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Q9NRX2

- RM17_HUMAN

UniProt

Q9NRX2 - RM17_HUMAN

Protein

39S ribosomal protein L17, mitochondrial

Gene

MRPL17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein domain specific binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L17, mitochondrial
    Short name:
    L17mt
    Short name:
    MRP-L17
    Alternative name(s):
    LYST-interacting protein 2
    Gene namesi
    Name:MRPL17
    Synonyms:LIP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14053. MRPL17.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 88MitochondrionBy similarity
    Chaini9 – 17516739S ribosomal protein L17, mitochondrialPRO_0000237331Add
    BLAST

    Proteomic databases

    MaxQBiQ9NRX2.
    PaxDbiQ9NRX2.
    PeptideAtlasiQ9NRX2.
    PRIDEiQ9NRX2.

    PTM databases

    PhosphoSiteiQ9NRX2.

    Expressioni

    Tissue specificityi

    Detected in adrenal gland, mammary gland and adipose tissue.1 Publication

    Gene expression databases

    ArrayExpressiQ9NRX2.
    BgeeiQ9NRX2.
    CleanExiHS_MRPL17.
    GenevestigatoriQ9NRX2.

    Organism-specific databases

    HPAiHPA043666.
    HPA050552.

    Interactioni

    Protein-protein interaction databases

    BioGridi121968. 13 interactions.
    IntActiQ9NRX2. 2 interactions.
    MINTiMINT-3064942.
    STRINGi9606.ENSP00000288937.

    Structurei

    Secondary structure

    1
    175
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi28 – 3811
    Beta strandi41 – 455
    Helixi46 – 6520
    Helixi70 – 7910
    Helixi85 – 906
    Helixi93 – 997
    Beta strandi105 – 1106
    Beta strandi114 – 1163
    Beta strandi120 – 1278

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CQMNMR-A28-136[»]
    ProteinModelPortaliQ9NRX2.
    SMRiQ9NRX2. Positions 28-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NRX2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L17P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0203.
    HOGENOMiHOG000019780.
    HOVERGENiHBG056029.
    InParanoidiQ9NRX2.
    KOiK02879.
    OMAiRYEDRQG.
    OrthoDBiEOG74TX11.
    PhylomeDBiQ9NRX2.
    TreeFamiTF105844.

    Family and domain databases

    Gene3Di3.90.1030.10. 1 hit.
    InterProiIPR000456. Ribosomal_L17.
    [Graphical view]
    PANTHERiPTHR14413. PTHR14413. 1 hit.
    PfamiPF01196. Ribosomal_L17. 1 hit.
    [Graphical view]
    SUPFAMiSSF64263. SSF64263. 1 hit.
    TIGRFAMsiTIGR00059. L17. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NRX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD    50
    EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ 100
    TGGYTRMLQI PNRSLDRAKM AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ 150
    GLRQDLRQSQ EASNHSSHTA QTPGI 175
    Length:175
    Mass (Da):20,050
    Last modified:October 1, 2000 - v1
    Checksum:i48C73425104200EA
    GO

    Sequence cautioni

    The sequence AAG49441.1 differs from that shown. Reason: Frameshift at position 8.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051T → A in CAG33458. (PubMed:11984006)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164797 mRNA. Translation: AAF80761.1.
    AF141338 mRNA. Translation: AAG49441.1. Frameshift.
    AK026857 mRNA. Translation: BAB15575.1.
    CR457177 mRNA. Translation: CAG33458.1.
    CH471064 Genomic DNA. Translation: EAW68681.1.
    CH471064 Genomic DNA. Translation: EAW68682.1.
    BC012306 mRNA. Translation: AAH12306.1.
    AB051620 Genomic DNA. Translation: BAB54948.1.
    CCDSiCCDS31412.1.
    RefSeqiNP_071344.1. NM_022061.3.
    UniGeneiHs.523456.
    Hs.708782.

    Genome annotation databases

    EnsembliENST00000288937; ENSP00000288937; ENSG00000158042.
    GeneIDi63875.
    KEGGihsa:63875.
    UCSCiuc001men.2. human.

    Polymorphism databases

    DMDMi74752931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF164797 mRNA. Translation: AAF80761.1 .
    AF141338 mRNA. Translation: AAG49441.1 . Frameshift.
    AK026857 mRNA. Translation: BAB15575.1 .
    CR457177 mRNA. Translation: CAG33458.1 .
    CH471064 Genomic DNA. Translation: EAW68681.1 .
    CH471064 Genomic DNA. Translation: EAW68682.1 .
    BC012306 mRNA. Translation: AAH12306.1 .
    AB051620 Genomic DNA. Translation: BAB54948.1 .
    CCDSi CCDS31412.1.
    RefSeqi NP_071344.1. NM_022061.3.
    UniGenei Hs.523456.
    Hs.708782.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CQM NMR - A 28-136 [» ]
    ProteinModelPortali Q9NRX2.
    SMRi Q9NRX2. Positions 28-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121968. 13 interactions.
    IntActi Q9NRX2. 2 interactions.
    MINTi MINT-3064942.
    STRINGi 9606.ENSP00000288937.

    PTM databases

    PhosphoSitei Q9NRX2.

    Polymorphism databases

    DMDMi 74752931.

    Proteomic databases

    MaxQBi Q9NRX2.
    PaxDbi Q9NRX2.
    PeptideAtlasi Q9NRX2.
    PRIDEi Q9NRX2.

    Protocols and materials databases

    DNASUi 63875.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288937 ; ENSP00000288937 ; ENSG00000158042 .
    GeneIDi 63875.
    KEGGi hsa:63875.
    UCSCi uc001men.2. human.

    Organism-specific databases

    CTDi 63875.
    GeneCardsi GC11M006659.
    HGNCi HGNC:14053. MRPL17.
    HPAi HPA043666.
    HPA050552.
    MIMi 611830. gene.
    neXtProti NX_Q9NRX2.
    PharmGKBi PA30946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0203.
    HOGENOMi HOG000019780.
    HOVERGENi HBG056029.
    InParanoidi Q9NRX2.
    KOi K02879.
    OMAi RYEDRQG.
    OrthoDBi EOG74TX11.
    PhylomeDBi Q9NRX2.
    TreeFami TF105844.

    Miscellaneous databases

    EvolutionaryTracei Q9NRX2.
    GeneWikii MRPL17.
    GenomeRNAii 63875.
    NextBioi 65556.
    PROi Q9NRX2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRX2.
    Bgeei Q9NRX2.
    CleanExi HS_MRPL17.
    Genevestigatori Q9NRX2.

    Family and domain databases

    Gene3Di 3.90.1030.10. 1 hit.
    InterProi IPR000456. Ribosomal_L17.
    [Graphical view ]
    PANTHERi PTHR14413. PTHR14413. 1 hit.
    Pfami PF01196. Ribosomal_L17. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64263. SSF64263. 1 hit.
    TIGRFAMsi TIGR00059. L17. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
      Tissue: Adrenal gland.
    2. "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
      Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
      Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-175.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the mitochondrial ribosomal protein L17 isolog."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 28-136.

    Entry informationi

    Entry nameiRM17_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRX2
    Secondary accession number(s): D3DQU3
    , Q6IAH8, Q96Q53, Q9C066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3