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Q9NRX2 (RM17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L17, mitochondrial

Short name=L17mt
Short name=MRP-L17
Alternative name(s):
LYST-interacting protein 2
Gene names
Name:MRPL17
Synonyms:LIP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion Potential.

Tissue specificity

Detected in adrenal gland, mammary gland and adipose tissue. Ref.1

Sequence similarities

Belongs to the ribosomal protein L17P family.

Sequence caution

The sequence AAG49441.1 differs from that shown. Reason: Frameshift at position 8.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 88Mitochondrion By similarity
Chain9 – 17516739S ribosomal protein L17, mitochondrial
PRO_0000237331

Experimental info

Sequence conflict1051T → A in CAG33458. Ref.2

Secondary structure

.................. 175
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NRX2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 48C73425104200EA

FASTA17520,050
        10         20         30         40         50         60 
MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI 

        70         80         90        100        110        120 
DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ TGGYTRMLQI PNRSLDRAKM 

       130        140        150        160        170 
AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ GLRQDLRQSQ EASNHSSHTA QTPGI 

« Hide

References

« Hide 'large scale' references
[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
Tissue: Adrenal gland.
[2]"The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[7]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-175.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Solution structure of the mitochondrial ribosomal protein L17 isolog."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 28-136.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF164797 mRNA. Translation: AAF80761.1.
AF141338 mRNA. Translation: AAG49441.1. Frameshift.
AK026857 mRNA. Translation: BAB15575.1.
CR457177 mRNA. Translation: CAG33458.1.
CH471064 Genomic DNA. Translation: EAW68681.1.
CH471064 Genomic DNA. Translation: EAW68682.1.
BC012306 mRNA. Translation: AAH12306.1.
AB051620 Genomic DNA. Translation: BAB54948.1.
CCDSCCDS31412.1.
RefSeqNP_071344.1. NM_022061.3.
UniGeneHs.523456.
Hs.708782.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQMNMR-A28-136[»]
ProteinModelPortalQ9NRX2.
SMRQ9NRX2. Positions 28-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121968. 13 interactions.
IntActQ9NRX2. 2 interactions.
MINTMINT-3064942.
STRING9606.ENSP00000288937.

PTM databases

PhosphoSiteQ9NRX2.

Polymorphism databases

DMDM74752931.

Proteomic databases

MaxQBQ9NRX2.
PaxDbQ9NRX2.
PeptideAtlasQ9NRX2.
PRIDEQ9NRX2.

Protocols and materials databases

DNASU63875.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288937; ENSP00000288937; ENSG00000158042.
GeneID63875.
KEGGhsa:63875.
UCSCuc001men.2. human.

Organism-specific databases

CTD63875.
GeneCardsGC11M006659.
HGNCHGNC:14053. MRPL17.
HPAHPA043666.
HPA050552.
MIM611830. gene.
neXtProtNX_Q9NRX2.
PharmGKBPA30946.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0203.
HOGENOMHOG000019780.
HOVERGENHBG056029.
InParanoidQ9NRX2.
KOK02879.
OMARYEDRQG.
OrthoDBEOG74TX11.
PhylomeDBQ9NRX2.
TreeFamTF105844.

Gene expression databases

ArrayExpressQ9NRX2.
BgeeQ9NRX2.
CleanExHS_MRPL17.
GenevestigatorQ9NRX2.

Family and domain databases

Gene3D3.90.1030.10. 1 hit.
InterProIPR000456. Ribosomal_L17.
[Graphical view]
PANTHERPTHR14413. PTHR14413. 1 hit.
PfamPF01196. Ribosomal_L17. 1 hit.
[Graphical view]
SUPFAMSSF64263. SSF64263. 1 hit.
TIGRFAMsTIGR00059. L17. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9NRX2.
GeneWikiMRPL17.
GenomeRNAi63875.
NextBio65556.
PROQ9NRX2.
SOURCESearch...

Entry information

Entry nameRM17_HUMAN
AccessionPrimary (citable) accession number: Q9NRX2
Secondary accession number(s): D3DQU3 expand/collapse secondary AC list , Q6IAH8, Q96Q53, Q9C066
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM