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Protein

Sorting nexin-15

Gene

SNX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei53Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei87Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei96Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-15
Gene namesi
Name:SNX15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14978. SNX15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110025.
PharmGKBiPA37953.

Polymorphism and mutation databases

BioMutaiSNX15.
DMDMi13124562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138621 – 342Sorting nexin-15Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105Omega-N-methylarginineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NRS6.
MaxQBiQ9NRS6.
PaxDbiQ9NRS6.
PeptideAtlasiQ9NRS6.
PRIDEiQ9NRS6.

PTM databases

iPTMnetiQ9NRS6.
PhosphoSitePlusiQ9NRS6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000110025.
CleanExiHS_SNX15.
ExpressionAtlasiQ9NRS6. baseline and differential.
GenevisibleiQ9NRS6. HS.

Organism-specific databases

HPAiHPA038955.

Interactioni

Subunit structurei

Homodimer. Interacts with SNX1, SNX2 and SNX4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-725924,EBI-714543
RABAC1Q9UI144EBI-725924,EBI-712367
REEP6Q96HR96EBI-725924,EBI-750345
RTN4Q9NQC34EBI-725924,EBI-715945

Protein-protein interaction databases

BioGridi118955. 10 interactors.
IntActiQ9NRS6. 6 interactors.
MINTiMINT-1380453.
STRINGi9606.ENSP00000366452.

Structurei

3D structure databases

ProteinModelPortaliQ9NRS6.
SMRiQ9NRS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 130PXPROSITE-ProRule annotationAdd BLAST130
Domaini265 – 342MITAdd BLAST78

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 MIT domain.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ9NRS6.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG091G0CNL.
PhylomeDBiQ9NRS6.
TreeFamiTF323964.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK
60 70 80 90 100
RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA
110 120 130 140 150
EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP
160 170 180 190 200
PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG
210 220 230 240 250
SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE
260 270 280 290 300
PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH
310 320 330 340
VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
Length:342
Mass (Da):38,291
Last modified:October 1, 2000 - v1
Checksum:i33F64A79EAF6BBDC
GO
Isoform 2 (identifier: Q9NRS6-2) [UniParc]FASTAAdd to basket
Also known as: SNX15A

The sequence of this isoform differs from the canonical sequence as follows:
     222-308: EGAAPSPTHV...VHVLLQGVPS → G

Show »
Length:256
Mass (Da):29,220
Checksum:iB2044AFF5C09059B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221Missing in AAF89956 (PubMed:11085978).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052478334R → C.Corresponds to variant rs495820dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006193222 – 308EGAAP…QGVPS → G in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175267 mRNA. Translation: AAF89955.1.
AF175268 mRNA. Translation: AAF89956.1.
HQ205586 Genomic DNA. Translation: ADP91255.1.
HQ205587 Genomic DNA. Translation: ADP91257.1.
HQ205588 Genomic DNA. Translation: ADP91259.1.
HQ205589 Genomic DNA. Translation: ADP91261.1.
HQ205590 Genomic DNA. Translation: ADP91263.1.
HQ205591 Genomic DNA. Translation: ADP91265.1.
HQ205592 Genomic DNA. Translation: ADP91267.1.
HQ205593 Genomic DNA. Translation: ADP91269.1.
HQ205594 Genomic DNA. Translation: ADP91271.1.
HQ205595 Genomic DNA. Translation: ADP91273.1.
HQ205596 Genomic DNA. Translation: ADP91275.1.
HQ205597 Genomic DNA. Translation: ADP91277.1.
HQ205598 Genomic DNA. Translation: ADP91279.1.
HQ205599 Genomic DNA. Translation: ADP91281.1.
HQ205600 Genomic DNA. Translation: ADP91283.1.
HQ205601 Genomic DNA. Translation: ADP91285.1.
HQ205602 Genomic DNA. Translation: ADP91287.1.
HQ205603 Genomic DNA. Translation: ADP91289.1.
HQ205604 Genomic DNA. Translation: ADP91291.1.
HQ205605 Genomic DNA. Translation: ADP91293.1.
HQ205606 Genomic DNA. Translation: ADP91295.1.
HQ205607 Genomic DNA. Translation: ADP91297.1.
HQ205608 Genomic DNA. Translation: ADP91299.1.
HQ205609 Genomic DNA. Translation: ADP91301.1.
HQ205610 Genomic DNA. Translation: ADP91303.1.
HQ205611 Genomic DNA. Translation: ADP91305.1.
HQ205612 Genomic DNA. Translation: ADP91307.1.
HQ205613 Genomic DNA. Translation: ADP91309.1.
HQ205614 Genomic DNA. Translation: ADP91311.1.
HQ205615 Genomic DNA. Translation: ADP91313.1.
HQ205616 Genomic DNA. Translation: ADP91315.1.
HQ205617 Genomic DNA. Translation: ADP91317.1.
HQ205618 Genomic DNA. Translation: ADP91319.1.
HQ205619 Genomic DNA. Translation: ADP91321.1.
HQ205620 Genomic DNA. Translation: ADP91323.1.
HQ205621 Genomic DNA. Translation: ADP91325.1.
HQ205622 Genomic DNA. Translation: ADP91327.1.
HQ205623 Genomic DNA. Translation: ADP91329.1.
HQ205624 Genomic DNA. Translation: ADP91331.1.
HQ205625 Genomic DNA. Translation: ADP91333.1.
BT006631 mRNA. Translation: AAP35277.1.
AP000436 Genomic DNA. No translation available.
AP003068 Genomic DNA. No translation available.
BC009897 mRNA. Translation: AAH09897.1.
BC012767 mRNA. Translation: AAH12767.1.
BC014520 mRNA. Translation: AAH14520.1.
CCDSiCCDS8089.1. [Q9NRS6-1]
CCDS8090.1. [Q9NRS6-2]
RefSeqiNP_037438.2. NM_013306.4. [Q9NRS6-1]
NP_680086.2. NM_147777.3. [Q9NRS6-2]
UniGeneiHs.80132.

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025. [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025. [Q9NRS6-1]
GeneIDi29907.
KEGGihsa:29907.
UCSCiuc001ock.4. human. [Q9NRS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175267 mRNA. Translation: AAF89955.1.
AF175268 mRNA. Translation: AAF89956.1.
HQ205586 Genomic DNA. Translation: ADP91255.1.
HQ205587 Genomic DNA. Translation: ADP91257.1.
HQ205588 Genomic DNA. Translation: ADP91259.1.
HQ205589 Genomic DNA. Translation: ADP91261.1.
HQ205590 Genomic DNA. Translation: ADP91263.1.
HQ205591 Genomic DNA. Translation: ADP91265.1.
HQ205592 Genomic DNA. Translation: ADP91267.1.
HQ205593 Genomic DNA. Translation: ADP91269.1.
HQ205594 Genomic DNA. Translation: ADP91271.1.
HQ205595 Genomic DNA. Translation: ADP91273.1.
HQ205596 Genomic DNA. Translation: ADP91275.1.
HQ205597 Genomic DNA. Translation: ADP91277.1.
HQ205598 Genomic DNA. Translation: ADP91279.1.
HQ205599 Genomic DNA. Translation: ADP91281.1.
HQ205600 Genomic DNA. Translation: ADP91283.1.
HQ205601 Genomic DNA. Translation: ADP91285.1.
HQ205602 Genomic DNA. Translation: ADP91287.1.
HQ205603 Genomic DNA. Translation: ADP91289.1.
HQ205604 Genomic DNA. Translation: ADP91291.1.
HQ205605 Genomic DNA. Translation: ADP91293.1.
HQ205606 Genomic DNA. Translation: ADP91295.1.
HQ205607 Genomic DNA. Translation: ADP91297.1.
HQ205608 Genomic DNA. Translation: ADP91299.1.
HQ205609 Genomic DNA. Translation: ADP91301.1.
HQ205610 Genomic DNA. Translation: ADP91303.1.
HQ205611 Genomic DNA. Translation: ADP91305.1.
HQ205612 Genomic DNA. Translation: ADP91307.1.
HQ205613 Genomic DNA. Translation: ADP91309.1.
HQ205614 Genomic DNA. Translation: ADP91311.1.
HQ205615 Genomic DNA. Translation: ADP91313.1.
HQ205616 Genomic DNA. Translation: ADP91315.1.
HQ205617 Genomic DNA. Translation: ADP91317.1.
HQ205618 Genomic DNA. Translation: ADP91319.1.
HQ205619 Genomic DNA. Translation: ADP91321.1.
HQ205620 Genomic DNA. Translation: ADP91323.1.
HQ205621 Genomic DNA. Translation: ADP91325.1.
HQ205622 Genomic DNA. Translation: ADP91327.1.
HQ205623 Genomic DNA. Translation: ADP91329.1.
HQ205624 Genomic DNA. Translation: ADP91331.1.
HQ205625 Genomic DNA. Translation: ADP91333.1.
BT006631 mRNA. Translation: AAP35277.1.
AP000436 Genomic DNA. No translation available.
AP003068 Genomic DNA. No translation available.
BC009897 mRNA. Translation: AAH09897.1.
BC012767 mRNA. Translation: AAH12767.1.
BC014520 mRNA. Translation: AAH14520.1.
CCDSiCCDS8089.1. [Q9NRS6-1]
CCDS8090.1. [Q9NRS6-2]
RefSeqiNP_037438.2. NM_013306.4. [Q9NRS6-1]
NP_680086.2. NM_147777.3. [Q9NRS6-2]
UniGeneiHs.80132.

3D structure databases

ProteinModelPortaliQ9NRS6.
SMRiQ9NRS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118955. 10 interactors.
IntActiQ9NRS6. 6 interactors.
MINTiMINT-1380453.
STRINGi9606.ENSP00000366452.

PTM databases

iPTMnetiQ9NRS6.
PhosphoSitePlusiQ9NRS6.

Polymorphism and mutation databases

BioMutaiSNX15.
DMDMi13124562.

Proteomic databases

EPDiQ9NRS6.
MaxQBiQ9NRS6.
PaxDbiQ9NRS6.
PeptideAtlasiQ9NRS6.
PRIDEiQ9NRS6.

Protocols and materials databases

DNASUi29907.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352068; ENSP00000316410; ENSG00000110025. [Q9NRS6-2]
ENST00000377244; ENSP00000366452; ENSG00000110025. [Q9NRS6-1]
GeneIDi29907.
KEGGihsa:29907.
UCSCiuc001ock.4. human. [Q9NRS6-1]

Organism-specific databases

CTDi29907.
GeneCardsiSNX15.
HGNCiHGNC:14978. SNX15.
HPAiHPA038955.
MIMi605964. gene.
neXtProtiNX_Q9NRS6.
OpenTargetsiENSG00000110025.
PharmGKBiPA37953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0603. Eukaryota.
KOG2101. Eukaryota.
ENOG4111HIS. LUCA.
GeneTreeiENSGT00530000063268.
HOGENOMiHOG000154362.
HOVERGENiHBG066336.
InParanoidiQ9NRS6.
KOiK17927.
OMAiLYNSPQL.
OrthoDBiEOG091G0CNL.
PhylomeDBiQ9NRS6.
TreeFamiTF323964.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110025-MONOMER.

Miscellaneous databases

GeneWikiiSNX15.
GenomeRNAii29907.
PROiQ9NRS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110025.
CleanExiHS_SNX15.
ExpressionAtlasiQ9NRS6. baseline and differential.
GenevisibleiQ9NRS6. HS.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR007330. MIT.
IPR001683. Phox.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX15_HUMAN
AccessioniPrimary (citable) accession number: Q9NRS6
Secondary accession number(s): E5KQS6, Q9NRS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.