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Q9NRW7

- VPS45_HUMAN

UniProt

Q9NRW7 - VPS45_HUMAN

Protein

Vacuolar protein sorting-associated protein 45

Gene

VPS45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. intracellular protein transport Source: UniProtKB
    3. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 45
    Short name:
    h-VPS45
    Short name:
    hlVps45
    Gene namesi
    Name:VPS45
    Synonyms:VPS45A, VPS45B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14579. VPS45.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Endosome membrane By similarity; Peripheral membrane protein By similarity
    Note: Associated with Golgi/endosomal vesicles and the trans-Golgi network.By similarity

    GO - Cellular componenti

    1. endosome membrane Source: Reactome
    2. Golgi apparatus Source: BHF-UCL
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Neutropenia, severe congenital 5, autosomal recessive (SCN5) [MIM:615285]: An autosomal recessive primary immunodeficiency disorder characterized primarily by neutropenia and neutrophil dysfunction, a lack of response to G-CSF, life-threatening infections, bone marrow fibrosis, and renal extramedullary hematopoiesis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241T → N in SCN5; patient fibroblasts are characterized by impaired motility and increased apoptosis. 1 Publication
    VAR_069865
    Natural varianti238 – 2381E → K in SCN5. 1 Publication
    VAR_069866

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615285. phenotype.
    Orphaneti369852. Recurrent infections-myelofibrosis-nephromegaly syndrome.
    PharmGKBiPA37901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Vacuolar protein sorting-associated protein 45PRO_0000206312Add
    BLAST

    Proteomic databases

    MaxQBiF5H8K1.
    Q9NRW7.
    PaxDbiQ9NRW7.
    PRIDEiQ9NRW7.

    PTM databases

    PhosphoSiteiQ9NRW7.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.

    Gene expression databases

    ArrayExpressiQ9NRW7.
    BgeeiQ9NRW7.
    CleanExiHS_VPS45.
    GenevestigatoriQ9NRW7.

    Organism-specific databases

    HPAiHPA027425.
    HPA027441.

    Interactioni

    Subunit structurei

    Interacts with STX6 By similarity. Interacts with ZFYVE20.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi116443. 6 interactions.
    STRINGi9606.ENSP00000358126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRW7.
    SMRiQ9NRW7. Positions 20-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the STXBP/unc-18/SEC1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5158.
    HOGENOMiHOG000200803.
    HOVERGENiHBG059810.
    InParanoidiQ9NRW7.
    KOiK12479.
    OMAiHSSALQX.
    OrthoDBiEOG7H791T.
    PhylomeDBiQ9NRW7.
    TreeFamiTF300407.

    Family and domain databases

    Gene3Di3.40.50.1910. 2 hits.
    InterProiIPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view]
    PANTHERiPTHR11679. PTHR11679. 1 hit.
    PfamiPF00995. Sec1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMiSSF56815. SSF56815. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NRW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY    50
    LFERIDSQNR EIMKHLKAIC FLRPTKENVD YIIQELRRPK YTIYFIYFSN 100
    VISKSDVKSL AEADEQEVVA EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW 150
    DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS SEAAKRLAEC VKQVITKEYE 200
    LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL GINNNRIDLS 250
    RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKKPK 300
    EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV 350
    SEVEQELACQ NDHSSALQNI KRLLQNPKVT EFDAARLVML YALHYERHSS 400
    NSLPGLMMDL RNKGVSEKYR KLVSAVVEYG GKRVRGSDLF SPKDAVAITK 450
    QFLKGLKGVE NVYTQHQPFL HETLDHLIKG RLKENLYPYL GPSTLRDRPQ 500
    DIIVFVIGGA TYEEALTVYN LNRTTPGVRI VLGGTTVHNT KSFLEEVLAS 550
    GLHSRSKESS QVTSRSASRR 570
    Length:570
    Mass (Da):65,077
    Last modified:October 1, 2000 - v1
    Checksum:i5574F0BE3A7D4EB3
    GO
    Isoform 2 (identifier: Q9NRW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.
         124-192: Missing.
         542-570: SFLEEVLASGLHSRSKESSQVTSRSASRR → RDGVSLCSPA...LCWLLELISR

    Show »
    Length:538
    Mass (Da):61,983
    Checksum:i7EAE64A2BB3349E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 822YI → SL in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti92 – 921T → S in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti163 – 1631T → A in BAD96934. 1 PublicationCurated
    Sequence conflicti188 – 1881A → G in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti196 – 1961T → S in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti219 – 2191C → L in CAB40417. (PubMed:10404641)Curated
    Sequence conflicti241 – 2411G → D in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti298 – 2981K → R in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti370 – 3701I → V in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti385 – 3851A → V in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti407 – 4082MM → IV in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti412 – 4121N → H in BAD96934. 1 PublicationCurated
    Sequence conflicti412 – 4121N → S in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti416 – 4161S → A in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti481 – 4811R → K in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti537 – 5371V → I in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti557 – 5571K → R in AAC50931. (PubMed:8996080)Curated
    Sequence conflicti562 – 5621V → A in AAC50931. (PubMed:8996080)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241T → N in SCN5; patient fibroblasts are characterized by impaired motility and increased apoptosis. 1 Publication
    VAR_069865
    Natural varianti238 – 2381E → K in SCN5. 1 Publication
    VAR_069866

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. CuratedVSP_056739Add
    BLAST
    Alternative sequencei124 – 19269Missing in isoform 2. CuratedVSP_056740Add
    BLAST
    Alternative sequencei542 – 57029SFLEE…SASRR → RDGVSLCSPAWFRTPGLKRS TRLSLPKCWDYSFPRGSSGF WTAQPKQGELSSHIKVSEQK MKRWLGEGHSFLSCPHYRFS LLNKGVGEQLWVLCWLLELI SR in isoform 2. CuratedVSP_056741Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35246 mRNA. Translation: AAC50931.1.
    AJ133421 mRNA. Translation: CAB40417.1.
    AF165513 mRNA. Translation: AAF86643.1.
    AK023170 mRNA. Translation: BAB14443.1.
    AK223214 mRNA. Translation: BAD96934.1.
    AL358073 Genomic DNA. Translation: CAI14265.1.
    CH471121 Genomic DNA. Translation: EAW53584.1.
    CH471121 Genomic DNA. Translation: EAW53585.1.
    BC012932 mRNA. Translation: AAH12932.1.
    BC028382 mRNA. Translation: AAH28382.1.
    CCDSiCCDS944.1.
    PIRiJC5722.
    RefSeqiNP_001266282.1. NM_001279353.1.
    NP_001266283.1. NM_001279354.1.
    NP_001266284.1. NM_001279355.1.
    NP_009190.2. NM_007259.4.
    UniGeneiHs.443750.

    Genome annotation databases

    EnsembliENST00000369128; ENSP00000358124; ENSG00000136631.
    ENST00000369130; ENSP00000358126; ENSG00000136631.
    GeneIDi11311.
    KEGGihsa:11311.
    UCSCiuc001etp.3. human.
    uc010pbs.2. human.

    Polymorphism databases

    DMDMi23396937.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35246 mRNA. Translation: AAC50931.1 .
    AJ133421 mRNA. Translation: CAB40417.1 .
    AF165513 mRNA. Translation: AAF86643.1 .
    AK023170 mRNA. Translation: BAB14443.1 .
    AK223214 mRNA. Translation: BAD96934.1 .
    AL358073 Genomic DNA. Translation: CAI14265.1 .
    CH471121 Genomic DNA. Translation: EAW53584.1 .
    CH471121 Genomic DNA. Translation: EAW53585.1 .
    BC012932 mRNA. Translation: AAH12932.1 .
    BC028382 mRNA. Translation: AAH28382.1 .
    CCDSi CCDS944.1.
    PIRi JC5722.
    RefSeqi NP_001266282.1. NM_001279353.1.
    NP_001266283.1. NM_001279354.1.
    NP_001266284.1. NM_001279355.1.
    NP_009190.2. NM_007259.4.
    UniGenei Hs.443750.

    3D structure databases

    ProteinModelPortali Q9NRW7.
    SMRi Q9NRW7. Positions 20-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116443. 6 interactions.
    STRINGi 9606.ENSP00000358126.

    PTM databases

    PhosphoSitei Q9NRW7.

    Polymorphism databases

    DMDMi 23396937.

    Proteomic databases

    MaxQBi F5H8K1.
    Q9NRW7.
    PaxDbi Q9NRW7.
    PRIDEi Q9NRW7.

    Protocols and materials databases

    DNASUi 11311.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369128 ; ENSP00000358124 ; ENSG00000136631 .
    ENST00000369130 ; ENSP00000358126 ; ENSG00000136631 .
    GeneIDi 11311.
    KEGGi hsa:11311.
    UCSCi uc001etp.3. human.
    uc010pbs.2. human.

    Organism-specific databases

    CTDi 11311.
    GeneCardsi GC01P150039.
    HGNCi HGNC:14579. VPS45.
    HPAi HPA027425.
    HPA027441.
    MIMi 610035. gene.
    615285. phenotype.
    neXtProti NX_Q9NRW7.
    Orphaneti 369852. Recurrent infections-myelofibrosis-nephromegaly syndrome.
    PharmGKBi PA37901.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5158.
    HOGENOMi HOG000200803.
    HOVERGENi HBG059810.
    InParanoidi Q9NRW7.
    KOi K12479.
    OMAi HSSALQX.
    OrthoDBi EOG7H791T.
    PhylomeDBi Q9NRW7.
    TreeFami TF300407.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    GeneWikii VPS45.
    GenomeRNAii 11311.
    NextBioi 42971.
    PROi Q9NRW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRW7.
    Bgeei Q9NRW7.
    CleanExi HS_VPS45.
    Genevestigatori Q9NRW7.

    Family and domain databases

    Gene3Di 3.40.50.1910. 2 hits.
    InterProi IPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view ]
    PANTHERi PTHR11679. PTHR11679. 1 hit.
    Pfami PF00995. Sec1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMi SSF56815. SSF56815. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking."
      Pevsner J., Hsu S.-C., Hyde P.S., Scheller R.H.
      Gene 183:7-14(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (hlVps45)."
      Rajasekariah P., Eyre H.J., Stanley K.K., Walls R.S., Sutherland G.R.
      Int. J. Biochem. Cell Biol. 31:683-694(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Leukocyte.
    3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Gu J., Huang Q., Yu Y., Xu S., Han Z., Fu G., Zhou J., Wang Y., Huang C., Ren S., Tu Y., Chen Z.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hematopoietic stem cell.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Gastric mucosa.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon and Hippocampus.
    9. "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain."
      Nielsen E., Christoforidis S., Uttenweiler-Joseph S., Miaczynska M., Dewitte F., Wilm M., Hoflack B., Zerial M.
      J. Cell Biol. 151:601-612(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFYVE20.
    10. "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes."
      de Renzis S., Soennichsen B., Zerial M.
      Nat. Cell Biol. 4:124-133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFYVE20.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: VARIANTS SCN5 ASN-224 AND LYS-238.

    Entry informationi

    Entry nameiVPS45_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRW7
    Secondary accession number(s): D3DUZ9
    , F5H8K1, Q15715, Q53FR8, Q5T4P6, Q9Y4Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3