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Protein

Ras-related protein Rab-6B

Gene

RAB6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTP8
Nucleotide bindingi68 – 72GTP5
Nucleotide bindingi126 – 129GTP4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • myosin V binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154917-MONOMER.
ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6B
Gene namesi
Name:RAB6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14902. RAB6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27T → N: Loss of APBA1-binding. 1 Publication1
Mutagenesisi72Q → L: Interacts with APBA1. 1 Publication1

Organism-specific databases

DisGeNETi51560.
OpenTargetsiENSG00000154917.
PharmGKBiPA34147.

Polymorphism and mutation databases

BioMutaiRAB6B.
DMDMi13633595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211151 – 208Ras-related protein Rab-6BAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82O-AMP-tyrosine; by Legionella DrrA1 Publication1
Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9NRW1.
MaxQBiQ9NRW1.
PaxDbiQ9NRW1.
PeptideAtlasiQ9NRW1.
PRIDEiQ9NRW1.

PTM databases

iPTMnetiQ9NRW1.
PhosphoSitePlusiQ9NRW1.
SwissPalmiQ9NRW1.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSG00000154917.
ExpressionAtlasiQ9NRW1. baseline and differential.
GenevisibleiQ9NRW1. HS.

Organism-specific databases

HPAiCAB017713.
HPA059131.

Interactioni

Subunit structurei

Interacts with BICDL1/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APBA1Q02410-24EBI-1760079,EBI-9247455
COG6Q9Y2V74EBI-1760079,EBI-3866319

GO - Molecular functioni

  • myosin V binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119610. 43 interactors.
IntActiQ9NRW1. 8 interactors.
STRINGi9606.ENSP00000285208.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 19Combined sources5
Helixi26 – 35Combined sources10
Beta strandi47 – 57Combined sources11
Beta strandi60 – 69Combined sources10
Helixi73 – 78Combined sources6
Helixi79 – 84Combined sources6
Beta strandi87 – 94Combined sources8
Helixi98 – 102Combined sources5
Helixi104 – 115Combined sources12
Beta strandi118 – 126Combined sources9
Helixi131 – 133Combined sources3
Helixi138 – 147Combined sources10
Beta strandi151 – 154Combined sources4
Turni157 – 159Combined sources3
Helixi163 – 174Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9SX-ray1.78A/B/C13-174[»]
2FE4X-ray2.30A13-174[»]
2FFQX-ray1.78A13-174[»]
ProteinModelPortaliQ9NRW1.
SMRiQ9NRW1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRW1.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9NRW1.
KOiK07894.
OMAiELNIMFM.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ9NRW1.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS
110 120 130 140 150
FQQTSKWIDD VRTERGSDVI IMLVGNKTDL ADKRQITIEE GEQRAKELSV
160 170 180 190 200
MFIETSAKTG YNVKQLFRRV ASALPGMENV QEKSKEGMID IKLDKPQEPP

ASEGGCSC
Length:208
Mass (Da):23,462
Last modified:October 1, 2000 - v1
Checksum:iE81C831996E2446D
GO
Isoform 2 (identifier: Q9NRW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MSAGGDFGNPLRKFKLVFLGEQSV → MWHMTRNWPLV

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,334
Checksum:iE772D44D7E9D2C2C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558311 – 24MSAGG…GEQSV → MWHMTRNWPLV in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166492 mRNA. Translation: AAF61637.1.
AF498940 mRNA. Translation: AAM21088.1.
BT007263 mRNA. Translation: AAP35927.1.
AK295451 mRNA. Translation: BAH12073.1.
AK312378 mRNA. Translation: BAG35296.1.
AC080128 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79158.1.
CH471052 Genomic DNA. Translation: EAW79159.1.
BC002510 mRNA. Translation: AAH02510.1.
U66623 mRNA. Translation: AAC51198.1.
CCDSiCCDS3082.1. [Q9NRW1-1]
RefSeqiNP_057661.3. NM_016577.3. [Q9NRW1-1]
XP_011511195.1. XM_011512893.2. [Q9NRW1-2]
UniGeneiHs.715344.

Genome annotation databases

EnsembliENST00000285208; ENSP00000285208; ENSG00000154917. [Q9NRW1-1]
ENST00000486858; ENSP00000419381; ENSG00000154917. [Q9NRW1-2]
ENST00000543906; ENSP00000437797; ENSG00000154917. [Q9NRW1-1]
GeneIDi51560.
KEGGihsa:51560.
UCSCiuc003epy.4. human. [Q9NRW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166492 mRNA. Translation: AAF61637.1.
AF498940 mRNA. Translation: AAM21088.1.
BT007263 mRNA. Translation: AAP35927.1.
AK295451 mRNA. Translation: BAH12073.1.
AK312378 mRNA. Translation: BAG35296.1.
AC080128 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79158.1.
CH471052 Genomic DNA. Translation: EAW79159.1.
BC002510 mRNA. Translation: AAH02510.1.
U66623 mRNA. Translation: AAC51198.1.
CCDSiCCDS3082.1. [Q9NRW1-1]
RefSeqiNP_057661.3. NM_016577.3. [Q9NRW1-1]
XP_011511195.1. XM_011512893.2. [Q9NRW1-2]
UniGeneiHs.715344.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9SX-ray1.78A/B/C13-174[»]
2FE4X-ray2.30A13-174[»]
2FFQX-ray1.78A13-174[»]
ProteinModelPortaliQ9NRW1.
SMRiQ9NRW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119610. 43 interactors.
IntActiQ9NRW1. 8 interactors.
STRINGi9606.ENSP00000285208.

PTM databases

iPTMnetiQ9NRW1.
PhosphoSitePlusiQ9NRW1.
SwissPalmiQ9NRW1.

Polymorphism and mutation databases

BioMutaiRAB6B.
DMDMi13633595.

Proteomic databases

EPDiQ9NRW1.
MaxQBiQ9NRW1.
PaxDbiQ9NRW1.
PeptideAtlasiQ9NRW1.
PRIDEiQ9NRW1.

Protocols and materials databases

DNASUi51560.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285208; ENSP00000285208; ENSG00000154917. [Q9NRW1-1]
ENST00000486858; ENSP00000419381; ENSG00000154917. [Q9NRW1-2]
ENST00000543906; ENSP00000437797; ENSG00000154917. [Q9NRW1-1]
GeneIDi51560.
KEGGihsa:51560.
UCSCiuc003epy.4. human. [Q9NRW1-1]

Organism-specific databases

CTDi51560.
DisGeNETi51560.
GeneCardsiRAB6B.
HGNCiHGNC:14902. RAB6B.
HPAiCAB017713.
HPA059131.
MIMi615852. gene.
neXtProtiNX_Q9NRW1.
OpenTargetsiENSG00000154917.
PharmGKBiPA34147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9NRW1.
KOiK07894.
OMAiELNIMFM.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ9NRW1.
TreeFamiTF300803.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154917-MONOMER.
ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiRAB6B. human.
EvolutionaryTraceiQ9NRW1.
GeneWikiiRAB6B.
GenomeRNAii51560.
PROiQ9NRW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154917.
ExpressionAtlasiQ9NRW1. baseline and differential.
GenevisibleiQ9NRW1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB6B_HUMAN
AccessioniPrimary (citable) accession number: Q9NRW1
Secondary accession number(s): B2R5Z9
, B7Z337, D3DND3, Q92929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.