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Protein

Heme-binding protein 1

Gene

HEBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.1 Publication

GO - Molecular functioni

GO - Biological processi

  • circadian rhythm Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 1
Alternative name(s):
p22HBP
Gene namesi
Name:HEBP1
Synonyms:HBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000013583.8.
HGNCiHGNC:17176. HEBP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi50865.
OpenTargetsiENSG00000013583.
PharmGKBiPA29236.

Polymorphism and mutation databases

BioMutaiHEBP1.
DMDMi74734327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001168971 – 189Heme-binding protein 1Add BLAST189

Proteomic databases

EPDiQ9NRV9.
MaxQBiQ9NRV9.
PaxDbiQ9NRV9.
PeptideAtlasiQ9NRV9.
PRIDEiQ9NRV9.
TopDownProteomicsiQ9NRV9.

2D gel databases

REPRODUCTION-2DPAGEiIPI00148063.

PTM databases

iPTMnetiQ9NRV9.
PhosphoSitePlusiQ9NRV9.

Expressioni

Gene expression databases

BgeeiENSG00000013583.
CleanExiHS_HEBP1.
ExpressionAtlasiQ9NRV9. baseline and differential.
GenevisibleiQ9NRV9. HS.

Organism-specific databases

HPAiHPA056417.
HPA075277.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi119164. 8 interactors.
IntActiQ9NRV9. 2 interactors.
MINTiMINT-5002021.
STRINGi9606.ENSP00000014930.

Structurei

3D structure databases

ProteinModelPortaliQ9NRV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).By similarity

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IKQ6. Eukaryota.
ENOG4111HGX. LUCA.
GeneTreeiENSGT00530000063312.
HOGENOMiHOG000237638.
HOVERGENiHBG053223.
InParanoidiQ9NRV9.
OMAiQRKQYFC.
OrthoDBiEOG091G0ZIG.
PhylomeDBiQ9NRV9.
TreeFamiTF328887.

Family and domain databases

InterProiView protein in InterPro
IPR011256. Reg_factor_effector_dom_sf.
IPR006917. SOUL_haem-bd.
PANTHERiPTHR11220. PTHR11220. 1 hit.
PfamiView protein in Pfam
PF04832. SOUL. 1 hit.
SUPFAMiSSF55136. SSF55136. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NRV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGMIKNSLF GSVETWPWQV LSKGDKEEVA YEERACEGGK FATVEVTDKP
60 70 80 90 100
VDEALREAMP KVAKYAGGTN DKGIGMGMTV PISFAVFPNE DGSLQKKLKV
110 120 130 140 150
WFRIPNQFQS DPPAPSDKSV KIEEREGITV YSMQFGGYAK EADYVAQATR
160 170 180
LRAALEGTAT YRGDIYFCTG YDPPMKPYGR RNEIWLLKT
Length:189
Mass (Da):21,097
Last modified:October 1, 2000 - v1
Checksum:i6ED12EA91B101B02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158T → P in AAD32098 (PubMed:10640688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053363183E → D. Corresponds to variant dbSNP:rs1941Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117615 mRNA. Translation: AAD32098.1.
AF167473 mRNA. Translation: AAF89618.1.
BT007294 mRNA. Translation: AAP35958.1.
AK289877 mRNA. Translation: BAF82566.1.
CH471094 Genomic DNA. Translation: EAW96295.1.
BC016277 mRNA. Translation: AAH16277.1.
CCDSiCCDS31749.1.
RefSeqiNP_057071.2. NM_015987.4.
UniGeneiHs.642618.

Genome annotation databases

EnsembliENST00000014930; ENSP00000014930; ENSG00000013583.
GeneIDi50865.
KEGGihsa:50865.
UCSCiuc001rbd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHEBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRV9
Secondary accession number(s): A8K1G2, Q9Y5Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families