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Protein

RNA-binding protein PNO1

Gene

PNO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115946-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein PNO1
Gene namesi
Name:PNO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32790. PNO1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56902.
OpenTargetsiENSG00000115946.
PharmGKBiPA162399854.

Polymorphism and mutation databases

BioMutaiPNO1.
DMDMi74734328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705401 – 252RNA-binding protein PNO1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NRX1.
MaxQBiQ9NRX1.
PaxDbiQ9NRX1.
PeptideAtlasiQ9NRX1.
PRIDEiQ9NRX1.

PTM databases

iPTMnetiQ9NRX1.
PhosphoSitePlusiQ9NRX1.

Expressioni

Tissue specificityi

Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000115946.
CleanExiHS_PNO1.
ExpressionAtlasiQ9NRX1. baseline and differential.
GenevisibleiQ9NRX1. HS.

Organism-specific databases

HPAiHPA056928.

Interactioni

Protein-protein interaction databases

BioGridi121232. 57 interactors.
IntActiQ9NRX1. 24 interactors.
MINTiMINT-1378821.
STRINGi9606.ENSP00000263657.

Structurei

3D structure databases

ProteinModelPortaliQ9NRX1.
SMRiQ9NRX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 225KHAdd BLAST53

Sequence similaritiesi

Belongs to the PNO1 family.Curated
Contains 1 KH domain.Curated

Phylogenomic databases

eggNOGiKOG3273. Eukaryota.
COG1094. LUCA.
GeneTreeiENSGT00390000018052.
HOGENOMiHOG000181708.
HOVERGENiHBG055635.
InParanoidiQ9NRX1.
KOiK11884.
OMAiFVKAFLC.
OrthoDBiEOG091G0L5I.
PhylomeDBiQ9NRX1.
TreeFamiTF300114.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NRX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEMETQSA RAEEGFTQVT RKGGRRAKKR QAEQLSAAGE GGDAGRMDTE
60 70 80 90 100
EARPAKRPVF PPLCGDGLLS GKEETRKIPV PANRYTPLKE NWMKIFTPIV
110 120 130 140 150
EHLGLQIRFN LKSRNVEIRT CKETKDVSAL TKAADFVKAF ILGFQVEDAL
160 170 180 190 200
ALIRLDDLFL ESFEITDVKP LKGDHLSRAI GRIAGKGGKT KFTIENVTRT
210 220 230 240 250
RIVLADVKVH ILGSFQNIKM ARTAICNLIL GNPPSKVYGN IRAVASRSAD

RF
Length:252
Mass (Da):27,924
Last modified:October 1, 2000 - v1
Checksum:iDDF2285D95D3D232
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02981411R → G.3 PublicationsCorresponds to variant rs2044693dbSNPEnsembl.1
Natural variantiVAR_02981571G → A.Corresponds to variant rs7590838dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349314 mRNA. Translation: AAK29434.1.
AF164799 mRNA. Translation: AAF80763.1.
AC017083 Genomic DNA. Translation: AAY14714.1.
CH471053 Genomic DNA. Translation: EAW99879.1.
BC008304 mRNA. Translation: AAH08304.1.
BC018152 mRNA. Translation: AAH18152.1.
AK223118 mRNA. Translation: BAD96838.1.
AK291715 mRNA. Translation: BAF84404.1.
CCDSiCCDS1885.1.
RefSeqiNP_064528.1. NM_020143.3.
UniGeneiHs.262858.

Genome annotation databases

EnsembliENST00000263657; ENSP00000263657; ENSG00000115946.
GeneIDi56902.
KEGGihsa:56902.
UCSCiuc002seh.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349314 mRNA. Translation: AAK29434.1.
AF164799 mRNA. Translation: AAF80763.1.
AC017083 Genomic DNA. Translation: AAY14714.1.
CH471053 Genomic DNA. Translation: EAW99879.1.
BC008304 mRNA. Translation: AAH08304.1.
BC018152 mRNA. Translation: AAH18152.1.
AK223118 mRNA. Translation: BAD96838.1.
AK291715 mRNA. Translation: BAF84404.1.
CCDSiCCDS1885.1.
RefSeqiNP_064528.1. NM_020143.3.
UniGeneiHs.262858.

3D structure databases

ProteinModelPortaliQ9NRX1.
SMRiQ9NRX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121232. 57 interactors.
IntActiQ9NRX1. 24 interactors.
MINTiMINT-1378821.
STRINGi9606.ENSP00000263657.

PTM databases

iPTMnetiQ9NRX1.
PhosphoSitePlusiQ9NRX1.

Polymorphism and mutation databases

BioMutaiPNO1.
DMDMi74734328.

Proteomic databases

EPDiQ9NRX1.
MaxQBiQ9NRX1.
PaxDbiQ9NRX1.
PeptideAtlasiQ9NRX1.
PRIDEiQ9NRX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263657; ENSP00000263657; ENSG00000115946.
GeneIDi56902.
KEGGihsa:56902.
UCSCiuc002seh.5. human.

Organism-specific databases

CTDi56902.
DisGeNETi56902.
GeneCardsiPNO1.
HGNCiHGNC:32790. PNO1.
HPAiHPA056928.
neXtProtiNX_Q9NRX1.
OpenTargetsiENSG00000115946.
PharmGKBiPA162399854.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3273. Eukaryota.
COG1094. LUCA.
GeneTreeiENSGT00390000018052.
HOGENOMiHOG000181708.
HOVERGENiHBG055635.
InParanoidiQ9NRX1.
KOiK11884.
OMAiFVKAFLC.
OrthoDBiEOG091G0L5I.
PhylomeDBiQ9NRX1.
TreeFamiTF300114.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115946-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiPNO1. human.
GeneWikiiPNO1.
GenomeRNAii56902.
PROiQ9NRX1.

Gene expression databases

BgeeiENSG00000115946.
CleanExiHS_PNO1.
ExpressionAtlasiQ9NRX1. baseline and differential.
GenevisibleiQ9NRX1. HS.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPNO1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRX1
Secondary accession number(s): A8K6Q0, Q53G13, Q8WVB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.