.
AB051620 Genomic DNA. Translation: BAB54948.1.

IPI

IPI00172591.

RefSeq

NP_071344.1. NM_022061.3.

UniGene

Hs.523456.
Hs.708782.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CQM	NMR	-	A	28-136	[»]

ProteinModelPortal

Q9NRX2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000288937.

PTM databases

PhosphoSite

Q9NRX2.

Polymorphism databases

DMDM

74752931.

Proteomic databases

PaxDb

Q9NRX2.

PeptideAtlas

Q9NRX2.

PRIDE

Q9NRX2.

Protocols and materials databases

DNASU

63875.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000288937; ENSP00000288937; ENSG00000158042.

GeneID

63875.

KEGG

hsa:63875.

UCSC

uc001men.2. human.

Organism-specific databases

CTD

63875.

GeneCards

GC11M006659.

HGNC

HGNC:14053. MRPL17.

HPA

HPA043666.
HPA050552.

MIM

611830. gene.

neXtProt

NX_Q9NRX2.

PharmGKB

PA30946.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0203.

HOGENOM

HOG000019780.

HOVERGEN

HBG056029.

InParanoid

Q9NRX2.

KO

K02879.

OMA

LIMNERI.

OrthoDB

EOG41C6XH.

Gene expression databases

ArrayExpress

Q9NRX2.

Bgee

Q9NRX2.

CleanEx

HS_MRPL17.

Genevestigator

Q9NRX2.

GermOnline

ENSG00000158042. Homo sapiens.

Family and domain databases

Gene3D

3.90.1030.10. 1 hit.

InterPro

IPR000456. Ribosomal_L17.
[Graphical view]

PANTHER

PTHR14413. PTHR14413. 1 hit.

Pfam

PF01196. Ribosomal_L17. 1 hit.
[Graphical view]

SUPFAM

SSF64263. Ribosomal_L17. 1 hit.

TIGRFAMs

TIGR00059. L17. 1 hit.

PROSITE

PS01167. RIBOSOMAL_L17. False negative.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NRX2.

GenomeRNAi

63875.

NextBio

65556.

SOURCE

Search...

Entry information

Entry name

RM17_HUMAN

Accession

Primary (citable) accession number: Q9NRX2
Secondary accession number(s): D3DQU3 , Q6IAH8, Q96Q53, Q9C066

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.