Reviewed,
UniProtKB/Swiss-Prot Q9NRR5 (UBQL4_HUMAN)
Last modified
January 19, 2010.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquilin-4 Alternative name(s): Ataxin-1 ubiquitin-like-interacting protein A1U | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 601 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum By similarity. |
| Subcellular location | Nucleus. Cytoplasm. Endoplasmic reticulum Probable. Note: May associate with the endoplasmic reticulum. Ref.1 |
| Tissue specificity | Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. Ref.1 |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 |
| Sequence similarities | Contains 1 UBA domain. Contains 1 ubiquitin-like domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Endoplasmic reticulum Nucleus |
| Coding sequence diversity | Polymorphism |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytosol Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum membraneInferred from sequence or structural similarity. Source: UniProtKB nucleus Ref.1Inferred from direct assay. Source: UniProtKB |
| Molecular function | identical protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 2 | EBI-711226,EBI-711226 | ||
| ATXN1 | P54253 | 3 | EBI-711226,EBI-930964 | |
| FKBP2 | P26885 | 1 | EBI-711226,EBI-719873 | |
| MLLT6 | P55198 | 1 | EBI-711226,EBI-740216 | |
| PDLIM7 | Q9NR12 | 1 | EBI-711226,EBI-350517 | |
| TRIM32 | Q13049 | 1 | EBI-711226,EBI-742790 | |
| ZNF205 | O95201 | 1 | EBI-711226,EBI-747343 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 601 | 600 | Ubiquilin-4 | PRO_0000211015 | |||||
Regions | |||||||||
| Domain | 13 – 87 | 75 | Ubiquitin-like | ||||||
| Domain | 553 – 598 | 46 | UBA | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.8 | ||||||
| Modified residue | 318 | 1 | Phosphoserine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 495 | 1 | I → M: dbSNP rs2297792. Ref.2 Ref.5 | VAR_052685 | |||||
Experimental info | |||||||||
| Sequence conflict | 188 – 189 | 2 | QL → HV in AAF80171. Ref.1 | ||||||
| Sequence conflict | 298 | 1 | R → Q in AAF80171. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein." Davidson J.D., Riley B., Burright E.N., Duvick L.A., Zoghbi H.Y., Orr H.T. Hum. Mol. Genet. 9:2305-2312(2000) [PubMed: 11001934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH SCA1, TISSUE SPECIFICITY. Tissue: Brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-495. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Colon and PNS. |
| [5] | "Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes." Fogli A., Giglio S., Lo Nigro C., Zollo M., Viggiano L., Rocchi M., Archidiacono N., Zuffardi O., Carrozzo R. Cytogenet. Cell Genet. 86:225-232(1999) [PubMed: 10575211] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-601, VARIANT MET-495. |
| [6] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318, MASS SPECTROMETRY. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [8] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF188240 mRNA. Translation: AAF80171.1. AK314413 mRNA. Translation: BAG37034.1. AL355388 Genomic DNA. Translation: CAH72633.1. BC006410 mRNA. Translation: AAH06410.1. Different initiation. BC018403 mRNA. Translation: AAH18403.1. BC063841 mRNA. Translation: AAH63841.1. AF113544 mRNA. Translation: AAF19084.1. Different initiation. |
| IPI | IPI00024502. |
| RefSeq | NP_064516.2. |
| UniGene | Hs.283739 |
3D structure databases | |
| SMR | Q9NRR5. Positions 13-88, 548-598. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NRR5. 145 interactions. |
| STRING | Q9NRR5. |
PTM databases | |
| PhosphoSite | Q9NRR5. |
Proteomic databases | |
| PRIDE | Q9NRR5. |
Genome annotation databases | |
| Ensembl | ENST00000368309; ENSP00000357292; ENSG00000160803; Homo sapiens. [Genome view] |
| GeneID | 56893. |
| KEGG | hsa:56893. |
| UCSC | uc001fna.1. human. |
Organism-specific databases | |
| CTD | 56893. |
| GeneCards | GC01M154271. |
| H-InvDB | HIX0001143. HIX0057277. |
| HGNC | HGNC:1237. UBQLN4. |
| MIM | 605440. gene. |
| PharmGKB | PA25619. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG560425. |
| HOVERGEN | Q9NRR5. |
| InParanoid | Q9NRR5. |
| OMA | EPSGAET. |
| OrthoDB | EOG99KJ90. |
| PhylomeDB | Q9NRR5. |
Gene expression databases | |
| ArrayExpress | Q9NRR5. |
| Bgee | Q9NRR5. |
| CleanEx | HS_UBQLN4. |
| Genevestigator | Q9NRR5. |
| GermOnline | ENSG00000160803. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006636. STI1_HS_bd. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. IPR015496. Ubiquilin. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view] |
| PANTHER | PTHR10677. Ubiquilin. 1 hit. |
| Pfam | PF00627. UBA. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view] |
| SMART | SM00727. STI1. 4 hits. SM00165. UBA. 1 hit. SM00213. UBQ. 1 hit. [Graphical view] |
| PROSITE | PS50030. UBA. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62315. |
| SOURCE | Search... |
Entry information
| Entry name | UBQL4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NRR5 Secondary accession number(s): B2RAY7 Q9UHX4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


