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Q9NRS6 (SNX15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-15
Gene names
Name:SNX15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Ref.1

Subunit structure

Homodimer. Interacts with SNX1, SNX2 and SNX4. Ref.1

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Ref.1.

Tissue specificity

Widely expressed. Ref.1

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 MIT domain.

Contains 1 PX (phox homology) domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NRS6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NRS6-2)

Also known as: SNX15A;

The sequence of this isoform differs from the canonical sequence as follows:
     222-308: EGAAPSPTHV...VHVLLQGVPS → G

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Sorting nexin-15
PRO_0000213862

Regions

Domain1 – 130130PX
Domain265 – 34278MIT

Sites

Binding site511Phosphatidylinositol 3-phosphate By similarity
Binding site531Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site871Phosphatidylinositol 3-phosphate By similarity
Binding site961Phosphatidylinositol 3-phosphate By similarity

Amino acid modifications

Modified residue2271Phosphoserine Ref.7

Natural variations

Alternative sequence222 – 30887EGAAP…QGVPS → G in isoform 2.
VSP_006193
Natural variant3341R → C.
Corresponds to variant rs495820 [ dbSNP | Ensembl ].
VAR_052478

Experimental info

Sequence conflict2211Missing in AAF89956. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 33F64A79EAF6BBDC

FASTA34238,291
        10         20         30         40         50         60 
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG 

        70         80         90        100        110        120 
DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK 

       130        140        150        160        170        180 
EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS 

       190        200        210        220        230        240 
PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE 

       250        260        270        280        290        300 
SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH 

       310        320        330        340 
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP 

« Hide

Isoform 2 (SNX15A) [UniParc].

Checksum: B2044AFF5C09059B
Show »

FASTA25629,220

References

« Hide 'large scale' references
[1]"Identification and characterization of snx15, a novel sorting nexin involved in protein trafficking."
Phillips S.A., Barr V.A., Haft D.H., Taylor S.I., Haft C.R.
J. Biol. Chem. 276:5074-5084(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
Tissue: Parathyroid.
[2]"Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Lymph.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF175267 mRNA. Translation: AAF89955.1.
AF175268 mRNA. Translation: AAF89956.1.
HQ205586 Genomic DNA. Translation: ADP91255.1.
HQ205587 Genomic DNA. Translation: ADP91257.1.
HQ205588 Genomic DNA. Translation: ADP91259.1.
HQ205589 Genomic DNA. Translation: ADP91261.1.
HQ205590 Genomic DNA. Translation: ADP91263.1.
HQ205591 Genomic DNA. Translation: ADP91265.1.
HQ205592 Genomic DNA. Translation: ADP91267.1.
HQ205593 Genomic DNA. Translation: ADP91269.1.
HQ205594 Genomic DNA. Translation: ADP91271.1.
HQ205595 Genomic DNA. Translation: ADP91273.1.
HQ205596 Genomic DNA. Translation: ADP91275.1.
HQ205597 Genomic DNA. Translation: ADP91277.1.
HQ205598 Genomic DNA. Translation: ADP91279.1.
HQ205599 Genomic DNA. Translation: ADP91281.1.
HQ205600 Genomic DNA. Translation: ADP91283.1.
HQ205601 Genomic DNA. Translation: ADP91285.1.
HQ205602 Genomic DNA. Translation: ADP91287.1.
HQ205603 Genomic DNA. Translation: ADP91289.1.
HQ205604 Genomic DNA. Translation: ADP91291.1.
HQ205605 Genomic DNA. Translation: ADP91293.1.
HQ205606 Genomic DNA. Translation: ADP91295.1.
HQ205607 Genomic DNA. Translation: ADP91297.1.
HQ205608 Genomic DNA. Translation: ADP91299.1.
HQ205609 Genomic DNA. Translation: ADP91301.1.
HQ205610 Genomic DNA. Translation: ADP91303.1.
HQ205611 Genomic DNA. Translation: ADP91305.1.
HQ205612 Genomic DNA. Translation: ADP91307.1.
HQ205613 Genomic DNA. Translation: ADP91309.1.
HQ205614 Genomic DNA. Translation: ADP91311.1.
HQ205615 Genomic DNA. Translation: ADP91313.1.
HQ205616 Genomic DNA. Translation: ADP91315.1.
HQ205617 Genomic DNA. Translation: ADP91317.1.
HQ205618 Genomic DNA. Translation: ADP91319.1.
HQ205619 Genomic DNA. Translation: ADP91321.1.
HQ205620 Genomic DNA. Translation: ADP91323.1.
HQ205621 Genomic DNA. Translation: ADP91325.1.
HQ205622 Genomic DNA. Translation: ADP91327.1.
HQ205623 Genomic DNA. Translation: ADP91329.1.
HQ205624 Genomic DNA. Translation: ADP91331.1.
HQ205625 Genomic DNA. Translation: ADP91333.1.
BT006631 mRNA. Translation: AAP35277.1.
AP000436 Genomic DNA. No translation available.
AP003068 Genomic DNA. No translation available.
BC009897 mRNA. Translation: AAH09897.1.
BC012767 mRNA. Translation: AAH12767.1.
BC014520 mRNA. Translation: AAH14520.1.
CCDSCCDS8089.1. [Q9NRS6-1]
RefSeqNP_037438.2. NM_013306.4. [Q9NRS6-1]
NP_680086.2. NM_147777.3. [Q9NRS6-2]
UniGeneHs.80132.

3D structure databases

ProteinModelPortalQ9NRS6.
SMRQ9NRS6. Positions 1-125, 269-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118955. 5 interactions.
IntActQ9NRS6. 5 interactions.
MINTMINT-1380453.
STRING9606.ENSP00000301886.

PTM databases

PhosphoSiteQ9NRS6.

Polymorphism databases

DMDM13124562.

Proteomic databases

MaxQBQ9NRS6.
PaxDbQ9NRS6.
PRIDEQ9NRS6.

Protocols and materials databases

DNASU29907.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000352068; ENSP00000316410; ENSG00000110025.
ENST00000377244; ENSP00000366452; ENSG00000110025. [Q9NRS6-1]
GeneID29907.
KEGGhsa:29907.
UCSCuc001oci.4. human. [Q9NRS6-1]

Organism-specific databases

CTD29907.
GeneCardsGC11P064782.
HGNCHGNC:14978. SNX15.
HPAHPA038955.
MIM605964. gene.
neXtProtNX_Q9NRS6.
PharmGKBPA37953.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245612.
HOGENOMHOG000154362.
HOVERGENHBG066336.
InParanoidQ9NRS6.
KOK17927.
OMAVSRDLHI.
OrthoDBEOG7B31NH.
PhylomeDBQ9NRS6.
TreeFamTF323964.

Gene expression databases

ArrayExpressQ9NRS6.
BgeeQ9NRS6.
CleanExHS_SNX15.
GenevestigatorQ9NRS6.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSNX15.
GenomeRNAi29907.
NextBio52486.
PROQ9NRS6.
SOURCESearch...

Entry information

Entry nameSNX15_HUMAN
AccessionPrimary (citable) accession number: Q9NRS6
Secondary accession number(s): E5KQS6, Q9NRS5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM