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Q9NRS6

- SNX15_HUMAN

UniProt

Q9NRS6 - SNX15_HUMAN

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Protein

Sorting nexin-15

Gene

SNX15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511Phosphatidylinositol 3-phosphateBy similarity
Binding sitei53 – 531Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei87 – 871Phosphatidylinositol 3-phosphateBy similarity
Binding sitei96 – 961Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:SNX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14978. SNX15.

Subcellular locationi

Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. membrane Source: UniProtKB
  5. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Sorting nexin-15PRO_0000213862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NRS6.
PaxDbiQ9NRS6.
PRIDEiQ9NRS6.

PTM databases

PhosphoSiteiQ9NRS6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ9NRS6.
CleanExiHS_SNX15.
ExpressionAtlasiQ9NRS6. baseline.
GenevestigatoriQ9NRS6.

Organism-specific databases

HPAiHPA038955.

Interactioni

Subunit structurei

Homodimer. Interacts with SNX1, SNX2 and SNX4.1 Publication

Protein-protein interaction databases

BioGridi118955. 5 interactions.
IntActiQ9NRS6. 5 interactions.
MINTiMINT-1380453.
STRINGi9606.ENSP00000301886.

Structurei

3D structure databases

ProteinModelPortaliQ9NRS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 130130PXPROSITE-ProRule annotationAdd
BLAST
Domaini265 – 34278MITAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 MIT domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245612.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ9NRS6.
KOiK17927.
OMAiVSRDLHI.
OrthoDBiEOG7B31NH.
PhylomeDBiQ9NRS6.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NRS6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP
160 170 180 190 200
PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG
210 220 230 240 250
SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE
260 270 280 290 300
PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
310 320 330 340
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
Length:342
Mass (Da):38,291
Last modified:October 1, 2000 - v1
Checksum:i33F64A79EAF6BBDC
GO
Isoform 2 (identifier: Q9NRS6-2) [UniParc]FASTAAdd to Basket

Also known as: SNX15A

The sequence of this isoform differs from the canonical sequence as follows:
     222-308: EGAAPSPTHV...VHVLLQGVPS → G

Show »
Length:256
Mass (Da):29,220
Checksum:iB2044AFF5C09059B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211Missing in AAF89956. (PubMed:11085978)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341R → C.
Corresponds to variant rs495820 [ dbSNP | Ensembl ].
VAR_052478

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei222 – 30887EGAAP…QGVPS → G in isoform 2. 1 PublicationVSP_006193Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175267 mRNA. Translation: AAF89955.1.
AF175268 mRNA. Translation: AAF89956.1.
HQ205586 Genomic DNA. Translation: ADP91255.1.
HQ205587 Genomic DNA. Translation: ADP91257.1.
HQ205588 Genomic DNA. Translation: ADP91259.1.
HQ205589 Genomic DNA. Translation: ADP91261.1.
HQ205590 Genomic DNA. Translation: ADP91263.1.
HQ205591 Genomic DNA. Translation: ADP91265.1.
HQ205592 Genomic DNA. Translation: ADP91267.1.
HQ205593 Genomic DNA. Translation: ADP91269.1.
HQ205594 Genomic DNA. Translation: ADP91271.1.
HQ205595 Genomic DNA. Translation: ADP91273.1.
HQ205596 Genomic DNA. Translation: ADP91275.1.
HQ205597 Genomic DNA. Translation: ADP91277.1.
HQ205598 Genomic DNA. Translation: ADP91279.1.
HQ205599 Genomic DNA. Translation: ADP91281.1.
HQ205600 Genomic DNA. Translation: ADP91283.1.
HQ205601 Genomic DNA. Translation: ADP91285.1.
HQ205602 Genomic DNA. Translation: ADP91287.1.
HQ205603 Genomic DNA. Translation: ADP91289.1.
HQ205604 Genomic DNA. Translation: ADP91291.1.
HQ205605 Genomic DNA. Translation: ADP91293.1.
HQ205606 Genomic DNA. Translation: ADP91295.1.
HQ205607 Genomic DNA. Translation: ADP91297.1.
HQ205608 Genomic DNA. Translation: ADP91299.1.
HQ205609 Genomic DNA. Translation: ADP91301.1.
HQ205610 Genomic DNA. Translation: ADP91303.1.
HQ205611 Genomic DNA. Translation: ADP91305.1.
HQ205612 Genomic DNA. Translation: ADP91307.1.
HQ205613 Genomic DNA. Translation: ADP91309.1.
HQ205614 Genomic DNA. Translation: ADP91311.1.
HQ205615 Genomic DNA. Translation: ADP91313.1.
HQ205616 Genomic DNA. Translation: ADP91315.1.
HQ205617 Genomic DNA. Translation: ADP91317.1.
HQ205618 Genomic DNA. Translation: ADP91319.1.
HQ205619 Genomic DNA. Translation: ADP91321.1.
HQ205620 Genomic DNA. Translation: ADP91323.1.
HQ205621 Genomic DNA. Translation: ADP91325.1.
HQ205622 Genomic DNA. Translation: ADP91327.1.
HQ205623 Genomic DNA. Translation: ADP91329.1.
HQ205624 Genomic DNA. Translation: ADP91331.1.
HQ205625 Genomic DNA. Translation: ADP91333.1.
BT006631 mRNA. Translation: AAP35277.1.
AP000436 Genomic DNA. No translation available.
AP003068 Genomic DNA. No translation available.
BC009897 mRNA. Translation: AAH09897.1.
BC012767 mRNA. Translation: AAH12767.1.
BC014520 mRNA. Translation: AAH14520.1.
CCDSiCCDS8089.1. [Q9NRS6-1]
CCDS8090.1. [Q9NRS6-2]
RefSeqiNP_037438.2. NM_013306.4. [Q9NRS6-1]
NP_680086.2. NM_147777.3. [Q9NRS6-2]
UniGeneiHs.80132.

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025. [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025. [Q9NRS6-1]
GeneIDi29907.
KEGGihsa:29907.
UCSCiuc001oci.4. human. [Q9NRS6-1]

Polymorphism databases

DMDMi13124562.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175267 mRNA. Translation: AAF89955.1 .
AF175268 mRNA. Translation: AAF89956.1 .
HQ205586 Genomic DNA. Translation: ADP91255.1 .
HQ205587 Genomic DNA. Translation: ADP91257.1 .
HQ205588 Genomic DNA. Translation: ADP91259.1 .
HQ205589 Genomic DNA. Translation: ADP91261.1 .
HQ205590 Genomic DNA. Translation: ADP91263.1 .
HQ205591 Genomic DNA. Translation: ADP91265.1 .
HQ205592 Genomic DNA. Translation: ADP91267.1 .
HQ205593 Genomic DNA. Translation: ADP91269.1 .
HQ205594 Genomic DNA. Translation: ADP91271.1 .
HQ205595 Genomic DNA. Translation: ADP91273.1 .
HQ205596 Genomic DNA. Translation: ADP91275.1 .
HQ205597 Genomic DNA. Translation: ADP91277.1 .
HQ205598 Genomic DNA. Translation: ADP91279.1 .
HQ205599 Genomic DNA. Translation: ADP91281.1 .
HQ205600 Genomic DNA. Translation: ADP91283.1 .
HQ205601 Genomic DNA. Translation: ADP91285.1 .
HQ205602 Genomic DNA. Translation: ADP91287.1 .
HQ205603 Genomic DNA. Translation: ADP91289.1 .
HQ205604 Genomic DNA. Translation: ADP91291.1 .
HQ205605 Genomic DNA. Translation: ADP91293.1 .
HQ205606 Genomic DNA. Translation: ADP91295.1 .
HQ205607 Genomic DNA. Translation: ADP91297.1 .
HQ205608 Genomic DNA. Translation: ADP91299.1 .
HQ205609 Genomic DNA. Translation: ADP91301.1 .
HQ205610 Genomic DNA. Translation: ADP91303.1 .
HQ205611 Genomic DNA. Translation: ADP91305.1 .
HQ205612 Genomic DNA. Translation: ADP91307.1 .
HQ205613 Genomic DNA. Translation: ADP91309.1 .
HQ205614 Genomic DNA. Translation: ADP91311.1 .
HQ205615 Genomic DNA. Translation: ADP91313.1 .
HQ205616 Genomic DNA. Translation: ADP91315.1 .
HQ205617 Genomic DNA. Translation: ADP91317.1 .
HQ205618 Genomic DNA. Translation: ADP91319.1 .
HQ205619 Genomic DNA. Translation: ADP91321.1 .
HQ205620 Genomic DNA. Translation: ADP91323.1 .
HQ205621 Genomic DNA. Translation: ADP91325.1 .
HQ205622 Genomic DNA. Translation: ADP91327.1 .
HQ205623 Genomic DNA. Translation: ADP91329.1 .
HQ205624 Genomic DNA. Translation: ADP91331.1 .
HQ205625 Genomic DNA. Translation: ADP91333.1 .
BT006631 mRNA. Translation: AAP35277.1 .
AP000436 Genomic DNA. No translation available.
AP003068 Genomic DNA. No translation available.
BC009897 mRNA. Translation: AAH09897.1 .
BC012767 mRNA. Translation: AAH12767.1 .
BC014520 mRNA. Translation: AAH14520.1 .
CCDSi CCDS8089.1. [Q9NRS6-1 ]
CCDS8090.1. [Q9NRS6-2 ]
RefSeqi NP_037438.2. NM_013306.4. [Q9NRS6-1 ]
NP_680086.2. NM_147777.3. [Q9NRS6-2 ]
UniGenei Hs.80132.

3D structure databases

ProteinModelPortali Q9NRS6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118955. 5 interactions.
IntActi Q9NRS6. 5 interactions.
MINTi MINT-1380453.
STRINGi 9606.ENSP00000301886.

PTM databases

PhosphoSitei Q9NRS6.

Polymorphism databases

DMDMi 13124562.

Proteomic databases

MaxQBi Q9NRS6.
PaxDbi Q9NRS6.
PRIDEi Q9NRS6.

Protocols and materials databases

DNASUi 29907.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000352068 ; ENSP00000316410 ; ENSG00000110025 . [Q9NRS6-2 ]
ENST00000377244 ; ENSP00000366452 ; ENSG00000110025 . [Q9NRS6-1 ]
GeneIDi 29907.
KEGGi hsa:29907.
UCSCi uc001oci.4. human. [Q9NRS6-1 ]

Organism-specific databases

CTDi 29907.
GeneCardsi GC11P064794.
HGNCi HGNC:14978. SNX15.
HPAi HPA038955.
MIMi 605964. gene.
neXtProti NX_Q9NRS6.
PharmGKBi PA37953.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245612.
GeneTreei ENSGT00530000063268.
HOGENOMi HOG000154362.
HOVERGENi HBG066336.
InParanoidi Q9NRS6.
KOi K17927.
OMAi VSRDLHI.
OrthoDBi EOG7B31NH.
PhylomeDBi Q9NRS6.
TreeFami TF323964.

Miscellaneous databases

GeneWikii SNX15.
GenomeRNAii 29907.
NextBioi 52486.
PROi Q9NRS6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRS6.
CleanExi HS_SNX15.
ExpressionAtlasi Q9NRS6. baseline.
Genevestigatori Q9NRS6.

Family and domain databases

Gene3Di 1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProi IPR007330. MIT.
IPR001683. Phox.
[Graphical view ]
Pfami PF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of snx15, a novel sorting nexin involved in protein trafficking."
    Phillips S.A., Barr V.A., Haft D.H., Taylor S.I., Haft C.R.
    J. Biol. Chem. 276:5074-5084(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Parathyroid.
  2. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lymph.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX15_HUMAN
AccessioniPrimary (citable) accession number: Q9NRS6
Secondary accession number(s): E5KQS6, Q9NRS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3