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Q9NRS6

- SNX15_HUMAN

UniProt

Q9NRS6 - SNX15_HUMAN

Protein

Sorting nexin-15

Gene

SNX15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei53 – 531Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei87 – 871Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei96 – 961Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-15
    Gene namesi
    Name:SNX15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14978. SNX15.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. cytosol Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37953.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Sorting nexin-15PRO_0000213862Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NRS6.
    PaxDbiQ9NRS6.
    PRIDEiQ9NRS6.

    PTM databases

    PhosphoSiteiQ9NRS6.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9NRS6.
    BgeeiQ9NRS6.
    CleanExiHS_SNX15.
    GenevestigatoriQ9NRS6.

    Organism-specific databases

    HPAiHPA038955.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SNX1, SNX2 and SNX4.1 Publication

    Protein-protein interaction databases

    BioGridi118955. 5 interactions.
    IntActiQ9NRS6. 5 interactions.
    MINTiMINT-1380453.
    STRINGi9606.ENSP00000301886.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRS6.
    SMRiQ9NRS6. Positions 1-125, 269-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 130130PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 34278MITAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 MIT domain.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245612.
    HOGENOMiHOG000154362.
    HOVERGENiHBG066336.
    InParanoidiQ9NRS6.
    KOiK17927.
    OMAiVSRDLHI.
    OrthoDBiEOG7B31NH.
    PhylomeDBiQ9NRS6.
    TreeFamiTF323964.

    Family and domain databases

    Gene3Di1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProiIPR007330. MIT.
    IPR001683. Phox.
    [Graphical view]
    PfamiPF04212. MIT. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF116846. SSF116846. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NRS6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK    50
    RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA 100
    EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP 150
    PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG 200
    SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE 250
    PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH 300
    VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP 342
    Length:342
    Mass (Da):38,291
    Last modified:October 1, 2000 - v1
    Checksum:i33F64A79EAF6BBDC
    GO
    Isoform 2 (identifier: Q9NRS6-2) [UniParc]FASTAAdd to Basket

    Also known as: SNX15A

    The sequence of this isoform differs from the canonical sequence as follows:
         222-308: EGAAPSPTHV...VHVLLQGVPS → G

    Show »
    Length:256
    Mass (Da):29,220
    Checksum:iB2044AFF5C09059B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2211Missing in AAF89956. (PubMed:11085978)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti334 – 3341R → C.
    Corresponds to variant rs495820 [ dbSNP | Ensembl ].
    VAR_052478

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei222 – 30887EGAAP…QGVPS → G in isoform 2. 1 PublicationVSP_006193Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175267 mRNA. Translation: AAF89955.1.
    AF175268 mRNA. Translation: AAF89956.1.
    HQ205586 Genomic DNA. Translation: ADP91255.1.
    HQ205587 Genomic DNA. Translation: ADP91257.1.
    HQ205588 Genomic DNA. Translation: ADP91259.1.
    HQ205589 Genomic DNA. Translation: ADP91261.1.
    HQ205590 Genomic DNA. Translation: ADP91263.1.
    HQ205591 Genomic DNA. Translation: ADP91265.1.
    HQ205592 Genomic DNA. Translation: ADP91267.1.
    HQ205593 Genomic DNA. Translation: ADP91269.1.
    HQ205594 Genomic DNA. Translation: ADP91271.1.
    HQ205595 Genomic DNA. Translation: ADP91273.1.
    HQ205596 Genomic DNA. Translation: ADP91275.1.
    HQ205597 Genomic DNA. Translation: ADP91277.1.
    HQ205598 Genomic DNA. Translation: ADP91279.1.
    HQ205599 Genomic DNA. Translation: ADP91281.1.
    HQ205600 Genomic DNA. Translation: ADP91283.1.
    HQ205601 Genomic DNA. Translation: ADP91285.1.
    HQ205602 Genomic DNA. Translation: ADP91287.1.
    HQ205603 Genomic DNA. Translation: ADP91289.1.
    HQ205604 Genomic DNA. Translation: ADP91291.1.
    HQ205605 Genomic DNA. Translation: ADP91293.1.
    HQ205606 Genomic DNA. Translation: ADP91295.1.
    HQ205607 Genomic DNA. Translation: ADP91297.1.
    HQ205608 Genomic DNA. Translation: ADP91299.1.
    HQ205609 Genomic DNA. Translation: ADP91301.1.
    HQ205610 Genomic DNA. Translation: ADP91303.1.
    HQ205611 Genomic DNA. Translation: ADP91305.1.
    HQ205612 Genomic DNA. Translation: ADP91307.1.
    HQ205613 Genomic DNA. Translation: ADP91309.1.
    HQ205614 Genomic DNA. Translation: ADP91311.1.
    HQ205615 Genomic DNA. Translation: ADP91313.1.
    HQ205616 Genomic DNA. Translation: ADP91315.1.
    HQ205617 Genomic DNA. Translation: ADP91317.1.
    HQ205618 Genomic DNA. Translation: ADP91319.1.
    HQ205619 Genomic DNA. Translation: ADP91321.1.
    HQ205620 Genomic DNA. Translation: ADP91323.1.
    HQ205621 Genomic DNA. Translation: ADP91325.1.
    HQ205622 Genomic DNA. Translation: ADP91327.1.
    HQ205623 Genomic DNA. Translation: ADP91329.1.
    HQ205624 Genomic DNA. Translation: ADP91331.1.
    HQ205625 Genomic DNA. Translation: ADP91333.1.
    BT006631 mRNA. Translation: AAP35277.1.
    AP000436 Genomic DNA. No translation available.
    AP003068 Genomic DNA. No translation available.
    BC009897 mRNA. Translation: AAH09897.1.
    BC012767 mRNA. Translation: AAH12767.1.
    BC014520 mRNA. Translation: AAH14520.1.
    CCDSiCCDS8089.1. [Q9NRS6-1]
    CCDS8090.1. [Q9NRS6-2]
    RefSeqiNP_037438.2. NM_013306.4. [Q9NRS6-1]
    NP_680086.2. NM_147777.3. [Q9NRS6-2]
    UniGeneiHs.80132.

    Genome annotation databases

    EnsembliENST00000352068; ENSP00000316410; ENSG00000110025. [Q9NRS6-2]
    ENST00000377244; ENSP00000366452; ENSG00000110025. [Q9NRS6-1]
    GeneIDi29907.
    KEGGihsa:29907.
    UCSCiuc001oci.4. human. [Q9NRS6-1]

    Polymorphism databases

    DMDMi13124562.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175267 mRNA. Translation: AAF89955.1 .
    AF175268 mRNA. Translation: AAF89956.1 .
    HQ205586 Genomic DNA. Translation: ADP91255.1 .
    HQ205587 Genomic DNA. Translation: ADP91257.1 .
    HQ205588 Genomic DNA. Translation: ADP91259.1 .
    HQ205589 Genomic DNA. Translation: ADP91261.1 .
    HQ205590 Genomic DNA. Translation: ADP91263.1 .
    HQ205591 Genomic DNA. Translation: ADP91265.1 .
    HQ205592 Genomic DNA. Translation: ADP91267.1 .
    HQ205593 Genomic DNA. Translation: ADP91269.1 .
    HQ205594 Genomic DNA. Translation: ADP91271.1 .
    HQ205595 Genomic DNA. Translation: ADP91273.1 .
    HQ205596 Genomic DNA. Translation: ADP91275.1 .
    HQ205597 Genomic DNA. Translation: ADP91277.1 .
    HQ205598 Genomic DNA. Translation: ADP91279.1 .
    HQ205599 Genomic DNA. Translation: ADP91281.1 .
    HQ205600 Genomic DNA. Translation: ADP91283.1 .
    HQ205601 Genomic DNA. Translation: ADP91285.1 .
    HQ205602 Genomic DNA. Translation: ADP91287.1 .
    HQ205603 Genomic DNA. Translation: ADP91289.1 .
    HQ205604 Genomic DNA. Translation: ADP91291.1 .
    HQ205605 Genomic DNA. Translation: ADP91293.1 .
    HQ205606 Genomic DNA. Translation: ADP91295.1 .
    HQ205607 Genomic DNA. Translation: ADP91297.1 .
    HQ205608 Genomic DNA. Translation: ADP91299.1 .
    HQ205609 Genomic DNA. Translation: ADP91301.1 .
    HQ205610 Genomic DNA. Translation: ADP91303.1 .
    HQ205611 Genomic DNA. Translation: ADP91305.1 .
    HQ205612 Genomic DNA. Translation: ADP91307.1 .
    HQ205613 Genomic DNA. Translation: ADP91309.1 .
    HQ205614 Genomic DNA. Translation: ADP91311.1 .
    HQ205615 Genomic DNA. Translation: ADP91313.1 .
    HQ205616 Genomic DNA. Translation: ADP91315.1 .
    HQ205617 Genomic DNA. Translation: ADP91317.1 .
    HQ205618 Genomic DNA. Translation: ADP91319.1 .
    HQ205619 Genomic DNA. Translation: ADP91321.1 .
    HQ205620 Genomic DNA. Translation: ADP91323.1 .
    HQ205621 Genomic DNA. Translation: ADP91325.1 .
    HQ205622 Genomic DNA. Translation: ADP91327.1 .
    HQ205623 Genomic DNA. Translation: ADP91329.1 .
    HQ205624 Genomic DNA. Translation: ADP91331.1 .
    HQ205625 Genomic DNA. Translation: ADP91333.1 .
    BT006631 mRNA. Translation: AAP35277.1 .
    AP000436 Genomic DNA. No translation available.
    AP003068 Genomic DNA. No translation available.
    BC009897 mRNA. Translation: AAH09897.1 .
    BC012767 mRNA. Translation: AAH12767.1 .
    BC014520 mRNA. Translation: AAH14520.1 .
    CCDSi CCDS8089.1. [Q9NRS6-1 ]
    CCDS8090.1. [Q9NRS6-2 ]
    RefSeqi NP_037438.2. NM_013306.4. [Q9NRS6-1 ]
    NP_680086.2. NM_147777.3. [Q9NRS6-2 ]
    UniGenei Hs.80132.

    3D structure databases

    ProteinModelPortali Q9NRS6.
    SMRi Q9NRS6. Positions 1-125, 269-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118955. 5 interactions.
    IntActi Q9NRS6. 5 interactions.
    MINTi MINT-1380453.
    STRINGi 9606.ENSP00000301886.

    PTM databases

    PhosphoSitei Q9NRS6.

    Polymorphism databases

    DMDMi 13124562.

    Proteomic databases

    MaxQBi Q9NRS6.
    PaxDbi Q9NRS6.
    PRIDEi Q9NRS6.

    Protocols and materials databases

    DNASUi 29907.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000352068 ; ENSP00000316410 ; ENSG00000110025 . [Q9NRS6-2 ]
    ENST00000377244 ; ENSP00000366452 ; ENSG00000110025 . [Q9NRS6-1 ]
    GeneIDi 29907.
    KEGGi hsa:29907.
    UCSCi uc001oci.4. human. [Q9NRS6-1 ]

    Organism-specific databases

    CTDi 29907.
    GeneCardsi GC11P064782.
    HGNCi HGNC:14978. SNX15.
    HPAi HPA038955.
    MIMi 605964. gene.
    neXtProti NX_Q9NRS6.
    PharmGKBi PA37953.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245612.
    HOGENOMi HOG000154362.
    HOVERGENi HBG066336.
    InParanoidi Q9NRS6.
    KOi K17927.
    OMAi VSRDLHI.
    OrthoDBi EOG7B31NH.
    PhylomeDBi Q9NRS6.
    TreeFami TF323964.

    Miscellaneous databases

    GeneWikii SNX15.
    GenomeRNAii 29907.
    NextBioi 52486.
    PROi Q9NRS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRS6.
    Bgeei Q9NRS6.
    CleanExi HS_SNX15.
    Genevestigatori Q9NRS6.

    Family and domain databases

    Gene3Di 1.20.58.280. 1 hit.
    3.30.1520.10. 1 hit.
    InterProi IPR007330. MIT.
    IPR001683. Phox.
    [Graphical view ]
    Pfami PF04212. MIT. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00745. MIT. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF116846. SSF116846. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of snx15, a novel sorting nexin involved in protein trafficking."
      Phillips S.A., Barr V.A., Haft D.H., Taylor S.I., Haft C.R.
      J. Biol. Chem. 276:5074-5084(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Parathyroid.
    2. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
      Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
      Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lymph.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNX15_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRS6
    Secondary accession number(s): E5KQS6, Q9NRS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3