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Protein
Submitted name:

Neurofibromatosis type 2

Gene

NF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. cell-cell junction organization Source: Ensembl
  2. ectoderm development Source: Ensembl
  3. hippocampus development Source: Ensembl
  4. lens fiber cell differentiation Source: Ensembl
  5. mesoderm formation Source: Ensembl
  6. negative regulation of cell proliferation Source: Ensembl
  7. negative regulation of MAPK cascade Source: Ensembl
  8. negative regulation of protein kinase activity Source: Ensembl
  9. odontogenesis of dentin-containing tooth Source: Ensembl
  10. positive regulation of cell differentiation Source: Ensembl
  11. regulation of neural precursor cell proliferation Source: Ensembl
  12. regulation of protein localization to nucleus Source: Ensembl
  13. regulation of protein stability Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurofibromatosis type 2Imported
Gene namesi
Name:NF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. adherens junction Source: Ensembl
  2. apical part of cell Source: Ensembl
  3. cleavage furrow Source: Ensembl
  4. cortical actin cytoskeleton Source: Ensembl
  5. filopodium Source: Ensembl
  6. lamellipodium Source: Ensembl
  7. nucleus Source: Ensembl
  8. ruffle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9NRW8.
ExpressionAtlasiQ9NRW8. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ9NRW8. 1 interaction.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000007113.

Sequencei

Sequence statusi: Fragment.

Q9NRW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCE
Length:38
Mass (Da):4,313
Last modified:October 1, 2000 - v1
Checksum:iBA94460A25B8EE33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei38 – 381Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165426 Genomic DNA. Translation: AAF80764.1.
UniGeneiHs.187898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165426 Genomic DNA. Translation: AAF80764.1.
UniGeneiHs.187898.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NRW8. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000007113.

Miscellaneous databases

ChiTaRSiNF2. human.

Gene expression databases

BgeeiQ9NRW8.
ExpressionAtlasiQ9NRW8. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma."
    Kino T., Takeshima H., Nakao M., Nishi T., Yamamoto K., Kimura T., Saito Y., Kochi M., Kuratsu J., Saya H., Ushio Y.
    Genes Cells 6:441-454(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9NRW8_HUMAN
AccessioniPrimary (citable) accession number: Q9NRW8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.